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The map label for this gene is pgi

Identifier: 145295022

GI number: 145295022

Start: 1072307

End: 1073929

Strand: Reverse

Name: pgi

Synonym: cgR_0966

Alternate gene names: 145295022

Gene position: 1073929-1072307 (Counterclockwise)

Preceding gene: 145295023

Following gene: 145295021

Centisome position: 32.4

GC content: 55.02

Gene sequence:

>1623_bases
ATGGCGGACATTTCGACCACCCAGGCTTGGCAAGACCTGACCGATCATTACTCAAACTTCCAGGCAACCACTCTGCGTGA
ACTTTTCAAGGAAGAAAACCGCGCCGAGAAGTACACCTTCTCCGCGGCTGGCCTCCACGTCGACCTGTCGAAGAATCTGC
TTGACGACGCCACCCTCACCAAGCTCCTTGCACTGACCGAAGAATCTGGCCTTCGCGAACGCATTGACGCGATGTTTGCC
GGTGAACACCTCAACAACACCGAAGACCGCGCTGTCCTCCACACCGCGCTGCGCCTTCCTGCCGAAGCTGATCTGTCAGT
AGATGGCCAAGATGTTGCTGCTGATGTCCACGAGGTTTTGGGACGCATGCGTGACTTCGCTACTGCGCTGCGCTCAGGCA
ACTGGTTGGGATACACCGGCCACACGATCAAGAAGATCGTCAACATTGGTATCGGTGGCTCTGACCTCGGACCAGCCATG
GCTACGAAGGCTCTGCGTGCATACGCGACCGCTGGTATCTCAGCAGAATTCGTCTCCAACGTCGACCCAGCAGACCTCGT
TTCTGTGTTGGAAGACCTCGATGCAGAATCCACATTGTTCGTGGTCGCTTCGAAAACTTTTACCACCCAGGAGACGCTGT
CTAACGCTCGTGCAGCTCGTGCTTGGCTGGTAGAGAAGCTCGGTGAAGAGGCTGTCGCGAAGCACTTCGTCGCAGTGTCC
ACCAATGCTGAAAAGGTCGCAGAGTTCGGTATCGACACGGACAACATGTTCGGCTTCTGGGACTGGGTCGGAGGTCGTTA
CTCCGTGGACTCCGCAGTTGGTCTTTCCCTCATGGCAGTGATCGGCCCTCGCGACTTCATGCGTTTCCTCGGTGGATTCC
ACGCGATGGATGAACACTTCCGCACCACCAAGTTCGAAGAGAACGTTCCAATCTTGATGGCTCTGCTCGGTGTCTGGTAC
TCCGATTTCTATGGTGCAGAAACCCACGCTGTCCTACCTTATTCCGAGGATCTCAGCCGTTTTGCTGCTTACCTCCAGCA
GCTGACCATGGAATCAAACGGCAAGTCAGTCCACCGCGACGGCTCCCCTGTTTCCACTGGCACTGGCGAAATTTACTGGG
GTGAGCCTGGCACAAATGGCCAGCACGCTTTCTTCCAGCTGATCCACCAGGGCACTCGCCTTGTTCCAGCTGATTTCATT
GGTTTCGCTCGTCCAAAGCAGGATCTTCCTGCCGGTGAGCGCACCATGCATGACCTTTTGATGAGCAACTTCTTCGCACA
GACCAAGGTTTTGGCTTTCGGTAAGAACGCTGAAGAGATCGCTGCCGAAGGTGTCGCACCTGAGCTGGTCAACCACAAGG
TCATGCCAGGTAATCGCCCAACCACCACCATTTTGGCGGAGGAACTTACCCCTTCTATTCTCGGTGCGTTGATCGCTTTG
TACGAACACATCGTGATGGTTCAGGGCGTGATTTGGGACATCAACTCCTTCGACCAATGGGGTGTTGAACTGGGCAAACA
GCAGGCAAATGACCTCGCTCCGGCTGTCTCTGGTGAAGAGGATGTTGACTCGGGAGATTCTTCCACTGATTCACTGATTA
AGTGGTACCGCGCAAATAGGTAG

Upstream 100 bases:

>100_bases
CTAAATTTGTCGTATTTCCCACTTTGAACACTTTCGATGCGCTTGGCCACAAAAGCAAGCTAACCTGAAGATGTTATTTA
ACGACAATAAAGGAGTTTTC

Downstream 100 bases:

>100_bases
TCGCTTGCTTATAGGATCAGGGGCGTGAAGAATCCTCGCCTCATAGCACTGGCCGCTATCATCCTGACCTCGTTCAATCT
GCGAACAGCTATTACTGCTT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MADISTTQAWQDLTDHYSNFQATTLRELFKEENRAEKYTFSAAGLHVDLSKNLLDDATLTKLLALTEESGLRERIDAMFA
GEHLNNTEDRAVLHTALRLPAEADLSVDGQDVAADVHEVLGRMRDFATALRSGNWLGYTGHTIKKIVNIGIGGSDLGPAM
ATKALRAYATAGISAEFVSNVDPADLVSVLEDLDAESTLFVVASKTFTTQETLSNARAARAWLVEKLGEEAVAKHFVAVS
TNAEKVAEFGIDTDNMFGFWDWVGGRYSVDSAVGLSLMAVIGPRDFMRFLGGFHAMDEHFRTTKFEENVPILMALLGVWY
SDFYGAETHAVLPYSEDLSRFAAYLQQLTMESNGKSVHRDGSPVSTGTGEIYWGEPGTNGQHAFFQLIHQGTRLVPADFI
GFARPKQDLPAGERTMHDLLMSNFFAQTKVLAFGKNAEEIAAEGVAPELVNHKVMPGNRPTTTILAEELTPSILGALIAL
YEHIVMVQGVIWDINSFDQWGVELGKQQANDLAPAVSGEEDVDSGDSSTDSLIKWYRANR

Sequences:

>Translated_540_residues
MADISTTQAWQDLTDHYSNFQATTLRELFKEENRAEKYTFSAAGLHVDLSKNLLDDATLTKLLALTEESGLRERIDAMFA
GEHLNNTEDRAVLHTALRLPAEADLSVDGQDVAADVHEVLGRMRDFATALRSGNWLGYTGHTIKKIVNIGIGGSDLGPAM
ATKALRAYATAGISAEFVSNVDPADLVSVLEDLDAESTLFVVASKTFTTQETLSNARAARAWLVEKLGEEAVAKHFVAVS
TNAEKVAEFGIDTDNMFGFWDWVGGRYSVDSAVGLSLMAVIGPRDFMRFLGGFHAMDEHFRTTKFEENVPILMALLGVWY
SDFYGAETHAVLPYSEDLSRFAAYLQQLTMESNGKSVHRDGSPVSTGTGEIYWGEPGTNGQHAFFQLIHQGTRLVPADFI
GFARPKQDLPAGERTMHDLLMSNFFAQTKVLAFGKNAEEIAAEGVAPELVNHKVMPGNRPTTTILAEELTPSILGALIAL
YEHIVMVQGVIWDINSFDQWGVELGKQQANDLAPAVSGEEDVDSGDSSTDSLIKWYRANR
>Mature_539_residues
ADISTTQAWQDLTDHYSNFQATTLRELFKEENRAEKYTFSAAGLHVDLSKNLLDDATLTKLLALTEESGLRERIDAMFAG
EHLNNTEDRAVLHTALRLPAEADLSVDGQDVAADVHEVLGRMRDFATALRSGNWLGYTGHTIKKIVNIGIGGSDLGPAMA
TKALRAYATAGISAEFVSNVDPADLVSVLEDLDAESTLFVVASKTFTTQETLSNARAARAWLVEKLGEEAVAKHFVAVST
NAEKVAEFGIDTDNMFGFWDWVGGRYSVDSAVGLSLMAVIGPRDFMRFLGGFHAMDEHFRTTKFEENVPILMALLGVWYS
DFYGAETHAVLPYSEDLSRFAAYLQQLTMESNGKSVHRDGSPVSTGTGEIYWGEPGTNGQHAFFQLIHQGTRLVPADFIG
FARPKQDLPAGERTMHDLLMSNFFAQTKVLAFGKNAEEIAAEGVAPELVNHKVMPGNRPTTTILAEELTPSILGALIALY
EHIVMVQGVIWDINSFDQWGVELGKQQANDLAPAVSGEEDVDSGDSSTDSLIKWYRANR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=555, Percent_Identity=49.009009009009, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI296080693, Length=555, Percent_Identity=45.5855855855856, Blast_Score=482, Evalue=1e-136,
Organism=Escherichia coli, GI1790457, Length=554, Percent_Identity=53.0685920577617, Blast_Score=555, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI71996703, Length=536, Percent_Identity=50.7462686567164, Blast_Score=523, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI71996708, Length=536, Percent_Identity=50.7462686567164, Blast_Score=523, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6319673, Length=539, Percent_Identity=49.5361781076067, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24651916, Length=555, Percent_Identity=51.5315315315315, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24651914, Length=555, Percent_Identity=51.5315315315315, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI17737445, Length=555, Percent_Identity=51.5315315315315, Blast_Score=551, Evalue=1e-157,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_CORGB (A4QCJ4)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001137843.1
- ProteinModelPortal:   A4QCJ4
- SMR:   A4QCJ4
- STRING:   A4QCJ4
- GeneID:   4992201
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_0966
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   LGKGVYQ
- ProtClustDB:   PRK00179
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59151; Mature: 59020

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 351-351 ACT_SITE 382-382 ACT_SITE 506-506

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADISTTQAWQDLTDHYSNFQATTLRELFKEENRAEKYTFSAAGLHVDLSKNLLDDATLT
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHEEEEECCEEEECHHHHHHHHHHH
KLLALTEESGLRERIDAMFAGEHLNNTEDRAVLHTALRLPAEADLSVDGQDVAADVHEVL
HHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
GRMRDFATALRSGNWLGYTGHTIKKIVNIGIGGSDLGPAMATKALRAYATAGISAEFVSN
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCC
VDPADLVSVLEDLDAESTLFVVASKTFTTQETLSNARAARAWLVEKLGEEAVAKHFVAVS
CCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TNAEKVAEFGIDTDNMFGFWDWVGGRYSVDSAVGLSLMAVIGPRDFMRFLGGFHAMDEHF
CCHHHHHHHCCCCCCCCCHHHCCCCCEECHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
RTTKFEENVPILMALLGVWYSDFYGAETHAVLPYSEDLSRFAAYLQQLTMESNGKSVHRD
HHCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCEECCC
GSPVSTGTGEIYWGEPGTNGQHAFFQLIHQGTRLVPADFIGFARPKQDLPAGERTMHDLL
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCHHHHHHHHH
MSNFFAQTKVLAFGKNAEEIAAEGVAPELVNHKVMPGNRPTTTILAEELTPSILGALIAL
HHHHHHHHHHHEECCCHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHCHHHHHHHHHH
YEHIVMVQGVIWDINSFDQWGVELGKQQANDLAPAVSGEEDVDSGDSSTDSLIKWYRANR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
ADISTTQAWQDLTDHYSNFQATTLRELFKEENRAEKYTFSAAGLHVDLSKNLLDDATLT
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHEEEEECCEEEECHHHHHHHHHHH
KLLALTEESGLRERIDAMFAGEHLNNTEDRAVLHTALRLPAEADLSVDGQDVAADVHEVL
HHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
GRMRDFATALRSGNWLGYTGHTIKKIVNIGIGGSDLGPAMATKALRAYATAGISAEFVSN
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCC
VDPADLVSVLEDLDAESTLFVVASKTFTTQETLSNARAARAWLVEKLGEEAVAKHFVAVS
CCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TNAEKVAEFGIDTDNMFGFWDWVGGRYSVDSAVGLSLMAVIGPRDFMRFLGGFHAMDEHF
CCHHHHHHHCCCCCCCCCHHHCCCCCEECHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
RTTKFEENVPILMALLGVWYSDFYGAETHAVLPYSEDLSRFAAYLQQLTMESNGKSVHRD
HHCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCEECCC
GSPVSTGTGEIYWGEPGTNGQHAFFQLIHQGTRLVPADFIGFARPKQDLPAGERTMHDLL
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCHHHHHHHHH
MSNFFAQTKVLAFGKNAEEIAAEGVAPELVNHKVMPGNRPTTTILAEELTPSILGALIAL
HHHHHHHHHHHEECCCHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHCHHHHHHHHHH
YEHIVMVQGVIWDINSFDQWGVELGKQQANDLAPAVSGEEDVDSGDSSTDSLIKWYRANR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA