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The map label for this gene is yheI [H]

Identifier: 145295566

GI number: 145295566

Start: 1653301

End: 1654749

Strand: Direct

Name: yheI [H]

Synonym: cgR_1493

Alternate gene names: 145295566

Gene position: 1653301-1654749 (Clockwise)

Preceding gene: 145295562

Following gene: 145295567

Centisome position: 49.89

GC content: 55.28

Gene sequence:

>1449_bases
GTGGCGTTGTCGCAGCGGCCGTGGAGCTTTGTGGCGTCTGCTGGCATGGCGGCGTCTTTTATCTGCAATGGGTTAACGCC
TGTGATTGTGGGTAAGGCGGTGGATGAGGCTATTGGCACGAGCGATCTGCAGCGATTGTGGTTCTGGATTGCCATGTTGG
CGGTTCTTTTCTTAACGGCGATGACGGTGAACTGGATTGCTCGGTACATGTTGGTGCGGAGCCAGCAGTTGGTCAGTCAT
GATTTGCGGATGTTGGTGACTGATCGGATTCAAGATCCGCGTGGTTTTGCTGGAAAAGAGCGCACTGCGGGTGGGTTGTT
GTCGATTGCGTCGTCGGATACGCAGCGTGTGGGCGATATCGTCATGATGACGGTGTTCCCGGTGGCGGAGTTGGCGTCGA
TTATTTATGGCGCCGTGGTGATGTACAGCATTAATCCGTGGTTGAGTGTGGCTGTGCTGATTGGTGGTCCGCTGCTGGTT
GTGGTGGCTATTCAGGTCTCAAAGCCCTTGCAGAAGCGTTCGGGCGCTCGTCAGCAGGCGGTGGCGCAGGCTGCGGCTAC
TGCAACTGATGTGGTGCAGGGCTTGAGAATTTTGAAGGGTTTGGGCGCGATTGTCACGGTGCGCCGTCGATACGAGGCGA
TTTCTGGTGAGGCTTATCGGAAGACGGTTCATGCGGAAGCTGCGGAAGCTCGCTTGAATGGTGTCACCGATGCGGCGGGC
GCCATCTTTGTGTCCGCGTTGGGTATTGGAGCAGGATTTTTGGCGCTGCATGGTCAGATGAGTATTGGTGATTTGATCAC
GGTTGTGGGACTCACACAGTTTTTGATCATGCCGATGACCATGCTTGGTCGAAATGTGGCATCGCGCTGGGCATCGGCGG
AGGCGTCGGCAAAGCGTATTAGGGGAGTGCTCGGTGCTGATTTTGAGAGAGTGTCTGCGCATGATGCGGACAAGGCTGAG
GAGATTATCCAACAACTTGCCAAAGGTTTGACGGTTATTCGAGGCACTGATGAGCAGCTCGTTGAGGTATTAGAGCAGTT
GCCACGTACTCGGGTGATTGTGGCTCCTCATGCGGCGGATCTTTTTGATCAAAGTGTCAGGGACAATGTGCATCCCGTGG
CAGAGGTCGCGGAGAAAGCCATTGAAGTTGCCTCCTGTGACGATATTCCAGGTGGTAGTTCCAAGATTGTGGGCGAGGGT
GGACGGTTGCTCTCGGGTGGTCAGCGTCAGCGCGTTGCACTGGCTCGGGCTATTGCTTTTGATCCAGAGGTGTTGGTGCT
TCAAGATCCCACAACGGCAGTGGATTCTGTGACGGAGCAAAACATTGCTCAGCAAGTGGCAGCACACCGTGCAGGAAAAG
TGACCATTGTGTTTAGTGAGGCACCCGCGTGGAGTGCGGTGGCTGATCAACACGTTGAGGCAGCTGCTTTGCGGGCGGTT
ATGAAATGA

Upstream 100 bases:

>100_bases
AACGAAATCCACACCTTTAGATAGGTATAAAAACCTCTCCGGGCCCGGCGCGCGGCCGTCCAAGATGCCGGCGTTGGATG
CCAAATTATGGACTCTCAAA

Downstream 100 bases:

>100_bases
GTGGGGAGACGTCGAAAAGCATGCGCTTTCCGTTGGCCAGCCTGCCGCAAGTGCGGCGCGAGGTGGCCCGGCAGGTGGGT
CGTATTCCGCGGGCAAAGTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MALSQRPWSFVASAGMAASFICNGLTPVIVGKAVDEAIGTSDLQRLWFWIAMLAVLFLTAMTVNWIARYMLVRSQQLVSH
DLRMLVTDRIQDPRGFAGKERTAGGLLSIASSDTQRVGDIVMMTVFPVAELASIIYGAVVMYSINPWLSVAVLIGGPLLV
VVAIQVSKPLQKRSGARQQAVAQAAATATDVVQGLRILKGLGAIVTVRRRYEAISGEAYRKTVHAEAAEARLNGVTDAAG
AIFVSALGIGAGFLALHGQMSIGDLITVVGLTQFLIMPMTMLGRNVASRWASAEASAKRIRGVLGADFERVSAHDADKAE
EIIQQLAKGLTVIRGTDEQLVEVLEQLPRTRVIVAPHAADLFDQSVRDNVHPVAEVAEKAIEVASCDDIPGGSSKIVGEG
GRLLSGGQRQRVALARAIAFDPEVLVLQDPTTAVDSVTEQNIAQQVAAHRAGKVTIVFSEAPAWSAVADQHVEAAALRAV
MK

Sequences:

>Translated_482_residues
MALSQRPWSFVASAGMAASFICNGLTPVIVGKAVDEAIGTSDLQRLWFWIAMLAVLFLTAMTVNWIARYMLVRSQQLVSH
DLRMLVTDRIQDPRGFAGKERTAGGLLSIASSDTQRVGDIVMMTVFPVAELASIIYGAVVMYSINPWLSVAVLIGGPLLV
VVAIQVSKPLQKRSGARQQAVAQAAATATDVVQGLRILKGLGAIVTVRRRYEAISGEAYRKTVHAEAAEARLNGVTDAAG
AIFVSALGIGAGFLALHGQMSIGDLITVVGLTQFLIMPMTMLGRNVASRWASAEASAKRIRGVLGADFERVSAHDADKAE
EIIQQLAKGLTVIRGTDEQLVEVLEQLPRTRVIVAPHAADLFDQSVRDNVHPVAEVAEKAIEVASCDDIPGGSSKIVGEG
GRLLSGGQRQRVALARAIAFDPEVLVLQDPTTAVDSVTEQNIAQQVAAHRAGKVTIVFSEAPAWSAVADQHVEAAALRAV
MK
>Mature_481_residues
ALSQRPWSFVASAGMAASFICNGLTPVIVGKAVDEAIGTSDLQRLWFWIAMLAVLFLTAMTVNWIARYMLVRSQQLVSHD
LRMLVTDRIQDPRGFAGKERTAGGLLSIASSDTQRVGDIVMMTVFPVAELASIIYGAVVMYSINPWLSVAVLIGGPLLVV
VAIQVSKPLQKRSGARQQAVAQAAATATDVVQGLRILKGLGAIVTVRRRYEAISGEAYRKTVHAEAAEARLNGVTDAAGA
IFVSALGIGAGFLALHGQMSIGDLITVVGLTQFLIMPMTMLGRNVASRWASAEASAKRIRGVLGADFERVSAHDADKAEE
IIQQLAKGLTVIRGTDEQLVEVLEQLPRTRVIVAPHAADLFDQSVRDNVHPVAEVAEKAIEVASCDDIPGGSSKIVGEGG
RLLSGGQRQRVALARAIAFDPEVLVLQDPTTAVDSVTEQNIAQQVAAHRAGKVTIVFSEAPAWSAVADQHVEAAALRAVM
K

Specific function: Involved in the transport of four structurally unrelated drugs, including doxorubicin and mitoxantrone. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1786653, Length=504, Percent_Identity=21.8253968253968, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787143, Length=525, Percent_Identity=20.5714285714286, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193202349, Length=140, Percent_Identity=32.1428571428571, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17541710, Length=171, Percent_Identity=29.2397660818713, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17567269, Length=122, Percent_Identity=32.7868852459016, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17558664, Length=117, Percent_Identity=35.8974358974359, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI115535101, Length=118, Percent_Identity=33.8983050847458, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17569145, Length=118, Percent_Identity=29.6610169491525, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17567265, Length=117, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17569143, Length=118, Percent_Identity=32.2033898305085, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322640, Length=98, Percent_Identity=34.6938775510204, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357851, Length=151, Percent_Identity=35.0993377483444, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45551501, Length=151, Percent_Identity=35.0993377483444, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45551502, Length=151, Percent_Identity=35.0993377483444, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI23397593, Length=97, Percent_Identity=39.1752577319588, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85726357, Length=118, Percent_Identity=35.5932203389831, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24653245, Length=133, Percent_Identity=33.0827067669173, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI281363262, Length=133, Percent_Identity=33.0827067669173, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 51263; Mature: 51132

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2 ; PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HC
>Mature Secondary Structure 
ALSQRPWSFVASAGMAASFICNGLTPVIVGKAVDEAIGTSDLQRLWFWIAMLAVLFLTA
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
MTVNWIARYMLVRSQQLVSHDLRMLVTDRIQDPRGFAGKERTAGGLLSIASSDTQRVGDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHHHHH
VMMTVFPVAELASIIYGAVVMYSINPWLSVAVLIGGPLLVVVAIQVSKPLQKRSGARQQA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHCCHHHHH
VAQAAATATDVVQGLRILKGLGAIVTVRRRYEAISGEAYRKTVHAEAAEARLNGVTDAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHH
AIFVSALGIGAGFLALHGQMSIGDLITVVGLTQFLIMPMTMLGRNVASRWASAEASAKRI
HHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGVLGADFERVSAHDADKAEEIIQQLAKGLTVIRGTDEQLVEVLEQLPRTRVIVAPHAAD
HHHHCCCHHHHHCCCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHCCCCEEEECCCHHH
LFDQSVRDNVHPVAEVAEKAIEVASCDDIPGGSSKIVGEGGRLLSGGQRQRVALARAIAF
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHC
DPEVLVLQDPTTAVDSVTEQNIAQQVAAHRAGKVTIVFSEAPAWSAVADQHVEAAALRAV
CCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
MK
HC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]