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The map label for this gene is zwf [H]

Identifier: 145295699

GI number: 145295699

Start: 1807765

End: 1809309

Strand: Direct

Name: zwf [H]

Synonym: cgR_1626

Alternate gene names: 145295699

Gene position: 1807765-1809309 (Clockwise)

Preceding gene: 145295698

Following gene: 145295700

Centisome position: 54.55

GC content: 55.28

Gene sequence:

>1545_bases
GTGAGCACAAACACGACCCCCTCCAGCTGGACAAACCCACTGCGCGACCCGCAGGATAAACGACTCCCCCGCATCGCTGG
CCCTTCCGGCATGGTGATCTTCGGTGTCACTGGCGACTTGGCTCGAAAGAAGCTGCTCCCCGCCATTTATGATCTAGCAA
ACCGCGGATTGCTGCCCCCAGGATTCTCGTTGGTAGGTTACGGCCGCCGCGAATGGTCCAAAGAAGACTTTGAAAAATAC
GTACGCGATGCCGCAAGTGCTGGTGCTCGTACGGAATTCCGTGAAAATGTTTGGGAGCGCCTCGCCGAGGGTATGGAATT
TGTTCGCGGCAACTTTGATGATGATGCAGCTTTCGACAACCTCGCTGCAACACTCAAGCGCATCGACAAAACCCGCGGCA
CCGCCGGCAACTGGGCTTACTACCTGTCCATTCCACCAGATTCCTTCGCAGCGGTCTGCCACCAGCTGGAGCGTTCCGGC
ATGGCTGAATCCACCGAAGAAGCATGGCGCCGCGTGATCATCGAGAAGCCTTTCGGCCACAACCTCGAATCCGCACACGA
GCTCAACCAGCTGGTCAACGCAGTCTTCCCAGAATCTTCTGTGTTCCGCATCGACCACTATTTGGGCAAGGAAACAGTTC
AAAACATCCTGGCTCTGCGTTTTGCTAACCAGCTGTTTGAGCCACTGTGGAACTCCAACTACGTTGACCACGTCCAGATC
ACCATGGCTGAAGATATTGGCTTGGGTGGACGTGCTGGTTACTACGACGGCATCGGCGCAGCCCGCGACGTCATCCAGAA
CCACCTGATCCAGCTCTTGGCTCTGGTTGCCATGGAAGAACCAATTTCTTTCGTGCCAGCGCAGCTGCAGGCAGAAAAGA
TCAAGGTGCTCTCTGCGACAAAGCCGTGCTACCCATTGGATAAAACCTCCGCTCGTGGTCAGTACGCTGCCGGTTGGCAG
GGCTCTGAGTTAGTCAAGGGACTTCGCGAAGAAGATGGCTTCAACCCTGAGTCCACCACTGAGACTTTTGCGGCTTGTAC
CTTAGAGATCACGTCTCGTCGCTGGGCTGGTGTGCCGTTCTACCTGCGCACCGGTAAGCGTCTTGGTCGCCGTGTTACTG
AGATTGCCGTGGTGTTTAAAGACGCACCACACCAGCCTTTCGACGGCGACATGACTGTATCCCTTGGCCAAAACGCCATC
GTGATTCGCGTGCAGCCTGATGAAGGTGTGCTCATCCGCTTCGGTTCCAAGGTTCCAGGTTCTGCCATGGAAGTCCGTGA
CGTCAACATGGACTTCTCCTACTCAGAATCCTTCACTGAAGAATCACCTGAAGCATACGAGCGCCTTATCTTGGATGCGC
TGTTGGATGAATCCAGCCTTTTCCCTACCAACGAGGAAGTGGAACTGAGCTGGAAGATTCTGGATCCAATTCTTGAAGCA
TGGGATGCCGATGGAGAACCAGAGGATTACCCAGCAGGTACGTGGGGTCCAAAGAGCGCTGATGAAATGCTTTCCCGCAA
CGGTCACACCTGGCGCAGGCCATAA

Upstream 100 bases:

>100_bases
AGCACGCTGCATCAGTAACGGCGACATGAAATCGAATTAGTTCGATCTTATGTGGCCGTTACACATCTTTCATTAAAGAA
AGGATCGTGACGCTACCATC

Downstream 100 bases:

>100_bases
TTTAGGGGCAAAAAATGATCTTTGAACTTCCGGATACCACCACCCAGCAAATTTCCAAGACCCTAACTCGACTGCGTGAA
TCGGGCACCCAGGTCACCAC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MSTNTTPSSWTNPLRDPQDKRLPRIAGPSGMVIFGVTGDLARKKLLPAIYDLANRGLLPPGFSLVGYGRREWSKEDFEKY
VRDAASAGARTEFRENVWERLAEGMEFVRGNFDDDAAFDNLAATLKRIDKTRGTAGNWAYYLSIPPDSFAAVCHQLERSG
MAESTEEAWRRVIIEKPFGHNLESAHELNQLVNAVFPESSVFRIDHYLGKETVQNILALRFANQLFEPLWNSNYVDHVQI
TMAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALVAMEEPISFVPAQLQAEKIKVLSATKPCYPLDKTSARGQYAAGWQ
GSELVKGLREEDGFNPESTTETFAACTLEITSRRWAGVPFYLRTGKRLGRRVTEIAVVFKDAPHQPFDGDMTVSLGQNAI
VIRVQPDEGVLIRFGSKVPGSAMEVRDVNMDFSYSESFTEESPEAYERLILDALLDESSLFPTNEEVELSWKILDPILEA
WDADGEPEDYPAGTWGPKSADEMLSRNGHTWRRP

Sequences:

>Translated_514_residues
MSTNTTPSSWTNPLRDPQDKRLPRIAGPSGMVIFGVTGDLARKKLLPAIYDLANRGLLPPGFSLVGYGRREWSKEDFEKY
VRDAASAGARTEFRENVWERLAEGMEFVRGNFDDDAAFDNLAATLKRIDKTRGTAGNWAYYLSIPPDSFAAVCHQLERSG
MAESTEEAWRRVIIEKPFGHNLESAHELNQLVNAVFPESSVFRIDHYLGKETVQNILALRFANQLFEPLWNSNYVDHVQI
TMAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALVAMEEPISFVPAQLQAEKIKVLSATKPCYPLDKTSARGQYAAGWQ
GSELVKGLREEDGFNPESTTETFAACTLEITSRRWAGVPFYLRTGKRLGRRVTEIAVVFKDAPHQPFDGDMTVSLGQNAI
VIRVQPDEGVLIRFGSKVPGSAMEVRDVNMDFSYSESFTEESPEAYERLILDALLDESSLFPTNEEVELSWKILDPILEA
WDADGEPEDYPAGTWGPKSADEMLSRNGHTWRRP
>Mature_513_residues
STNTTPSSWTNPLRDPQDKRLPRIAGPSGMVIFGVTGDLARKKLLPAIYDLANRGLLPPGFSLVGYGRREWSKEDFEKYV
RDAASAGARTEFRENVWERLAEGMEFVRGNFDDDAAFDNLAATLKRIDKTRGTAGNWAYYLSIPPDSFAAVCHQLERSGM
AESTEEAWRRVIIEKPFGHNLESAHELNQLVNAVFPESSVFRIDHYLGKETVQNILALRFANQLFEPLWNSNYVDHVQIT
MAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALVAMEEPISFVPAQLQAEKIKVLSATKPCYPLDKTSARGQYAAGWQG
SELVKGLREEDGFNPESTTETFAACTLEITSRRWAGVPFYLRTGKRLGRRVTEIAVVFKDAPHQPFDGDMTVSLGQNAIV
IRVQPDEGVLIRFGSKVPGSAMEVRDVNMDFSYSESFTEESPEAYERLILDALLDESSLFPTNEEVELSWKILDPILEAW
DADGEPEDYPAGTWGPKSADEMLSRNGHTWRRP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=485, Percent_Identity=36.0824742268041, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI109389365, Length=485, Percent_Identity=36.0824742268041, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI52145310, Length=512, Percent_Identity=28.515625, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1788158, Length=497, Percent_Identity=42.0523138832998, Blast_Score=384, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17538218, Length=512, Percent_Identity=36.5234375, Blast_Score=334, Evalue=6e-92,
Organism=Saccharomyces cerevisiae, GI6324088, Length=484, Percent_Identity=37.8099173553719, Blast_Score=318, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24643350, Length=488, Percent_Identity=34.6311475409836, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI24643352, Length=488, Percent_Identity=34.6311475409836, Blast_Score=295, Evalue=6e-80,
Organism=Drosophila melanogaster, GI221513548, Length=489, Percent_Identity=27.8118609406953, Blast_Score=196, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57477; Mature: 57346

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNTTPSSWTNPLRDPQDKRLPRIAGPSGMVIFGVTGDLARKKLLPAIYDLANRGLLPP
CCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCC
GFSLVGYGRREWSKEDFEKYVRDAASAGARTEFRENVWERLAEGMEFVRGNFDDDAAFDN
CCHHCCCCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LAATLKRIDKTRGTAGNWAYYLSIPPDSFAAVCHQLERSGMAESTEEAWRRVIIEKPFGH
HHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
NLESAHELNQLVNAVFPESSVFRIDHYLGKETVQNILALRFANQLFEPLWNSNYVDHVQI
CHHHHHHHHHHHHHHCCCCCEEHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
TMAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALVAMEEPISFVPAQLQAEKIKVLSAT
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHCCC
KPCYPLDKTSARGQYAAGWQGSELVKGLREEDGFNPESTTETFAACTLEITSRRWAGVPF
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHEEEEECCCCCCCCCH
YLRTGKRLGRRVTEIAVVFKDAPHQPFDGDMTVSLGQNAIVIRVQPDEGVLIRFGSKVPG
HHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEECCCEEEEEEECCCCEEEEECCCCCC
SAMEVRDVNMDFSYSESFTEESPEAYERLILDALLDESSLFPTNEEVELSWKILDPILEA
CCEEEEECCCCCCCCCHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHH
WDADGEPEDYPAGTWGPKSADEMLSRNGHTWRRP
HCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure 
STNTTPSSWTNPLRDPQDKRLPRIAGPSGMVIFGVTGDLARKKLLPAIYDLANRGLLPP
CCCCCCCCCCCCCCCCHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCC
GFSLVGYGRREWSKEDFEKYVRDAASAGARTEFRENVWERLAEGMEFVRGNFDDDAAFDN
CCHHCCCCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LAATLKRIDKTRGTAGNWAYYLSIPPDSFAAVCHQLERSGMAESTEEAWRRVIIEKPFGH
HHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
NLESAHELNQLVNAVFPESSVFRIDHYLGKETVQNILALRFANQLFEPLWNSNYVDHVQI
CHHHHHHHHHHHHHHCCCCCEEHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
TMAEDIGLGGRAGYYDGIGAARDVIQNHLIQLLALVAMEEPISFVPAQLQAEKIKVLSAT
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHCCC
KPCYPLDKTSARGQYAAGWQGSELVKGLREEDGFNPESTTETFAACTLEITSRRWAGVPF
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHEEEEECCCCCCCCCH
YLRTGKRLGRRVTEIAVVFKDAPHQPFDGDMTVSLGQNAIVIRVQPDEGVLIRFGSKVPG
HHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEECCCEEEEEEECCCCEEEEECCCCCC
SAMEVRDVNMDFSYSESFTEESPEAYERLILDALLDESSLFPTNEEVELSWKILDPILEA
CCEEEEECCCCCCCCCHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHH
WDADGEPEDYPAGTWGPKSADEMLSRNGHTWRRP
HCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]