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The map label for this gene is rsbW [H]

Identifier: 138897000

GI number: 138897000

Start: 3476359

End: 3476838

Strand: Direct

Name: rsbW [H]

Synonym: GTNG_3371

Alternate gene names: 138897000

Gene position: 3476359-3476838 (Clockwise)

Preceding gene: 138896999

Following gene: 138897001

Centisome position: 97.92

GC content: 48.75

Gene sequence:

>480_bases
ATGAAACCGTCGTACAACTATCGATTCCAGCTGATGCGCAGTTTTATCGATATCGCGCGTTTGACGTTGTACGGGCTGGC
CGCTAAGATGGGATTTTCGTATGAAGAGATTGAGGATATGAAAGTCGCTGTTTCAGAAGCATGCAATAACGCCGTTTTGC
ATGCGTACAACGGAAGAAGGGGAATGATTCATCTCCGCTTTGAAATGAGCGCCGATGCCTTAGCGATTGTTATTAAAGAT
GAAGGCAAAGGATTTGATTACAAACAAGTAGCGAAACAGGCAGCACCACTGTCCGCTAAGCCGATTGAGGACGTCAAAAT
CGGCGGTCTCGGCCTCTTTTTAATGGAAGCGCTCATGGACGATGTAAGTGTCACAACAGCGGACGGAACAGAAGTCCGCC
TCACGAAATTCCGCCATCGCGGCGAAGGAGAGCATGCCCATGAATGTATATCCCCCTCCTCTGTCCAAGAGCAAGCTTGA

Upstream 100 bases:

>100_bases
AGGGGCAGCGTTTTGTTTGATTTAACGGGAGTATCTTACTTTTTTTTCCGAAGCGAACGATACGACAGAAAAGGATCGGA
GGCCAATCCATGAAAAGAGC

Downstream 100 bases:

>100_bases
CGCCCTCATTTCCGCCTATCAACAAACAAAGACGGAAGAAGCGGCGACAGCACTGCTCGTTCGCTTCGAGCCGCTCATTG
CGGCCGCAGCAAAAAAAATG

Product: serine-protein kinase RsbW

Products: NA

Alternate protein names: Anti-sigma-B factor; Sigma-B negative effector rsbW [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MKPSYNYRFQLMRSFIDIARLTLYGLAAKMGFSYEEIEDMKVAVSEACNNAVLHAYNGRRGMIHLRFEMSADALAIVIKD
EGKGFDYKQVAKQAAPLSAKPIEDVKIGGLGLFLMEALMDDVSVTTADGTEVRLTKFRHRGEGEHAHECISPSSVQEQA

Sequences:

>Translated_159_residues
MKPSYNYRFQLMRSFIDIARLTLYGLAAKMGFSYEEIEDMKVAVSEACNNAVLHAYNGRRGMIHLRFEMSADALAIVIKD
EGKGFDYKQVAKQAAPLSAKPIEDVKIGGLGLFLMEALMDDVSVTTADGTEVRLTKFRHRGEGEHAHECISPSSVQEQA
>Mature_159_residues
MKPSYNYRFQLMRSFIDIARLTLYGLAAKMGFSYEEIEDMKVAVSEACNNAVLHAYNGRRGMIHLRFEMSADALAIVIKD
EGKGFDYKQVAKQAAPLSAKPIEDVKIGGLGLFLMEALMDDVSVTTADGTEVRLTKFRHRGEGEHAHECISPSSVQEQA

Specific function: Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, rsbV. Upon phosphorylation of rsbV, rsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B

COG id: COG2172

COG function: function code T; Anti-sigma regulatory factor (Ser/Thr protein kinase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anti-sigma-factor family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010193
- InterPro:   IPR003594 [H]

Pfam domain/function: PF02518 HATPase_c [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 17678; Mature: 17678

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPSYNYRFQLMRSFIDIARLTLYGLAAKMGFSYEEIEDMKVAVSEACNNAVLHAYNGRR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCC
GMIHLRFEMSADALAIVIKDEGKGFDYKQVAKQAAPLSAKPIEDVKIGGLGLFLMEALMD
CEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHH
DVSVTTADGTEVRLTKFRHRGEGEHAHECISPSSVQEQA
CCEEEECCCCEEEHHHHHCCCCCCHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKPSYNYRFQLMRSFIDIARLTLYGLAAKMGFSYEEIEDMKVAVSEACNNAVLHAYNGRR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCC
GMIHLRFEMSADALAIVIKDEGKGFDYKQVAKQAAPLSAKPIEDVKIGGLGLFLMEALMD
CEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHH
DVSVTTADGTEVRLTKFRHRGEGEHAHECISPSSVQEQA
CCEEEECCCCEEEHHHHHCCCCCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA