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The map label for this gene is glmU

Identifier: 145295101

GI number: 145295101

Start: 1151671

End: 1153128

Strand: Reverse

Name: glmU

Synonym: cgR_1044

Alternate gene names: 145295101

Gene position: 1153128-1151671 (Counterclockwise)

Preceding gene: 145295102

Following gene: 145295100

Centisome position: 34.79

GC content: 58.64

Gene sequence:

>1458_bases
TTGAGCGCAAGCGATTTCTCGAGCGCAGTTGTCGTTTTGGCAGCTGGTGCCGGAACCCGAATGAAATCAGACTTACAAAA
AACGTTGCATAGCATCGGTGGACGCAGTCTCATTTCACATAGCTTGCATGCAGCTGCCGGGCTTAATCCCGAGCACATTG
TTGCAGTAATTGGACATGGACGCGACCAGGTGGGTCCAGCCGTTGCCCAGGTTGCAGAAGAACTGGACCGGGAAGTCCTC
ATCGCTATCCAAGAGGAACAAAATGGCACGGGACACGCTGTGCAGTGCGCCATGGATCAGCTTGATGGCTTTGAGGGCAC
GATCATTGTCACCAACGGCGATGTTCCCCTGCTCACCGACCACACTCTGTCTGCGCTGCTGGATGCACACGTGGAAGTTC
CCACCGCAGTCACCGTGTTGACCATGCGCCTGGATGACCCCACCGGCTACGGCCGCATCGTGCGCAACGAAGAAGGCGAA
GTCACCGCCATCGTTGAGCAAAAAGATGCTTCCGCAGAAATCCAAGCCATCGATGAGGTCAACTCCGGTGTCTTCGCTTT
CGACGCGGCCATCTTGCGTTCCGCACTGGCTGAACTGAAGTCCGACAACGCTCAGGGCGAGCTGTACCTGACCGACGTAT
TGGGCATTGCTCGTGGCGAGGGCCACCCAGTGCGCGCCCACACCGCCACCGATGCCCGTGAACTCGCTGGCGTCAACGAC
CGTGTGCAGCTCGCAGAAGCCGGCGCAGAACTAAACCGTCGCACCGTCATCGCCGCTATGCGTGGTGGCGCAACCATCGT
TGATCCAGCAACCACCTGGATCGATGTGGAGGTTTCTATCGGCCGCGACGTGATCATCCACCCTGGCACTCAGCTCAAGG
GCGAAACCGTCATCGGCGACCGCGTTGAAGTTGGTCCAGACACCACCTTGACCAACATGACCATCAACGAAGGCGCATCC
GTGGTCCGCACCCACGGTTTCGACTCCACCATCGGTGAAAACGCCACCGTTGGCCCCTTCACCTACATCCGCCCAGGAAC
CACACTGGGACCAGAAGGCAAGCTCGGTGGCTTCGTAGAAACCAAGAAGGCCACAATCGGCCGTGGCTCCAAGGTTCCAC
ACCTCACCTATGTCGGCGACGCCACCATCGGCGAGGAATCCAACATCGGAGCCTCCTCGGTCTTCGTGAACTACGACGGT
GAAAACAAGCACCACACCACCATCGGCAGCCACGTTCGCACTGGATCTGACACCATGTTTATCGCTCCAGTGACCGTGGG
TGACGGAGCGTATTCCGGAGCCGGTACAGTAATTAAAGACGATGTTCCGCCAGGAGCCCTTGCCGTGTCCGGCGGACGCC
AACGAAACATCGAAGGCTGGGTGCAAAAGAAGCGCCCTGGAACCGCTGCAGCACAAGCCGCAGAAGCCGCCCAAAACGTC
CACAACCAGGAAGGCTAA

Upstream 100 bases:

>100_bases
TACAACTTTTCCACCCAAATAGGCAGGTTTTGGGGTTCGGGGCATTATGCTTGCTTGGGTATAAGTGCCCCGCAAGAACT
TTTAAGGATTTGAGATAATC

Downstream 100 bases:

>100_bases
GCAGGATCCTCATGACTGCTCACTGGAAACAAAACCAAAAGAACCTCATGCTGTTTTCGGGTCGTGCGCACCCAGAACTG
GCAGAAGCTGTAGCTAAAGA

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSASDFSSAVVVLAAGAGTRMKSDLQKTLHSIGGRSLISHSLHAAAGLNPEHIVAVIGHGRDQVGPAVAQVAEELDREVL
IAIQEEQNGTGHAVQCAMDQLDGFEGTIIVTNGDVPLLTDHTLSALLDAHVEVPTAVTVLTMRLDDPTGYGRIVRNEEGE
VTAIVEQKDASAEIQAIDEVNSGVFAFDAAILRSALAELKSDNAQGELYLTDVLGIARGEGHPVRAHTATDARELAGVND
RVQLAEAGAELNRRTVIAAMRGGATIVDPATTWIDVEVSIGRDVIIHPGTQLKGETVIGDRVEVGPDTTLTNMTINEGAS
VVRTHGFDSTIGENATVGPFTYIRPGTTLGPEGKLGGFVETKKATIGRGSKVPHLTYVGDATIGEESNIGASSVFVNYDG
ENKHHTTIGSHVRTGSDTMFIAPVTVGDGAYSGAGTVIKDDVPPGALAVSGGRQRNIEGWVQKKRPGTAAAQAAEAAQNV
HNQEG

Sequences:

>Translated_485_residues
MSASDFSSAVVVLAAGAGTRMKSDLQKTLHSIGGRSLISHSLHAAAGLNPEHIVAVIGHGRDQVGPAVAQVAEELDREVL
IAIQEEQNGTGHAVQCAMDQLDGFEGTIIVTNGDVPLLTDHTLSALLDAHVEVPTAVTVLTMRLDDPTGYGRIVRNEEGE
VTAIVEQKDASAEIQAIDEVNSGVFAFDAAILRSALAELKSDNAQGELYLTDVLGIARGEGHPVRAHTATDARELAGVND
RVQLAEAGAELNRRTVIAAMRGGATIVDPATTWIDVEVSIGRDVIIHPGTQLKGETVIGDRVEVGPDTTLTNMTINEGAS
VVRTHGFDSTIGENATVGPFTYIRPGTTLGPEGKLGGFVETKKATIGRGSKVPHLTYVGDATIGEESNIGASSVFVNYDG
ENKHHTTIGSHVRTGSDTMFIAPVTVGDGAYSGAGTVIKDDVPPGALAVSGGRQRNIEGWVQKKRPGTAAAQAAEAAQNV
HNQEG
>Mature_484_residues
SASDFSSAVVVLAAGAGTRMKSDLQKTLHSIGGRSLISHSLHAAAGLNPEHIVAVIGHGRDQVGPAVAQVAEELDREVLI
AIQEEQNGTGHAVQCAMDQLDGFEGTIIVTNGDVPLLTDHTLSALLDAHVEVPTAVTVLTMRLDDPTGYGRIVRNEEGEV
TAIVEQKDASAEIQAIDEVNSGVFAFDAAILRSALAELKSDNAQGELYLTDVLGIARGEGHPVRAHTATDARELAGVNDR
VQLAEAGAELNRRTVIAAMRGGATIVDPATTWIDVEVSIGRDVIIHPGTQLKGETVIGDRVEVGPDTTLTNMTINEGASV
VRTHGFDSTIGENATVGPFTYIRPGTTLGPEGKLGGFVETKKATIGRGSKVPHLTYVGDATIGEESNIGASSVFVNYDGE
NKHHTTIGSHVRTGSDTMFIAPVTVGDGAYSGAGTVIKDDVPPGALAVSGGRQRNIEGWVQKKRPGTAAAQAAEAAQNVH
NQEG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=461, Percent_Identity=40.7809110629067, Blast_Score=310, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6320148, Length=380, Percent_Identity=23.6842105263158, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_CORGB (A4QCS3)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001137922.1
- ProteinModelPortal:   A4QCS3
- SMR:   A4QCS3
- STRING:   A4QCS3
- GeneID:   4992513
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1044
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   PRK14352
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 50545; Mature: 50414

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 374-374 BINDING 84-84 BINDING 151-151 BINDING 166-166 BINDING 181-181 BINDING 398-398 BINDING 416-416 BINDING 434-434

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASDFSSAVVVLAAGAGTRMKSDLQKTLHSIGGRSLISHSLHAAAGLNPEHIVAVIGHG
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHEEEEEECC
RDQVGPAVAQVAEELDREVLIAIQEEQNGTGHAVQCAMDQLDGFEGTIIVTNGDVPLLTD
CCCCCHHHHHHHHHCCCEEEEEEEECCCCCCHHEEHHHHHCCCCCCEEEEECCCEEEEEH
HTLSALLDAHVEVPTAVTVLTMRLDDPTGYGRIVRNEEGEVTAIVEQKDASAEIQAIDEV
HHHHHHHHHHCCCCCEEEEEEEEECCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHC
NSGVFAFDAAILRSALAELKSDNAQGELYLTDVLGIARGEGHPVRAHTATDARELAGVND
CCCEEEHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHCCCCCCEEEECCCCHHHHCCCCC
RVQLAEAGAELNRRTVIAAMRGGATIVDPATTWIDVEVSIGRDVIIHPGTQLKGETVIGD
HHHHHHHCCCCCCEEEEEEECCCCEEECCCCEEEEEEEECCCEEEECCCCCCCCCEEECC
RVEVGPDTTLTNMTINEGASVVRTHGFDSTIGENATVGPFTYIRPGTTLGPEGKLGGFVE
EEECCCCCEEEEEEECCCCCEEEECCCCCCCCCCCEECCEEEECCCCCCCCCCCCCCEEE
TKKATIGRGSKVPHLTYVGDATIGEESNIGASSVFVNYDGENKHHTTIGSHVRTGSDTMF
ECHHHCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCEECCCCCEEECCCCEEE
IAPVTVGDGAYSGAGTVIKDDVPPGALAVSGGRQRNIEGWVQKKRPGTAAAQAAEAAQNV
EEEEEECCCCCCCCCCEEECCCCCCEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHH
HNQEG
CCCCC
>Mature Secondary Structure 
SASDFSSAVVVLAAGAGTRMKSDLQKTLHSIGGRSLISHSLHAAAGLNPEHIVAVIGHG
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHEEEEEECC
RDQVGPAVAQVAEELDREVLIAIQEEQNGTGHAVQCAMDQLDGFEGTIIVTNGDVPLLTD
CCCCCHHHHHHHHHCCCEEEEEEEECCCCCCHHEEHHHHHCCCCCCEEEEECCCEEEEEH
HTLSALLDAHVEVPTAVTVLTMRLDDPTGYGRIVRNEEGEVTAIVEQKDASAEIQAIDEV
HHHHHHHHHHCCCCCEEEEEEEEECCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHC
NSGVFAFDAAILRSALAELKSDNAQGELYLTDVLGIARGEGHPVRAHTATDARELAGVND
CCCEEEHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHCCCCCCEEEECCCCHHHHCCCCC
RVQLAEAGAELNRRTVIAAMRGGATIVDPATTWIDVEVSIGRDVIIHPGTQLKGETVIGD
HHHHHHHCCCCCCEEEEEEECCCCEEECCCCEEEEEEEECCCEEEECCCCCCCCCEEECC
RVEVGPDTTLTNMTINEGASVVRTHGFDSTIGENATVGPFTYIRPGTTLGPEGKLGGFVE
EEECCCCCEEEEEEECCCCCEEEECCCCCCCCCCCEECCEEEECCCCCCCCCCCCCCEEE
TKKATIGRGSKVPHLTYVGDATIGEESNIGASSVFVNYDGENKHHTTIGSHVRTGSDTMF
ECHHHCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCEECCCCCEEECCCCEEE
IAPVTVGDGAYSGAGTVIKDDVPPGALAVSGGRQRNIEGWVQKKRPGTAAAQAAEAAQNV
EEEEEECCCCCCCCCCEEECCCCCCEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHH
HNQEG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA