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The map label for this gene is aceE [H]

Identifier: 145296203

GI number: 145296203

Start: 2340975

End: 2343743

Strand: Direct

Name: aceE [H]

Synonym: cgR_2120

Alternate gene names: 145296203

Gene position: 2340975-2343743 (Clockwise)

Preceding gene: 145296201

Following gene: 145296207

Centisome position: 70.64

GC content: 56.16

Gene sequence:

>2769_bases
ATGGCCGATCAAGCAAAACTTGGTGGCAAGCCCTCGGATGACTCTAACTTCGCGATGATCCGCGATGGCGTGGCATCTTA
TTTGAACGACTCAGATCCGGAGGAGACCAACGAGTGGATGGATTCACTCGACGGACTACTGCAGGAGTCTTCACCAGAAC
GTGCTCGTTACCTCATGCTTCGTTTGCTTGAGCGTGCATCTGCAAAGCGCGTATCTCTTCCCCCAATGACGTCAACCGAC
TACGTCAACACCATTCCAACCTCTATGGAACCTGAATTCCCAGGCGACGAGGAAATGGAAAAGCGTTACCGTCGTTGGAT
TCGCTGGAACGCAGCCATCATGGTTCACCGAGCTCAGCGACCAGGCATCGGCGTCGGCGGACACATTTCCACTTACGCAG
GCGCAGCCCCTCTGTACGAAGTTGGCTTCAACCACTTCTTCCGCGGCAAGGATCACCCAGGCGGCGGCGACCAGATCTTC
TTCCAGGGCCACGCATCACCAGGTATGTACGCACGTGCATTCATGGAGGGTCGCCTTTCTGAAGACGATCTCGATGGCTT
CCGTCAGGAAGTTTCCCGTGAGCAGGGTGGCATTCCGTCCTACCCTCACCCACACGGTATGAAGGACTTCTGGGAGTTCC
CAACTGTGTCCATGGGTCTTGGCCCAATGGATGCCATTTACCAGGCACGTTTCAACCGCTACCTCGAAAACCGTGGCATC
AAGGACACCTCTGACCAGCACGTCTGGGCCTTCCTTGGCGACGGCGAAATGGACGAGCCAGAATCACGTGGTCTCATCCA
GCAGGCTGCACTGAACAACCTGGACAACCTGACCTTCGTGGTTAACTGCAACCTGCAGCGTCTCGACGGACCTGTCCGCG
GTAACACCAAGATCATCCAGGAACTCGAGTCCTTCTTCCGTGGCGCAGGCTGGTCTGTGATCAAGGTTGTTTGGGGTCGC
GAGTGGGATGAACTTCTGGAGAAGGACCAGGATGGTGCACTTGTTGAGATCATGAACAACACCTCCGATGGTGACTACCA
GACCTTCAAGGCTAACGACGGCGCATATGTTCGTGAGCACTTCTTCGGACGTGACCCACGCACCGCAAAGCTCGTTGAGA
ACATGACCGACGAAGAAATCTGGAAGCTGCCACGTGGCGGCCACGATTACCGCAAGGTTTACGCAGCCTACAAGCGAGCT
CTTGAGACCAAGGATCGCCCAACCGTCATCCTTGCTCACACCATTAAGGGCTACGGACTCGGCCACAACTTCGAAGGCCG
TAACGCAACCCACCAGATGAAGAAGCTGACGCTTGATGATCTGAAGTTGTTCCGCGACAAGCAGGGCATCCCGATCACCG
ATGAGCAGCTGGAGAAGGATCCTTACCTTCCTCCTTACTACCACCCAGGTGAAGACGCTCCTGAAATCAAGTACATGAAG
GAACGTCGCGCAGCGCTCGGTGGCTACCTGCCAGAGCGTCGTGAGAACTACGATCCAATTCAGGTTCCACCACTGGATAA
GCTTCGCTCTGTCCGTAAGGGCTCCGGCAAGCAGCAGATCGCTACCACCATGGCGACTGTTCGTACCTTCAAGGAACTGA
TGCGCGATAAGGGCTTGGCTGATCGCCTTGTCCCAATCATTCCTGATGAGGCACGTACCTTCGGTCTTGACTCTTGGTTC
CCAACCTTGAAGATCTACAACCCGCACGGTCAGAACTACGTGCCTGTTGACCACGACCTGATGCTCTCCTACCGTGAGGC
ACCTGAAGGACAGATCCTGCACGAAGGCATCAACGAGGCTGGTTCCATGGCATCGTTCATCGCTGCGGGTACCTCCTACG
CCACCCACGGCAAGGCCATGATTCCGCTGTACATCTTCTACTCGATGTTCGGATTCCAGCGCACCGGTGACTCCATCTGG
GCAGCAGCCGATCAGATGGCACGTGGCTTCCTCTTGGGCGCTACCGCAGGTCGCACCACCCTGACCGGTGAAGGCCTCCA
GCACATGGATGGACACTCCCCTGTCTTGGCTTCCACCAACGAGGGTGTCGAGACCTACGACCCATCCTTTGCGTACGAGA
TCGCACACCTGGTTCACCGTGGCATCGACCGCATGTACGGCCCAGGCAAGGGTGAAGATGTTATCTACTACATCACCATC
TACAACGAGCCAACCCCACAGCCAGCTGAGCCAGAAGGACTGGATGTAGAAGGCCTGCACAAGGGCATCTACCTCTACTC
CCGCGGTGAAGGCACCGGCCATGAGGCAAACATCTTGGCTTCCGGTGTTGGTATGCAGTGGGCTCTCAAGGCTGCATCCA
TCCTTGAGGCTGACTACGGAGTTCGTGCCAACATTTACTCCGCTACTTCTTGGGTTAACTTGGCTCGCGATGGCGCTGCT
CGTAACAAGGCACAGCTGCGCAACCCAGGTGCAGATGCTGGCGAGGCATTCGTCACCACCCAGCTGAAGCAGACCTCCGG
CCCATACGTTGCAGTGTCTGACTTCTCCACTGATCTGCCAAACCAGATCCGTGAATGGGTCCCAGGCGACTACACCGTTC
TCGGTGCAGATGGCTTCGGTTTCTCTGATACCCGCCCAGCTGCTCGTCGCTTCTTCAACATCGACGCTGAGTCCATTGTT
GTTGCCGTGCTGAACTCCCTGGCACGCGAAGGCAAGATCGACGTCTCCGTTGCTGCTCAGGCTGCTGAGAAGTTCAAGTT
GGATGATCCTACGAGTGTTTCCGTAGATCCAAACGCTCCTGAGGAATAA

Upstream 100 bases:

>100_bases
TTAGTGCACTTCGGTGTGCCACAATTAGGTACGACCAAAAATGGGACCGGAAAACCGGGACGTATAAACAAAATAAAACA
TTCCAACAGGAGGTGTGGAA

Downstream 100 bases:

>100_bases
ATCACCTCAAGGGACAGATAAATCCCGCCGCCAGACGTTAGTCTGGCGGCGGGATTCGTCGTAAAGCAAGCTCTTTTTAG
CCGAGGAACGCCTTGTCGGA

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 922; Mature: 921

Protein sequence:

>922_residues
MADQAKLGGKPSDDSNFAMIRDGVASYLNDSDPEETNEWMDSLDGLLQESSPERARYLMLRLLERASAKRVSLPPMTSTD
YVNTIPTSMEPEFPGDEEMEKRYRRWIRWNAAIMVHRAQRPGIGVGGHISTYAGAAPLYEVGFNHFFRGKDHPGGGDQIF
FQGHASPGMYARAFMEGRLSEDDLDGFRQEVSREQGGIPSYPHPHGMKDFWEFPTVSMGLGPMDAIYQARFNRYLENRGI
KDTSDQHVWAFLGDGEMDEPESRGLIQQAALNNLDNLTFVVNCNLQRLDGPVRGNTKIIQELESFFRGAGWSVIKVVWGR
EWDELLEKDQDGALVEIMNNTSDGDYQTFKANDGAYVREHFFGRDPRTAKLVENMTDEEIWKLPRGGHDYRKVYAAYKRA
LETKDRPTVILAHTIKGYGLGHNFEGRNATHQMKKLTLDDLKLFRDKQGIPITDEQLEKDPYLPPYYHPGEDAPEIKYMK
ERRAALGGYLPERRENYDPIQVPPLDKLRSVRKGSGKQQIATTMATVRTFKELMRDKGLADRLVPIIPDEARTFGLDSWF
PTLKIYNPHGQNYVPVDHDLMLSYREAPEGQILHEGINEAGSMASFIAAGTSYATHGKAMIPLYIFYSMFGFQRTGDSIW
AAADQMARGFLLGATAGRTTLTGEGLQHMDGHSPVLASTNEGVETYDPSFAYEIAHLVHRGIDRMYGPGKGEDVIYYITI
YNEPTPQPAEPEGLDVEGLHKGIYLYSRGEGTGHEANILASGVGMQWALKAASILEADYGVRANIYSATSWVNLARDGAA
RNKAQLRNPGADAGEAFVTTQLKQTSGPYVAVSDFSTDLPNQIREWVPGDYTVLGADGFGFSDTRPAARRFFNIDAESIV
VAVLNSLAREGKIDVSVAAQAAEKFKLDDPTSVSVDPNAPEE

Sequences:

>Translated_922_residues
MADQAKLGGKPSDDSNFAMIRDGVASYLNDSDPEETNEWMDSLDGLLQESSPERARYLMLRLLERASAKRVSLPPMTSTD
YVNTIPTSMEPEFPGDEEMEKRYRRWIRWNAAIMVHRAQRPGIGVGGHISTYAGAAPLYEVGFNHFFRGKDHPGGGDQIF
FQGHASPGMYARAFMEGRLSEDDLDGFRQEVSREQGGIPSYPHPHGMKDFWEFPTVSMGLGPMDAIYQARFNRYLENRGI
KDTSDQHVWAFLGDGEMDEPESRGLIQQAALNNLDNLTFVVNCNLQRLDGPVRGNTKIIQELESFFRGAGWSVIKVVWGR
EWDELLEKDQDGALVEIMNNTSDGDYQTFKANDGAYVREHFFGRDPRTAKLVENMTDEEIWKLPRGGHDYRKVYAAYKRA
LETKDRPTVILAHTIKGYGLGHNFEGRNATHQMKKLTLDDLKLFRDKQGIPITDEQLEKDPYLPPYYHPGEDAPEIKYMK
ERRAALGGYLPERRENYDPIQVPPLDKLRSVRKGSGKQQIATTMATVRTFKELMRDKGLADRLVPIIPDEARTFGLDSWF
PTLKIYNPHGQNYVPVDHDLMLSYREAPEGQILHEGINEAGSMASFIAAGTSYATHGKAMIPLYIFYSMFGFQRTGDSIW
AAADQMARGFLLGATAGRTTLTGEGLQHMDGHSPVLASTNEGVETYDPSFAYEIAHLVHRGIDRMYGPGKGEDVIYYITI
YNEPTPQPAEPEGLDVEGLHKGIYLYSRGEGTGHEANILASGVGMQWALKAASILEADYGVRANIYSATSWVNLARDGAA
RNKAQLRNPGADAGEAFVTTQLKQTSGPYVAVSDFSTDLPNQIREWVPGDYTVLGADGFGFSDTRPAARRFFNIDAESIV
VAVLNSLAREGKIDVSVAAQAAEKFKLDDPTSVSVDPNAPEE
>Mature_921_residues
ADQAKLGGKPSDDSNFAMIRDGVASYLNDSDPEETNEWMDSLDGLLQESSPERARYLMLRLLERASAKRVSLPPMTSTDY
VNTIPTSMEPEFPGDEEMEKRYRRWIRWNAAIMVHRAQRPGIGVGGHISTYAGAAPLYEVGFNHFFRGKDHPGGGDQIFF
QGHASPGMYARAFMEGRLSEDDLDGFRQEVSREQGGIPSYPHPHGMKDFWEFPTVSMGLGPMDAIYQARFNRYLENRGIK
DTSDQHVWAFLGDGEMDEPESRGLIQQAALNNLDNLTFVVNCNLQRLDGPVRGNTKIIQELESFFRGAGWSVIKVVWGRE
WDELLEKDQDGALVEIMNNTSDGDYQTFKANDGAYVREHFFGRDPRTAKLVENMTDEEIWKLPRGGHDYRKVYAAYKRAL
ETKDRPTVILAHTIKGYGLGHNFEGRNATHQMKKLTLDDLKLFRDKQGIPITDEQLEKDPYLPPYYHPGEDAPEIKYMKE
RRAALGGYLPERRENYDPIQVPPLDKLRSVRKGSGKQQIATTMATVRTFKELMRDKGLADRLVPIIPDEARTFGLDSWFP
TLKIYNPHGQNYVPVDHDLMLSYREAPEGQILHEGINEAGSMASFIAAGTSYATHGKAMIPLYIFYSMFGFQRTGDSIWA
AADQMARGFLLGATAGRTTLTGEGLQHMDGHSPVLASTNEGVETYDPSFAYEIAHLVHRGIDRMYGPGKGEDVIYYITIY
NEPTPQPAEPEGLDVEGLHKGIYLYSRGEGTGHEANILASGVGMQWALKAASILEADYGVRANIYSATSWVNLARDGAAR
NKAQLRNPGADAGEAFVTTQLKQTSGPYVAVSDFSTDLPNQIREWVPGDYTVLGADGFGFSDTRPAARRFFNIDAESIVV
AVLNSLAREGKIDVSVAAQAAEKFKLDDPTSVSVDPNAPEE

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=883, Percent_Identity=51.1891279728199, Blast_Score=907, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 102859; Mature: 102728

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADQAKLGGKPSDDSNFAMIRDGVASYLNDSDPEETNEWMDSLDGLLQESSPERARYLML
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
RLLERASAKRVSLPPMTSTDYVNTIPTSMEPEFPGDEEMEKRYRRWIRWNAAIMVHRAQR
HHHHHHCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEEECCC
PGIGVGGHISTYAGAAPLYEVGFNHFFRGKDHPGGGDQIFFQGHASPGMYARAFMEGRLS
CCCCCCCCHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCC
EDDLDGFRQEVSREQGGIPSYPHPHGMKDFWEFPTVSMGLGPMDAIYQARFNRYLENRGI
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
KDTSDQHVWAFLGDGEMDEPESRGLIQQAALNNLDNLTFVVNCNLQRLDGPVRGNTKIIQ
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHCCCCCCCCHHHHH
ELESFFRGAGWSVIKVVWGREWDELLEKDQDGALVEIMNNTSDGDYQTFKANDGAYVREH
HHHHHHCCCCCEEEEEECCCCHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCCCHHHHH
FFGRDPRTAKLVENMTDEEIWKLPRGGHDYRKVYAAYKRALETKDRPTVILAHTIKGYGL
HCCCCCCHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
GHNFEGRNATHQMKKLTLDDLKLFRDKQGIPITDEQLEKDPYLPPYYHPGEDAPEIKYMK
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHH
ERRAALGGYLPERRENYDPIQVPPLDKLRSVRKGSGKQQIATTMATVRTFKELMRDKGLA
HHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCH
DRLVPIIPDEARTFGLDSWFPTLKIYNPHGQNYVPVDHDLMLSYREAPEGQILHEGINEA
HHCCCCCCCCHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHH
GSMASFIAAGTSYATHGKAMIPLYIFYSMFGFQRTGDSIWAAADQMARGFLLGATAGRTT
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCCE
LTGEGLQHMDGHSPVLASTNEGVETYDPSFAYEIAHLVHRGIDRMYGPGKGEDVIYYITI
ECCCCHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEE
YNEPTPQPAEPEGLDVEGLHKGIYLYSRGEGTGHEANILASGVGMQWALKAASILEADYG
ECCCCCCCCCCCCCCHHHHCCCEEEEECCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCC
VRANIYSATSWVNLARDGAARNKAQLRNPGADAGEAFVTTQLKQTSGPYVAVSDFSTDLP
CEEEEEHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHEEEEHHHCCCCEEEECCCCCCCH
NQIREWVPGDYTVLGADGFGFSDTRPAARRFFNIDAESIVVAVLNSLAREGKIDVSVAAQ
HHHHHHCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
AAEKFKLDDPTSVSVDPNAPEE
HHHHCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
ADQAKLGGKPSDDSNFAMIRDGVASYLNDSDPEETNEWMDSLDGLLQESSPERARYLML
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
RLLERASAKRVSLPPMTSTDYVNTIPTSMEPEFPGDEEMEKRYRRWIRWNAAIMVHRAQR
HHHHHHCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEEECCC
PGIGVGGHISTYAGAAPLYEVGFNHFFRGKDHPGGGDQIFFQGHASPGMYARAFMEGRLS
CCCCCCCCHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCC
EDDLDGFRQEVSREQGGIPSYPHPHGMKDFWEFPTVSMGLGPMDAIYQARFNRYLENRGI
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
KDTSDQHVWAFLGDGEMDEPESRGLIQQAALNNLDNLTFVVNCNLQRLDGPVRGNTKIIQ
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHCCCCCCCCHHHHH
ELESFFRGAGWSVIKVVWGREWDELLEKDQDGALVEIMNNTSDGDYQTFKANDGAYVREH
HHHHHHCCCCCEEEEEECCCCHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCCCHHHHH
FFGRDPRTAKLVENMTDEEIWKLPRGGHDYRKVYAAYKRALETKDRPTVILAHTIKGYGL
HCCCCCCHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
GHNFEGRNATHQMKKLTLDDLKLFRDKQGIPITDEQLEKDPYLPPYYHPGEDAPEIKYMK
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHH
ERRAALGGYLPERRENYDPIQVPPLDKLRSVRKGSGKQQIATTMATVRTFKELMRDKGLA
HHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCH
DRLVPIIPDEARTFGLDSWFPTLKIYNPHGQNYVPVDHDLMLSYREAPEGQILHEGINEA
HHCCCCCCCCHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHH
GSMASFIAAGTSYATHGKAMIPLYIFYSMFGFQRTGDSIWAAADQMARGFLLGATAGRTT
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCCE
LTGEGLQHMDGHSPVLASTNEGVETYDPSFAYEIAHLVHRGIDRMYGPGKGEDVIYYITI
ECCCCHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEE
YNEPTPQPAEPEGLDVEGLHKGIYLYSRGEGTGHEANILASGVGMQWALKAASILEADYG
ECCCCCCCCCCCCCCHHHHCCCEEEEECCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCC
VRANIYSATSWVNLARDGAARNKAQLRNPGADAGEAFVTTQLKQTSGPYVAVSDFSTDLP
CEEEEEHHHHHHHHHHCCCCCCHHHHCCCCCCCCCHHEEEEHHHCCCCEEEECCCCCCCH
NQIREWVPGDYTVLGADGFGFSDTRPAARRFFNIDAESIVVAVLNSLAREGKIDVSVAAQ
HHHHHHCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
AAEKFKLDDPTSVSVDPNAPEE
HHHHCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA