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The map label for this gene is uppS2

Identifier: 145296237

GI number: 145296237

Start: 2378020

End: 2378751

Strand: Reverse

Name: uppS2

Synonym: cgR_2154

Alternate gene names: 145296237

Gene position: 2378751-2378020 (Counterclockwise)

Preceding gene: 145296238

Following gene: 145296236

Centisome position: 71.77

GC content: 56.01

Gene sequence:

>732_bases
GTGAGTGAATTCCAAGTCCCCGAAATCCCTGCCCAATTCCTACCCAAGCATATTGCGCTTGTCATGGATGGAAATGGACG
CTGGGCTACCGAGCGCGGCATGAAGCGCACCGAAGGCCATAAGCGTGGCGAGGCAGTCCTGCTTGATGTTGTTGATGCAT
GCATTGAACTTGGTGTTCCGTACCTTTCTGCTTATGCCTTCTCTACTGAAAACTGGCGTCGTTCCACCGATGAGGTCCGT
TTCCTCATGGGATTCAACCGAGATGTGCTGCGACGACAACGCGATGACCTACATGAAAAGGGCGTTCGTGTGCGTTGGGT
TGGCCGTCGTCCCCGCCTGTGGCGCTCGGTTATCCGTGAGCTGGAAACTGCGGAAGAGCTAACCAAAGACAACACCACCA
TGACCTTGGCCATGTGTGTGAACTATGGTGGACGCGCCGAAATCATCGACGCAGCCCGCGACATCGCCCGCCTTGCAGCT
GAAGGCAAACTGCGCCCGGAACAAATCACTGAGAAGACCTTCCCGAACTTCCTCGACGAACCTGACATGCCAGACGTCGA
CCTGTTCCTGCGCCCATCCGGTGAGAAGCGCACGTCAAACTTCCTGCTGTGGCAGTCTGCCTACGCGGAAATGGTCTACC
AAGACAAGCTGTTCCCCGATTTCACGCAGCAAGATCTGTACGACGCGGTCCTGGAATACGCCAAGCGGGATCGCAGATTC
GGAAGCGCATAA

Upstream 100 bases:

>100_bases
GGCTTTAAGGCCGAGGTGCCTGGCTGAACTGCAGCCCCTCCAGACCCTGAGATCAGGCTAAATGGCAAACACAAATAGTT
TGCATGGCAGAATAGCTTAG

Downstream 100 bases:

>100_bases
TGCCCACCAACCAGCCGACGCCAGCCCAAATCAAACGCTGGCGCGGATACCTGGCCAATGAGCAAGCAGAGGCCGCAGCC
TACCGCGACCTGGCCAAACG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 2; Di-trans,poly-cis-decaprenylcistransferase 2; Undecaprenyl diphosphate synthase 2; UDS 2

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSEFQVPEIPAQFLPKHIALVMDGNGRWATERGMKRTEGHKRGEAVLLDVVDACIELGVPYLSAYAFSTENWRRSTDEVR
FLMGFNRDVLRRQRDDLHEKGVRVRWVGRRPRLWRSVIRELETAEELTKDNTTMTLAMCVNYGGRAEIIDAARDIARLAA
EGKLRPEQITEKTFPNFLDEPDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQDKLFPDFTQQDLYDAVLEYAKRDRRF
GSA

Sequences:

>Translated_243_residues
MSEFQVPEIPAQFLPKHIALVMDGNGRWATERGMKRTEGHKRGEAVLLDVVDACIELGVPYLSAYAFSTENWRRSTDEVR
FLMGFNRDVLRRQRDDLHEKGVRVRWVGRRPRLWRSVIRELETAEELTKDNTTMTLAMCVNYGGRAEIIDAARDIARLAA
EGKLRPEQITEKTFPNFLDEPDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQDKLFPDFTQQDLYDAVLEYAKRDRRF
GSA
>Mature_242_residues
SEFQVPEIPAQFLPKHIALVMDGNGRWATERGMKRTEGHKRGEAVLLDVVDACIELGVPYLSAYAFSTENWRRSTDEVRF
LMGFNRDVLRRQRDDLHEKGVRVRWVGRRPRLWRSVIRELETAEELTKDNTTMTLAMCVNYGGRAEIIDAARDIARLAAE
GKLRPEQITEKTFPNFLDEPDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQDKLFPDFTQQDLYDAVLEYAKRDRRFG
SA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=228, Percent_Identity=35.5263157894737, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI45580742, Length=228, Percent_Identity=35.5263157894737, Blast_Score=146, Evalue=2e-35,
Organism=Escherichia coli, GI1786371, Length=235, Percent_Identity=40, Blast_Score=181, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=32.1739130434783, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=34.2592592592593, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=230, Percent_Identity=30.4347826086957, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI18857969, Length=229, Percent_Identity=32.7510917030568, Blast_Score=123, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS2_CORGL (Q8NNC1)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927154
- RefSeq:   NP_601483.1
- RefSeq:   YP_226526.1
- ProteinModelPortal:   Q8NNC1
- SMR:   Q8NNC1
- GeneID:   1020236
- GeneID:   3344555
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg2508
- KEGG:   cgl:NCgl2203
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- PhylomeDB:   Q8NNC1
- ProtClustDB:   PRK14829
- BioCyc:   CGLU196627:CG2508-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28226; Mature: 28095

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 23-23

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFQVPEIPAQFLPKHIALVMDGNGRWATERGMKRTEGHKRGEAVLLDVVDACIELGVP
CCCCCCCCCCHHHCHHHEEEEECCCCCCHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCH
YLSAYAFSTENWRRSTDEVRFLMGFNRDVLRRQRDDLHEKGVRVRWVGRRPRLWRSVIRE
HHHHHHHCCHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHH
LETAEELTKDNTTMTLAMCVNYGGRAEIIDAARDIARLAAEGKLRPEQITEKTFPNFLDE
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHCCC
PDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQDKLFPDFTQQDLYDAVLEYAKRDRRF
CCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
GSA
CCC
>Mature Secondary Structure 
SEFQVPEIPAQFLPKHIALVMDGNGRWATERGMKRTEGHKRGEAVLLDVVDACIELGVP
CCCCCCCCCHHHCHHHEEEEECCCCCCHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCCH
YLSAYAFSTENWRRSTDEVRFLMGFNRDVLRRQRDDLHEKGVRVRWVGRRPRLWRSVIRE
HHHHHHHCCHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHH
LETAEELTKDNTTMTLAMCVNYGGRAEIIDAARDIARLAAEGKLRPEQITEKTFPNFLDE
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHCCC
PDMPDVDLFLRPSGEKRTSNFLLWQSAYAEMVYQDKLFPDFTQQDLYDAVLEYAKRDRRF
CCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
GSA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626