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The map label for this gene is gyrA [H]

Identifier: 145294055

GI number: 145294055

Start: 11832

End: 14402

Strand: Direct

Name: gyrA [H]

Synonym: cgR_0013

Alternate gene names: 145294055

Gene position: 11832-14402 (Clockwise)

Preceding gene: 145294049

Following gene: 145294056

Centisome position: 0.36

GC content: 59.16

Gene sequence:

>2571_bases
GTGAGCGACGACAATACCGGACAATTTGACCGCGTTAATCCCATTGATATCAATGAGGAAATGCAGTCGAGCTACATCGA
CTACGCGATGTCAGTCATCGTCGGACGTGCCCTCCCAGAGGTGCGCGACGGCCTGAAGCCAGTCCACCGCCGCGTCTTGT
ACGCGATGTTCGACAACGGCTACCGCCCCGACCGCAGCTACGTGAAGTCTGCAAAACCAGTGGCAGACACCATGGGTAAC
TTCCACCCACACGGCGACACCGCAATTTATGACACTTTGGTGCGCATGGCTCAGCCATGGTCCATGCGATACCCGCTGGT
AGACGGCCAGGGTAACTTCGGTTCCCGCGGCAACGACGGCCCTGCAGCAATGCGTTACACCGAGTGTCGCATGACCCCAC
TGGCCATGGAGATGGTGCGCGACATCCGCGAAAACACCGTCAACTTCTCACCAAACTACGACGGTAAAACCCTCGAACCA
GACGTTTTGCCATCGCGCGTTCCAAACTTGTTGATGAACGGTTCGGGCGGCATTGCGGTCGGCATGGCCACCAACATCCC
ACCGCACAACCTCAACGAGCTTGCCGACGCCATCTTCTGGCTCCTGGAAAACCCAGACGCCGAAGAATCCGAAGCTCTCG
AAGCCTGCATGAAGTTTGTGAAGGGCCCAGACTTCCCAACCGCTGGCCTCATCATCGGTGACAAGGGCATCCACGATGCC
TACACCACCGGCCGCGGCTCCATCCGCATGCGCGGTGTCACCTCCATCGAGGAGGAAGGCAACCGCACCGTCATCGTTAT
CACCGAGCTGCCATACCAGGTCAACCCGGATAACCTGATCTCCAACATCGCGGAGCAGGTGCGCGACGGCAAGCTCGTGG
GCATCTCCAAGATTGAAGATGAATCCTCCGACCGCGTCGGCATGCGCATTGTGGTCACCCTCAAGCGCGACGCAGTTGCC
CGCGTGGTGCTGAACAACCTGTTCAAGCACTCCCAGCTGCAAGCCAACTTTGGTGCGAACATGCTCTCCATCGTCGATGG
CGTGCCACGCACCCTTCGCCTGGACCAGATGCTGCGCTACTACGTGGCACACCAGATCGAAGTCATCGTGCGCCGCACCC
AATACCGCCTCGACAAGGCTGAAGAGCGCGCCCACCTCCTCCGCGGCCTGGTCAAGGCCCTGGATATGCTGGACGAGGTC
ATCGCGCTCATCCGCCGCAGCCCAACCCCAGATGAAGCCCGCACCGGCCTCATGTCGCTTCTCGACGTCGACGAGGCGCA
GGCTGACGCAATTCTGGCAATGCAGCTGCGTCGCCTGGCGGCACTGGAACGCCAAAAGATCATCGATGAGCTCGCTGAAA
TCGAGCTGGAAATCGCTGACCTGAAGGACATCCTGGCAAGCCCAGAACGTCAGCGCACCATCGTTCGCGATGAGCTGACC
GAAATCGTGGAAAAGTACGGCGACGAGCGTCGTTCCCAGATCATCGCTGCCACCGGCGACGTGTCTGAAGAAGACCTCAT
TGCGCGTGAAAACGTTGTCATCACTATTACCTCCACCGGTTACGCAAAGCGCACCAAGGTCGATGCCTACAAGTCGCAAA
AGCGTGGCGGCAAGGGTGTTCGTGGCGCGGAGCTCAAGCAAGATGACATTGTTCGTCACTTCTTCGTCAGCTCCACCCAC
GACTGGATTTTGTTCTTCACCAACTACGGTCGCGTGTACCGCCTCAAGGCATTCGAACTTCCAGAGGCATCCCGCACCGC
ACGTGGACAGCACGTGGCCAACCTTCTGGAATTCCAACCTGGTGAGCAAATTGCCCAGGTCATCCAGTTGGAAAGCTACA
ACGACTTCCCATACCTGGTGCTCGCAACCGCACACGGTCGCGTGAAGAAGTCCCGCCTACTCGACTACGAATCAGCACGT
TCCGGTGGCCTCATCGCCATCAACCTGAATGAGGACGATCGCCTTATCGGCGCCGCACTTTGCGGTGAAGAAGACGATCT
GCTGCTGGTCTCTGAATTCGGACAGTCCATCCGCTTCACCGCCGACGATGAGCAGCTCCGCCCCATGGGCCGCGCCACCG
CCGGTGTCAAGGGCATGCGCTTCCGCGACAACGACCAACTGCTGTCCATGTCCGTGGTCCGCGACGGCGAATTCCTCCTC
GTTGCCACCTCCGGTGGCTACGGCAAGCGCACCCCACTTGAGGATTACTCCACCCAGGGCCGTGGTGGCCTCGGCGTGGT
GACCTTCAAGTACACCCCGAAGCGCGGTCGCCTCGTCAGCGCCATCGCAGTTGAGGAAGATGACGAGATCTTCGCCATCA
CCTCCGCCGGCGGCGTTGTTCGCACCGAAGTCAAGCAGATCCGACCATCCTCCCGTGCAACAATGGGTGTTCGACTGGTC
AACTTGGAAGAAGGTGTAGAACTGCTTGCCATCGACAAGAACGTCGAAGACCAGGGCGAAGCATCCGCAGAAGCAGTAGC
AAAGGGTGCAGTCGAAGGACCAGCATCCAAGACTGCTGCCGAAGAAACCGACTCCGTTGACAACGGATCCGACGAAAACG
GCGAGGAATAA

Upstream 100 bases:

>100_bases
CCCAAAATGGTATCGCTTTGATACCAGTTTCGGGGCATGCAAGGCGTTAAAACGGCCTGTGGACTAAAATCGGTAGGGTT
GACACGAAGAAAGGTGATCA

Downstream 100 bases:

>100_bases
TTTATGGCATCCCGAGAAGTATCCATCACCCGAATCTCACCACTATCAACCTTCCGAGTTGCACTGGCAATGTCCATCAT
CGGACTCGTGGCGTGGATCA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 856; Mature: 855

Protein sequence:

>856_residues
MSDDNTGQFDRVNPIDINEEMQSSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDNGYRPDRSYVKSAKPVADTMGN
FHPHGDTAIYDTLVRMAQPWSMRYPLVDGQGNFGSRGNDGPAAMRYTECRMTPLAMEMVRDIRENTVNFSPNYDGKTLEP
DVLPSRVPNLLMNGSGGIAVGMATNIPPHNLNELADAIFWLLENPDAEESEALEACMKFVKGPDFPTAGLIIGDKGIHDA
YTTGRGSIRMRGVTSIEEEGNRTVIVITELPYQVNPDNLISNIAEQVRDGKLVGISKIEDESSDRVGMRIVVTLKRDAVA
RVVLNNLFKHSQLQANFGANMLSIVDGVPRTLRLDQMLRYYVAHQIEVIVRRTQYRLDKAEERAHLLRGLVKALDMLDEV
IALIRRSPTPDEARTGLMSLLDVDEAQADAILAMQLRRLAALERQKIIDELAEIELEIADLKDILASPERQRTIVRDELT
EIVEKYGDERRSQIIAATGDVSEEDLIARENVVITITSTGYAKRTKVDAYKSQKRGGKGVRGAELKQDDIVRHFFVSSTH
DWILFFTNYGRVYRLKAFELPEASRTARGQHVANLLEFQPGEQIAQVIQLESYNDFPYLVLATAHGRVKKSRLLDYESAR
SGGLIAINLNEDDRLIGAALCGEEDDLLLVSEFGQSIRFTADDEQLRPMGRATAGVKGMRFRDNDQLLSMSVVRDGEFLL
VATSGGYGKRTPLEDYSTQGRGGLGVVTFKYTPKRGRLVSAIAVEEDDEIFAITSAGGVVRTEVKQIRPSSRATMGVRLV
NLEEGVELLAIDKNVEDQGEASAEAVAKGAVEGPASKTAAEETDSVDNGSDENGEE

Sequences:

>Translated_856_residues
MSDDNTGQFDRVNPIDINEEMQSSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDNGYRPDRSYVKSAKPVADTMGN
FHPHGDTAIYDTLVRMAQPWSMRYPLVDGQGNFGSRGNDGPAAMRYTECRMTPLAMEMVRDIRENTVNFSPNYDGKTLEP
DVLPSRVPNLLMNGSGGIAVGMATNIPPHNLNELADAIFWLLENPDAEESEALEACMKFVKGPDFPTAGLIIGDKGIHDA
YTTGRGSIRMRGVTSIEEEGNRTVIVITELPYQVNPDNLISNIAEQVRDGKLVGISKIEDESSDRVGMRIVVTLKRDAVA
RVVLNNLFKHSQLQANFGANMLSIVDGVPRTLRLDQMLRYYVAHQIEVIVRRTQYRLDKAEERAHLLRGLVKALDMLDEV
IALIRRSPTPDEARTGLMSLLDVDEAQADAILAMQLRRLAALERQKIIDELAEIELEIADLKDILASPERQRTIVRDELT
EIVEKYGDERRSQIIAATGDVSEEDLIARENVVITITSTGYAKRTKVDAYKSQKRGGKGVRGAELKQDDIVRHFFVSSTH
DWILFFTNYGRVYRLKAFELPEASRTARGQHVANLLEFQPGEQIAQVIQLESYNDFPYLVLATAHGRVKKSRLLDYESAR
SGGLIAINLNEDDRLIGAALCGEEDDLLLVSEFGQSIRFTADDEQLRPMGRATAGVKGMRFRDNDQLLSMSVVRDGEFLL
VATSGGYGKRTPLEDYSTQGRGGLGVVTFKYTPKRGRLVSAIAVEEDDEIFAITSAGGVVRTEVKQIRPSSRATMGVRLV
NLEEGVELLAIDKNVEDQGEASAEAVAKGAVEGPASKTAAEETDSVDNGSDENGEE
>Mature_855_residues
SDDNTGQFDRVNPIDINEEMQSSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDNGYRPDRSYVKSAKPVADTMGNF
HPHGDTAIYDTLVRMAQPWSMRYPLVDGQGNFGSRGNDGPAAMRYTECRMTPLAMEMVRDIRENTVNFSPNYDGKTLEPD
VLPSRVPNLLMNGSGGIAVGMATNIPPHNLNELADAIFWLLENPDAEESEALEACMKFVKGPDFPTAGLIIGDKGIHDAY
TTGRGSIRMRGVTSIEEEGNRTVIVITELPYQVNPDNLISNIAEQVRDGKLVGISKIEDESSDRVGMRIVVTLKRDAVAR
VVLNNLFKHSQLQANFGANMLSIVDGVPRTLRLDQMLRYYVAHQIEVIVRRTQYRLDKAEERAHLLRGLVKALDMLDEVI
ALIRRSPTPDEARTGLMSLLDVDEAQADAILAMQLRRLAALERQKIIDELAEIELEIADLKDILASPERQRTIVRDELTE
IVEKYGDERRSQIIAATGDVSEEDLIARENVVITITSTGYAKRTKVDAYKSQKRGGKGVRGAELKQDDIVRHFFVSSTHD
WILFFTNYGRVYRLKAFELPEASRTARGQHVANLLEFQPGEQIAQVIQLESYNDFPYLVLATAHGRVKKSRLLDYESARS
GGLIAINLNEDDRLIGAALCGEEDDLLLVSEFGQSIRFTADDEQLRPMGRATAGVKGMRFRDNDQLLSMSVVRDGEFLLV
ATSGGYGKRTPLEDYSTQGRGGLGVVTFKYTPKRGRLVSAIAVEEDDEIFAITSAGGVVRTEVKQIRPSSRATMGVRLVN
LEEGVELLAIDKNVEDQGEASAEAVAKGAVEGPASKTAAEETDSVDNGSDENGEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=339, Percent_Identity=27.7286135693215, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI19913408, Length=328, Percent_Identity=25.609756097561, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1788562, Length=858, Percent_Identity=43.7062937062937, Blast_Score=721, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=679, Percent_Identity=35.7879234167894, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17535065, Length=194, Percent_Identity=31.4432989690722, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=304, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136538, Length=297, Percent_Identity=26.2626262626263, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 94849; Mature: 94717

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDNTGQFDRVNPIDINEEMQSSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDNG
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
YRPDRSYVKSAKPVADTMGNFHPHGDTAIYDTLVRMAQPWSMRYPLVDGQGNFGSRGNDG
CCCCHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCC
PAAMRYTECRMTPLAMEMVRDIRENTVNFSPNYDGKTLEPDVLPSRVPNLLMNGSGGIAV
CCCEEEHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCHHEECCCCCEEE
GMATNIPPHNLNELADAIFWLLENPDAEESEALEACMKFVKGPDFPTAGLIIGDKGIHDA
EEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCC
YTTGRGSIRMRGVTSIEEEGNRTVIVITELPYQVNPDNLISNIAEQVRDGKLVGISKIED
CCCCCCCEEEECCCCHHHCCCEEEEEEEECCCEECHHHHHHHHHHHHHCCCEEEEEECCC
ESSDRVGMRIVVTLKRDAVARVVLNNLFKHSQLQANFGANMLSIVDGVPRTLRLDQMLRY
CCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHH
YVAHQIEVIVRRTQYRLDKAEERAHLLRGLVKALDMLDEVIALIRRSPTPDEARTGLMSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LDVDEAQADAILAMQLRRLAALERQKIIDELAEIELEIADLKDILASPERQRTIVRDELT
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCHHHHHHHHHHHH
EIVEKYGDERRSQIIAATGDVSEEDLIARENVVITITSTGYAKRTKVDAYKSQKRGGKGV
HHHHHHCCHHHHEEEEECCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCC
RGAELKQDDIVRHFFVSSTHDWILFFTNYGRVYRLKAFELPEASRTARGQHVANLLEFQP
CCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCC
GEQIAQVIQLESYNDFPYLVLATAHGRVKKSRLLDYESARSGGLIAINLNEDDRLIGAAL
HHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHCCCCCCCCCCEEEEEECCCCCEEEHHH
CGEEDDLLLVSEFGQSIRFTADDEQLRPMGRATAGVKGMRFRDNDQLLSMSVVRDGEFLL
CCCCCCEEEEHHCCCCEEECCCHHHHHHHHHHHCCCCCCEECCCCCEEEEEEEECCCEEE
VATSGGYGKRTPLEDYSTQGRGGLGVVTFKYTPKRGRLVSAIAVEEDDEIFAITSAGGVV
EEECCCCCCCCCCHHCCCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCEEEEECCCCCH
RTEVKQIRPSSRATMGVRLVNLEEGVELLAIDKNVEDQGEASAEAVAKGAVEGPASKTAA
HHHHHHHCCCCCCEEEEEEEEHHCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCHHHH
EETDSVDNGSDENGEE
HHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDDNTGQFDRVNPIDINEEMQSSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDNG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
YRPDRSYVKSAKPVADTMGNFHPHGDTAIYDTLVRMAQPWSMRYPLVDGQGNFGSRGNDG
CCCCHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCC
PAAMRYTECRMTPLAMEMVRDIRENTVNFSPNYDGKTLEPDVLPSRVPNLLMNGSGGIAV
CCCEEEHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCHHEECCCCCEEE
GMATNIPPHNLNELADAIFWLLENPDAEESEALEACMKFVKGPDFPTAGLIIGDKGIHDA
EEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCC
YTTGRGSIRMRGVTSIEEEGNRTVIVITELPYQVNPDNLISNIAEQVRDGKLVGISKIED
CCCCCCCEEEECCCCHHHCCCEEEEEEEECCCEECHHHHHHHHHHHHHCCCEEEEEECCC
ESSDRVGMRIVVTLKRDAVARVVLNNLFKHSQLQANFGANMLSIVDGVPRTLRLDQMLRY
CCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHH
YVAHQIEVIVRRTQYRLDKAEERAHLLRGLVKALDMLDEVIALIRRSPTPDEARTGLMSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LDVDEAQADAILAMQLRRLAALERQKIIDELAEIELEIADLKDILASPERQRTIVRDELT
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCHHHHHHHHHHHH
EIVEKYGDERRSQIIAATGDVSEEDLIARENVVITITSTGYAKRTKVDAYKSQKRGGKGV
HHHHHHCCHHHHEEEEECCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCC
RGAELKQDDIVRHFFVSSTHDWILFFTNYGRVYRLKAFELPEASRTARGQHVANLLEFQP
CCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCC
GEQIAQVIQLESYNDFPYLVLATAHGRVKKSRLLDYESARSGGLIAINLNEDDRLIGAAL
HHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHCCCCCCCCCCEEEEEECCCCCEEEHHH
CGEEDDLLLVSEFGQSIRFTADDEQLRPMGRATAGVKGMRFRDNDQLLSMSVVRDGEFLL
CCCCCCEEEEHHCCCCEEECCCHHHHHHHHHHHCCCCCCEECCCCCEEEEEEEECCCEEE
VATSGGYGKRTPLEDYSTQGRGGLGVVTFKYTPKRGRLVSAIAVEEDDEIFAITSAGGVV
EEECCCCCCCCCCHHCCCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCEEEEECCCCCH
RTEVKQIRPSSRATMGVRLVNLEEGVELLAIDKNVEDQGEASAEAVAKGAVEGPASKTAA
HHHHHHHCCCCCCEEEEEEEEHHCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCHHHH
EETDSVDNGSDENGEE
HHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8031045; 9634230; 12218036; 8294019; 8035042 [H]