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The map label for this gene is accD5 [H]

Identifier: 145294880

GI number: 145294880

Start: 915308

End: 916921

Strand: Reverse

Name: accD5 [H]

Synonym: cgR_0827

Alternate gene names: 145294880

Gene position: 916921-915308 (Counterclockwise)

Preceding gene: 145294881

Following gene: 145294879

Centisome position: 27.67

GC content: 54.58

Gene sequence:

>1614_bases
ATGACTGCAGCACAGACCAAACCTGACCTCACCACCACGGCTGGAAAGCTGTCCGATCTTCGCTCCCGTCTTGCAGAAGC
TCAAGCTCCAATGGGCGAGGCAACTGTAGAAAAAGTGCACGCTGCTGGCAGGAAGACTGCCCGCGAACGTATCGAGTATT
TGCTCGATGAGGGCTCTTTCGTAGAGATCGATGCTCTTGCTCGTCACCGTTCCAAGAACTTCGGCCTGGATGCTAAGCGT
CCAGTTACTGACGGTGTTGTGACTGGTTACGGCACCATCGATGGCCGTAAGGTCTGTGTGTTCTCCCAGGACGGCGCTGT
ATTCGGTGGCGCTTTGGGCGAGGTTTATGGTGAAAAGATCGTTAAGGTTATGGATCTTGCGATCAAGACCGGTGTGCCTT
TGATCGGTATCAATGAGGGTGCTGGTGCGCGTATCCAGGAAGGTGTTGTGTCTCTGGGTCTGTACTCACAGATTTTCCAC
CGCAACACCCAGGCGTCTGGTGTTATCCCACAGATCTCTTTGATCATGGGTGCCTGCGCTGGTGGTCATGTGTACTCCCC
TGCTCTGACTGACTTCATCGTCATGGTGGATCAGACTTCCAAGATGTTTATTACCGGCCCTGATGTCATCAAGACTGTCA
CCGGTGAAGATGTCACCCAGGAAGAGCTCGGTGGCGCGCACACCCACATGGCTACCTCCGGTACCTCCCATTACTCTGCG
TCTGATGATTCAGATGCTTTGGATTGGGTTCGCGAGCTGACCTCTTATCTTCCATCCAACAACCGTGCGGAAACTCCTCG
CCAGGAGGCCGACATCATGATCGGTTCCATCCAGGAAAACATCAACGATGTGGATCTGGAATTGGACACCATCATCCCGG
ATTCCCCGAACCAGCCTTATGACATGAAGGAAGTTATTTCCCGCATCGTCGACGACGCCGAGTTTTTCGAGATCCAGGAA
AACTACGCAGAGAACATCCTGTGTGGCTTCGCTCGCGTTGAGGGCCGTTCTGTTGGCATCGTGGCTAACCAGCCAACCCA
GTTCGCTGGCTGCTTGGATATTAAGGCATCTGAGAAGGCTGCCCGTTTCATCCGCACCTGCGATGCGTTCAACATCCCAA
TCGTTGAGTTCGTGGACGTTCCAGGCTTCCTGCCTGGCACCAACCAGGAATTCGACGGCATCATCCGCCGCGGCGCAAAG
CTGCTTTACGCTTACGCTGAAGCAACCGTCGGCAAGATCACCGTCATCACCCGCAAGTCCTACGGCGGAGCGTACTGCGT
GATGGGTTCCAAGGATATGGGCGCTGACCTCGTATTCGCTTGGCCTACCGCACAGATCGCCGTCATGGGTGCTTCAGGTG
CTGTTGGATTTATTTACCGCAAGGAACTCAAGCAGGCCGCCACCGAAGGCAAGGACGTTGCTGAGGTCATGAAGGGCTAC
GAGCAGGAGTACGAAGAAACTCTGGTCAACCCTTATGTCGCAGCTGAGCGTGGCCTGGTTGATGCCGTTATCCCACCTTC
TGAGACCCGCGGCCAGATCATTGAGGGTCTGCGTCTGCTGGATCGCAAGGTGGTCAATGTTCCTGCTAAAAAGCACGGTA
ACATTCCACTATAG

Upstream 100 bases:

>100_bases
GTATGTTCACACAAGAACCCTGCACAACGCCTTCAAAGTACGTCGACCACAACCAAGCGCATTATTCACTCTCACCCTTC
AGGATTTAGACTAAGAAACC

Downstream 100 bases:

>100_bases
AAACTGTTTTTTAAAGGAGAACCATGTCTGAAGAAACCACTCAGGACACCAAGGCTGCAGAGAAGCCTTTTCTGCAGATC
GTATCTGGCAACCCAACCGA

Product: hypothetical protein

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MTAAQTKPDLTTTAGKLSDLRSRLAEAQAPMGEATVEKVHAAGRKTARERIEYLLDEGSFVEIDALARHRSKNFGLDAKR
PVTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGEVYGEKIVKVMDLAIKTGVPLIGINEGAGARIQEGVVSLGLYSQIFH
RNTQASGVIPQISLIMGACAGGHVYSPALTDFIVMVDQTSKMFITGPDVIKTVTGEDVTQEELGGAHTHMATSGTSHYSA
SDDSDALDWVRELTSYLPSNNRAETPRQEADIMIGSIQENINDVDLELDTIIPDSPNQPYDMKEVISRIVDDAEFFEIQE
NYAENILCGFARVEGRSVGIVANQPTQFAGCLDIKASEKAARFIRTCDAFNIPIVEFVDVPGFLPGTNQEFDGIIRRGAK
LLYAYAEATVGKITVITRKSYGGAYCVMGSKDMGADLVFAWPTAQIAVMGASGAVGFIYRKELKQAATEGKDVAEVMKGY
EQEYEETLVNPYVAAERGLVDAVIPPSETRGQIIEGLRLLDRKVVNVPAKKHGNIPL

Sequences:

>Translated_537_residues
MTAAQTKPDLTTTAGKLSDLRSRLAEAQAPMGEATVEKVHAAGRKTARERIEYLLDEGSFVEIDALARHRSKNFGLDAKR
PVTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGEVYGEKIVKVMDLAIKTGVPLIGINEGAGARIQEGVVSLGLYSQIFH
RNTQASGVIPQISLIMGACAGGHVYSPALTDFIVMVDQTSKMFITGPDVIKTVTGEDVTQEELGGAHTHMATSGTSHYSA
SDDSDALDWVRELTSYLPSNNRAETPRQEADIMIGSIQENINDVDLELDTIIPDSPNQPYDMKEVISRIVDDAEFFEIQE
NYAENILCGFARVEGRSVGIVANQPTQFAGCLDIKASEKAARFIRTCDAFNIPIVEFVDVPGFLPGTNQEFDGIIRRGAK
LLYAYAEATVGKITVITRKSYGGAYCVMGSKDMGADLVFAWPTAQIAVMGASGAVGFIYRKELKQAATEGKDVAEVMKGY
EQEYEETLVNPYVAAERGLVDAVIPPSETRGQIIEGLRLLDRKVVNVPAKKHGNIPL
>Mature_536_residues
TAAQTKPDLTTTAGKLSDLRSRLAEAQAPMGEATVEKVHAAGRKTARERIEYLLDEGSFVEIDALARHRSKNFGLDAKRP
VTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGEVYGEKIVKVMDLAIKTGVPLIGINEGAGARIQEGVVSLGLYSQIFHR
NTQASGVIPQISLIMGACAGGHVYSPALTDFIVMVDQTSKMFITGPDVIKTVTGEDVTQEELGGAHTHMATSGTSHYSAS
DDSDALDWVRELTSYLPSNNRAETPRQEADIMIGSIQENINDVDLELDTIIPDSPNQPYDMKEVISRIVDDAEFFEIQEN
YAENILCGFARVEGRSVGIVANQPTQFAGCLDIKASEKAARFIRTCDAFNIPIVEFVDVPGFLPGTNQEFDGIIRRGAKL
LYAYAEATVGKITVITRKSYGGAYCVMGSKDMGADLVFAWPTAQIAVMGASGAVGFIYRKELKQAATEGKDVAEVMKGYE
QEYEETLVNPYVAAERGLVDAVIPPSETRGQIIEGLRLLDRKVVNVPAKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=508, Percent_Identity=54.7244094488189, Blast_Score=537, Evalue=1e-152,
Organism=Homo sapiens, GI295821216, Length=528, Percent_Identity=52.6515151515151, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI11545863, Length=549, Percent_Identity=29.8724954462659, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI1788655, Length=189, Percent_Identity=30.1587301587302, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25147359, Length=506, Percent_Identity=53.7549407114625, Blast_Score=541, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI25147362, Length=506, Percent_Identity=53.7549407114625, Blast_Score=541, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17552936, Length=512, Percent_Identity=31.8359375, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24586065, Length=539, Percent_Identity=33.0241187384045, Blast_Score=249, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 57956; Mature: 57825

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAQTKPDLTTTAGKLSDLRSRLAEAQAPMGEATVEKVHAAGRKTARERIEYLLDEGSF
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VEIDALARHRSKNFGLDAKRPVTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGEVYGEKI
EEHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCEECHHHHHHHHHHH
VKVMDLAIKTGVPLIGINEGAGARIQEGVVSLGLYSQIFHRNTQASGVIPQISLIMGACA
HHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
GGHVYSPALTDFIVMVDQTSKMFITGPDVIKTVTGEDVTQEELGGAHTHMATSGTSHYSA
CCCEECHHHHHEEEEEECCCEEEEECCHHHHCCCCCCCCHHHCCCCHHEEECCCCCCCCC
SDDSDALDWVRELTSYLPSNNRAETPRQEADIMIGSIQENINDVDLELDTIIPDSPNQPY
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHEEEEHHHCCCCCCCEEEEEECCCCCCCCC
DMKEVISRIVDDAEFFEIQENYAENILCGFARVEGRSVGIVANQPTQFAGCLDIKASEKA
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCEEEEECCCHHHH
ARFIRTCDAFNIPIVEFVDVPGFLPGTNQEFDGIIRRGAKLLYAYAEATVGKITVITRKS
HHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
YGGAYCVMGSKDMGADLVFAWPTAQIAVMGASGAVGFIYRKELKQAATEGKDVAEVMKGY
CCCEEEEECCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
EQEYEETLVNPYVAAERGLVDAVIPPSETRGQIIEGLRLLDRKVVNVPAKKHGNIPL
HHHHHHHHCCCHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TAAQTKPDLTTTAGKLSDLRSRLAEAQAPMGEATVEKVHAAGRKTARERIEYLLDEGSF
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VEIDALARHRSKNFGLDAKRPVTDGVVTGYGTIDGRKVCVFSQDGAVFGGALGEVYGEKI
EEHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCEECHHHHHHHHHHH
VKVMDLAIKTGVPLIGINEGAGARIQEGVVSLGLYSQIFHRNTQASGVIPQISLIMGACA
HHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
GGHVYSPALTDFIVMVDQTSKMFITGPDVIKTVTGEDVTQEELGGAHTHMATSGTSHYSA
CCCEECHHHHHEEEEEECCCEEEEECCHHHHCCCCCCCCHHHCCCCHHEEECCCCCCCCC
SDDSDALDWVRELTSYLPSNNRAETPRQEADIMIGSIQENINDVDLELDTIIPDSPNQPY
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHEEEEHHHCCCCCCCEEEEEECCCCCCCCC
DMKEVISRIVDDAEFFEIQENYAENILCGFARVEGRSVGIVANQPTQFAGCLDIKASEKA
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCEEEEECCCHHHH
ARFIRTCDAFNIPIVEFVDVPGFLPGTNQEFDGIIRRGAKLLYAYAEATVGKITVITRKS
HHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
YGGAYCVMGSKDMGADLVFAWPTAQIAVMGASGAVGFIYRKELKQAATEGKDVAEVMKGY
CCCEEEEECCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
EQEYEETLVNPYVAAERGLVDAVIPPSETRGQIIEGLRLLDRKVVNVPAKKHGNIPL
HHHHHHHHCCCHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]