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The map label for this gene is uppS1 [H]

Identifier: 145295141

GI number: 145295141

Start: 1196242

End: 1197012

Strand: Direct

Name: uppS1 [H]

Synonym: cgR_1084

Alternate gene names: 145295141

Gene position: 1196242-1197012 (Clockwise)

Preceding gene: 145295140

Following gene: 145295142

Centisome position: 36.09

GC content: 54.6

Gene sequence:

>771_bases
GTGTTAAACCTGCCCAGACTGCTGTACCCGGTGTATGAGCGCCGTCTTTTAAGAGAACTAGACGGCGCCAAACAGCCCGG
TCACGTTGCCATCATGTGTGATGGCAACCGACGCTGGGCCCGGGAAGCGGGCTTCACTGATGTCAGCCATGGGCACCGAG
TGGGTGCCAAAAAGATCGGCGAGATGGTCCGCTGGTGTGATGATGTAGACGTCAATCTCGTGACCGTTTATTTGCTGTCT
ATGGAAAACCTTGGGCGATCCTCCGAAGAGCTGCAATTGCTGTTCGATATCATCGCCGATGTCGCTGATGAACTCGCGCG
TCCTGAAACCAACTGTCGAGTCCGCCTCGTTGGTCATTTAGATCTGCTCCCAGACCCAGTTGCTTGTCGTTTACGCAAAG
CTGAAGAAGCTACCGTTAACAACACAGGCATCGCAGTCAACATGGCTGTCGGTTATGGCGGACGCCAGGAAATCGTTGAT
GCCGTGCAAAAACTTCTGACCATCGGCAAGGACGAGGGCCTCAGCGTTGATGAACTGATCGAATCAGTCAAGGTAGATGC
GATCTCCACTCACCTGTACACCTCTGGCCAACCAGACCCAGACCTGGTGATCCGCACCTCTGGTGAGCAGCGACTTTCCG
GATTCATGCTGTGGCAATCTGCCTACTCCGAAATCTGGTTCACAGACACCTACTGGCCAGCCTTCCGACGCATCGACTTC
CTCCGCGCCATTCGCGACTACTCGCAGCGCAGCAGAAGATTCGGTAAATAA

Upstream 100 bases:

>100_bases
TCGATATTGACACCACCATCGATTTGCTCGCTGAGCTGGCCGCAGCAGTAAGGGAACGCCGAGCAGCAGCCAAGTAATTA
AGGGCGCTAGACTGTTAAAT

Downstream 100 bases:

>100_bases
CTTATTCTCCAAGGAGAGACATGTCTGACTACATCGTCGCATTTGAATCCGCATACGGCTCTACCAAGCAGTACGCAGAA
TCTCTAGCGCAACGCCTCGG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 1; Di-trans,poly-cis-decaprenylcistransferase 1; Undecaprenyl diphosphate synthase 1; UDS 1 [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MLNLPRLLYPVYERRLLRELDGAKQPGHVAIMCDGNRRWAREAGFTDVSHGHRVGAKKIGEMVRWCDDVDVNLVTVYLLS
MENLGRSSEELQLLFDIIADVADELARPETNCRVRLVGHLDLLPDPVACRLRKAEEATVNNTGIAVNMAVGYGGRQEIVD
AVQKLLTIGKDEGLSVDELIESVKVDAISTHLYTSGQPDPDLVIRTSGEQRLSGFMLWQSAYSEIWFTDTYWPAFRRIDF
LRAIRDYSQRSRRFGK

Sequences:

>Translated_256_residues
MLNLPRLLYPVYERRLLRELDGAKQPGHVAIMCDGNRRWAREAGFTDVSHGHRVGAKKIGEMVRWCDDVDVNLVTVYLLS
MENLGRSSEELQLLFDIIADVADELARPETNCRVRLVGHLDLLPDPVACRLRKAEEATVNNTGIAVNMAVGYGGRQEIVD
AVQKLLTIGKDEGLSVDELIESVKVDAISTHLYTSGQPDPDLVIRTSGEQRLSGFMLWQSAYSEIWFTDTYWPAFRRIDF
LRAIRDYSQRSRRFGK
>Mature_256_residues
MLNLPRLLYPVYERRLLRELDGAKQPGHVAIMCDGNRRWAREAGFTDVSHGHRVGAKKIGEMVRWCDDVDVNLVTVYLLS
MENLGRSSEELQLLFDIIADVADELARPETNCRVRLVGHLDLLPDPVACRLRKAEEATVNNTGIAVNMAVGYGGRQEIVD
AVQKLLTIGKDEGLSVDELIESVKVDAISTHLYTSGQPDPDLVIRTSGEQRLSGFMLWQSAYSEIWFTDTYWPAFRRIDF
LRAIRDYSQRSRRFGK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=242, Percent_Identity=32.6446280991736, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI45580742, Length=242, Percent_Identity=32.6446280991736, Blast_Score=132, Evalue=4e-31,
Organism=Escherichia coli, GI1786371, Length=230, Percent_Identity=36.0869565217391, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71993029, Length=243, Percent_Identity=32.0987654320988, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319474, Length=217, Percent_Identity=35.0230414746544, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=272, Percent_Identity=26.1029411764706, Blast_Score=99, Evalue=8e-22,
Organism=Drosophila melanogaster, GI18857969, Length=250, Percent_Identity=38.4, Blast_Score=149, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29038; Mature: 29038

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLPRLLYPVYERRLLRELDGAKQPGHVAIMCDGNRRWAREAGFTDVSHGHRVGAKKIG
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCCHHHHH
EMVRWCDDVDVNLVTVYLLSMENLGRSSEELQLLFDIIADVADELARPETNCRVRLVGHL
HHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
DLLPDPVACRLRKAEEATVNNTGIAVNMAVGYGGRQEIVDAVQKLLTIGKDEGLSVDELI
CCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHH
ESVKVDAISTHLYTSGQPDPDLVIRTSGEQRLSGFMLWQSAYSEIWFTDTYWPAFRRIDF
HHHHHHHHHHEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHH
LRAIRDYSQRSRRFGK
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLNLPRLLYPVYERRLLRELDGAKQPGHVAIMCDGNRRWAREAGFTDVSHGHRVGAKKIG
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCCHHHHH
EMVRWCDDVDVNLVTVYLLSMENLGRSSEELQLLFDIIADVADELARPETNCRVRLVGHL
HHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
DLLPDPVACRLRKAEEATVNNTGIAVNMAVGYGGRQEIVDAVQKLLTIGKDEGLSVDELI
CCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHH
ESVKVDAISTHLYTSGQPDPDLVIRTSGEQRLSGFMLWQSAYSEIWFTDTYWPAFRRIDF
HHHHHHHHHHEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHH
LRAIRDYSQRSRRFGK
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8097175; 12948626 [H]