| Definition | Corynebacterium glutamicum R chromosome, complete genome. |
|---|---|
| Accession | NC_009342 |
| Length | 3,314,179 |
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The map label for this gene is dkgB [H]
Identifier: 145294676
GI number: 145294676
Start: 684753
End: 685562
Strand: Reverse
Name: dkgB [H]
Synonym: cgR_0624
Alternate gene names: 145294676
Gene position: 685562-684753 (Counterclockwise)
Preceding gene: 145294677
Following gene: 145294671
Centisome position: 20.69
GC content: 56.42
Gene sequence:
>810_bases ATGACTCTTTCCCTTCCTCCAATTGGTTTCGGCACCGTTCATCTTGATGGCGCACCTGGTGTTGAAGCCATCGCTACTGC CATTGATGCTGGTTACCGCCTCATCGACACCGCGTACAACTATGAAAATGAAGGTACCGTGGGCAAGGCTTTCCGCGAGT CGGGTGTCCCCCGCGAGGAATTGATTGTCACCAGTAAGCTTCCTGGCCGCTTCCATGCTCGCGAGTTGGGACGCGTTCGC ATTGAGGAAAGTCTGTACCGCCTCAACTTAGATTACATCGATCTCCTCTTGATTCACTGGCCTAATCCCAGCAAGGATCT CTACGTCGAGGCGTGGGAAACGCTGATTGAAGTCCGCGATGCTGGCCTGGTCAAACACATTGGAGTGTCAAACTTCCTTC CGAATCACATTGATCGCCTGCGCCGTGAGACCGGTGAGCTGCCGGCGGTCAACCAGATCGAGCTGCACCCCTATTTCCCG CAGGTAGAGCAGGTAGATTTCCACGACGAGCTGGGCATCATCACCGAGGCCTGGAGCCCGCTCAGCAACGGTCGCGGACT CGTCGAAGAGCCATTGCTCAAGGAAATTGGAGAGCGCTACGGGGTCGGGGGCGGCGAAATCGCCCTCGCCTGGCATCACG CCAGGGGAATCGTTCCGATTCCACGCTCCACCAACCCGGCCAGGCAGCGCAGCAACTTGGAGGCGGTAAAGATTTCGCTT ATCGACGAAGACGTCCAGGCGATTACCGCTTTGGCGCGCAAAAACGGCCGGATCAAAGATCAAGATCCAGCTGTCTATGA AGAATTCTAG
Upstream 100 bases:
>100_bases CCTGCGTATCGGCTGCCTTTTTGAATTCTTTTCCTCCTCGAGGCCTAACCTTCAATTCCTCTCCGAGCCCCTTCCCTGAA GTTTCGCTAACCTGGCGTGC
Downstream 100 bases:
>100_bases ATAGTTACATCAAGGTTCCGAGGAGGCCCGCGGTCACTTCATCTCCCTTTGGAGATGGGTGCCAGGTGCCTCCTACAGCG TTTACCCGCATATCCAGCAC
Product: hypothetical protein
Products: NA
Alternate protein names: 2,5-DKG reductase B; 2,5-DKGR B; 25DKGR-B; AKR5D [H]
Number of amino acids: Translated: 269; Mature: 268
Protein sequence:
>269_residues MTLSLPPIGFGTVHLDGAPGVEAIATAIDAGYRLIDTAYNYENEGTVGKAFRESGVPREELIVTSKLPGRFHARELGRVR IEESLYRLNLDYIDLLLIHWPNPSKDLYVEAWETLIEVRDAGLVKHIGVSNFLPNHIDRLRRETGELPAVNQIELHPYFP QVEQVDFHDELGIITEAWSPLSNGRGLVEEPLLKEIGERYGVGGGEIALAWHHARGIVPIPRSTNPARQRSNLEAVKISL IDEDVQAITALARKNGRIKDQDPAVYEEF
Sequences:
>Translated_269_residues MTLSLPPIGFGTVHLDGAPGVEAIATAIDAGYRLIDTAYNYENEGTVGKAFRESGVPREELIVTSKLPGRFHARELGRVR IEESLYRLNLDYIDLLLIHWPNPSKDLYVEAWETLIEVRDAGLVKHIGVSNFLPNHIDRLRRETGELPAVNQIELHPYFP QVEQVDFHDELGIITEAWSPLSNGRGLVEEPLLKEIGERYGVGGGEIALAWHHARGIVPIPRSTNPARQRSNLEAVKISL IDEDVQAITALARKNGRIKDQDPAVYEEF >Mature_268_residues TLSLPPIGFGTVHLDGAPGVEAIATAIDAGYRLIDTAYNYENEGTVGKAFRESGVPREELIVTSKLPGRFHARELGRVRI EESLYRLNLDYIDLLLIHWPNPSKDLYVEAWETLIEVRDAGLVKHIGVSNFLPNHIDRLRRETGELPAVNQIELHPYFPQ VEQVDFHDELGIITEAWSPLSNGRGLVEEPLLKEIGERYGVGGGEIALAWHHARGIVPIPRSTNPARQRSNLEAVKISLI DEDVQAITALARKNGRIKDQDPAVYEEF
Specific function: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 25DKGR-B has higher catalytic efficiency than 25DKGR-A [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm (Probable) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI223468663, Length=283, Percent_Identity=34.982332155477, Blast_Score=162, Evalue=2e-40, Organism=Homo sapiens, GI291291012, Length=265, Percent_Identity=35.0943396226415, Blast_Score=151, Evalue=6e-37, Organism=Homo sapiens, GI24497583, Length=286, Percent_Identity=34.6153846153846, Blast_Score=150, Evalue=1e-36, Organism=Homo sapiens, GI5174695, Length=293, Percent_Identity=35.1535836177474, Blast_Score=150, Evalue=2e-36, Organism=Homo sapiens, GI5453543, Length=287, Percent_Identity=34.8432055749129, Blast_Score=149, Evalue=3e-36, Organism=Homo sapiens, GI310109922, Length=268, Percent_Identity=36.5671641791045, Blast_Score=149, Evalue=3e-36, Organism=Homo sapiens, GI310109920, Length=287, Percent_Identity=34.8432055749129, Blast_Score=148, Evalue=4e-36, Organism=Homo sapiens, GI45446745, Length=287, Percent_Identity=34.4947735191638, Blast_Score=147, Evalue=8e-36, Organism=Homo sapiens, GI4503285, Length=287, Percent_Identity=34.4947735191638, Blast_Score=147, Evalue=8e-36, Organism=Homo sapiens, GI24497585, Length=287, Percent_Identity=33.4494773519164, Blast_Score=144, Evalue=8e-35, Organism=Homo sapiens, GI300116273, Length=274, Percent_Identity=34.6715328467153, Blast_Score=141, Evalue=6e-34, Organism=Homo sapiens, GI24497577, Length=286, Percent_Identity=33.9160839160839, Blast_Score=141, Evalue=7e-34, Organism=Homo sapiens, GI5174391, Length=286, Percent_Identity=33.9160839160839, Blast_Score=141, Evalue=7e-34, Organism=Homo sapiens, GI93277124, Length=295, Percent_Identity=30.1694915254237, Blast_Score=140, Evalue=2e-33, Organism=Homo sapiens, GI4502049, Length=305, Percent_Identity=32.4590163934426, Blast_Score=131, Evalue=7e-31, Organism=Homo sapiens, GI300116271, Length=276, Percent_Identity=32.6086956521739, Blast_Score=117, Evalue=1e-26, Organism=Homo sapiens, GI310109924, Length=149, Percent_Identity=32.8859060402685, Blast_Score=83, Evalue=3e-16, Organism=Homo sapiens, GI310109926, Length=117, Percent_Identity=41.8803418803419, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI207028673, Length=117, Percent_Identity=41.025641025641, Blast_Score=78, Evalue=7e-15, Organism=Escherichia coli, GI87082198, Length=248, Percent_Identity=40.7258064516129, Blast_Score=192, Evalue=1e-50, Organism=Escherichia coli, GI1786400, Length=251, Percent_Identity=36.6533864541833, Blast_Score=157, Evalue=6e-40, Organism=Escherichia coli, GI1788081, Length=256, Percent_Identity=29.6875, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI48994888, Length=247, Percent_Identity=28.3400809716599, Blast_Score=64, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17552492, Length=268, Percent_Identity=36.5671641791045, Blast_Score=168, Evalue=2e-42, Organism=Caenorhabditis elegans, GI17561298, Length=271, Percent_Identity=33.5793357933579, Blast_Score=155, Evalue=2e-38, Organism=Caenorhabditis elegans, GI71998625, Length=264, Percent_Identity=31.8181818181818, Blast_Score=144, Evalue=4e-35, Organism=Caenorhabditis elegans, GI17564128, Length=302, Percent_Identity=33.7748344370861, Blast_Score=140, Evalue=1e-33, Organism=Caenorhabditis elegans, GI17537075, Length=292, Percent_Identity=33.5616438356164, Blast_Score=139, Evalue=1e-33, Organism=Caenorhabditis elegans, GI17537077, Length=289, Percent_Identity=33.9100346020761, Blast_Score=139, Evalue=2e-33, Organism=Caenorhabditis elegans, GI17561300, Length=264, Percent_Identity=31.4393939393939, Blast_Score=134, Evalue=6e-32, Organism=Caenorhabditis elegans, GI17566692, Length=281, Percent_Identity=32.0284697508897, Blast_Score=120, Evalue=6e-28, Organism=Caenorhabditis elegans, GI17538386, Length=273, Percent_Identity=28.9377289377289, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17550248, Length=293, Percent_Identity=31.3993174061433, Blast_Score=117, Evalue=5e-27, Organism=Caenorhabditis elegans, GI17562292, Length=276, Percent_Identity=28.9855072463768, Blast_Score=117, Evalue=8e-27, Organism=Caenorhabditis elegans, GI17537079, Length=284, Percent_Identity=27.4647887323944, Blast_Score=106, Evalue=1e-23, Organism=Saccharomyces cerevisiae, GI6324694, Length=281, Percent_Identity=37.7224199288256, Blast_Score=178, Evalue=8e-46, Organism=Saccharomyces cerevisiae, GI6320576, Length=282, Percent_Identity=35.1063829787234, Blast_Score=162, Evalue=4e-41, Organism=Saccharomyces cerevisiae, GI6319625, Length=288, Percent_Identity=34.7222222222222, Blast_Score=138, Evalue=7e-34, Organism=Saccharomyces cerevisiae, GI6322556, Length=255, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=1e-31, Organism=Saccharomyces cerevisiae, GI6321896, Length=311, Percent_Identity=30.5466237942122, Blast_Score=121, Evalue=1e-28, Organism=Saccharomyces cerevisiae, GI6320079, Length=245, Percent_Identity=30.2040816326531, Blast_Score=98, Evalue=2e-21, Organism=Drosophila melanogaster, GI24644950, Length=298, Percent_Identity=34.2281879194631, Blast_Score=134, Evalue=5e-32, Organism=Drosophila melanogaster, GI24657054, Length=267, Percent_Identity=32.5842696629214, Blast_Score=134, Evalue=7e-32, Organism=Drosophila melanogaster, GI24662789, Length=295, Percent_Identity=31.864406779661, Blast_Score=131, Evalue=5e-31, Organism=Drosophila melanogaster, GI221378297, Length=315, Percent_Identity=31.4285714285714, Blast_Score=127, Evalue=1e-29, Organism=Drosophila melanogaster, GI20129731, Length=269, Percent_Identity=31.2267657992565, Blast_Score=126, Evalue=1e-29, Organism=Drosophila melanogaster, GI21356425, Length=273, Percent_Identity=30.7692307692308, Blast_Score=125, Evalue=3e-29, Organism=Drosophila melanogaster, GI24663317, Length=274, Percent_Identity=29.5620437956204, Blast_Score=120, Evalue=6e-28, Organism=Drosophila melanogaster, GI24662785, Length=267, Percent_Identity=36.3295880149813, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI24662781, Length=267, Percent_Identity=36.3295880149813, Blast_Score=116, Evalue=1e-26, Organism=Drosophila melanogaster, GI45553081, Length=272, Percent_Identity=30.5147058823529, Blast_Score=115, Evalue=3e-26, Organism=Drosophila melanogaster, GI281366140, Length=246, Percent_Identity=30.8943089430894, Blast_Score=101, Evalue=5e-22,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.274 [H]
Molecular weight: Translated: 30078; Mature: 29947
Theoretical pI: Translated: 4.98; Mature: 4.98
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 0.4 %Met (Translated Protein) 0.4 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 0.0 %Met (Mature Protein) 0.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTLSLPPIGFGTVHLDGAPGVEAIATAIDAGYRLIDTAYNYENEGTVGKAFRESGVPREE CCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEHHHHCCCCCCCHHHHHHHCCCCHHH LIVTSKLPGRFHARELGRVRIEESLYRLNLDYIDLLLIHWPNPSKDLYVEAWETLIEVRD EEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHH AGLVKHIGVSNFLPNHIDRLRRETGELPAVNQIELHPYFPQVEQVDFHDELGIITEAWSP CCHHHHCCHHHCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHCCHHHHCCCC LSNGRGLVEEPLLKEIGERYGVGGGEIALAWHHARGIVPIPRSTNPARQRSNLEAVKISL CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCCCHHHHHCCCEEEEEEE IDEDVQAITALARKNGRIKDQDPAVYEEF HHHHHHHHHHHHHHCCCCCCCCCCHHCCC >Mature Secondary Structure TLSLPPIGFGTVHLDGAPGVEAIATAIDAGYRLIDTAYNYENEGTVGKAFRESGVPREE CCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEHHHHCCCCCCCHHHHHHHCCCCHHH LIVTSKLPGRFHARELGRVRIEESLYRLNLDYIDLLLIHWPNPSKDLYVEAWETLIEVRD EEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHH AGLVKHIGVSNFLPNHIDRLRRETGELPAVNQIELHPYFPQVEQVDFHDELGIITEAWSP CCHHHHCCHHHCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHCCHHHHCCCC LSNGRGLVEEPLLKEIGERYGVGGGEIALAWHHARGIVPIPRSTNPARQRSNLEAVKISL CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCCCHHHHHCCCEEEEEEE IDEDVQAITALARKNGRIKDQDPAVYEEF HHHHHHHHHHHHHHCCCCCCCCCCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA