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The map label for this gene is mtr [H]

Identifier: 145295907

GI number: 145295907

Start: 2035933

End: 2037330

Strand: Direct

Name: mtr [H]

Synonym: cgR_1832

Alternate gene names: 145295907

Gene position: 2035933-2037330 (Clockwise)

Preceding gene: 145295906

Following gene: 145295908

Centisome position: 61.43

GC content: 53.51

Gene sequence:

>1398_bases
ATGTCTGAGCAGCCAGCTTCCATTAAGCATTATGACCTCATCATCATTGGTACCGGCTCTGGAAACTCCATTCCTGGACC
AGAGTTTGATGATAAATCCATTGCCATCGTGGAAAAGGGTGCTTTCGGCGGAACTTGCCTCAATGTGGGCTGCATCCCTA
CCAAGATGTACGTTTACGCTGCGGATATCGCTCAAGAAATTCAGGAGTCTGCTCGCCTGGGTATCGATGCGACGGTCAAC
AGCGTGGATTGGCCTTCCATCGTCAGCCGCGTTTTCGACAAACGCATCGACCTCATCGCGCAAGGCGGCGAGGCTTATCG
ACGTGGCCCCGAAACTCCAAACATCGATGTGTATGACATGCACGCATCGTTTGTTGATTCCAAGACAATCTCCACTGGTA
TTGCCGGCCAAGAACAGCTGATCAGCGGTACTGACATTGTAATCGCAACCGGCTCCCGCCCTTACATCCCTGAAGCTATT
GCAGAGTCCGGCGCACGCTACTACACCAACGAAGACATCATGCGCCTGCCACAGCAGCCTGAATCTTTGGTGATTGTTGG
TGGCGGTTTCATCGCTTTGGAATTTGCTCACGTTTTTGAAGCGCTTGGCACCAAGGTCACCATCCTCAACCGCTCTGACG
TGCTGCTGCGCGAGGCAGATGCAGACATCTCCGCGAAAATCCTCGAGCTTTCCAAAAAGCGTTTCGACGTCCGCCTCAGC
ACTGCGGTCACCGCAGTACACAACAAGGCCGACGGAGGCGTGAAGATCTCCATCGACACCGGCGACGACATCGAGGCAGA
TATTTTGCTCGTTGCCACTGGTCGCACCCCTAACGGCAACCAAATGAACTTGGACGCCGCAGGCATCGAGATGAACGGTC
GTTCCATCAAGGTTGATGAATTCGGTCGCACCAGTGTTGAAGGCGTGTGGGCGCTTGGCGATGTCTCCTCCCCTTACAAG
CTCAAGCACGTGGCCAATGCAGAAATGCGAGCAATCAAGCACAACCTCGCTAACCCTGATGACCTGCAGAAGATGCCACA
TGATTTCGTGCCATCAGCTGTTTTCACCAACCCACAGATCGCCCAGGTCGGCATGACTGAACAGGAGGCGCGTGAAGCAG
GCCTCAACATCACCGTGAAGATCCAGAATTACTCCGACGTTGCTTACGGCTGGGCAATGGAAGATAAGGACGGGTTCGTC
AAGCTCATTGCCGATAAGGACACCGGCAAGTTGGTCGGGGCGCACATCATTGGTGCTCAGGCCTCAACACTGATCCAGCA
ACTGATCACGGTCATGGCATTTGGAATCGATGCACGAGAAGCAGCAACCAAGCAGTACTGGATTCACCCTGCTCTTCCAG
AAGTCATTGAAAATGCTCTTCTGGGGTTAGAGTTTTAG

Upstream 100 bases:

>100_bases
TTTTATAGTCATATGCGTTGAGATACGTGGACGACAAAGCACCAGTTGGTTGCCTTCCCAGTCCAGCCCACATCCGATTT
CTAAATTAGGAGCATATCTT

Downstream 100 bases:

>100_bases
AAGCTTACGCAGCCGTAAGTTTTGAGTGCAGAAAATTTTCCATGTCAAGTTAAACTCGTTAATGAAGATGGAAAATAAGT
TGTTTCTAAGATTAAATTAA

Product: mycothione reductase

Products: NA

Alternate protein names: Mycothiol-disulfide reductase; NADPH-dependent mycothione reductase [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSEQPASIKHYDLIIIGTGSGNSIPGPEFDDKSIAIVEKGAFGGTCLNVGCIPTKMYVYAADIAQEIQESARLGIDATVN
SVDWPSIVSRVFDKRIDLIAQGGEAYRRGPETPNIDVYDMHASFVDSKTISTGIAGQEQLISGTDIVIATGSRPYIPEAI
AESGARYYTNEDIMRLPQQPESLVIVGGGFIALEFAHVFEALGTKVTILNRSDVLLREADADISAKILELSKKRFDVRLS
TAVTAVHNKADGGVKISIDTGDDIEADILLVATGRTPNGNQMNLDAAGIEMNGRSIKVDEFGRTSVEGVWALGDVSSPYK
LKHVANAEMRAIKHNLANPDDLQKMPHDFVPSAVFTNPQIAQVGMTEQEAREAGLNITVKIQNYSDVAYGWAMEDKDGFV
KLIADKDTGKLVGAHIIGAQASTLIQQLITVMAFGIDAREAATKQYWIHPALPEVIENALLGLEF

Sequences:

>Translated_465_residues
MSEQPASIKHYDLIIIGTGSGNSIPGPEFDDKSIAIVEKGAFGGTCLNVGCIPTKMYVYAADIAQEIQESARLGIDATVN
SVDWPSIVSRVFDKRIDLIAQGGEAYRRGPETPNIDVYDMHASFVDSKTISTGIAGQEQLISGTDIVIATGSRPYIPEAI
AESGARYYTNEDIMRLPQQPESLVIVGGGFIALEFAHVFEALGTKVTILNRSDVLLREADADISAKILELSKKRFDVRLS
TAVTAVHNKADGGVKISIDTGDDIEADILLVATGRTPNGNQMNLDAAGIEMNGRSIKVDEFGRTSVEGVWALGDVSSPYK
LKHVANAEMRAIKHNLANPDDLQKMPHDFVPSAVFTNPQIAQVGMTEQEAREAGLNITVKIQNYSDVAYGWAMEDKDGFV
KLIADKDTGKLVGAHIIGAQASTLIQQLITVMAFGIDAREAATKQYWIHPALPEVIENALLGLEF
>Mature_464_residues
SEQPASIKHYDLIIIGTGSGNSIPGPEFDDKSIAIVEKGAFGGTCLNVGCIPTKMYVYAADIAQEIQESARLGIDATVNS
VDWPSIVSRVFDKRIDLIAQGGEAYRRGPETPNIDVYDMHASFVDSKTISTGIAGQEQLISGTDIVIATGSRPYIPEAIA
ESGARYYTNEDIMRLPQQPESLVIVGGGFIALEFAHVFEALGTKVTILNRSDVLLREADADISAKILELSKKRFDVRLST
AVTAVHNKADGGVKISIDTGDDIEADILLVATGRTPNGNQMNLDAAGIEMNGRSIKVDEFGRTSVEGVWALGDVSSPYKL
KHVANAEMRAIKHNLANPDDLQKMPHDFVPSAVFTNPQIAQVGMTEQEAREAGLNITVKIQNYSDVAYGWAMEDKDGFVK
LIADKDTGKLVGAHIIGAQASTLIQQLITVMAFGIDAREAATKQYWIHPALPEVIENALLGLEF

Specific function: Catalyzes the NAD(P)H-dependent reduction of mycothione (the oxidized disulfide form of mycothiol) to mycothiol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=439, Percent_Identity=28.7015945330296, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI91199540, Length=469, Percent_Identity=27.2921108742004, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI22035672, Length=435, Percent_Identity=30.1149425287356, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI291045266, Length=436, Percent_Identity=26.8348623853211, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI148277065, Length=439, Percent_Identity=25.9681093394077, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI148277071, Length=437, Percent_Identity=26.0869565217391, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI33519430, Length=439, Percent_Identity=25.9681093394077, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI33519428, Length=439, Percent_Identity=25.9681093394077, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI33519426, Length=439, Percent_Identity=25.9681093394077, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI291045268, Length=435, Percent_Identity=25.5172413793103, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1789915, Length=434, Percent_Identity=31.1059907834101, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1786307, Length=434, Percent_Identity=30.184331797235, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI87081717, Length=466, Percent_Identity=28.1115879828326, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI87082354, Length=465, Percent_Identity=25.8064516129032, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17557007, Length=476, Percent_Identity=30.4621848739496, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI32565766, Length=466, Percent_Identity=27.8969957081545, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI71983429, Length=345, Percent_Identity=31.0144927536232, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71983419, Length=345, Percent_Identity=31.0144927536232, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71982272, Length=491, Percent_Identity=26.4765784114053, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325166, Length=470, Percent_Identity=29.1489361702128, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321091, Length=477, Percent_Identity=26.6247379454927, Blast_Score=146, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6325240, Length=485, Percent_Identity=22.2680412371134, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21358499, Length=482, Percent_Identity=27.1784232365145, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24640549, Length=456, Percent_Identity=27.6315789473684, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24640553, Length=456, Percent_Identity=27.6315789473684, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24640551, Length=456, Percent_Identity=27.6315789473684, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI17737741, Length=476, Percent_Identity=28.3613445378151, Blast_Score=125, Evalue=7e-29,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017817
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.15 [H]

Molecular weight: Translated: 50173; Mature: 50042

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQPASIKHYDLIIIGTGSGNSIPGPEFDDKSIAIVEKGAFGGTCLNVGCIPTKMYVYA
CCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCCCEEEEEH
ADIAQEIQESARLGIDATVNSVDWPSIVSRVFDKRIDLIAQGGEAYRRGPETPNIDVYDM
HHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEEC
HASFVDSKTISTGIAGQEQLISGTDIVIATGSRPYIPEAIAESGARYYTNEDIMRLPQQP
CHHHHCCCHHHCCCCCHHHHCCCCCEEEECCCCCCCCHHHHCCCCEEECCHHHHHCCCCC
ESLVIVGGGFIALEFAHVFEALGTKVTILNRSDVLLREADADISAKILELSKKRFDVRLS
CCEEEECCCHHHHHHHHHHHHHCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHEEEEH
TAVTAVHNKADGGVKISIDTGDDIEADILLVATGRTPNGNQMNLDAAGIEMNGRSIKVDE
HHEEEHCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCCEEEEEEECEEECCCEEEECC
FGRTSVEGVWALGDVSSPYKLKHVANAEMRAIKHNLANPDDLQKMPHDFVPSAVFTNPQI
CCCCCCCEEEEECCCCCCEEEHHHCCHHHHHHHHCCCCHHHHHHCCHHHCCCCCCCCCCE
AQVGMTEQEAREAGLNITVKIQNYSDVAYGWAMEDKDGFVKLIADKDTGKLVGAHIIGAQ
EECCCCHHHHHHCCCEEEEEEECCCCEEEEEEEECCCCEEEEEEECCCCCEEEEEEECCC
ASTLIQQLITVMAFGIDAREAATKQYWIHPALPEVIENALLGLEF
HHHHHHHHHHHHHCCCCHHHHHCCEEEECCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEQPASIKHYDLIIIGTGSGNSIPGPEFDDKSIAIVEKGAFGGTCLNVGCIPTKMYVYA
CCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCCCEEEEEH
ADIAQEIQESARLGIDATVNSVDWPSIVSRVFDKRIDLIAQGGEAYRRGPETPNIDVYDM
HHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEEC
HASFVDSKTISTGIAGQEQLISGTDIVIATGSRPYIPEAIAESGARYYTNEDIMRLPQQP
CHHHHCCCHHHCCCCCHHHHCCCCCEEEECCCCCCCCHHHHCCCCEEECCHHHHHCCCCC
ESLVIVGGGFIALEFAHVFEALGTKVTILNRSDVLLREADADISAKILELSKKRFDVRLS
CCEEEECCCHHHHHHHHHHHHHCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHEEEEH
TAVTAVHNKADGGVKISIDTGDDIEADILLVATGRTPNGNQMNLDAAGIEMNGRSIKVDE
HHEEEHCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCCEEEEEEECEEECCCEEEECC
FGRTSVEGVWALGDVSSPYKLKHVANAEMRAIKHNLANPDDLQKMPHDFVPSAVFTNPQI
CCCCCCCEEEEECCCCCCEEEHHHCCHHHHHHHHCCCCHHHHHHCCHHHCCCCCCCCCCE
AQVGMTEQEAREAGLNITVKIQNYSDVAYGWAMEDKDGFVKLIADKDTGKLVGAHIIGAQ
EECCCCHHHHHHCCCEEEEEEECCCCEEEEEEEECCCCEEEEEEECCCCCEEEEEEECCC
ASTLIQQLITVMAFGIDAREAATKQYWIHPALPEVIENALLGLEF
HHHHHHHHHHHHHCCCCHHHHHCCEEEECCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]