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The map label for this gene is thrC [H]

Identifier: 145296180

GI number: 145296180

Start: 2316034

End: 2317479

Strand: Reverse

Name: thrC [H]

Synonym: cgR_2099

Alternate gene names: 145296180

Gene position: 2317479-2316034 (Counterclockwise)

Preceding gene: 145296184

Following gene: 145296176

Centisome position: 69.93

GC content: 56.15

Gene sequence:

>1446_bases
GTGGACTACATTTCGACGCGTGATGCCAGCCGTACCCCTGCCCGCTTCAGTGATATTTTGCTGGGCGGTCTAGCACCAGA
CGGCGGCCTATACCTGCCTGCAACCTACCCTCAACTAGATGATGCCCAGCTGAGTAAATGGCGTGAGGTATTAGCCAACG
AAGGATACGCAGCTTTGGCTGCTGAAGTTATCTCCCTGTTTGTTGATGACATCCCAGTAGAAGACATCAAGGCGATCACC
GCACGCGCCTACACCTACCCGAAGTTCAACAGCGAAGACATCGTTCCTGTCACCGAACTCGAGGACAACATTTACCTGGG
CCACCTTTCCGAAGGCCCAACCGCTGCATTCAAAGACATGGCCATGCAGCTGCTCGGCGAACTTTTCGAATACGAGCTTC
GCCGCCGCAACGAAACCATCAACATCCTAGGCGCTACCTCTGGCGATACCGGCTCCTCTGCGGAATACGCCATGCGCGGC
CGCGAGGGAATCCGCGTATTCATGCTGACCCCAGCTGGCCGCATGACCCCATTCCAGCAAGCACAGATGTTTGGCCTTGA
CGATCCAAACATCTTCAACATCGCCCTCGACGGCGTTTTCGACGATTGCCAAGACGTAGTCAAGGCTGTCTCCGCCGACG
CGGAATTTAAAAAAGACAACCGCATCGGTGCCGTGAACTCCATCAACTGGGCTCGCCTCATGGCACAGGTTGTGTACTAC
GTTTCCTCATGGATCCGCACCACAACCAGCAATGACCAAAAGGTCAGCTTCTCCGTACCAACCGGCAACTTCGGTGACAT
TTGCGCAGGCCACATCGCCCGCCAAATGGGACTTCCCATCGATCGCCTCATCGTGGCCACCAACGAAAACGATGTGCTCG
ACGAGTTCTTCCGTACCGGCGACTACCGAGTCCGCAGCTCCGCAGACACCCACGAGACCTCCTCACCTTCGATGGATATC
TCCCGCGCCTCCAACTTCGAGCGTTTCATCTTCGACCTGCTCGGCCGCGACGCCACCCGCGTCAACGATCTATTTGGTAC
CCAGGTTCGCCAAGGCGGATTCTCACTGGCTGATGACGCCAACTTTGAAAAGGCTGCAGCAGAATACGGTTTCGCCTCCG
GACGATCCACCCATGCTGACCGTGTGGCAACCATCGCTGACGTGCATTCCCGCCTCGACGTACTAATCGATCCCCACACC
GCCGACGGCGTTCACGTGGCACGCCAGTGGAGGGACGAGGTCAACACCCCAATCATCGTCCTAGAAACTGCACTCCCAGT
GAAATTTGCCGACACCATCGTCGAAGCAATTGGTGAAGCACCTCAAACTCCAGAGCGTTTCGCCGCGATCATGGATGCTC
CATTCAAGGTTTCCGACCTACCAAACGACACCGATGCAGTTAAGCAGTACATCGTCGATGCGATTGCAAGCACTTCCGTG
AAGTAA

Upstream 100 bases:

>100_bases
GCAACACTTTAGGGTATCGCGTGGGCGAAGTCACCTTTTTCAACATATTTGAGACGGTGTGGGGGAGTATTGTGTCACCC
CTTGGGATAGGGTTATATCC

Downstream 100 bases:

>100_bases
CTTGCTTTACGCCAAGGCCTGATTCCTCTCTTTATGGGATGGAACCAGGCCTTTCGCATTGAGTGGCGTTTTAAGGCCCC
CAATTCTTAGAACGGGTATT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MDYISTRDASRTPARFSDILLGGLAPDGGLYLPATYPQLDDAQLSKWREVLANEGYAALAAEVISLFVDDIPVEDIKAIT
ARAYTYPKFNSEDIVPVTELEDNIYLGHLSEGPTAAFKDMAMQLLGELFEYELRRRNETINILGATSGDTGSSAEYAMRG
REGIRVFMLTPAGRMTPFQQAQMFGLDDPNIFNIALDGVFDDCQDVVKAVSADAEFKKDNRIGAVNSINWARLMAQVVYY
VSSWIRTTTSNDQKVSFSVPTGNFGDICAGHIARQMGLPIDRLIVATNENDVLDEFFRTGDYRVRSSADTHETSSPSMDI
SRASNFERFIFDLLGRDATRVNDLFGTQVRQGGFSLADDANFEKAAAEYGFASGRSTHADRVATIADVHSRLDVLIDPHT
ADGVHVARQWRDEVNTPIIVLETALPVKFADTIVEAIGEAPQTPERFAAIMDAPFKVSDLPNDTDAVKQYIVDAIASTSV
K

Sequences:

>Translated_481_residues
MDYISTRDASRTPARFSDILLGGLAPDGGLYLPATYPQLDDAQLSKWREVLANEGYAALAAEVISLFVDDIPVEDIKAIT
ARAYTYPKFNSEDIVPVTELEDNIYLGHLSEGPTAAFKDMAMQLLGELFEYELRRRNETINILGATSGDTGSSAEYAMRG
REGIRVFMLTPAGRMTPFQQAQMFGLDDPNIFNIALDGVFDDCQDVVKAVSADAEFKKDNRIGAVNSINWARLMAQVVYY
VSSWIRTTTSNDQKVSFSVPTGNFGDICAGHIARQMGLPIDRLIVATNENDVLDEFFRTGDYRVRSSADTHETSSPSMDI
SRASNFERFIFDLLGRDATRVNDLFGTQVRQGGFSLADDANFEKAAAEYGFASGRSTHADRVATIADVHSRLDVLIDPHT
ADGVHVARQWRDEVNTPIIVLETALPVKFADTIVEAIGEAPQTPERFAAIMDAPFKVSDLPNDTDAVKQYIVDAIASTSV
K
>Mature_481_residues
MDYISTRDASRTPARFSDILLGGLAPDGGLYLPATYPQLDDAQLSKWREVLANEGYAALAAEVISLFVDDIPVEDIKAIT
ARAYTYPKFNSEDIVPVTELEDNIYLGHLSEGPTAAFKDMAMQLLGELFEYELRRRNETINILGATSGDTGSSAEYAMRG
REGIRVFMLTPAGRMTPFQQAQMFGLDDPNIFNIALDGVFDDCQDVVKAVSADAEFKKDNRIGAVNSINWARLMAQVVYY
VSSWIRTTTSNDQKVSFSVPTGNFGDICAGHIARQMGLPIDRLIVATNENDVLDEFFRTGDYRVRSSADTHETSSPSMDI
SRASNFERFIFDLLGRDATRVNDLFGTQVRQGGFSLADDANFEKAAAEYGFASGRSTHADRVATIADVHSRLDVLIDPHT
ADGVHVARQWRDEVNTPIIVLETALPVKFADTIVEAIGEAPQTPERFAAIMDAPFKVSDLPNDTDAVKQYIVDAIASTSV
K

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=458, Percent_Identity=29.4759825327511, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI153792148, Length=460, Percent_Identity=31.5217391304348, Blast_Score=207, Evalue=2e-53,
Organism=Escherichia coli, GI1786185, Length=464, Percent_Identity=28.8793103448276, Blast_Score=183, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6319901, Length=467, Percent_Identity=39.6145610278373, Blast_Score=316, Evalue=4e-87,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 52905; Mature: 52905

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYISTRDASRTPARFSDILLGGLAPDGGLYLPATYPQLDDAQLSKWREVLANEGYAALA
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCHHHHH
AEVISLFVDDIPVEDIKAITARAYTYPKFNSEDIVPVTELEDNIYLGHLSEGPTAAFKDM
HHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCCCEECCCCEEEEECCCCCHHHHHHH
AMQLLGELFEYELRRRNETINILGATSGDTGSSAEYAMRGREGIRVFMLTPAGRMTPFQQ
HHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHCCCCCCEEEEECCCCCCCCHHH
AQMFGLDDPNIFNIALDGVFDDCQDVVKAVSADAEFKKDNRIGAVNSINWARLMAQVVYY
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCHHHHHHHHHHHH
VSSWIRTTTSNDQKVSFSVPTGNFGDICAGHIARQMGLPIDRLIVATNENDVLDEFFRTG
HHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHCC
DYRVRSSADTHETSSPSMDISRASNFERFIFDLLGRDATRVNDLFGTQVRQGGFSLADDA
CEEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCC
NFEKAAAEYGFASGRSTHADRVATIADVHSRLDVLIDPHTADGVHVARQWRDEVNTPIIV
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCEEECCCCCCHHHHHHHHHHHCCCCEEE
LETALPVKFADTIVEAIGEAPQTPERFAAIMDAPFKVSDLPNDTDAVKQYIVDAIASTSV
EECCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHCCC
K
C
>Mature Secondary Structure
MDYISTRDASRTPARFSDILLGGLAPDGGLYLPATYPQLDDAQLSKWREVLANEGYAALA
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCHHHHH
AEVISLFVDDIPVEDIKAITARAYTYPKFNSEDIVPVTELEDNIYLGHLSEGPTAAFKDM
HHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCCCEECCCCEEEEECCCCCHHHHHHH
AMQLLGELFEYELRRRNETINILGATSGDTGSSAEYAMRGREGIRVFMLTPAGRMTPFQQ
HHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHCCCCCCEEEEECCCCCCCCHHH
AQMFGLDDPNIFNIALDGVFDDCQDVVKAVSADAEFKKDNRIGAVNSINWARLMAQVVYY
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCHHHHHHHHHHHH
VSSWIRTTTSNDQKVSFSVPTGNFGDICAGHIARQMGLPIDRLIVATNENDVLDEFFRTG
HHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHCC
DYRVRSSADTHETSSPSMDISRASNFERFIFDLLGRDATRVNDLFGTQVRQGGFSLADDA
CEEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCC
NFEKAAAEYGFASGRSTHADRVATIADVHSRLDVLIDPHTADGVHVARQWRDEVNTPIIV
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCEEECCCCCCHHHHHHHHHHHCCCCEEE
LETALPVKFADTIVEAIGEAPQTPERFAAIMDAPFKVSDLPNDTDAVKQYIVDAIASTSV
EECCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2127631; 12948626 [H]