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The map label for this gene is uvrC

Identifier: 145295713

GI number: 145295713

Start: 1825284

End: 1827374

Strand: Reverse

Name: uvrC

Synonym: cgR_1640

Alternate gene names: 145295713

Gene position: 1827374-1825284 (Counterclockwise)

Preceding gene: 145295714

Following gene: 145295712

Centisome position: 55.14

GC content: 57.2

Gene sequence:

>2091_bases
GTGGCTGATCCAACAACTTATCGCCCGGCTCCAGGAACAATTCCAACGGAGCCGGGTGTTTATAAATTCAGGGACGAAAA
CCGCCGCGTGATCTACGTGGGCAAGGCCAAAAACTTGCGTTCGCGGTTGTCGAACTATTTCCAGGATGTCACCCAACTGC
ATCCGCGCACCCGCCAAATGGTGTTCGCAGCGTCGTCTGTGGAGTGGACCGTGGTATCCAGCGAAGTCGAGGCGCTGCAG
CTGGAATACACCTGGATTAAACGCTTTGATCCGCGGTTCAACGTAAAATACCGCGACGATAAAACCTATCCCATGCTGGC
AGTATCCACAGGGGAGAGGTTCCCGCGCGCGTTCTTCTTCCGAGGTCCGCGCCGCAAAGGTGTGCGCTATTTCGGACCGT
ATTCCCACGCGTGGGCAGTGCGGGAAACCCTTGATCTTCTCACCCGCGTTTTCCCCATGCGCACCTGTTCAAAGGGTGTG
TTTAACCGCCACGAAAGCCTCGGCCGGCCGTGTTTGTTGGGCTATATCGATAAATGTGCGGCCCCGTGCGTGGGCCGCGT
GAGCGAAGAGGAACACCGCGAAATCGTTGACGGTTTCACCTCTTTCATGGCTGGTCACACCGACAAAGTCACTCGCAAAC
TCAACGCCGACATGATGGCTGCGGCCGAGGAACTCGATTTCGAGCGCGCGGCCCGCCTGCGCGACGATCTGGAAGCCATT
GACAAGGTCATGGAAAAACAGGCCGTCGTCCTTGGCGATGGCACCGACGCCGACATCATCGCATTCGCCACCGATCAGCT
AGAAGCCGCCGTGCAAGTCTTCAACATCCGAGGCGGCCGAATCCGCGGCCAGCGCGGCTGGGTTGTGGATAAGCCCGGCG
ACTACGCCGGATTGCTTGTCGACGCTACGACCCAACCTGAGGGCGATGCCCCGGAAACAGATCCCGCACTGCCATTTTTG
ATGCAAGATTTCCTCGTTCAGTTTTATGGCGACGCTGTCGAGCGTGCTGAAACTGAGGCTAAGGAAGATGCTGCGGTGAT
CGAGCGACGTGGCGTCGATAAGCATTCTTTTGAAGAGGCAGCCCCGGTGACGCGCGCTTCGGTCGTGCCCCGTGAAATCC
TCGTGCAAGTGGCGCCCAATGAAGCTGAGCAAACCCTGAAAGTGCTGGAGGAATTGCGCGGTGCTGGCGTTGATGCGCGC
GTGCCGCAGCGCGGTGACAAGCGAGCGCTCATGGAAACGGTCGAGCGCAACGCCAAAGAGCTGCTGAAACAGCACAAGCT
CAAGCGTGTCGGTGATCTCACCGCGCGTTCAGCGGCTCTGCAGGAATTGCAGGAAGCGCTGGACATGGAACAGGCTCCGC
TGCGCATCGAATGTACCGATATTTCCCATATTCAGGGCACCGATGTGGTGGCATCTCTGGTGGTTTTTGAAGATGGTTTG
CCTCGAAAATCGGACTACCGACGCTACCGAGTCAAAGAAGCCGCAGGCGATGGACATTCCAACGACGTGGCATCCATTGC
GGAAATCACCAGGCGCCGCTTCCTGCGCCACAACCAAGACAAACTCGCTGTTCCCGAAGCCGAAGAGTTTGACGGCTCGA
CCTTCAGCGACGAAAAAGTCGAGGAAATGAGCACCGACGCCAGGCGTTTTGCGTACCCTCCTCAGATTTTCATCGTCGAT
GGTGGTGCCCCGCAGGTAGCTGCAGCCCAAGAAGTCTTTGATGAATTAGGCATCGTTGACGTGGTGCTCATTGGCCTAGC
CAAGCGCTTGGAAGAAATCTGGCTGCCCGGCGACCCCGATCCCGTCATCTTGCCGAGAAACTCCCAAGCACTGTTTTTGC
TCCAGCAAATCCGTGACGAAGCCCACCGCTTTGCCATCACCTACCACCGCCAGCAACGATCCAAGCGCATGCGTGTTTCC
GAACTAGACAGCATCAAGGGCCTTGGCCAGAGCCGTCGCACTGAACTAGTCAAGCACTTTGGATCCGTGGCAAAACTGAA
AGAGGCAAGCGTTGAAGACATTTCCCAAGTGAAAGGCTTCGGCCCGAAACTTGCGGAGGCTGTCTATGAAGGTCTTCACG
CGTCAAAATAA

Upstream 100 bases:

>100_bases
ATGTGGGCTTTCCAGTCCCGCGATGGCCAAGATGTGGTGCGCGCGGTTGCGACCTTCCGCGACCTCGAAAACAAGTACAT
GCCAGAGGACTAATTAAGCT

Downstream 100 bases:

>100_bases
GTAGATCGCTAGGATGTAACCATGATTCAATCCACTGGGGTCACGCACACTGATAAGTCTGCACAAGAAAATCCTGTGAA
GTACAGGGATAATTTCACAC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MADPTTYRPAPGTIPTEPGVYKFRDENRRVIYVGKAKNLRSRLSNYFQDVTQLHPRTRQMVFAASSVEWTVVSSEVEALQ
LEYTWIKRFDPRFNVKYRDDKTYPMLAVSTGERFPRAFFFRGPRRKGVRYFGPYSHAWAVRETLDLLTRVFPMRTCSKGV
FNRHESLGRPCLLGYIDKCAAPCVGRVSEEEHREIVDGFTSFMAGHTDKVTRKLNADMMAAAEELDFERAARLRDDLEAI
DKVMEKQAVVLGDGTDADIIAFATDQLEAAVQVFNIRGGRIRGQRGWVVDKPGDYAGLLVDATTQPEGDAPETDPALPFL
MQDFLVQFYGDAVERAETEAKEDAAVIERRGVDKHSFEEAAPVTRASVVPREILVQVAPNEAEQTLKVLEELRGAGVDAR
VPQRGDKRALMETVERNAKELLKQHKLKRVGDLTARSAALQELQEALDMEQAPLRIECTDISHIQGTDVVASLVVFEDGL
PRKSDYRRYRVKEAAGDGHSNDVASIAEITRRRFLRHNQDKLAVPEAEEFDGSTFSDEKVEEMSTDARRFAYPPQIFIVD
GGAPQVAAAQEVFDELGIVDVVLIGLAKRLEEIWLPGDPDPVILPRNSQALFLLQQIRDEAHRFAITYHRQQRSKRMRVS
ELDSIKGLGQSRRTELVKHFGSVAKLKEASVEDISQVKGFGPKLAEAVYEGLHASK

Sequences:

>Translated_696_residues
MADPTTYRPAPGTIPTEPGVYKFRDENRRVIYVGKAKNLRSRLSNYFQDVTQLHPRTRQMVFAASSVEWTVVSSEVEALQ
LEYTWIKRFDPRFNVKYRDDKTYPMLAVSTGERFPRAFFFRGPRRKGVRYFGPYSHAWAVRETLDLLTRVFPMRTCSKGV
FNRHESLGRPCLLGYIDKCAAPCVGRVSEEEHREIVDGFTSFMAGHTDKVTRKLNADMMAAAEELDFERAARLRDDLEAI
DKVMEKQAVVLGDGTDADIIAFATDQLEAAVQVFNIRGGRIRGQRGWVVDKPGDYAGLLVDATTQPEGDAPETDPALPFL
MQDFLVQFYGDAVERAETEAKEDAAVIERRGVDKHSFEEAAPVTRASVVPREILVQVAPNEAEQTLKVLEELRGAGVDAR
VPQRGDKRALMETVERNAKELLKQHKLKRVGDLTARSAALQELQEALDMEQAPLRIECTDISHIQGTDVVASLVVFEDGL
PRKSDYRRYRVKEAAGDGHSNDVASIAEITRRRFLRHNQDKLAVPEAEEFDGSTFSDEKVEEMSTDARRFAYPPQIFIVD
GGAPQVAAAQEVFDELGIVDVVLIGLAKRLEEIWLPGDPDPVILPRNSQALFLLQQIRDEAHRFAITYHRQQRSKRMRVS
ELDSIKGLGQSRRTELVKHFGSVAKLKEASVEDISQVKGFGPKLAEAVYEGLHASK
>Mature_695_residues
ADPTTYRPAPGTIPTEPGVYKFRDENRRVIYVGKAKNLRSRLSNYFQDVTQLHPRTRQMVFAASSVEWTVVSSEVEALQL
EYTWIKRFDPRFNVKYRDDKTYPMLAVSTGERFPRAFFFRGPRRKGVRYFGPYSHAWAVRETLDLLTRVFPMRTCSKGVF
NRHESLGRPCLLGYIDKCAAPCVGRVSEEEHREIVDGFTSFMAGHTDKVTRKLNADMMAAAEELDFERAARLRDDLEAID
KVMEKQAVVLGDGTDADIIAFATDQLEAAVQVFNIRGGRIRGQRGWVVDKPGDYAGLLVDATTQPEGDAPETDPALPFLM
QDFLVQFYGDAVERAETEAKEDAAVIERRGVDKHSFEEAAPVTRASVVPREILVQVAPNEAEQTLKVLEELRGAGVDARV
PQRGDKRALMETVERNAKELLKQHKLKRVGDLTARSAALQELQEALDMEQAPLRIECTDISHIQGTDVVASLVVFEDGLP
RKSDYRRYRVKEAAGDGHSNDVASIAEITRRRFLRHNQDKLAVPEAEEFDGSTFSDEKVEEMSTDARRFAYPPQIFIVDG
GAPQVAAAQEVFDELGIVDVVLIGLAKRLEEIWLPGDPDPVILPRNSQALFLLQQIRDEAHRFAITYHRQQRSKRMRVSE
LDSIKGLGQSRRTELVKHFGSVAKLKEASVEDISQVKGFGPKLAEAVYEGLHASK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=704, Percent_Identity=32.9545454545455, Blast_Score=340, Evalue=2e-94,
Organism=Escherichia coli, GI1788037, Length=195, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_CORGB (A4QEG6)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138534.1
- ProteinModelPortal:   A4QEG6
- STRING:   A4QEG6
- GeneID:   4993265
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1640
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 78335; Mature: 78203

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPTTYRPAPGTIPTEPGVYKFRDENRRVIYVGKAKNLRSRLSNYFQDVTQLHPRTRQM
CCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHH
VFAASSVEWTVVSSEVEALQLEYTWIKRFDPRFNVKYRDDKTYPMLAVSTGERFPRAFFF
EEEECCCEEEEEECCHHHHEEEEHHHHHCCCCCCEEECCCCCCCEEEECCCCCCCHHHHC
RGPRRKGVRYFGPYSHAWAVRETLDLLTRVFPMRTCSKGVFNRHESLGRPCLLGYIDKCA
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
APCVGRVSEEEHREIVDGFTSFMAGHTDKVTRKLNADMMAAAEELDFERAARLRDDLEAI
CHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHCHHHHHHHHHHHHHH
DKVMEKQAVVLGDGTDADIIAFATDQLEAAVQVFNIRGGRIRGQRGWVVDKPGDYAGLLV
HHHHHHCEEEEECCCCCCEEEEEHHHHHHHHHHHCCCCCEEECCCCEEECCCCCCEEEEE
DATTQPEGDAPETDPALPFLMQDFLVQFYGDAVERAETEAKEDAAVIERRGVDKHSFEEA
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
APVTRASVVPREILVQVAPNEAEQTLKVLEELRGAGVDARVPQRGDKRALMETVERNAKE
CCCHHHHHCCHHHHEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
LLKQHKLKRVGDLTARSAALQELQEALDMEQAPLRIECTDISHIQGTDVVASLVVFEDGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCC
PRKSDYRRYRVKEAAGDGHSNDVASIAEITRRRFLRHNQDKLAVPEAEEFDGSTFSDEKV
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHH
EEMSTDARRFAYPPQIFIVDGGAPQVAAAQEVFDELGIVDVVLIGLAKRLEEIWLPGDPD
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PVILPRNSQALFLLQQIRDEAHRFAITYHRQQRSKRMRVSELDSIKGLGQSRRTELVKHF
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHH
GSVAKLKEASVEDISQVKGFGPKLAEAVYEGLHASK
HHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADPTTYRPAPGTIPTEPGVYKFRDENRRVIYVGKAKNLRSRLSNYFQDVTQLHPRTRQM
CCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHH
VFAASSVEWTVVSSEVEALQLEYTWIKRFDPRFNVKYRDDKTYPMLAVSTGERFPRAFFF
EEEECCCEEEEEECCHHHHEEEEHHHHHCCCCCCEEECCCCCCCEEEECCCCCCCHHHHC
RGPRRKGVRYFGPYSHAWAVRETLDLLTRVFPMRTCSKGVFNRHESLGRPCLLGYIDKCA
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
APCVGRVSEEEHREIVDGFTSFMAGHTDKVTRKLNADMMAAAEELDFERAARLRDDLEAI
CHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHCHHHHHHHHHHHHHH
DKVMEKQAVVLGDGTDADIIAFATDQLEAAVQVFNIRGGRIRGQRGWVVDKPGDYAGLLV
HHHHHHCEEEEECCCCCCEEEEEHHHHHHHHHHHCCCCCEEECCCCEEECCCCCCEEEEE
DATTQPEGDAPETDPALPFLMQDFLVQFYGDAVERAETEAKEDAAVIERRGVDKHSFEEA
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
APVTRASVVPREILVQVAPNEAEQTLKVLEELRGAGVDARVPQRGDKRALMETVERNAKE
CCCHHHHHCCHHHHEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
LLKQHKLKRVGDLTARSAALQELQEALDMEQAPLRIECTDISHIQGTDVVASLVVFEDGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCC
PRKSDYRRYRVKEAAGDGHSNDVASIAEITRRRFLRHNQDKLAVPEAEEFDGSTFSDEKV
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHH
EEMSTDARRFAYPPQIFIVDGGAPQVAAAQEVFDELGIVDVVLIGLAKRLEEIWLPGDPD
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PVILPRNSQALFLLQQIRDEAHRFAITYHRQQRSKRMRVSELDSIKGLGQSRRTELVKHF
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHH
GSVAKLKEASVEDISQVKGFGPKLAEAVYEGLHASK
HHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA