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The map label for this gene is mco [H]

Identifier: 145295103

GI number: 145295103

Start: 1154545

End: 1156086

Strand: Direct

Name: mco [H]

Synonym: cgR_1046

Alternate gene names: 145295103

Gene position: 1154545-1156086 (Clockwise)

Preceding gene: 145295098

Following gene: 145295104

Centisome position: 34.84

GC content: 55.38

Gene sequence:

>1542_bases
ATGTTGTTGCCAGAGTTGAATCGTCGGACTTTTTTCAAAGGGGCCGGGGTGCTGGCAGCAACGGTGGTGGGATCGCAGGT
GCTGGTGGCGTGTTCGTCGGATGATGTGCGTGGTTATGGGGGAGAGCCGCGGACGTTGCCTATTCCACCAGCAGATTTAG
GTACGCGTGAGGGATCTAGCGTGCACTTTGCCCTGGAGGCTCAGACTGGGGAGAGTCAGATTTTGCCGGATGTCACAACG
AAGACGTGGGGTTTCAACGGCACTCATTTGGGGCCGACGTTGGTGGTGAAGAAAGGTGATGACGTCCACGTTGATGTAAT
AAACAATTTGGATGAAATGACCACTGTGCATTGGCATGGCATGAAGTTGCCAGCGATTGCTGATGGCGGTCCGCACTCAC
CGATTGAACCTGGTCAGACGTGGTCACCGACGTGGACTGTGGCCAATGATGCAGCCACTTTGTGGTACCACCCGCACACT
CATGGCCTGACAGGTTTGCATGCGTACCGTGGTTTGGCGGGCATGATCATTGTGGAAGATGAAGCAACAGACAAACTTGA
TCTGCCACGCGATTACGGCGTGGATGATATTCCGCTGGTTTTAATGGATCACCGCTTCTTAGAAGACGGTGCCTTTGATG
AGGAAGACCTCCCTGATCTTGGGCTGTTGGGCGATACCCCCACGGTTAATGGCATTACCAATGCGCACTTTGATGCCACC
ACGCGCCGGGTTCGGTTCCGCGTGCTCAACGGCTCCAACATGCGGTTCTATAACTTGGCGTTTTCAGACAAGCGCACCTT
CCAAGTCATTGCCAGCGATTCTGGTTTGCTTAATGAACCTCAAGACCGCACCACCTTAGCTATTGGACCAGGCGAGCGGT
GGGAAATCGTTGTAGATCTGGAGCCCGGCGAGGACGTCACCTTGGAATCTGTAGGTTTTGAGGACAATTACGGCGTGCCT
GATGATGAGTTTGTGCCCGATTTCGGCATGTCAGATTCCTTCCAGCTGCTCACCATCACCGGCCCTTCCGATGATGCTGC
GCAAGCACCAGCTCTGCCTGGCGTACTGGTGAAATCCACCGAGCCAGATGTCATCGATGCCACCGAACGCACCTTCATCA
TGAACACTTTCTCCATCAACGATCTACAGATGGACATGCAGCGCGTTGACGTGGTGATTGACCATGACCAGCCAGAAGTG
TGGATTGTCACCAACGACAACTCCGACTGGCCCCACAACTTCCACGTCCACGACGCCCGCTTTAAAGTGCTGAAATTTGA
AGGTACCGACGTGGAACTCTTCAACGACGGCTGGAAAGACACCGTCGGCCTACCACCGGCAGCGACCGCAACTTTAGCCG
TGGAATTTGGCCACTACCCAGACCCACAGTGGCCCTACATGTATCACTGTCACATGCTCTACCACGAGGATCAAGGCATG
ATGGGGCAGTTCGTCATCGTGGAGCCAGGTGACGAGCCGGCGGCGGTGCTGGGGTCGGGCACGGGCTCCAGCATTGGTTC
CGCCGGCGGACATGCGCACTAG

Upstream 100 bases:

>100_bases
TCTGTGGGATTTGTCATGGGTGAAAGCTTAGAAGAACTACACCGTTTGGTTGATAAGATGTGGGGTGTTTATGAAAATTT
GTTTGAGGGAGTGAAGGCGC

Downstream 100 bases:

>100_bases
GGGCGTGGGGCGGCGTCGATAAGCGAGATTTTTAGCCCTTTAGAAGCCACATGACATATGTCATGAAAATTATGTGCAGG
GTGCAGAAAGACTCCTGACA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MLLPELNRRTFFKGAGVLAATVVGSQVLVACSSDDVRGYGGEPRTLPIPPADLGTREGSSVHFALEAQTGESQILPDVTT
KTWGFNGTHLGPTLVVKKGDDVHVDVINNLDEMTTVHWHGMKLPAIADGGPHSPIEPGQTWSPTWTVANDAATLWYHPHT
HGLTGLHAYRGLAGMIIVEDEATDKLDLPRDYGVDDIPLVLMDHRFLEDGAFDEEDLPDLGLLGDTPTVNGITNAHFDAT
TRRVRFRVLNGSNMRFYNLAFSDKRTFQVIASDSGLLNEPQDRTTLAIGPGERWEIVVDLEPGEDVTLESVGFEDNYGVP
DDEFVPDFGMSDSFQLLTITGPSDDAAQAPALPGVLVKSTEPDVIDATERTFIMNTFSINDLQMDMQRVDVVIDHDQPEV
WIVTNDNSDWPHNFHVHDARFKVLKFEGTDVELFNDGWKDTVGLPPAATATLAVEFGHYPDPQWPYMYHCHMLYHEDQGM
MGQFVIVEPGDEPAAVLGSGTGSSIGSAGGHAH

Sequences:

>Translated_513_residues
MLLPELNRRTFFKGAGVLAATVVGSQVLVACSSDDVRGYGGEPRTLPIPPADLGTREGSSVHFALEAQTGESQILPDVTT
KTWGFNGTHLGPTLVVKKGDDVHVDVINNLDEMTTVHWHGMKLPAIADGGPHSPIEPGQTWSPTWTVANDAATLWYHPHT
HGLTGLHAYRGLAGMIIVEDEATDKLDLPRDYGVDDIPLVLMDHRFLEDGAFDEEDLPDLGLLGDTPTVNGITNAHFDAT
TRRVRFRVLNGSNMRFYNLAFSDKRTFQVIASDSGLLNEPQDRTTLAIGPGERWEIVVDLEPGEDVTLESVGFEDNYGVP
DDEFVPDFGMSDSFQLLTITGPSDDAAQAPALPGVLVKSTEPDVIDATERTFIMNTFSINDLQMDMQRVDVVIDHDQPEV
WIVTNDNSDWPHNFHVHDARFKVLKFEGTDVELFNDGWKDTVGLPPAATATLAVEFGHYPDPQWPYMYHCHMLYHEDQGM
MGQFVIVEPGDEPAAVLGSGTGSSIGSAGGHAH
>Mature_513_residues
MLLPELNRRTFFKGAGVLAATVVGSQVLVACSSDDVRGYGGEPRTLPIPPADLGTREGSSVHFALEAQTGESQILPDVTT
KTWGFNGTHLGPTLVVKKGDDVHVDVINNLDEMTTVHWHGMKLPAIADGGPHSPIEPGQTWSPTWTVANDAATLWYHPHT
HGLTGLHAYRGLAGMIIVEDEATDKLDLPRDYGVDDIPLVLMDHRFLEDGAFDEEDLPDLGLLGDTPTVNGITNAHFDAT
TRRVRFRVLNGSNMRFYNLAFSDKRTFQVIASDSGLLNEPQDRTTLAIGPGERWEIVVDLEPGEDVTLESVGFEDNYGVP
DDEFVPDFGMSDSFQLLTITGPSDDAAQAPALPGVLVKSTEPDVIDATERTFIMNTFSINDLQMDMQRVDVVIDHDQPEV
WIVTNDNSDWPHNFHVHDARFKVLKFEGTDVELFNDGWKDTVGLPPAATATLAVEFGHYPDPQWPYMYHCHMLYHEDQGM
MGQFVIVEPGDEPAAVLGSGTGSSIGSAGGHAH

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=536, Percent_Identity=32.6492537313433, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1789394, Length=490, Percent_Identity=30.8163265306122, Blast_Score=221, Evalue=7e-59,
Organism=Drosophila melanogaster, GI18859919, Length=235, Percent_Identity=34.0425531914894, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 56130; Mature: 56130

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLPELNRRTFFKGAGVLAATVVGSQVLVACSSDDVRGYGGEPRTLPIPPADLGTREGSS
CCCCCCCCCEEECCCCEEEEEECCCEEEEEECCCCCCCCCCCCCEECCCCCCCCCCCCCE
VHFALEAQTGESQILPDVTTKTWGFNGTHLGPTLVVKKGDDVHVDVINNLDEMTTVHWHG
EEEEEEECCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCEEEEECCCCCHHEEEEECC
MKLPAIADGGPHSPIEPGQTWSPTWTVANDAATLWYHPHTHGLTGLHAYRGLAGMIIVED
EECCEECCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCHHHHHCCCEEEEEEEC
EATDKLDLPRDYGVDDIPLVLMDHRFLEDGAFDEEDLPDLGLLGDTPTVNGITNAHFDAT
CCCCCCCCCHHCCCCCCEEEEECCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TRRVRFRVLNGSNMRFYNLAFSDKRTFQVIASDSGLLNEPQDRTTLAIGPGERWEIVVDL
EEEEEEEEECCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCCEEEEECCCCCEEEEEEE
EPGEDVTLESVGFEDNYGVPDDEFVPDFGMSDSFQLLTITGPSDDAAQAPALPGVLVKST
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEECC
EPDVIDATERTFIMNTFSINDLQMDMQRVDVVIDHDQPEVWIVTNDNSDWPHNFHVHDAR
CCCEEECCCCEEEEEEEECCHHHCCEEEEEEEEECCCCCEEEEECCCCCCCCEEEEECCE
FKVLKFEGTDVELFNDGWKDTVGLPPAATATLAVEFGHYPDPQWPYMYHCHMLYHEDQGM
EEEEEEECCEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEEEEEECCCCC
MGQFVIVEPGDEPAAVLGSGTGSSIGSAGGHAH
CEEEEEEECCCCCCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MLLPELNRRTFFKGAGVLAATVVGSQVLVACSSDDVRGYGGEPRTLPIPPADLGTREGSS
CCCCCCCCCEEECCCCEEEEEECCCEEEEEECCCCCCCCCCCCCEECCCCCCCCCCCCCE
VHFALEAQTGESQILPDVTTKTWGFNGTHLGPTLVVKKGDDVHVDVINNLDEMTTVHWHG
EEEEEEECCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCEEEEECCCCCHHEEEEECC
MKLPAIADGGPHSPIEPGQTWSPTWTVANDAATLWYHPHTHGLTGLHAYRGLAGMIIVED
EECCEECCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCHHHHHCCCEEEEEEEC
EATDKLDLPRDYGVDDIPLVLMDHRFLEDGAFDEEDLPDLGLLGDTPTVNGITNAHFDAT
CCCCCCCCCHHCCCCCCEEEEECCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TRRVRFRVLNGSNMRFYNLAFSDKRTFQVIASDSGLLNEPQDRTTLAIGPGERWEIVVDL
EEEEEEEEECCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCCEEEEECCCCCEEEEEEE
EPGEDVTLESVGFEDNYGVPDDEFVPDFGMSDSFQLLTITGPSDDAAQAPALPGVLVKST
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEECC
EPDVIDATERTFIMNTFSINDLQMDMQRVDVVIDHDQPEVWIVTNDNSDWPHNFHVHDAR
CCCEEECCCCEEEEEEEECCHHHCCEEEEEEEEECCCCCEEEEECCCCCCCCEEEEECCE
FKVLKFEGTDVELFNDGWKDTVGLPPAATATLAVEFGHYPDPQWPYMYHCHMLYHEDQGM
EEEEEEECCEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEEEEEECCCCC
MGQFVIVEPGDEPAAVLGSGTGSSIGSAGGHAH
CEEEEEEECCCCCCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]