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The map label for this gene is hemH

Identifier: 145295668

GI number: 145295668

Start: 1764961

End: 1766073

Strand: Reverse

Name: hemH

Synonym: cgR_1595

Alternate gene names: 145295668

Gene position: 1766073-1764961 (Counterclockwise)

Preceding gene: 145295669

Following gene: 145295666

Centisome position: 53.29

GC content: 55.62

Gene sequence:

>1113_bases
ATGAATGAACGCACATCGGATGCATTTGACGCCCTCCTTGTGCTCTCCTTCGGTGGTCCCGAAGGGCACGAGGAGGTTCG
TCCATTTTTGGAGAATGTCACTCGCGGAAGGGGGATCCCGCCGGAACGTCTAGATGATGTGGCGGTTCATTACCACCACT
TCGGTGGTATCAGCCCGATCAATGCGCTGAACAGGGAAATTATCGCCAATGTGGAAAAAGAATTGGCGTCTCGAAACCGC
GAGCTGCCTGTCTATTTTGGCAACCGCAACTGGAAGCCGTTTGGTAATGAGGCCGCTGAACAAATGGCTGATGACGGCGT
GAAGAACGCGCTGGTGTTGGCAACTTCCGCGTGGGGTGGCTACTCAGGTTGCCAGCAATACCAGGAAGATATTCGGGGCA
TGATCAAGCACTTGGAGTCCCAGGGGCAGTCGGTCACGTTCACCAAGTTGCGTCAGTTCTACGATCACCCTCGTTTTGTC
TCCACCATGGCTCAATTGGTTCAGGATTCCTACGCGAAGCTTCCTGATGAGCTGCGCGACGAGGCGCGTTTGGTTTTCAC
TGCGCACTCCATTCCGCTGGCTGCGGACAATGCTGCGGGAACCCCTCAGGATGGTTCCTTGTATTCCTCACAGGTCAAGG
AAGCATCAGCGTTGATTGCTAAGGCTGTTGGTGTGTCAGATTTTGATGTGGTGTGGCAGTCGCGTTCAGGCAGTCCGCAC
ACTCCGTGGCTGGAGCCTGACATCGTGGATCACGCAGTTGAGCTCAACGAGAAGGGTCAGAAAGCACTCGTTGTCTGCCC
TGTAGGCTTTATTTCCGATCATATGGAAGTCATTTGGGATCTTGATTCCGAGCTGATGGAAGAAGCAGAGAAGCGCAACA
TGGTGGTCGAGCGCGTCGCTACCGTTGGCCCCACCGATGAATTCGCAGCCCTAGTGGTTGATCTCATCGAGGAAGCGGAG
CTCAAGCGCGTTATCGAGCGTCTTGGAAAGCTACCAGCTCGCGGAAGCTCCATCAATGGCGCACCGTGTAGCGAAGGCTG
CTGTGGCACCGCCAAGCATCAAACTGCGCGGGTGAACCCCAACGCTCGCTCAGCGGCGCCAGCTGCCAACTAG

Upstream 100 bases:

>100_bases
ACTGAGAGTGTGGTACGCCTCATTTAGTTTCATCCTATGAATCTTGGTGTGGTTCATGCGTTTTTATGCAATATCAATCA
AAAGTTGGTACGATGCTCGT

Downstream 100 bases:

>100_bases
GAGTGACAGTCCCTCGCAAACTCTGCGAGGGCATAACTCACCCCAGCCATGCGCGCGGTCCGAATATGGCTCCACAGGGA
AATCAATTGCGGATCCAGGC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MNERTSDAFDALLVLSFGGPEGHEEVRPFLENVTRGRGIPPERLDDVAVHYHHFGGISPINALNREIIANVEKELASRNR
ELPVYFGNRNWKPFGNEAAEQMADDGVKNALVLATSAWGGYSGCQQYQEDIRGMIKHLESQGQSVTFTKLRQFYDHPRFV
STMAQLVQDSYAKLPDELRDEARLVFTAHSIPLAADNAAGTPQDGSLYSSQVKEASALIAKAVGVSDFDVVWQSRSGSPH
TPWLEPDIVDHAVELNEKGQKALVVCPVGFISDHMEVIWDLDSELMEEAEKRNMVVERVATVGPTDEFAALVVDLIEEAE
LKRVIERLGKLPARGSSINGAPCSEGCCGTAKHQTARVNPNARSAAPAAN

Sequences:

>Translated_370_residues
MNERTSDAFDALLVLSFGGPEGHEEVRPFLENVTRGRGIPPERLDDVAVHYHHFGGISPINALNREIIANVEKELASRNR
ELPVYFGNRNWKPFGNEAAEQMADDGVKNALVLATSAWGGYSGCQQYQEDIRGMIKHLESQGQSVTFTKLRQFYDHPRFV
STMAQLVQDSYAKLPDELRDEARLVFTAHSIPLAADNAAGTPQDGSLYSSQVKEASALIAKAVGVSDFDVVWQSRSGSPH
TPWLEPDIVDHAVELNEKGQKALVVCPVGFISDHMEVIWDLDSELMEEAEKRNMVVERVATVGPTDEFAALVVDLIEEAE
LKRVIERLGKLPARGSSINGAPCSEGCCGTAKHQTARVNPNARSAAPAAN
>Mature_370_residues
MNERTSDAFDALLVLSFGGPEGHEEVRPFLENVTRGRGIPPERLDDVAVHYHHFGGISPINALNREIIANVEKELASRNR
ELPVYFGNRNWKPFGNEAAEQMADDGVKNALVLATSAWGGYSGCQQYQEDIRGMIKHLESQGQSVTFTKLRQFYDHPRFV
STMAQLVQDSYAKLPDELRDEARLVFTAHSIPLAADNAAGTPQDGSLYSSQVKEASALIAKAVGVSDFDVVWQSRSGSPH
TPWLEPDIVDHAVELNEKGQKALVVCPVGFISDHMEVIWDLDSELMEEAEKRNMVVERVATVGPTDEFAALVVDLIEEAE
LKRVIERLGKLPARGSSINGAPCSEGCCGTAKHQTARVNPNARSAAPAAN

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=286, Percent_Identity=25.5244755244755, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI60499021, Length=286, Percent_Identity=25.5244755244755, Blast_Score=93, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324750, Length=326, Percent_Identity=23.6196319018405, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17864156, Length=315, Percent_Identity=24.7619047619048, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI45552018, Length=163, Percent_Identity=28.2208588957055, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24651774, Length=255, Percent_Identity=24.3137254901961, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_CORGB (A4QEC1)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138489.1
- ProteinModelPortal:   A4QEC1
- SMR:   A4QEC1
- STRING:   A4QEC1
- GeneID:   4992908
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1595
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   GNRNWHP
- ProtClustDB:   PRK00035
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 40544; Mature: 40544

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNERTSDAFDALLVLSFGGPEGHEEVRPFLENVTRGRGIPPERLDDVAVHYHHFGGISPI
CCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHH
NALNREIIANVEKELASRNRELPVYFGNRNWKPFGNEAAEQMADDGVKNALVLATSAWGG
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCC
YSGCQQYQEDIRGMIKHLESQGQSVTFTKLRQFYDHPRFVSTMAQLVQDSYAKLPDELRD
HHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHH
EARLVFTAHSIPLAADNAAGTPQDGSLYSSQVKEASALIAKAVGVSDFDVVWQSRSGSPH
CCEEEEEECCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCC
TPWLEPDIVDHAVELNEKGQKALVVCPVGFISDHMEVIWDLDSELMEEAEKRNMVVERVA
CCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TVGPTDEFAALVVDLIEEAELKRVIERLGKLPARGSSINGAPCSEGCCGTAKHQTARVNP
HCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCC
NARSAAPAAN
CCCCCCCCCC
>Mature Secondary Structure
MNERTSDAFDALLVLSFGGPEGHEEVRPFLENVTRGRGIPPERLDDVAVHYHHFGGISPI
CCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHH
NALNREIIANVEKELASRNRELPVYFGNRNWKPFGNEAAEQMADDGVKNALVLATSAWGG
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCC
YSGCQQYQEDIRGMIKHLESQGQSVTFTKLRQFYDHPRFVSTMAQLVQDSYAKLPDELRD
HHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHH
EARLVFTAHSIPLAADNAAGTPQDGSLYSSQVKEASALIAKAVGVSDFDVVWQSRSGSPH
CCEEEEEECCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCC
TPWLEPDIVDHAVELNEKGQKALVVCPVGFISDHMEVIWDLDSELMEEAEKRNMVVERVA
CCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TVGPTDEFAALVVDLIEEAELKRVIERLGKLPARGSSINGAPCSEGCCGTAKHQTARVNP
HCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCC
NARSAAPAAN
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA