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The map label for this gene is glyQS [H]

Identifier: 145296232

GI number: 145296232

Start: 2372604

End: 2373989

Strand: Reverse

Name: glyQS [H]

Synonym: cgR_2149

Alternate gene names: 145296232

Gene position: 2373989-2372604 (Counterclockwise)

Preceding gene: 145296236

Following gene: 145296231

Centisome position: 71.63

GC content: 54.11

Gene sequence:

>1386_bases
GTGGCTCAGCAATCGATCATCGACACCGTGGTTAACCTGTGTAAACGACGTGGACTGGTGTACCCCTGTGGTGAGATCTA
CGGCGGTACCCGCTCTGCGTGGGACTACGGCCCGCTGGGTGTGGAGCTGAAGGAAAACATCAAGCGCCAGTGGTGGCGTT
CTATGGTTACTTCCCGCCCAGATGTTGTGGGTGTTGATACTTCTGTCATCCTTCCTCGCCAGGTGTGGGTAACTTCCGGC
CACGTTGAGGTCTTCACTGACCCACTGGTTGAGTCTTTGAACACCCACAAGCGTTACCGTGCGGACCACCTGCTGGAGCA
GTACGAAGAGAAGCATGGTCACCCACCTGTAAACGGCTTGGCTGACATCAACGATCCAGAGACCGGCCAGCCAGGTAACT
GGACTGAGCCTAAGGCGTTCTCTGGTCTTCTGAAGACTTTCTTGGGACCTGTGGACGACGAAGAGGGTCTGCACTACCTG
CGCCCTGAAACTGCTCAGGGTATCTTCGTGAACTTCAAGAACGTGATGAACACTTCACGCATGAAGCCACCTTTCGGTAT
CGCGAACATCGGTAAGTCTTTCCGTAACGAGATCACCCCAGGTAACTTCATTTTCCGTACTCGTGAGTTCGAGCAGATGG
AGATGGAGTTCTTCGTCAAGCCTGGTGAGGACGAAGAGTGGCACCAGCACTGGATTGATACTCGCCTGCAGTGGTACATC
AACCTGGGCATTAAGCCTGAGAACCTGCGTCTGTACGAGCACCCTCAGGAGAAGCTGTCTCACTACTCCAAGCGCACTGT
TGATATTGAGTACGCATTCAACTTTGCTAACACCAAGTGGGGCGAGTTAGAGGGTATCGCGAACCGTACTGATTACGATC
TTCGCGTGCACTCTGAGGGCTCTGGTGAGGACCTGTCATTCTTCGATCAGGAGACCAATGAGCGTTGGATTCCTTTCGTA
ATCGAGCCTGCTGCAGGTCTTGGTCGCGCAATGATGATGTTCCTGATGGATGCTTATCACGAGGACGAGGCACCAAACTC
AAAGGGTGGCGTCGATAAGCGTGTTGTTCTGAAGCTTGACCGTCGCCTTGCGCCGGTTAAGGTTGCGGTCTTGCCGCTGT
CAAAGAAGGACACTTTGACGCCTTTGGCGGAAAAGCTCGCAGCAGAGCTGCGTGAATTCTGGAACGTTGATTACGACACT
TCAGGTGCGATTGGTCGCCGTTACCGTCGTCAGGACGAGATCGGTACTCCATTCTGCGTCACCGTTGACTTTGATTCTCT
CGAGGACAACGCTGTGACCGTGCGTGAGCGCGACACCATGGAGCAGGTTCGTGTTCCACTTGATGAGCTGCAGGGTTACT
TGGCTCAGCGCCTCATCGGCTGCTAA

Upstream 100 bases:

>100_bases
GGGTCAGCGGAAGCAACATCGTTAGTTGGGCTAGGATTGGTTGGGTATGTCCTAAAAGGGACGGTTATTTTTTCATTCGA
CGTGGAGGAGAGCATCCGAC

Downstream 100 bases:

>100_bases
ACGGCAACCGATAGAGCGATAATTCGCTAAGACGAATGTAATCGCAGCAACATATAGCACCGGCTTAACAGGCCGGTGCT
ATTCTGTTCGCATGACTTCG

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MAQQSIIDTVVNLCKRRGLVYPCGEIYGGTRSAWDYGPLGVELKENIKRQWWRSMVTSRPDVVGVDTSVILPRQVWVTSG
HVEVFTDPLVESLNTHKRYRADHLLEQYEEKHGHPPVNGLADINDPETGQPGNWTEPKAFSGLLKTFLGPVDDEEGLHYL
RPETAQGIFVNFKNVMNTSRMKPPFGIANIGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDEEWHQHWIDTRLQWYI
NLGIKPENLRLYEHPQEKLSHYSKRTVDIEYAFNFANTKWGELEGIANRTDYDLRVHSEGSGEDLSFFDQETNERWIPFV
IEPAAGLGRAMMMFLMDAYHEDEAPNSKGGVDKRVVLKLDRRLAPVKVAVLPLSKKDTLTPLAEKLAAELREFWNVDYDT
SGAIGRRYRRQDEIGTPFCVTVDFDSLEDNAVTVRERDTMEQVRVPLDELQGYLAQRLIGC

Sequences:

>Translated_461_residues
MAQQSIIDTVVNLCKRRGLVYPCGEIYGGTRSAWDYGPLGVELKENIKRQWWRSMVTSRPDVVGVDTSVILPRQVWVTSG
HVEVFTDPLVESLNTHKRYRADHLLEQYEEKHGHPPVNGLADINDPETGQPGNWTEPKAFSGLLKTFLGPVDDEEGLHYL
RPETAQGIFVNFKNVMNTSRMKPPFGIANIGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDEEWHQHWIDTRLQWYI
NLGIKPENLRLYEHPQEKLSHYSKRTVDIEYAFNFANTKWGELEGIANRTDYDLRVHSEGSGEDLSFFDQETNERWIPFV
IEPAAGLGRAMMMFLMDAYHEDEAPNSKGGVDKRVVLKLDRRLAPVKVAVLPLSKKDTLTPLAEKLAAELREFWNVDYDT
SGAIGRRYRRQDEIGTPFCVTVDFDSLEDNAVTVRERDTMEQVRVPLDELQGYLAQRLIGC
>Mature_460_residues
AQQSIIDTVVNLCKRRGLVYPCGEIYGGTRSAWDYGPLGVELKENIKRQWWRSMVTSRPDVVGVDTSVILPRQVWVTSGH
VEVFTDPLVESLNTHKRYRADHLLEQYEEKHGHPPVNGLADINDPETGQPGNWTEPKAFSGLLKTFLGPVDDEEGLHYLR
PETAQGIFVNFKNVMNTSRMKPPFGIANIGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDEEWHQHWIDTRLQWYIN
LGIKPENLRLYEHPQEKLSHYSKRTVDIEYAFNFANTKWGELEGIANRTDYDLRVHSEGSGEDLSFFDQETNERWIPFVI
EPAAGLGRAMMMFLMDAYHEDEAPNSKGGVDKRVVLKLDRRLAPVKVAVLPLSKKDTLTPLAEKLAAELREFWNVDYDTS
GAIGRRYRRQDEIGTPFCVTVDFDSLEDNAVTVRERDTMEQVRVPLDELQGYLAQRLIGC

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=356, Percent_Identity=31.4606741573034, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI70887790, Length=433, Percent_Identity=24.2494226327945, Blast_Score=96, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI32564541, Length=402, Percent_Identity=27.6119402985075, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17554996, Length=402, Percent_Identity=27.6119402985075, Blast_Score=148, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6325338, Length=370, Percent_Identity=29.4594594594595, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319597, Length=397, Percent_Identity=27.455919395466, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI21357965, Length=360, Percent_Identity=31.6666666666667, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24664462, Length=360, Percent_Identity=31.6666666666667, Blast_Score=166, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 53044; Mature: 52913

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50862 AA_TRNA_LIGASE_II ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQSIIDTVVNLCKRRGLVYPCGEIYGGTRSAWDYGPLGVELKENIKRQWWRSMVTSRP
CCHHHHHHHHHHHHHHCCCCEECHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
DVVGVDTSVILPRQVWVTSGHVEVFTDPLVESLNTHKRYRADHLLEQYEEKHGHPPVNGL
CEEECCCCEECCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ADINDPETGQPGNWTEPKAFSGLLKTFLGPVDDEEGLHYLRPETAQGIFVNFKNVMNTSR
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEEEEHHHHHHHHC
MKPPFGIANIGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDEEWHQHWIDTRLQWYI
CCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHHCEEEEECCCCCHHHHHHHHHCEEEEEE
NLGIKPENLRLYEHPQEKLSHYSKRTVDIEYAFNFANTKWGELEGIANRTDYDLRVHSEG
ECCCCCCCCEECCCHHHHHHHHHHCEEEEEEEEECCCCCCCHHCCCCCCCCCEEEEECCC
SGEDLSFFDQETNERWIPFVIEPAAGLGRAMMMFLMDAYHEDEAPNSKGGVDKRVVLKLD
CCCCCHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RRLAPVKVAVLPLSKKDTLTPLAEKLAAELREFWNVDYDTSGAIGRRYRRQDEIGTPFCV
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEE
TVDFDSLEDNAVTVRERDTMEQVRVPLDELQGYLAQRLIGC
EEECCCCCCCEEEEECHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQQSIIDTVVNLCKRRGLVYPCGEIYGGTRSAWDYGPLGVELKENIKRQWWRSMVTSRP
CHHHHHHHHHHHHHHCCCCEECHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
DVVGVDTSVILPRQVWVTSGHVEVFTDPLVESLNTHKRYRADHLLEQYEEKHGHPPVNGL
CEEECCCCEECCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ADINDPETGQPGNWTEPKAFSGLLKTFLGPVDDEEGLHYLRPETAQGIFVNFKNVMNTSR
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEEEEHHHHHHHHC
MKPPFGIANIGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDEEWHQHWIDTRLQWYI
CCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHHCEEEEECCCCCHHHHHHHHHCEEEEEE
NLGIKPENLRLYEHPQEKLSHYSKRTVDIEYAFNFANTKWGELEGIANRTDYDLRVHSEG
ECCCCCCCCEECCCHHHHHHHHHHCEEEEEEEEECCCCCCCHHCCCCCCCCCEEEEECCC
SGEDLSFFDQETNERWIPFVIEPAAGLGRAMMMFLMDAYHEDEAPNSKGGVDKRVVLKLD
CCCCCHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RRLAPVKVAVLPLSKKDTLTPLAEKLAAELREFWNVDYDTSGAIGRRYRRQDEIGTPFCV
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEE
TVDFDSLEDNAVTVRERDTMEQVRVPLDELQGYLAQRLIGC
EEECCCCCCCEEEEECHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]