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The map label for this gene is nadC [H]

Identifier: 145295210

GI number: 145295210

Start: 1259355

End: 1260194

Strand: Reverse

Name: nadC [H]

Synonym: cgR_1151

Alternate gene names: 145295210

Gene position: 1260194-1259355 (Counterclockwise)

Preceding gene: 145295211

Following gene: 145295209

Centisome position: 38.02

GC content: 52.86

Gene sequence:

>840_bases
ATGACTAACCATACTGACCGTATCGTTGGCGCAGCGTTATCCGAGGATGCGCCATGGGGCGACATTACCTCCGACACTTT
TATCCCAGGATCGGCGCAGCTGAGCGCCAAGGTTGTTGCCCGGGAGCCAGGTGTGTTCAGCGGGCAGGCGCTTTTCGACG
CCTCCTTCCGGCTCGTTGATCCTAGGATAAATGCATCCCTTAAGGTGGCTGATGGTGACAGCTTTGAGACCGGGGACATC
CTAGGAACAATTACCGGCAGTGCTAGAAGCATCCTCCGTTCAGAGCGCATTGCTCTCAACTTCATTCAGAGGACGTCCGG
CATCGCTACATTGACATCGTGCTATGTTGCAGAGGTTAAAGGCACCAAAGCCCGCATTGTTGATACCCGGAAAACTACAC
CCGGCCTGCGCATCATTGAACGCCAAGCTGTCCGTGACGGTGGCGGATTTAATCACCGAGCCACCTTGTCCGATGCTGTC
ATGGTGAAAGATAACCATCTCGCAGCCATCGCATCCCAGGGGCTCAGCATCACTGAAGCGCTGTTGAATATGAAAGCTAA
ACTCCCCCACACCACCCATGTGGAAGTCGAAGTTGATCATATAGAGCAGATCGAACCAGTTCTTGCTGCTGGTGTGGACA
CCATCATGTTGGATAATTTCACCATTGATCAGCTCATCGAAGGCGTTGATCTCATTGGTGGACGTGCGCTGGTGGAAGCA
TCTGGCGGAGTCAACCTCAACACCGTGGGAAAGATTGCATCAACCGGTGTCGATGTCATTTCCGTTGGAGCGCTTACCCA
TTCTGTGCATGCACTTGACCTAGGACTCGATATTTTCTAA

Upstream 100 bases:

>100_bases
TGAATCTGTGGCGGCACCGGCGCGTGTTGCCCTGGAGAGGATGCTGTCTGTTGTCCCAGCGGCTCCTGTTACTCCTAGCT
CCTCGAAGGATGCGTAATTT

Downstream 100 bases:

>100_bases
TGCTCTACCTTGATAATGCAGCCACCACCAGTGTGCGCAAAGAAGCACTTGAGGCCATGTGGCCTTATCTCACCGGAGCG
TTTGGCAATCCGTCAAGTCC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTNHTDRIVGAALSEDAPWGDITSDTFIPGSAQLSAKVVAREPGVFSGQALFDASFRLVDPRINASLKVADGDSFETGDI
LGTITGSARSILRSERIALNFIQRTSGIATLTSCYVAEVKGTKARIVDTRKTTPGLRIIERQAVRDGGGFNHRATLSDAV
MVKDNHLAAIASQGLSITEALLNMKAKLPHTTHVEVEVDHIEQIEPVLAAGVDTIMLDNFTIDQLIEGVDLIGGRALVEA
SGGVNLNTVGKIASTGVDVISVGALTHSVHALDLGLDIF

Sequences:

>Translated_279_residues
MTNHTDRIVGAALSEDAPWGDITSDTFIPGSAQLSAKVVAREPGVFSGQALFDASFRLVDPRINASLKVADGDSFETGDI
LGTITGSARSILRSERIALNFIQRTSGIATLTSCYVAEVKGTKARIVDTRKTTPGLRIIERQAVRDGGGFNHRATLSDAV
MVKDNHLAAIASQGLSITEALLNMKAKLPHTTHVEVEVDHIEQIEPVLAAGVDTIMLDNFTIDQLIEGVDLIGGRALVEA
SGGVNLNTVGKIASTGVDVISVGALTHSVHALDLGLDIF
>Mature_278_residues
TNHTDRIVGAALSEDAPWGDITSDTFIPGSAQLSAKVVAREPGVFSGQALFDASFRLVDPRINASLKVADGDSFETGDIL
GTITGSARSILRSERIALNFIQRTSGIATLTSCYVAEVKGTKARIVDTRKTTPGLRIIERQAVRDGGGFNHRATLSDAVM
VKDNHLAAIASQGLSITEALLNMKAKLPHTTHVEVEVDHIEQIEPVLAAGVDTIMLDNFTIDQLIEGVDLIGGRALVEAS
GGVNLNTVGKIASTGVDVISVGALTHSVHALDLGLDIF

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=277, Percent_Identity=32.129963898917, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1786299, Length=258, Percent_Identity=40.6976744186046, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321162, Length=280, Percent_Identity=32.1428571428571, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29432; Mature: 29301

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNHTDRIVGAALSEDAPWGDITSDTFIPGSAQLSAKVVAREPGVFSGQALFDASFRLVD
CCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEECCCEEEEC
PRINASLKVADGDSFETGDILGTITGSARSILRSERIALNFIQRTSGIATLTSCYVAEVK
CCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEECC
GTKARIVDTRKTTPGLRIIERQAVRDGGGFNHRATLSDAVMVKDNHLAAIASQGLSITEA
CCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEECCCEEEEECCCEEEHHHCCCHHHHH
LLNMKAKLPHTTHVEVEVDHIEQIEPVLAAGVDTIMLDNFTIDQLIEGVDLIGGRALVEA
HHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCEEEEEE
SGGVNLNTVGKIASTGVDVISVGALTHSVHALDLGLDIF
CCCCCCHHHHHHHHCCCCEEEECHHHHHEEEEECCCCCC
>Mature Secondary Structure 
TNHTDRIVGAALSEDAPWGDITSDTFIPGSAQLSAKVVAREPGVFSGQALFDASFRLVD
CCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEECCCEEEEC
PRINASLKVADGDSFETGDILGTITGSARSILRSERIALNFIQRTSGIATLTSCYVAEVK
CCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEECC
GTKARIVDTRKTTPGLRIIERQAVRDGGGFNHRATLSDAVMVKDNHLAAIASQGLSITEA
CCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEECCCEEEEECCCEEEHHHCCCHHHHH
LLNMKAKLPHTTHVEVEVDHIEQIEPVLAAGVDTIMLDNFTIDQLIEGVDLIGGRALVEA
HHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCEEEEEE
SGGVNLNTVGKIASTGVDVISVGALTHSVHALDLGLDIF
CCCCCCHHHHHHHHCCCCEEEECHHHHHEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]