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The map label for this gene is argH

Identifier: 145295536

GI number: 145295536

Start: 1617410

End: 1618843

Strand: Direct

Name: argH

Synonym: cgR_1464

Alternate gene names: 145295536

Gene position: 1617410-1618843 (Clockwise)

Preceding gene: 145295535

Following gene: 145295537

Centisome position: 48.8

GC content: 59.41

Gene sequence:

>1434_bases
ATGGAACAGCACGGAACCAATGAAGGTGCGCTGTGGGGCGGCCGCTTCTCCGGTGGACCCTCCGAGGCCATGTTCGCCTT
GAGTGTCTCCACTCATTTCGACTGGGTTTTGGCCCCTTATGATGTGTTGGCCTCCAAGGCACACGCCAAGGTTTTGCACC
AAGCAGAGCTACTTTCTGATGAAGATCTAGCCACCATGTTGGCTGGGCTTGATCAGCTGGGCAAGGATGTCGCCGACGGA
GCCTTCGGTCCGCTGCCTTCTGATGAGGATGTGCACGGCGCGATGGAACGCGGTCTGATTGACCGCGTTGGTCCTGAGGT
GGGCGGCCGTCTGCGCGCTGGTCGTTCCCGCAACGACCAGGTGGCAACCCTGTTCCGCATGTGGGTCCGCGACGCAGTGC
GCGACATCGCGCTGGGAACAACCGAGCTTGTCGACGCCCTCAGCGCCCAAGCTAAGGCACATGCAGACGCGATCATGCCA
GGCAAGACCCACTTCCAGGCAGCTCAGCCGGTCCTTCTGGCACACCAGCTGCTGGCACACGCACAGCCTTTGCTGCGCGA
TATTGATCGTATCCGTGACCTGGACAAGCGTCTTGCGGTGTCTCCTTACGGTTCCGGCGCCCTTGCTGGTTCCTCTTTGA
AGCTCAACCCTGAAGCAATCGCTGAAGAACTCGGCTTTGATTCCGCAGCAGATAACTCCATTGATGCCACCAGCTCCCGC
GATTTCGCATCTGAAACCGCCTTCGTGCTGGCGCAGCTTGCAGTGGATATGTCCCGCTTGGCTGAAGAAATCATCGCATG
GTGCACCCCAGAATTTGGTTACATCACCTTGTCTGATTCCTGGTCCACAGGCAGCTCAATCATGCCGCAGAAGAAGAACC
CTGACGTGGCAGAGCTGACCCGTGGCAAGTCTGGTCGCTTGATCGGTAACCTCACCGGTCTGCTGGCTACCCTGAAGGCA
CAGCCTTTGGCGTACAACCGCGACCTGCAGGAAGATAAGGAACCAATCGTAGATTCCGTGGCGCAGCTCAACCTGCTGCT
CCCTGCAATGACTGGTTTGGTTTCCACCTTGACCTTCAACACCGAGCGCATGCGTGAACTTGCACCAGCAGGTTTCACCC
TTGCCACCGACTTGGCTGAGTGGATGGTGCGCCAGGGCGTTCCATTCCGTGAGGCACACGAAGCATCCGGCGCTTGCGTG
CGGATCGCGGAGTCCAGGGGAGTGGACCTTATCGATCTCACTGATGAAGAACTCAGTGGCGTTGATGCACGTCTGACCCC
AGAGGTACGGGAAGTGCTCACTATTGATGGTGCAGTGGCTTCCCGTGCAACGCGCGGTGGAACCGCGGGCGTGCGGGTTG
CGGAGCAACGCGCACGTGTCGATGCCGCAAGTACCGCTCACGCGGAGTGGGCACGTGCGGGGGTACGTCGATAA

Upstream 100 bases:

>100_bases
GATCGCTAACAAGCGCGATCGCGAAGCTGGCAACAACTAAGCCACCTTTTCAAGCATCCAGACTAGAACTTCAAGTATTT
AGAAAGTAGAAGAACAACAC

Downstream 100 bases:

>100_bases
GCATTAGTTTATGGCCTGTGCTGCTTTCCGATTGCGGGAGTTGCACAGGCCATTTATTATCAATTCGTGAATGGTTCCCC
TGATTACTCAAGAAAATCTC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MEQHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHAKVLHQAELLSDEDLATMLAGLDQLGKDVADG
AFGPLPSDEDVHGAMERGLIDRVGPEVGGRLRAGRSRNDQVATLFRMWVRDAVRDIALGTTELVDALSAQAKAHADAIMP
GKTHFQAAQPVLLAHQLLAHAQPLLRDIDRIRDLDKRLAVSPYGSGALAGSSLKLNPEAIAEELGFDSAADNSIDATSSR
DFASETAFVLAQLAVDMSRLAEEIIAWCTPEFGYITLSDSWSTGSSIMPQKKNPDVAELTRGKSGRLIGNLTGLLATLKA
QPLAYNRDLQEDKEPIVDSVAQLNLLLPAMTGLVSTLTFNTERMRELAPAGFTLATDLAEWMVRQGVPFREAHEASGACV
RIAESRGVDLIDLTDEELSGVDARLTPEVREVLTIDGAVASRATRGGTAGVRVAEQRARVDAASTAHAEWARAGVRR

Sequences:

>Translated_477_residues
MEQHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHAKVLHQAELLSDEDLATMLAGLDQLGKDVADG
AFGPLPSDEDVHGAMERGLIDRVGPEVGGRLRAGRSRNDQVATLFRMWVRDAVRDIALGTTELVDALSAQAKAHADAIMP
GKTHFQAAQPVLLAHQLLAHAQPLLRDIDRIRDLDKRLAVSPYGSGALAGSSLKLNPEAIAEELGFDSAADNSIDATSSR
DFASETAFVLAQLAVDMSRLAEEIIAWCTPEFGYITLSDSWSTGSSIMPQKKNPDVAELTRGKSGRLIGNLTGLLATLKA
QPLAYNRDLQEDKEPIVDSVAQLNLLLPAMTGLVSTLTFNTERMRELAPAGFTLATDLAEWMVRQGVPFREAHEASGACV
RIAESRGVDLIDLTDEELSGVDARLTPEVREVLTIDGAVASRATRGGTAGVRVAEQRARVDAASTAHAEWARAGVRR
>Mature_477_residues
MEQHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHAKVLHQAELLSDEDLATMLAGLDQLGKDVADG
AFGPLPSDEDVHGAMERGLIDRVGPEVGGRLRAGRSRNDQVATLFRMWVRDAVRDIALGTTELVDALSAQAKAHADAIMP
GKTHFQAAQPVLLAHQLLAHAQPLLRDIDRIRDLDKRLAVSPYGSGALAGSSLKLNPEAIAEELGFDSAADNSIDATSSR
DFASETAFVLAQLAVDMSRLAEEIIAWCTPEFGYITLSDSWSTGSSIMPQKKNPDVAELTRGKSGRLIGNLTGLLATLKA
QPLAYNRDLQEDKEPIVDSVAQLNLLLPAMTGLVSTLTFNTERMRELAPAGFTLATDLAEWMVRQGVPFREAHEASGACV
RIAESRGVDLIDLTDEELSGVDARLTPEVREVLTIDGAVASRATRGGTAGVRVAEQRARVDAASTAHAEWARAGVRR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=458, Percent_Identity=42.3580786026201, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI68303542, Length=458, Percent_Identity=42.3580786026201, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI68303549, Length=458, Percent_Identity=39.9563318777293, Blast_Score=315, Evalue=7e-86,
Organism=Homo sapiens, GI68303547, Length=458, Percent_Identity=39.7379912663755, Blast_Score=315, Evalue=8e-86,
Organism=Escherichia coli, GI1790398, Length=447, Percent_Identity=41.834451901566, Blast_Score=318, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6321806, Length=448, Percent_Identity=42.6339285714286, Blast_Score=350, Evalue=4e-97,
Organism=Drosophila melanogaster, GI221473854, Length=446, Percent_Identity=40.5829596412556, Blast_Score=325, Evalue=6e-89,
Organism=Drosophila melanogaster, GI78706858, Length=446, Percent_Identity=40.5829596412556, Blast_Score=325, Evalue=6e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_CORGB (A4QDZ5)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138357.1
- ProteinModelPortal:   A4QDZ5
- SMR:   A4QDZ5
- STRING:   A4QDZ5
- GeneID:   4992932
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1464
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MPGRTHL
- ProtClustDB:   PRK00855
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51084; Mature: 51084

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHAKVLHQAELLSD
CCCCCCCCCCEECCCCCCCCCCEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHCCC
EDLATMLAGLDQLGKDVADGAFGPLPSDEDVHGAMERGLIDRVGPEVGGRLRAGRSRNDQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCHHHCCCCCCCCCCCHH
VATLFRMWVRDAVRDIALGTTELVDALSAQAKAHADAIMPGKTHFQAAQPVLLAHQLLAH
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHH
AQPLLRDIDRIRDLDKRLAVSPYGSGALAGSSLKLNPEAIAEELGFDSAADNSIDATSSR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECHHHHHHHHCCCCCCCCCCCCCCCC
DFASETAFVLAQLAVDMSRLAEEIIAWCTPEFGYITLSDSWSTGSSIMPQKKNPDVAELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHH
RGKSGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPIVDSVAQLNLLLPAMTGLVSTLTFN
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TERMRELAPAGFTLATDLAEWMVRQGVPFREAHEASGACVRIAESRGVDLIDLTDEELSG
HHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEECCCCCEEEECCCHHHCC
VDARLTPEVREVLTIDGAVASRATRGGTAGVRVAEQRARVDAASTAHAEWARAGVRR
CCCCCCHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEQHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHAKVLHQAELLSD
CCCCCCCCCCEECCCCCCCCCCEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHCCC
EDLATMLAGLDQLGKDVADGAFGPLPSDEDVHGAMERGLIDRVGPEVGGRLRAGRSRNDQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCHHHCCCCCCCCCCCHH
VATLFRMWVRDAVRDIALGTTELVDALSAQAKAHADAIMPGKTHFQAAQPVLLAHQLLAH
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHH
AQPLLRDIDRIRDLDKRLAVSPYGSGALAGSSLKLNPEAIAEELGFDSAADNSIDATSSR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECHHHHHHHHCCCCCCCCCCCCCCCC
DFASETAFVLAQLAVDMSRLAEEIIAWCTPEFGYITLSDSWSTGSSIMPQKKNPDVAELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHH
RGKSGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPIVDSVAQLNLLLPAMTGLVSTLTFN
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TERMRELAPAGFTLATDLAEWMVRQGVPFREAHEASGACVRIAESRGVDLIDLTDEELSG
HHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEECCCCCEEEECCCHHHCC
VDARLTPEVREVLTIDGAVASRATRGGTAGVRVAEQRARVDAASTAHAEWARAGVRR
CCCCCCHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA