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The map label for this gene is ung [H]

Identifier: 145295465

GI number: 145295465

Start: 1532002

End: 1532766

Strand: Direct

Name: ung [H]

Synonym: cgR_1398

Alternate gene names: 145295465

Gene position: 1532002-1532766 (Clockwise)

Preceding gene: 145295464

Following gene: 145295466

Centisome position: 46.23

GC content: 54.77

Gene sequence:

>765_bases
ATGGAGAAGCTTCTAATGACCAACACCCTATGGAATTCAGTAGACGAACTCCCCATCCACGACTCCTGGAAACCAGTACT
CAAACCAGTCGAAGACACCATCCGAAAACTCGGTGCATTCCTCGCGGAAGAAGAATTCCTTCCACCAGTAGATGACGTAT
TCAGAGCATTTGCCTACCCCTTTGACGCAGTAAAAGTACTGATCATGGGACAAGACCCATATCCCACCCCAGGACATGCC
ATGGGACTGAGCTTTTCCACCCAACCAGACGTACGACCACTGCCACGGAGCCTGAACAATATCTTCAAAGAGCTGGTGAG
TGATGTCGGCTCTTTAGGCGATTCGGCGTCAGCGCAGGGGGCCTTGGACTTAGGTATTAACGCGCCGGGCTCTGTCGCTG
GCACACAAGTTGCCTTGCCCGCGGACGGCGACCTCCGTGCATGGAGCAACCAGGGCGTCGCATTGTTCAACCGCGTACTC
ACCGTCCACCCAGGGCAGGCCGGAAGCCACAAGGGTAAAGGCTGGGAAGCGGTAACCGAACAGGCGATTAAAGCCTTGGC
GGAGCGGGATCAACCCTTGGTGGCAATCCTGTGGGGTAAACAAGCCCAAGAGGTACAGAAATTCCTTGGAGATACGCCGT
GTATCTGCTCAGTGCACCCATCGCCGCTGTCGGCGTCGAGAGGCTTTTTTGGCTCTAAGCCTTTTAGTCGTGCAAACGAA
ATCTTAAGCAGCCTCGGTGCCACCGAGATCGATTGGTCGCTGTAA

Upstream 100 bases:

>100_bases
GCGATGCCCCCTCTGGATTCCGCACCATCGGCCACGTCACCAAAACACGCCACGAAGACCTCGTCACCGTAGATAAGAAA
ACCCCCGCATTTTCCGATGG

Downstream 100 bases:

>100_bases
GGTATCTGATTATGTCCAGTTCCGAAAGCTCGAGTTCCGAAGGCTCGCAGCCAGCACCGTCTGTACAGCCTGAACACCGT
GCTGATTCAACGGGGGCTCC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MEKLLMTNTLWNSVDELPIHDSWKPVLKPVEDTIRKLGAFLAEEEFLPPVDDVFRAFAYPFDAVKVLIMGQDPYPTPGHA
MGLSFSTQPDVRPLPRSLNNIFKELVSDVGSLGDSASAQGALDLGINAPGSVAGTQVALPADGDLRAWSNQGVALFNRVL
TVHPGQAGSHKGKGWEAVTEQAIKALAERDQPLVAILWGKQAQEVQKFLGDTPCICSVHPSPLSASRGFFGSKPFSRANE
ILSSLGATEIDWSL

Sequences:

>Translated_254_residues
MEKLLMTNTLWNSVDELPIHDSWKPVLKPVEDTIRKLGAFLAEEEFLPPVDDVFRAFAYPFDAVKVLIMGQDPYPTPGHA
MGLSFSTQPDVRPLPRSLNNIFKELVSDVGSLGDSASAQGALDLGINAPGSVAGTQVALPADGDLRAWSNQGVALFNRVL
TVHPGQAGSHKGKGWEAVTEQAIKALAERDQPLVAILWGKQAQEVQKFLGDTPCICSVHPSPLSASRGFFGSKPFSRANE
ILSSLGATEIDWSL
>Mature_254_residues
MEKLLMTNTLWNSVDELPIHDSWKPVLKPVEDTIRKLGAFLAEEEFLPPVDDVFRAFAYPFDAVKVLIMGQDPYPTPGHA
MGLSFSTQPDVRPLPRSLNNIFKELVSDVGSLGDSASAQGALDLGINAPGSVAGTQVALPADGDLRAWSNQGVALFNRVL
TVHPGQAGSHKGKGWEAVTEQAIKALAERDQPLVAILWGKQAQEVQKFLGDTPCICSVHPSPLSASRGFFGSKPFSRANE
ILSSLGATEIDWSL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI6224979, Length=225, Percent_Identity=39.1111111111111, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI19718751, Length=224, Percent_Identity=39.2857142857143, Blast_Score=135, Evalue=5e-32,
Organism=Escherichia coli, GI1788934, Length=208, Percent_Identity=39.9038461538462, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17556304, Length=245, Percent_Identity=34.6938775510204, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323620, Length=263, Percent_Identity=36.5019011406844, Blast_Score=131, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 27371; Mature: 27371

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLLMTNTLWNSVDELPIHDSWKPVLKPVEDTIRKLGAFLAEEEFLPPVDDVFRAFAYP
CCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
FDAVKVLIMGQDPYPTPGHAMGLSFSTQPDVRPLPRSLNNIFKELVSDVGSLGDSASAQG
HHHEEEEEECCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ALDLGINAPGSVAGTQVALPADGDLRAWSNQGVALFNRVLTVHPGQAGSHKGKGWEAVTE
CEEECCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHH
QAIKALAERDQPLVAILWGKQAQEVQKFLGDTPCICSVHPSPLSASRGFFGSKPFSRANE
HHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
ILSSLGATEIDWSL
HHHHCCCCCCCCCC
>Mature Secondary Structure
MEKLLMTNTLWNSVDELPIHDSWKPVLKPVEDTIRKLGAFLAEEEFLPPVDDVFRAFAYP
CCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
FDAVKVLIMGQDPYPTPGHAMGLSFSTQPDVRPLPRSLNNIFKELVSDVGSLGDSASAQG
HHHEEEEEECCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ALDLGINAPGSVAGTQVALPADGDLRAWSNQGVALFNRVLTVHPGQAGSHKGKGWEAVTE
CEEECCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHH
QAIKALAERDQPLVAILWGKQAQEVQKFLGDTPCICSVHPSPLSASRGFFGSKPFSRANE
HHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
ILSSLGATEIDWSL
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]