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The map label for this gene is pyrG

Identifier: 145295551

GI number: 145295551

Start: 1637893

End: 1639557

Strand: Direct

Name: pyrG

Synonym: cgR_1478

Alternate gene names: 145295551

Gene position: 1637893-1639557 (Clockwise)

Preceding gene: 145295550

Following gene: 145295552

Centisome position: 49.42

GC content: 54.65

Gene sequence:

>1665_bases
ATGACCTCTAGTCGAAAAGTCCGTCCCACCAAACACATTTTCGTCACCGGTGGAGTTGTTTCCTCACTCGGCAAAGGCCT
GACCGCAGCAAGCCTTGGTCAATTGCTGATTGCACGGGGACTGTCGGTGACCATGCAGAAGCTAGATCCATACCTCAATG
TTGATCCGGGCACCATGAATCCTTTTGAACACGGTGAAGTCTTTGTCACCGAAGACGGGGCAGAAACAGACCTGGATTTG
GGCCACTACGAGCGTTTCCTCGATCGCAACCTGGGGCTCAACGCCAATGTCACCACCGGCAAGGTGTATTCCACTGTGAT
CGCCAAGGAGCGCAGGGGAGAGTACCTGGGTAAAACTGTGCAGGTCATCCCACACATCACTGATGAGATCAAAGCTCGTA
TTTTGAGCATGGGGGAACCAGATGCTCATGGTAACGCCCCAGACGTGGTGATCTCTGAGGTCGGTGGCACCGTCGGTGAC
ATTGAATCCCAGCCATTCCTTGAAGCAGCTCGCCAGGTACGCCATGAAATTGGTCGTGAAAACTGCTTCTTCATCCACTG
TTCTTTGGTGCCATACTTGGCTACCTCAGGTGAGCTGAAGACCAAACCCACCCAGCATTCTGTCGCAGAGCTGCGCGGCA
TCGGTATTTTGCCGGATGCTCTCGTGCTTCGTTGCGATCGGGAGGTCCCTCAAGGTCTGAAAGATAAGATCGCGATGATG
TGCGATGTTGATTATGAAGGCGTTGTATCTTGCCCTGATTCCAGTTCTATTTACAACATTCCAGATGTCCTCTACCGCGA
GCACCTGGACACCTTCATTATTCGTCGCCTGGGCCTTCCGTTCCGTGATGTTGACTGGAGCACCTGGCACGATCTGCTGG
AACGGGTGAACAACCCACGCCATGAGCTCACCGTCGGCATCGTGGGCAAGTACATTGATCTTCCCGATGCTTATCTCTCA
GTGGTGGAAGCTGTTCGCGCTGCAGGCTACGCCAATTGGACGCGCACCAACATTAAGTGGATTACCTCAGATGATTGCGA
AACCCCATCTGGCGCCATGAAAGCGCTCAGCGGTTTGGATGCCATCGTGGTTCCCGGAGGTTTCGGTATCCGAGGTATCG
AAGGCAAAATCGGTGCGATCACGTTTGCACGTGAGCACAAGATCCCGCTTCTTGGCCTATGCCTTGGCCTGCAGTGCACC
GTCATCGAGGCAGCACGCCAGGCAGGACTAGAGCAGGCATCATCCACTGAGTTTGACCCAGCTGCAACGCAGCCAGTGAT
CGCCACCATGGAAGAGCAGAAAGCTGCTGTGTCGGGTGAAGCTGATCTGGGTGGCACCATGCGTCTTGGCGCATATCCTG
CAACCCTGGAGGAAGGCTCCTTAGTAGCGGAACTGTATGGCACAACGGAAGTCTCCGAGCGCCACCGTCACCGCTATGAG
GTCAATAATGCCTACCGCGCCCAGATTGCTGAAGGTTCAGATTTGGTCTTCTCCGGAACCTCACCTGATGGACATTTGGT
GGAGTTCGTGGAGTACCCCAAAGAGGTGCATCCTTATCTGGTGGCGACCCAGGCGCACCCTGAGTACAAATCCCGTCCAA
CCCATGCTCATCCACTGTTTTACGGCCTGGTGAAGACCGCTTTGGAGCTGCGTGTCCACCCTTAG

Upstream 100 bases:

>100_bases
ACACCGAACGTTTAAGTTTTCCGCACCGCCTGACTCGAAAAGATCTTTTTAAAGAACTGTTCGATGTTTAGGTTCAACCA
GGAAGGTCGTCTCAGACATC

Downstream 100 bases:

>100_bases
CTCTACAATGTGATCATGGTTTCGAAGATTCACATTCCCGGTACCCATGAGTTCACGGTGACAGATACTGAACTGTTGTT
AGAGTCCCCAATTTTGGGCG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MTSSRKVRPTKHIFVTGGVVSSLGKGLTAASLGQLLIARGLSVTMQKLDPYLNVDPGTMNPFEHGEVFVTEDGAETDLDL
GHYERFLDRNLGLNANVTTGKVYSTVIAKERRGEYLGKTVQVIPHITDEIKARILSMGEPDAHGNAPDVVISEVGGTVGD
IESQPFLEAARQVRHEIGRENCFFIHCSLVPYLATSGELKTKPTQHSVAELRGIGILPDALVLRCDREVPQGLKDKIAMM
CDVDYEGVVSCPDSSSIYNIPDVLYREHLDTFIIRRLGLPFRDVDWSTWHDLLERVNNPRHELTVGIVGKYIDLPDAYLS
VVEAVRAAGYANWTRTNIKWITSDDCETPSGAMKALSGLDAIVVPGGFGIRGIEGKIGAITFAREHKIPLLGLCLGLQCT
VIEAARQAGLEQASSTEFDPAATQPVIATMEEQKAAVSGEADLGGTMRLGAYPATLEEGSLVAELYGTTEVSERHRHRYE
VNNAYRAQIAEGSDLVFSGTSPDGHLVEFVEYPKEVHPYLVATQAHPEYKSRPTHAHPLFYGLVKTALELRVHP

Sequences:

>Translated_554_residues
MTSSRKVRPTKHIFVTGGVVSSLGKGLTAASLGQLLIARGLSVTMQKLDPYLNVDPGTMNPFEHGEVFVTEDGAETDLDL
GHYERFLDRNLGLNANVTTGKVYSTVIAKERRGEYLGKTVQVIPHITDEIKARILSMGEPDAHGNAPDVVISEVGGTVGD
IESQPFLEAARQVRHEIGRENCFFIHCSLVPYLATSGELKTKPTQHSVAELRGIGILPDALVLRCDREVPQGLKDKIAMM
CDVDYEGVVSCPDSSSIYNIPDVLYREHLDTFIIRRLGLPFRDVDWSTWHDLLERVNNPRHELTVGIVGKYIDLPDAYLS
VVEAVRAAGYANWTRTNIKWITSDDCETPSGAMKALSGLDAIVVPGGFGIRGIEGKIGAITFAREHKIPLLGLCLGLQCT
VIEAARQAGLEQASSTEFDPAATQPVIATMEEQKAAVSGEADLGGTMRLGAYPATLEEGSLVAELYGTTEVSERHRHRYE
VNNAYRAQIAEGSDLVFSGTSPDGHLVEFVEYPKEVHPYLVATQAHPEYKSRPTHAHPLFYGLVKTALELRVHP
>Mature_553_residues
TSSRKVRPTKHIFVTGGVVSSLGKGLTAASLGQLLIARGLSVTMQKLDPYLNVDPGTMNPFEHGEVFVTEDGAETDLDLG
HYERFLDRNLGLNANVTTGKVYSTVIAKERRGEYLGKTVQVIPHITDEIKARILSMGEPDAHGNAPDVVISEVGGTVGDI
ESQPFLEAARQVRHEIGRENCFFIHCSLVPYLATSGELKTKPTQHSVAELRGIGILPDALVLRCDREVPQGLKDKIAMMC
DVDYEGVVSCPDSSSIYNIPDVLYREHLDTFIIRRLGLPFRDVDWSTWHDLLERVNNPRHELTVGIVGKYIDLPDAYLSV
VEAVRAAGYANWTRTNIKWITSDDCETPSGAMKALSGLDAIVVPGGFGIRGIEGKIGAITFAREHKIPLLGLCLGLQCTV
IEAARQAGLEQASSTEFDPAATQPVIATMEEQKAAVSGEADLGGTMRLGAYPATLEEGSLVAELYGTTEVSERHRHRYEV
NNAYRAQIAEGSDLVFSGTSPDGHLVEFVEYPKEVHPYLVATQAHPEYKSRPTHAHPLFYGLVKTALELRVHP

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=551, Percent_Identity=44.6460980036298, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI28559085, Length=554, Percent_Identity=45.1263537906137, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI28559083, Length=554, Percent_Identity=45.1263537906137, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI221316689, Length=554, Percent_Identity=45.1263537906137, Blast_Score=456, Evalue=1e-128,
Organism=Escherichia coli, GI1789142, Length=549, Percent_Identity=55.0091074681239, Blast_Score=562, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI25148299, Length=607, Percent_Identity=36.9028006589786, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6322563, Length=567, Percent_Identity=43.7389770723104, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319432, Length=562, Percent_Identity=42.5266903914591, Blast_Score=416, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24664469, Length=556, Percent_Identity=45.5035971223022, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI21357815, Length=504, Percent_Identity=44.047619047619, Blast_Score=377, Evalue=1e-104,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_CORGB (A4QE10)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138372.1
- ProteinModelPortal:   A4QE10
- SMR:   A4QE10
- STRING:   A4QE10
- GeneID:   4992505
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1478
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 60575; Mature: 60443

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 394-394 ACT_SITE 526-526 ACT_SITE 528-528

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSRKVRPTKHIFVTGGVVSSLGKGLTAASLGQLLIARGLSVTMQKLDPYLNVDPGTMN
CCCCCCCCCCCEEEEECHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCEECCCCCCC
PFEHGEVFVTEDGAETDLDLGHYERFLDRNLGLNANVTTGKVYSTVIAKERRGEYLGKTV
CCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCHH
QVIPHITDEIKARILSMGEPDAHGNAPDVVISEVGGTVGDIESQPFLEAARQVRHEIGRE
HHHHCHHHHHHHHHHHCCCCCCCCCCCCEEHHHCCCCCCCCCCCHHHHHHHHHHHHCCCC
NCFFIHCSLVPYLATSGELKTKPTQHSVAELRGIGILPDALVLRCDREVPQGLKDKIAMM
CEEEEEEEEHHHHCCCCCCCCCCCHHHHHHHCCCCCCCHHHHEECCCHHCCCHHHHHHEE
CDVDYEGVVSCPDSSSIYNIPDVLYREHLDTFIIRRLGLPFRDVDWSTWHDLLERVNNPR
ECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
HELTVGIVGKYIDLPDAYLSVVEAVRAAGYANWTRTNIKWITSDDCETPSGAMKALSGLD
CEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEECCEEEEECCCCCCCHHHHHHHCCCC
AIVVPGGFGIRGIEGKIGAITFAREHKIPLLGLCLGLQCTVIEAARQAGLEQASSTEFDP
EEEECCCCCEECCCCCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHCCHHCCCCCCCC
AATQPVIATMEEQKAAVSGEADLGGTMRLGAYPATLEEGSLVAELYGTTEVSERHRHRYE
CCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
VNNAYRAQIAEGSDLVFSGTSPDGHLVEFVEYPKEVHPYLVATQAHPEYKSRPTHAHPLF
CCCCEEEEECCCCCEEEECCCCCCCHHHHHHCHHHHCCEEEEECCCCCCCCCCCCCCHHH
YGLVKTALELRVHP
HHHHHHHHHHCCCC
>Mature Secondary Structure 
TSSRKVRPTKHIFVTGGVVSSLGKGLTAASLGQLLIARGLSVTMQKLDPYLNVDPGTMN
CCCCCCCCCCEEEEECHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCEECCCCCCC
PFEHGEVFVTEDGAETDLDLGHYERFLDRNLGLNANVTTGKVYSTVIAKERRGEYLGKTV
CCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCHH
QVIPHITDEIKARILSMGEPDAHGNAPDVVISEVGGTVGDIESQPFLEAARQVRHEIGRE
HHHHCHHHHHHHHHHHCCCCCCCCCCCCEEHHHCCCCCCCCCCCHHHHHHHHHHHHCCCC
NCFFIHCSLVPYLATSGELKTKPTQHSVAELRGIGILPDALVLRCDREVPQGLKDKIAMM
CEEEEEEEEHHHHCCCCCCCCCCCHHHHHHHCCCCCCCHHHHEECCCHHCCCHHHHHHEE
CDVDYEGVVSCPDSSSIYNIPDVLYREHLDTFIIRRLGLPFRDVDWSTWHDLLERVNNPR
ECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
HELTVGIVGKYIDLPDAYLSVVEAVRAAGYANWTRTNIKWITSDDCETPSGAMKALSGLD
CEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEECCEEEEECCCCCCCHHHHHHHCCCC
AIVVPGGFGIRGIEGKIGAITFAREHKIPLLGLCLGLQCTVIEAARQAGLEQASSTEFDP
EEEECCCCCEECCCCCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHCCHHCCCCCCCC
AATQPVIATMEEQKAAVSGEADLGGTMRLGAYPATLEEGSLVAELYGTTEVSERHRHRYE
CCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
VNNAYRAQIAEGSDLVFSGTSPDGHLVEFVEYPKEVHPYLVATQAHPEYKSRPTHAHPLF
CCCCEEEEECCCCCEEEECCCCCCCHHHHHHCHHHHCCEEEEECCCCCCCCCCCCCCHHH
YGLVKTALELRVHP
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA