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The map label for this gene is hmuO [H]

Identifier: 145296185

GI number: 145296185

Start: 2321207

End: 2321854

Strand: Reverse

Name: hmuO [H]

Synonym: cgR_2104

Alternate gene names: 145296185

Gene position: 2321854-2321207 (Counterclockwise)

Preceding gene: 145296186

Following gene: 145296184

Centisome position: 70.06

GC content: 52.31

Gene sequence:

>648_bases
ATGACAAGCATTATTGCAAGCAACAGCGACCTATCGGAGGAGCTGCGCACCCACACTGCGCGGGCCCATGAAGAGGCCGA
GCACTCAACGTTTATGAATGATCTGCTCATCGGGAAGCTCGATGCGCAGGCATTTATCAAGTTGCAGGAGCAATCATGGT
TGTTCTACACCGCTTTGGAAGCTGCAGCTCGCGCATGTGCAGAGGATTCCCGTGCGACTGGTCTGCTGGACCCACGCCTC
GAGCGCAAGGAAACGTTGGAAGCTGATCTGGATAAGCTGCACGAAAACACCACCTGGCGTGACAACGTCACGGCCACTGC
AGCGACAGCGTCTTATGTGGAACGTCTTGAAAGCATCGAAGCGGCCAAGGATTTCCCTCGTTTGGTTGCTCATCACTATG
TCCGCTACCTGGGTGATTTGTCCGGTGGGCAGGTTATTGCACGTCTGGTGAACAGGGAATATGGAGTTTCGGAAGAGGCG
TTGAGCTTCTATCGCTTTGAAGATCTTGGCAAGCTCAAGCCGTACAAGGATAATTACCGTGCAGAGCTTGATGCTTTGGA
ATTAACAGCAGAGGAGCGTGCTGCGTTGCTGGATGAAGCATCTGATGCGTTCAGGTTTAATCAGCAAGTTTTTCAGGCTC
TTGCTTAA

Upstream 100 bases:

>100_bases
AGGATTTCTCTGAGGAATCTAGACGCAGATTAACTTCCGCTTGGCAGCGACCGGGATAACACCGCGGTTGCGGCCACGCA
GGCTCACAAAGGACACCACT

Downstream 100 bases:

>100_bases
CCGAAGGTGAAGTCTTGGCGAAGAGTCGGGGAGTTCCCTGATCTTTGCCCCTAAGTGGTTTACGGGCTGGAAAATGGTAC
GTAGTCTCGGGTGTAAAGCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MTSIIASNSDLSEELRTHTARAHEEAEHSTFMNDLLIGKLDAQAFIKLQEQSWLFYTALEAAARACAEDSRATGLLDPRL
ERKETLEADLDKLHENTTWRDNVTATAATASYVERLESIEAAKDFPRLVAHHYVRYLGDLSGGQVIARLVNREYGVSEEA
LSFYRFEDLGKLKPYKDNYRAELDALELTAEERAALLDEASDAFRFNQQVFQALA

Sequences:

>Translated_215_residues
MTSIIASNSDLSEELRTHTARAHEEAEHSTFMNDLLIGKLDAQAFIKLQEQSWLFYTALEAAARACAEDSRATGLLDPRL
ERKETLEADLDKLHENTTWRDNVTATAATASYVERLESIEAAKDFPRLVAHHYVRYLGDLSGGQVIARLVNREYGVSEEA
LSFYRFEDLGKLKPYKDNYRAELDALELTAEERAALLDEASDAFRFNQQVFQALA
>Mature_214_residues
TSIIASNSDLSEELRTHTARAHEEAEHSTFMNDLLIGKLDAQAFIKLQEQSWLFYTALEAAARACAEDSRATGLLDPRLE
RKETLEADLDKLHENTTWRDNVTATAATASYVERLESIEAAKDFPRLVAHHYVRYLGDLSGGQVIARLVNREYGVSEEAL
SFYRFEDLGKLKPYKDNYRAELDALELTAEERAALLDEASDAFRFNQQVFQALA

Specific function: Allows the bacteria to use the host heme as an iron source. Involved in the oxidation of heme and subsequent release of iron from the heme moiety [H]

COG id: COG5398

COG function: function code P; Heme oxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme oxygenase family [H]

Homologues:

Organism=Homo sapiens, GI187761311, Length=210, Percent_Identity=34.2857142857143, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI187761309, Length=210, Percent_Identity=34.2857142857143, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI187761307, Length=210, Percent_Identity=34.2857142857143, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI8051608, Length=210, Percent_Identity=34.2857142857143, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI4504437, Length=209, Percent_Identity=33.9712918660287, Blast_Score=107, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002051
- InterPro:   IPR016053
- InterPro:   IPR016084
- InterPro:   IPR018207 [H]

Pfam domain/function: PF01126 Heme_oxygenase [H]

EC number: =1.14.99.3 [H]

Molecular weight: Translated: 24306; Mature: 24175

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00593 HEME_OXYGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSIIASNSDLSEELRTHTARAHEEAEHSTFMNDLLIGKLDAQAFIKLQEQSWLFYTALE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHH
AAARACAEDSRATGLLDPRLERKETLEADLDKLHENTTWRDNVTATAATASYVERLESIE
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
AAKDFPRLVAHHYVRYLGDLSGGQVIARLVNREYGVSEEALSFYRFEDLGKLKPYKDNYR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHH
AELDALELTAEERAALLDEASDAFRFNQQVFQALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TSIIASNSDLSEELRTHTARAHEEAEHSTFMNDLLIGKLDAQAFIKLQEQSWLFYTALE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHH
AAARACAEDSRATGLLDPRLERKETLEADLDKLHENTTWRDNVTATAATASYVERLESIE
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
AAKDFPRLVAHHYVRYLGDLSGGQVIARLVNREYGVSEEALSFYRFEDLGKLKPYKDNYR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHH
AELDALELTAEERAALLDEASDAFRFNQQVFQALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9006041; 14602910 [H]