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The map label for this gene is panB

Identifier: 145294234

GI number: 145294234

Start: 208224

End: 209039

Strand: Reverse

Name: panB

Synonym: cgR_0190

Alternate gene names: 145294234

Gene position: 209039-208224 (Counterclockwise)

Preceding gene: 145294235

Following gene: 145294233

Centisome position: 6.31

GC content: 58.95

Gene sequence:

>816_bases
ATGCCCATGTCAGGCATTGATGCAAAGAAAATCCGCACCCGTCATTTCCGCGAAGCTAAAGTAAACGGCCAGAAAGTTTC
GGTCCTCACCAGCTATGATGCGCTTTCGGCGCGCATTTTTGATGAGGCTGGCGTCGATATGCTCCTTGTTGGTGATTCCG
CTGCCAACGTTGTGTTGGGCCGCGACACTACCTTGTCGATCACCTTGGATGAGATGATTGTGCTGGCCAAGGCGGTGACG
ATCGCTACGAAGCGTGCGCTTGTGGTGGTTGATCTGCCGTTTGGTACCTATGAGGTGAGCCCAAATCAGGCGGTGGAGTC
CGCGATCCGCATCATGCGTGAAACGGGTGCGGCTGCGGTGAAGATCGAGGGTGGCGTGGAGATCGCGCAGACGATTCGAC
GTATTGTTGATGCTGGAATTCCGGTTGTCGGCCACATCGGGTACACCCCGCAGTCCGAGCATTCCTTGGGCGGCCACGTG
GTTCAGGGTCGTGGCGCGAGTTCTGGAAAGCTCATCGCCGATGCCCGCGCGGTGGAGCAGGCGGGTGCGTTTGCGGTTGT
GTTGGAGATGGTTCCAGCAGAGGCAGCGCGCGAGGTTACCGAGGATCTTTCCATCACCACTATCGGAATCGGTGCCGGCA
ATGGCACAGATGGGCAGGTTTTGGTGTGGCAGGATGCCTTCGGCCTCAACCGCGGCAAGAAGCCACGCTTCGTCCGCGAG
TACGCCACCTTGGGCGATTCCTTGCACGACGCCGCGCAGGCCTACATCGCCGATATCCACGCGGGTACCTTCCCAGGCGA
AGCGGAGTCCTTTTAA

Upstream 100 bases:

>100_bases
AAAATTTGACTCCATATCGAGAACTTAATCGAGCAACACCCCTGAATAGTGAATCAAATCGGAATTTATTTATTCTGAGC
TGGTCATCACATCTATACTC

Downstream 100 bases:

>100_bases
TGCAGGTAGCAACCACAAAGAAGGCGCTTATCGACGCCCTCCTCCACCACAAATCCGTCGGGCTCGTCCCCACCATGGGT
GCGCTACACAGCGGACACGC

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MPMSGIDAKKIRTRHFREAKVNGQKVSVLTSYDALSARIFDEAGVDMLLVGDSAANVVLGRDTTLSITLDEMIVLAKAVT
IATKRALVVVDLPFGTYEVSPNQAVESAIRIMRETGAAAVKIEGGVEIAQTIRRIVDAGIPVVGHIGYTPQSEHSLGGHV
VQGRGASSGKLIADARAVEQAGAFAVVLEMVPAEAAREVTEDLSITTIGIGAGNGTDGQVLVWQDAFGLNRGKKPRFVRE
YATLGDSLHDAAQAYIADIHAGTFPGEAESF

Sequences:

>Translated_271_residues
MPMSGIDAKKIRTRHFREAKVNGQKVSVLTSYDALSARIFDEAGVDMLLVGDSAANVVLGRDTTLSITLDEMIVLAKAVT
IATKRALVVVDLPFGTYEVSPNQAVESAIRIMRETGAAAVKIEGGVEIAQTIRRIVDAGIPVVGHIGYTPQSEHSLGGHV
VQGRGASSGKLIADARAVEQAGAFAVVLEMVPAEAAREVTEDLSITTIGIGAGNGTDGQVLVWQDAFGLNRGKKPRFVRE
YATLGDSLHDAAQAYIADIHAGTFPGEAESF
>Mature_270_residues
PMSGIDAKKIRTRHFREAKVNGQKVSVLTSYDALSARIFDEAGVDMLLVGDSAANVVLGRDTTLSITLDEMIVLAKAVTI
ATKRALVVVDLPFGTYEVSPNQAVESAIRIMRETGAAAVKIEGGVEIAQTIRRIVDAGIPVVGHIGYTPQSEHSLGGHVV
QGRGASSGKLIADARAVEQAGAFAVVLEMVPAEAAREVTEDLSITTIGIGAGNGTDGQVLVWQDAFGLNRGKKPRFVREY
ATLGDSLHDAAQAYIADIHAGTFPGEAESF

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family

Homologues:

Organism=Escherichia coli, GI1786326, Length=257, Percent_Identity=41.6342412451362, Blast_Score=204, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6319653, Length=263, Percent_Identity=37.6425855513308, Blast_Score=179, Evalue=4e-46,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PANB_CORGB (A4QAA6)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001137055.1
- ProteinModelPortal:   A4QAA6
- SMR:   A4QAA6
- STRING:   A4QAA6
- GeneID:   4993576
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_0190
- eggNOG:   COG0413
- HOGENOM:   HBG299908
- OMA:   YATPEQT
- ProtClustDB:   PRK00311
- GO:   GO:0005737
- HAMAP:   MF_00156
- InterPro:   IPR003700
- InterPro:   IPR015813
- Gene3D:   G3DSA:3.20.20.60
- PANTHER:   PTHR20881
- PIRSF:   PIRSF000388
- TIGRFAMs:   TIGR00222

Pfam domain/function: PF02548 Pantoate_transf; SSF51621 Pyrv/PenolPyrv_Kinase_cat

EC number: =2.1.2.11

Molecular weight: Translated: 28553; Mature: 28422

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: ACT_SITE 189-189 BINDING 91-91 BINDING 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMSGIDAKKIRTRHFREAKVNGQKVSVLTSYDALSARIFDEAGVDMLLVGDSAANVVLG
CCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCEEEEECCCCCEEEEE
RDTTLSITLDEMIVLAKAVTIATKRALVVVDLPFGTYEVSPNQAVESAIRIMRETGAAAV
CCCEEEEEHHHHHHHHHHHHHEECCEEEEEECCCCCEEECHHHHHHHHHHHHHHCCCEEE
KIEGGVEIAQTIRRIVDAGIPVVGHIGYTPQSEHSLGGHVVQGRGASSGKLIADARAVEQ
EECCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEHHHHHHH
AGAFAVVLEMVPAEAAREVTEDLSITTIGIGAGNGTDGQVLVWQDAFGLNRGKKPRFVRE
CCHHEEEEHHHCCHHHHHHHHCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHH
YATLGDSLHDAAQAYIADIHAGTFPGEAESF
HHHHCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PMSGIDAKKIRTRHFREAKVNGQKVSVLTSYDALSARIFDEAGVDMLLVGDSAANVVLG
CCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCEEEEECCCCCEEEEE
RDTTLSITLDEMIVLAKAVTIATKRALVVVDLPFGTYEVSPNQAVESAIRIMRETGAAAV
CCCEEEEEHHHHHHHHHHHHHEECCEEEEEECCCCCEEECHHHHHHHHHHHHHHCCCEEE
KIEGGVEIAQTIRRIVDAGIPVVGHIGYTPQSEHSLGGHVVQGRGASSGKLIADARAVEQ
EECCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEHHHHHHH
AGAFAVVLEMVPAEAAREVTEDLSITTIGIGAGNGTDGQVLVWQDAFGLNRGKKPRFVRE
CCHHEEEEHHHCCHHHHHHHHCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHH
YATLGDSLHDAAQAYIADIHAGTFPGEAESF
HHHHCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA