Click here to switch to the map view.

The map label for this gene is pyrD

Identifier: 145295651

GI number: 145295651

Start: 1745165

End: 1746280

Strand: Direct

Name: pyrD

Synonym: cgR_1578

Alternate gene names: 145295651

Gene position: 1745165-1746280 (Clockwise)

Preceding gene: 145295650

Following gene: 145295658

Centisome position: 52.66

GC content: 56.99

Gene sequence:

>1116_bases
ATGAGCAAGCAATCCCCCACCCGCAAGCTGCGTCAAACCGTCTACGATGCCAGCCTCAAAGTGATGTTCACCCTGCGCCC
CGAACGCATCCACGGACTGATGAACAAAGCACTCGGAGTTGTCGACGGCGTCGCACCGCTAAACCGCACCATGGAAAAAA
TCATCGCAGTCCACGATGATTCCCTCTCCCAGGAAGTCTTCGGAGTCACCTTCCCACGACCACTAGGCCTCGCCGCAGGT
TTCGACAAAAACGCATCAATGGCTGATGCCTGGGGTGCCGTTGGATTCGGATACGCCGAACTTGGCACCGTCACCGCCTC
CCCACAGCCAGGAAACCCCACCCCGCGCCTTTTCCGTCTGCCTGCCGACAAAGCAATCTTGAACCGCATGGGATTCAACA
ACCTCGGCGCAGCAGAAGTCGCAACCAACCTGAGCAACCGGAAATCCACCGATGTCATCGGCATCAACATTGGTAAAACC
AAAGTGGTTCCCGCTGAACACGCAGTAGATGACTACCGCCGTTCTGCATCTTTGTTGGGTGATCTTGCTGATTACCTGGT
TGTCAACGTTTCCTCCCCCAACACTCCGGGTCTCCGCGATCTGCAGGCTGTGGAATCTTTGCGACCAATCCTCGCCGCAG
TGCAGGAATCCACCACCGTCCCAGTCTTGGTGAAAATCGCACCAGACCTCTCCGACGAAGACATCGACGCCGTAGCTGAC
CTGGCAGTTGAGCTCAAACTCGCCGGAATCGTAGCCACCAATACCACCATTTCCCGCGAAGGCCTCAACACTCCTGCCGG
TGAAGTCGAAGCCATGGGTGCTGGCGGAATCTCCGGTGCTCCAGTAGCAGCCCGATCTTTGGAGGTACTCAAGCGCCTCT
ACGCACGGGTAGGCAAAGAGATGGTGTTGATCTCTGTCGGTGGCATCAGCACTCCTGAGCAAGCCTGGGAACGCATCACC
TCCGGCGCAACCCTTCTGCAGGGATACACCCCATTCATCTACGGTGGCCCCGATTGGATCAGAGATATCCACCTTGGTAT
CGCCAAGCAGCTGAAAGCTCACGGTCTGCGCAACATCGCTGACGCTGTGGGCAGCGAATTGGAGTGGAAGAACTAA

Upstream 100 bases:

>100_bases
AAAACCTCGTGGTATTAAGCGATTCCACCCTCGTCGTAGCATCCGCAACCGGCGACGGCATCCAAATCATCGACAACCCA
GCATCTTAAAAAGGACCCCC

Downstream 100 bases:

>100_bases
ACAGACCAAACACACGTGCCAGGATCTTGCTGAAACAGCGGATCTTGGCACGTGTGTCCGTCTTTTGTCTGTTCTGGTGC
CTCACATGCCGCTTTGGACT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSKQSPTRKLRQTVYDASLKVMFTLRPERIHGLMNKALGVVDGVAPLNRTMEKIIAVHDDSLSQEVFGVTFPRPLGLAAG
FDKNASMADAWGAVGFGYAELGTVTASPQPGNPTPRLFRLPADKAILNRMGFNNLGAAEVATNLSNRKSTDVIGINIGKT
KVVPAEHAVDDYRRSASLLGDLADYLVVNVSSPNTPGLRDLQAVESLRPILAAVQESTTVPVLVKIAPDLSDEDIDAVAD
LAVELKLAGIVATNTTISREGLNTPAGEVEAMGAGGISGAPVAARSLEVLKRLYARVGKEMVLISVGGISTPEQAWERIT
SGATLLQGYTPFIYGGPDWIRDIHLGIAKQLKAHGLRNIADAVGSELEWKN

Sequences:

>Translated_371_residues
MSKQSPTRKLRQTVYDASLKVMFTLRPERIHGLMNKALGVVDGVAPLNRTMEKIIAVHDDSLSQEVFGVTFPRPLGLAAG
FDKNASMADAWGAVGFGYAELGTVTASPQPGNPTPRLFRLPADKAILNRMGFNNLGAAEVATNLSNRKSTDVIGINIGKT
KVVPAEHAVDDYRRSASLLGDLADYLVVNVSSPNTPGLRDLQAVESLRPILAAVQESTTVPVLVKIAPDLSDEDIDAVAD
LAVELKLAGIVATNTTISREGLNTPAGEVEAMGAGGISGAPVAARSLEVLKRLYARVGKEMVLISVGGISTPEQAWERIT
SGATLLQGYTPFIYGGPDWIRDIHLGIAKQLKAHGLRNIADAVGSELEWKN
>Mature_370_residues
SKQSPTRKLRQTVYDASLKVMFTLRPERIHGLMNKALGVVDGVAPLNRTMEKIIAVHDDSLSQEVFGVTFPRPLGLAAGF
DKNASMADAWGAVGFGYAELGTVTASPQPGNPTPRLFRLPADKAILNRMGFNNLGAAEVATNLSNRKSTDVIGINIGKTK
VVPAEHAVDDYRRSASLLGDLADYLVVNVSSPNTPGLRDLQAVESLRPILAAVQESTTVPVLVKIAPDLSDEDIDAVADL
AVELKLAGIVATNTTISREGLNTPAGEVEAMGAGGISGAPVAARSLEVLKRLYARVGKEMVLISVGGISTPEQAWERITS
GATLLQGYTPFIYGGPDWIRDIHLGIAKQLKAHGLRNIADAVGSELEWKN

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=324, Percent_Identity=40.7407407407407, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1787177, Length=333, Percent_Identity=41.1411411411411, Blast_Score=243, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17509475, Length=321, Percent_Identity=36.4485981308411, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI281361352, Length=328, Percent_Identity=39.3292682926829, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI17137316, Length=328, Percent_Identity=39.3292682926829, Blast_Score=230, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_CORGB (A4QEA4)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138472.1
- ProteinModelPortal:   A4QEA4
- SMR:   A4QEA4
- STRING:   A4QEA4
- GeneID:   4992953
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1578
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- ProtClustDB:   PRK05286
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 39450; Mature: 39318

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 192-192

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQSPTRKLRQTVYDASLKVMFTLRPERIHGLMNKALGVVDGVAPLNRTMEKIIAVHDD
CCCCCHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC
SLSQEVFGVTFPRPLGLAAGFDKNASMADAWGAVGFGYAELGTVTASPQPGNPTPRLFRL
CCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHCEEECCCCCCCCCCCEEEC
PADKAILNRMGFNNLGAAEVATNLSNRKSTDVIGINIGKTKVVPAEHAVDDYRRSASLLG
CCHHHHHHHCCCCCCCHHHHHHHCCCCCCCCEEEEECCCEEECCHHHHHHHHHHHHHHHH
DLADYLVVNVSSPNTPGLRDLQAVESLRPILAAVQESTTVPVLVKIAPDLSDEDIDAVAD
HHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHH
LAVELKLAGIVATNTTISREGLNTPAGEVEAMGAGGISGAPVAARSLEVLKRLYARVGKE
HHHHEEEEEEEEECCEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCE
MVLISVGGISTPEQAWERITSGATLLQGYTPFIYGGPDWIRDIHLGIAKQLKAHGLRNIA
EEEEEECCCCCHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHH
DAVGSELEWKN
HHHCCCCCCCC
>Mature Secondary Structure 
SKQSPTRKLRQTVYDASLKVMFTLRPERIHGLMNKALGVVDGVAPLNRTMEKIIAVHDD
CCCCHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC
SLSQEVFGVTFPRPLGLAAGFDKNASMADAWGAVGFGYAELGTVTASPQPGNPTPRLFRL
CCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHCEEECCCCCCCCCCCEEEC
PADKAILNRMGFNNLGAAEVATNLSNRKSTDVIGINIGKTKVVPAEHAVDDYRRSASLLG
CCHHHHHHHCCCCCCCHHHHHHHCCCCCCCCEEEEECCCEEECCHHHHHHHHHHHHHHHH
DLADYLVVNVSSPNTPGLRDLQAVESLRPILAAVQESTTVPVLVKIAPDLSDEDIDAVAD
HHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHH
LAVELKLAGIVATNTTISREGLNTPAGEVEAMGAGGISGAPVAARSLEVLKRLYARVGKE
HHHHEEEEEEEEECCEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCE
MVLISVGGISTPEQAWERITSGATLLQGYTPFIYGGPDWIRDIHLGIAKQLKAHGLRNIA
EEEEEECCCCCHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHH
DAVGSELEWKN
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA