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The map label for this gene is purK [H]

Identifier: 145294884

GI number: 145294884

Start: 920414

End: 921577

Strand: Direct

Name: purK [H]

Synonym: cgR_0831

Alternate gene names: 145294884

Gene position: 920414-921577 (Clockwise)

Preceding gene: 145294883

Following gene: 145294885

Centisome position: 27.77

GC content: 57.39

Gene sequence:

>1164_bases
ATGCCCATCGTCGCAGTAATTGGTGACGGCCAATTAGCCCGCATGATGCAGACCTCCGCCATCGAACTCGGACAATCACT
GCGAGTTCTAGCTGGAGCGCCGGATTCCTCCGCAGCCCAAGTAGCTGCTGATGTTGTTCTCGGCGATTACACCAACATTG
ATGATCTGCGCGTCGCCATCGAAGGCGCCGATGTGATGACCTTCGACCACGAGCACGTCCCCAACGAACACCTGCACCAA
CTCATCGCAGAAGGCGTCAACGTTCAGCCACGCCCAGAAGCGCTGGTCAACGCACAAGACAAACTTGTCATGCGCAAGCG
TCTACGTGAACTCGGCGCACCAGTCCCACCATTTGCTGCCATTGAATCAGTCGAAGATGCAGTGGGATTCTTCGAAGCAG
TCGATGGCCAGGTTTGCCTCAAAGCACGCCGTGGCGGATACGACGGCAAGGGCGTATGGTTCCCGGCCGATGTAGCAGAA
CTTCAATCGCTTGTGGCTGAGCTTCTCGACGGTGGCACCCCACTCATGGCTGAAAAGAAAGTTGCCCTCAACAGGGAATT
GTCCGCCATGGTTGCCCGCACCCCAAGTGGAGAAACCAAAGCGTGGCCAGTCGTAGAATCCGTGCAGAAGAACGGTGTGT
GTGCAGAAGCAATCGCTCCCGCACCTGAACTATCCGCAGAGCTGCAGGAATCCACCAGGGGATTGGCCCAGAAGATCGCC
ACTGAACTCGGCGTCACTGGTGTCTTGGCAGTGGAGCTTTTTGAAACCCTCGACCAGAACGGCCAGCCAGAGATCTTTGT
TAACGAGCTCGCCATGCGTCCACACAACACCGGCCACTGGACTCAAGATGGCTGCGTGACCAGCCAATTCGAACAGCACC
TCCGCGCAGTCCTTGACTACCCACTGGGTGCCACCGACACTTTGGCCGATTACACCGTGATGGCCAACGTGCTCGGTGCC
GACACCGACCCAGAGATGCCCATGGCAACCCGCATGGTGGAAGTATGGCGCAAATACCCAGATGCCAAGATCCACCTTTA
CGGCAAGGGACATCGACCGGGACGAAAGATCGGCCACGTCAACATGGTCGGATCCGACCTTGAAAAGACCCGAACCGAAG
CCCTGGCCTGTGCATACTTCCTGGTCAACGCTCGCTGGGATTAG

Upstream 100 bases:

>100_bases
CTCGAAAAGTGGAAGCGCTGCTCAAAGATCTTACATTTTGGTGAAGGCGTTATAGTTAGGACTTGTGACTTCTACAGGAA
ACCAAGCCCACGCTCCAGGA

Downstream 100 bases:

>100_bases
GTCTTTCTGAGCGCTAGCATTTCTCCACTCAAAGGAGCATGCTTAACCGCATGAAAAGTGCGCGGCCAAAATCAGTCGCT
CCAAAATCCGGACAAGCTTT

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MPIVAVIGDGQLARMMQTSAIELGQSLRVLAGAPDSSAAQVAADVVLGDYTNIDDLRVAIEGADVMTFDHEHVPNEHLHQ
LIAEGVNVQPRPEALVNAQDKLVMRKRLRELGAPVPPFAAIESVEDAVGFFEAVDGQVCLKARRGGYDGKGVWFPADVAE
LQSLVAELLDGGTPLMAEKKVALNRELSAMVARTPSGETKAWPVVESVQKNGVCAEAIAPAPELSAELQESTRGLAQKIA
TELGVTGVLAVELFETLDQNGQPEIFVNELAMRPHNTGHWTQDGCVTSQFEQHLRAVLDYPLGATDTLADYTVMANVLGA
DTDPEMPMATRMVEVWRKYPDAKIHLYGKGHRPGRKIGHVNMVGSDLEKTRTEALACAYFLVNARWD

Sequences:

>Translated_387_residues
MPIVAVIGDGQLARMMQTSAIELGQSLRVLAGAPDSSAAQVAADVVLGDYTNIDDLRVAIEGADVMTFDHEHVPNEHLHQ
LIAEGVNVQPRPEALVNAQDKLVMRKRLRELGAPVPPFAAIESVEDAVGFFEAVDGQVCLKARRGGYDGKGVWFPADVAE
LQSLVAELLDGGTPLMAEKKVALNRELSAMVARTPSGETKAWPVVESVQKNGVCAEAIAPAPELSAELQESTRGLAQKIA
TELGVTGVLAVELFETLDQNGQPEIFVNELAMRPHNTGHWTQDGCVTSQFEQHLRAVLDYPLGATDTLADYTVMANVLGA
DTDPEMPMATRMVEVWRKYPDAKIHLYGKGHRPGRKIGHVNMVGSDLEKTRTEALACAYFLVNARWD
>Mature_386_residues
PIVAVIGDGQLARMMQTSAIELGQSLRVLAGAPDSSAAQVAADVVLGDYTNIDDLRVAIEGADVMTFDHEHVPNEHLHQL
IAEGVNVQPRPEALVNAQDKLVMRKRLRELGAPVPPFAAIESVEDAVGFFEAVDGQVCLKARRGGYDGKGVWFPADVAEL
QSLVAELLDGGTPLMAEKKVALNRELSAMVARTPSGETKAWPVVESVQKNGVCAEAIAPAPELSAELQESTRGLAQKIAT
ELGVTGVLAVELFETLDQNGQPEIFVNELAMRPHNTGHWTQDGCVTSQFEQHLRAVLDYPLGATDTLADYTVMANVLGAD
TDPEMPMATRMVEVWRKYPDAKIHLYGKGHRPGRKIGHVNMVGSDLEKTRTEALACAYFLVNARWD

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=370, Percent_Identity=28.3783783783784, Blast_Score=138, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6324702, Length=384, Percent_Identity=32.03125, Blast_Score=182, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 41891; Mature: 41760

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIVAVIGDGQLARMMQTSAIELGQSLRVLAGAPDSSAAQVAADVVLGDYTNIDDLRVAI
CCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEE
EGADVMTFDHEHVPNEHLHQLIAEGVNVQPRPEALVNAQDKLVMRKRLRELGAPVPPFAA
ECCEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHHHHHHHHCCCCCCHHH
IESVEDAVGFFEAVDGQVCLKARRGGYDGKGVWFPADVAELQSLVAELLDGGTPLMAEKK
HHHHHHHHHHHHHCCCHHEEHHHCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCHHHHH
VALNRELSAMVARTPSGETKAWPVVESVQKNGVCAEAIAPAPELSAELQESTRGLAQKIA
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHH
TELGVTGVLAVELFETLDQNGQPEIFVNELAMRPHNTGHWTQDGCVTSQFEQHLRAVLDY
HHHCCHHHHHHHHHHHHCCCCCCCEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
PLGATDTLADYTVMANVLGADTDPEMPMATRMVEVWRKYPDAKIHLYGKGHRPGRKIGHV
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEE
NMVGSDLEKTRTEALACAYFLVNARWD
EECCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PIVAVIGDGQLARMMQTSAIELGQSLRVLAGAPDSSAAQVAADVVLGDYTNIDDLRVAI
CEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEE
EGADVMTFDHEHVPNEHLHQLIAEGVNVQPRPEALVNAQDKLVMRKRLRELGAPVPPFAA
ECCEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHHHHHHHHCCCCCCHHH
IESVEDAVGFFEAVDGQVCLKARRGGYDGKGVWFPADVAELQSLVAELLDGGTPLMAEKK
HHHHHHHHHHHHHCCCHHEEHHHCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCHHHHH
VALNRELSAMVARTPSGETKAWPVVESVQKNGVCAEAIAPAPELSAELQESTRGLAQKIA
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHH
TELGVTGVLAVELFETLDQNGQPEIFVNELAMRPHNTGHWTQDGCVTSQFEQHLRAVLDY
HHHCCHHHHHHHHHHHHCCCCCCCEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
PLGATDTLADYTVMANVLGADTDPEMPMATRMVEVWRKYPDAKIHLYGKGHRPGRKIGHV
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEE
NMVGSDLEKTRTEALACAYFLVNARWD
EECCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8998996 [H]