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The map label for this gene is manA [H]

Identifier: 145294910

GI number: 145294910

Start: 945828

End: 947012

Strand: Direct

Name: manA [H]

Synonym: cgR_0857

Alternate gene names: 145294910

Gene position: 945828-947012 (Clockwise)

Preceding gene: 145294909

Following gene: 145294911

Centisome position: 28.54

GC content: 56.88

Gene sequence:

>1185_bases
ATGGAGCTATTGGAAGGCTCACTGCGCACTTACCCATGGGGTTCAAGAACACTGATCGCTGATCTCAAAGGCGAAGAATC
ACCATCGTCTCGCCCAGAGGCCGAAGTCTGGTTCGGTGCCCACCCAGGATCACCATCAACCATCGGTGGAAACGCACTCA
ACGAAGTCATCGCAGCGAACCCCGAAGAAGCATTGGGCACGCGTGTTGCCGAAGCGTTTGAAAATGAGCTTCCATTCCTC
CTCAAAATCCTCGCAGCGGGAGCACCCCTATCACTGCAGGCCCACCCATCGCTGGAACAGGCCCGTGAAGGATTCGCCCG
CGAAAACTCAGCAGGAATTGACCTCGCCGCACCGAACCGCAACTACCGCGACCCAAACCACAAGCCAGAGCTGATCGTTG
CTCTCACGGATTTTATCGCGATGGCAGGCTTCCGCCCACTGCGGAACACCCTCACCATTTTCGACGCCCTCGCCTGCGAA
CCCCTCGACCGCTACCGCAGCATGCTCACCGTCGACAACGAGGAAGAATCCCTCCGCGCACTGTTTACCACCTGGATCAC
CATCCCCATCGGTAAACGACACGAACTCATCGATGCCCTCATCAGCAACGCCCACACCTACCTTGAGGCAAGCGATCGTG
ACGAGGACATCGCATTCGTGCTCTCACACATCATCGAGCTCAACGAACAATACCCCGGCGATGTCGGCGTTCTGGGTGCT
CTGCTGTTGAACTTCTACAAACTTGCCCCAGGCGAAGCCCTCTACCTCGACGCCGCAAACCTTCACGCATACATCAGCGG
CCTCGGCGTAGAGATCATGGCGAACTCCGACAACGTGCTCCGCGGCGGACTGACATCCAAATACGTCGACGTCCCAGAGC
TCGTGCGCGTGTTGGATTTCAACTCTTTGGAAAACGCTCGCGTGGACGTTGAAGAAGACGGTGCAACGACCCACTACCCA
GTTCCAATCAACGAATTCCAACTCGATCGCGTTGCAGTTCAGGGCGAAGCAGAAGCCAACCACGATGGTCCCATGATTGT
TCTGTGCACCTCCGGAACTGTTTCCTTGGAAGCAGGGGAGAAGACCCTCGAAGTAGCAGCAGGTCACGCCGCATGGGTTC
CAGCAAACGACCCAACCATTGCGATGCGTTCTGAGGACGCAGAAGTATTCCTCGCTAGGGTTTAG

Upstream 100 bases:

>100_bases
CTGCGACGGACCTAGCAAAGGGGCGCTGACACAAGCACTGCGTTTGCTGGTGCGCGGACAGTCAGCCACGATCTATTCCA
TTGAAGAAAAGGACTTGTAA

Downstream 100 bases:

>100_bases
ATCTTTTTAGATTAAAATCATGCGCCCCGCCAGAACTTGGCGGGGCGTAAATCTATTTTGTGCTCGGATTGGCTGACGGG
GCGTGTCTGCTGCCGTCAAA

Product: hypothetical protein

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MELLEGSLRTYPWGSRTLIADLKGEESPSSRPEAEVWFGAHPGSPSTIGGNALNEVIAANPEEALGTRVAEAFENELPFL
LKILAAGAPLSLQAHPSLEQAREGFARENSAGIDLAAPNRNYRDPNHKPELIVALTDFIAMAGFRPLRNTLTIFDALACE
PLDRYRSMLTVDNEEESLRALFTTWITIPIGKRHELIDALISNAHTYLEASDRDEDIAFVLSHIIELNEQYPGDVGVLGA
LLLNFYKLAPGEALYLDAANLHAYISGLGVEIMANSDNVLRGGLTSKYVDVPELVRVLDFNSLENARVDVEEDGATTHYP
VPINEFQLDRVAVQGEAEANHDGPMIVLCTSGTVSLEAGEKTLEVAAGHAAWVPANDPTIAMRSEDAEVFLARV

Sequences:

>Translated_394_residues
MELLEGSLRTYPWGSRTLIADLKGEESPSSRPEAEVWFGAHPGSPSTIGGNALNEVIAANPEEALGTRVAEAFENELPFL
LKILAAGAPLSLQAHPSLEQAREGFARENSAGIDLAAPNRNYRDPNHKPELIVALTDFIAMAGFRPLRNTLTIFDALACE
PLDRYRSMLTVDNEEESLRALFTTWITIPIGKRHELIDALISNAHTYLEASDRDEDIAFVLSHIIELNEQYPGDVGVLGA
LLLNFYKLAPGEALYLDAANLHAYISGLGVEIMANSDNVLRGGLTSKYVDVPELVRVLDFNSLENARVDVEEDGATTHYP
VPINEFQLDRVAVQGEAEANHDGPMIVLCTSGTVSLEAGEKTLEVAAGHAAWVPANDPTIAMRSEDAEVFLARV
>Mature_394_residues
MELLEGSLRTYPWGSRTLIADLKGEESPSSRPEAEVWFGAHPGSPSTIGGNALNEVIAANPEEALGTRVAEAFENELPFL
LKILAAGAPLSLQAHPSLEQAREGFARENSAGIDLAAPNRNYRDPNHKPELIVALTDFIAMAGFRPLRNTLTIFDALACE
PLDRYRSMLTVDNEEESLRALFTTWITIPIGKRHELIDALISNAHTYLEASDRDEDIAFVLSHIIELNEQYPGDVGVLGA
LLLNFYKLAPGEALYLDAANLHAYISGLGVEIMANSDNVLRGGLTSKYVDVPELVRVLDFNSLENARVDVEEDGATTHYP
VPINEFQLDRVAVQGEAEANHDGPMIVLCTSGTVSLEAGEKTLEVAAGHAAWVPANDPTIAMRSEDAEVFLARV

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=423, Percent_Identity=30.4964539007092, Blast_Score=179, Evalue=4e-45,
Organism=Escherichia coli, GI1787899, Length=403, Percent_Identity=36.7245657568238, Blast_Score=246, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI71997620, Length=398, Percent_Identity=29.6482412060301, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17557650, Length=404, Percent_Identity=28.960396039604, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320839, Length=429, Percent_Identity=30.3030303030303, Blast_Score=161, Evalue=1e-40,
Organism=Drosophila melanogaster, GI21356061, Length=392, Percent_Identity=29.0816326530612, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 42835; Mature: 42835

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: PS00965 PMI_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLEGSLRTYPWGSRTLIADLKGEESPSSRPEAEVWFGAHPGSPSTIGGNALNEVIAAN
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCC
PEEALGTRVAEAFENELPFLLKILAAGAPLSLQAHPSLEQAREGFARENSAGIDLAAPNR
CHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCCCEEEECCCC
NYRDPNHKPELIVALTDFIAMAGFRPLRNTLTIFDALACEPLDRYRSMLTVDNEEESLRA
CCCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHEECCCCHHHHHH
LFTTWITIPIGKRHELIDALISNAHTYLEASDRDEDIAFVLSHIIELNEQYPGDVGVLGA
HHHHHEEECCCCHHHHHHHHHHCCHHEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHH
LLLNFYKLAPGEALYLDAANLHAYISGLGVEIMANSDNVLRGGLTSKYVDVPELVRVLDF
HHHHHHHCCCCCEEEEEHHHHHHHHHCCCEEEEECCCCEEECCCCCCCCCHHHHHHHHCC
NSLENARVDVEEDGATTHYPVPINEFQLDRVAVQGEAEANHDGPMIVLCTSGTVSLEAGE
CCCCCCEEEEECCCCCEECCCCCCCEEEEEEEEECCCCCCCCCCEEEEECCCEEEEECCC
KTLEVAAGHAAWVPANDPTIAMRSEDAEVFLARV
CEEEEECCCEEEECCCCCEEEEECCCCEEEEEEC
>Mature Secondary Structure
MELLEGSLRTYPWGSRTLIADLKGEESPSSRPEAEVWFGAHPGSPSTIGGNALNEVIAAN
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCC
PEEALGTRVAEAFENELPFLLKILAAGAPLSLQAHPSLEQAREGFARENSAGIDLAAPNR
CHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCCCEEEECCCC
NYRDPNHKPELIVALTDFIAMAGFRPLRNTLTIFDALACEPLDRYRSMLTVDNEEESLRA
CCCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHEECCCCHHHHHH
LFTTWITIPIGKRHELIDALISNAHTYLEASDRDEDIAFVLSHIIELNEQYPGDVGVLGA
HHHHHEEECCCCHHHHHHHHHHCCHHEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHH
LLLNFYKLAPGEALYLDAANLHAYISGLGVEIMANSDNVLRGGLTSKYVDVPELVRVLDF
HHHHHHHCCCCCEEEEEHHHHHHHHHCCCEEEEECCCCEEECCCCCCCCCHHHHHHHHCC
NSLENARVDVEEDGATTHYPVPINEFQLDRVAVQGEAEANHDGPMIVLCTSGTVSLEAGE
CCCCCCEEEEECCCCCEECCCCCCCEEEEEEEEECCCCCCCCCCEEEEECCCEEEEECCC
KTLEVAAGHAAWVPANDPTIAMRSEDAEVFLARV
CEEEEECCCEEEECCCCCEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6397402; 9097039; 9278503 [H]