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The map label for this gene is crt [H]

Identifier: 145295077

GI number: 145295077

Start: 1126357

End: 1127376

Strand: Direct

Name: crt [H]

Synonym: cgR_1020

Alternate gene names: 145295077

Gene position: 1126357-1127376 (Clockwise)

Preceding gene: 145295075

Following gene: 145295078

Centisome position: 33.99

GC content: 54.22

Gene sequence:

>1020_bases
ATGTCTAACGTAGTGAACACTTTTGTCCAGAATTCCACCGGTATGGTGGAGCTTAATCGTCCCAAAGCGCTCAATTCTCT
TAATCAGGAAATGATCGATCTCGTTCAGGAAGCTCTAACCACTTGGGCTGATGATGATCAGGTGCAGCAGGTTCTCATTT
ACTCATCCTCGGAGCGTGCATTTTGTGCCGGCGGTGATGTGCGCGCGGTCCGTGAGAGCGTGTTGGAGGGCGATGTTGCG
GCCGGCGATAAGTATTTCATCGATGAGTTCGCGATGAACAACACTTTGGGAACCTATCCGAAGCCGGTCATTTCTGTGAT
CAACGGCGTCGCGATGGGCGGCGGAATGGGAATTTCCATGCATGGATCGCACCGGATCGTCACGGAAAAAGCGTTCGCGT
CGATGCCTGAGATGGCGATCGGCTATGTTCCCGATGTGGGCTTTACTTATTTCGGTCAGCGTGCATCGTCGCTGGCCATC
GCCACATTTTTGGCGGTGACCGGGTGGCGCATGAGCCCTGCCGATATGCTGTGGGCTGGCGTCGCAACGCATTTTGTTGA
GGATGCGCAAGGGTTCATTGATGCGGTCTTGAACGAGTCGCTTGATAGCGCGTTGGAGAAATTCTCCACGCAACCTACGG
GCAGCAGCGAGCTGGCCGGCGTCGCCAGCCAGATTGAGGAGACCTTTGGGCACAGCTCTTGGGCGCTTATCGACGCCTCC
CTCCGGTCTCACCCCGATGCTGAATTTGTTGCCAAGGTGGATGGGCTGATGGCGTCGGCAGCACCAGCATCGGTGGTGGC
TACCGTGAAGCTGATGCATCAAAACAGTGAGGCGACCACTCTGCGTGAAGGCTTGGACAATGAATTGGCGATGTCTCTTT
ATATGATCCGCCAGCCTGATTTTGCTGAAGGTGTGCGTGCAGTGTTGGTTGATAAAGACCGCAATGCAGCCTTCTCCCCA
GCCAACTACGAAGATGTTGATGAGTCACATTTTGTGACCTTGTTCCAGCACAGTTCATAA

Upstream 100 bases:

>100_bases
TTTGGATTCCTTTCCGATTATGTCTTGATCGCCCATTCTGTCACATCCGGGTTGTCTAAACACCCGCGAAGATTTCCTGT
GATGTGCCACACTGGTTCTC

Downstream 100 bases:

>100_bases
AACCGCCAAACTTTTGATAGCGTAGCAATGGCCCTTTCGGTGGATGGGGCCATGTTTGCACAATGCTTGAAGAAGGGTAG
GGCAGTGAAGCCGCTGGGCA

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSNVVNTFVQNSTGMVELNRPKALNSLNQEMIDLVQEALTTWADDDQVQQVLIYSSSERAFCAGGDVRAVRESVLEGDVA
AGDKYFIDEFAMNNTLGTYPKPVISVINGVAMGGGMGISMHGSHRIVTEKAFASMPEMAIGYVPDVGFTYFGQRASSLAI
ATFLAVTGWRMSPADMLWAGVATHFVEDAQGFIDAVLNESLDSALEKFSTQPTGSSELAGVASQIEETFGHSSWALIDAS
LRSHPDAEFVAKVDGLMASAAPASVVATVKLMHQNSEATTLREGLDNELAMSLYMIRQPDFAEGVRAVLVDKDRNAAFSP
ANYEDVDESHFVTLFQHSS

Sequences:

>Translated_339_residues
MSNVVNTFVQNSTGMVELNRPKALNSLNQEMIDLVQEALTTWADDDQVQQVLIYSSSERAFCAGGDVRAVRESVLEGDVA
AGDKYFIDEFAMNNTLGTYPKPVISVINGVAMGGGMGISMHGSHRIVTEKAFASMPEMAIGYVPDVGFTYFGQRASSLAI
ATFLAVTGWRMSPADMLWAGVATHFVEDAQGFIDAVLNESLDSALEKFSTQPTGSSELAGVASQIEETFGHSSWALIDAS
LRSHPDAEFVAKVDGLMASAAPASVVATVKLMHQNSEATTLREGLDNELAMSLYMIRQPDFAEGVRAVLVDKDRNAAFSP
ANYEDVDESHFVTLFQHSS
>Mature_338_residues
SNVVNTFVQNSTGMVELNRPKALNSLNQEMIDLVQEALTTWADDDQVQQVLIYSSSERAFCAGGDVRAVRESVLEGDVAA
GDKYFIDEFAMNNTLGTYPKPVISVINGVAMGGGMGISMHGSHRIVTEKAFASMPEMAIGYVPDVGFTYFGQRASSLAIA
TFLAVTGWRMSPADMLWAGVATHFVEDAQGFIDAVLNESLDSALEKFSTQPTGSSELAGVASQIEETFGHSSWALIDASL
RSHPDAEFVAKVDGLMASAAPASVVATVKLMHQNSEATTLREGLDNELAMSLYMIRQPDFAEGVRAVLVDKDRNAAFSPA
NYEDVDESHFVTLFQHSS

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=341, Percent_Identity=33.4310850439883, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI37594469, Length=295, Percent_Identity=31.864406779661, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI194097323, Length=244, Percent_Identity=29.0983606557377, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI221142681, Length=191, Percent_Identity=27.7486910994764, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144157, Length=330, Percent_Identity=33.9393939393939, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25144160, Length=330, Percent_Identity=33.9393939393939, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25145438, Length=197, Percent_Identity=28.9340101522843, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17554946, Length=160, Percent_Identity=32.5, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17540714, Length=186, Percent_Identity=27.4193548387097, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=350, Percent_Identity=30.8571428571429, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28571730, Length=341, Percent_Identity=33.4310850439883, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI28571729, Length=341, Percent_Identity=33.4310850439883, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI20129971, Length=187, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24653477, Length=187, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 36541; Mature: 36410

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVVNTFVQNSTGMVELNRPKALNSLNQEMIDLVQEALTTWADDDQVQQVLIYSSSERA
CCHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEECCCCE
FCAGGDVRAVRESVLEGDVAAGDKYFIDEFAMNNTLGTYPKPVISVINGVAMGGGMGISM
EECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEE
HGSHRIVTEKAFASMPEMAIGYVPDVGFTYFGQRASSLAIATFLAVTGWRMSPADMLWAG
CCCCEEEHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VATHFVEDAQGFIDAVLNESLDSALEKFSTQPTGSSELAGVASQIEETFGHSSWALIDAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECH
LRSHPDAEFVAKVDGLMASAAPASVVATVKLMHQNSEATTLREGLDNELAMSLYMIRQPD
HHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHCCCC
FAEGVRAVLVDKDRNAAFSPANYEDVDESHFVTLFQHSS
HHHHHEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
SNVVNTFVQNSTGMVELNRPKALNSLNQEMIDLVQEALTTWADDDQVQQVLIYSSSERA
CHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEECCCCE
FCAGGDVRAVRESVLEGDVAAGDKYFIDEFAMNNTLGTYPKPVISVINGVAMGGGMGISM
EECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEE
HGSHRIVTEKAFASMPEMAIGYVPDVGFTYFGQRASSLAIATFLAVTGWRMSPADMLWAG
CCCCEEEHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VATHFVEDAQGFIDAVLNESLDSALEKFSTQPTGSSELAGVASQIEETFGHSSWALIDAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECH
LRSHPDAEFVAKVDGLMASAAPASVVATVKLMHQNSEATTLREGLDNELAMSLYMIRQPD
HHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHCCCC
FAEGVRAVLVDKDRNAAFSPANYEDVDESHFVTLFQHSS
HHHHHEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]