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The map label for this gene is menA [H]

Identifier: 138896995

GI number: 138896995

Start: 3472834

End: 3473793

Strand: Direct

Name: menA [H]

Synonym: GTNG_3366

Alternate gene names: 138896995

Gene position: 3472834-3473793 (Clockwise)

Preceding gene: 138896994

Following gene: 138896999

Centisome position: 97.82

GC content: 55.1

Gene sequence:

>960_bases
TTGTCGTACTCATCCTATGCATGCTTTTACTTTCCTGATGGAAACGAGGGGTTGGCATTGCGATATGAACATTGCGAAGA
AGATCAGCGTTGGTTTTATCGTTTTTCATGGTTTCACTTAATGCGTCCGTTGACATGGAGCGGGACGATCAGCCCTGTGC
TGGCCGCTACCGCGCTGGCGGCAAAAAAAGGAGCTGTTCGGATCGACGTGTTGTTGGCAATGCTGGCCGCCTCTGTGCTG
ATCCAGTCGGCAGTCAACATGCTGAATGACTATTTCGATCGATTGCGTGGCCAAGACGTTGATAAATGGACAAACAAGCA
TGACGACGGTCCCGCCCATCGCTCGATCCCTGCCGTTGCGAGCGCCATGCTGACCGCCGCGGTTGCGTTAGGCGCGTACT
TGGCATGGCAAAGCTATGCAGCTATCGCGTGGATCGGCACCGTAGCGATCATATGCGGGATTGCGTATTCAGCCGGGCCA
CGCCCGCTCGCCTCGCTCGGCTTAGGCGAGTTGACTGCCGCTACTTGTATGGGGCCGGTAGTGACCGTACTCGCTTATGC
CGTACAAAGACATGCGCCAAACGCCGCTCCGTTTGCCTTGTCCATCCCGTTCGCCTTGCTCATTGCCTCGATGATTTTGA
CGAACAACATCCGCGACATCGAAAAAGACCGACCGTTTCGCCGCACGTTAGCCATTCGGCTTGGGCGGAAAAACGCAGCA
CGGCTTCTCGCTGTTTTGCTCGCTTCCACCTACTTGTCGATCGCCGTCTTAATTTTTTGGCATGTCGTCCCTTTGCTTGC
CGCGATCACAGTGCTCGCACTGCCGCTTGCTATCCGGCTTTGTCTTTGTTTCCGTCCCAGCGCTAGCCGAGCTGAGGAAA
TCAGCGGCATGAAATGGGCCGCTCGGCATCATTGGGCGGTTGGTCTGCTACTGACGTTAAGTCTATGGCTTTCACCATAA

Upstream 100 bases:

>100_bases
GATGAAGAACTTTGGCAACAAGCCGAACATGGCAATGACGCACCGTTAAAAAACGCGATGACTTCGATCATTGCCATTCA
GTCGGTCGAAGCGGCCGGGT

Downstream 100 bases:

>100_bases
GATGAATATAGACGCCAGCCAAAAAAACGGAGCGCTCGGCTCCTGCGCTCCGTTTACAACCATTTTAACGCCGCATAACC
AATCATCACCCAGGCGATTA

Product: 1,4-dihydroxy-2-naphthodate octaprenyltransferase-like protein

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSYSSYACFYFPDGNEGLALRYEHCEEDQRWFYRFSWFHLMRPLTWSGTISPVLAATALAAKKGAVRIDVLLAMLAASVL
IQSAVNMLNDYFDRLRGQDVDKWTNKHDDGPAHRSIPAVASAMLTAAVALGAYLAWQSYAAIAWIGTVAIICGIAYSAGP
RPLASLGLGELTAATCMGPVVTVLAYAVQRHAPNAAPFALSIPFALLIASMILTNNIRDIEKDRPFRRTLAIRLGRKNAA
RLLAVLLASTYLSIAVLIFWHVVPLLAAITVLALPLAIRLCLCFRPSASRAEEISGMKWAARHHWAVGLLLTLSLWLSP

Sequences:

>Translated_319_residues
MSYSSYACFYFPDGNEGLALRYEHCEEDQRWFYRFSWFHLMRPLTWSGTISPVLAATALAAKKGAVRIDVLLAMLAASVL
IQSAVNMLNDYFDRLRGQDVDKWTNKHDDGPAHRSIPAVASAMLTAAVALGAYLAWQSYAAIAWIGTVAIICGIAYSAGP
RPLASLGLGELTAATCMGPVVTVLAYAVQRHAPNAAPFALSIPFALLIASMILTNNIRDIEKDRPFRRTLAIRLGRKNAA
RLLAVLLASTYLSIAVLIFWHVVPLLAAITVLALPLAIRLCLCFRPSASRAEEISGMKWAARHHWAVGLLLTLSLWLSP
>Mature_318_residues
SYSSYACFYFPDGNEGLALRYEHCEEDQRWFYRFSWFHLMRPLTWSGTISPVLAATALAAKKGAVRIDVLLAMLAASVLI
QSAVNMLNDYFDRLRGQDVDKWTNKHDDGPAHRSIPAVASAMLTAAVALGAYLAWQSYAAIAWIGTVAIICGIAYSAGPR
PLASLGLGELTAATCMGPVVTVLAYAVQRHAPNAAPFALSIPFALLIASMILTNNIRDIEKDRPFRRTLAIRLGRKNAAR
LLAVLLASTYLSIAVLIFWHVVPLLAAITVLALPLAIRLCLCFRPSASRAEEISGMKWAARHHWAVGLLLTLSLWLSP

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=323, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790365, Length=257, Percent_Identity=26.8482490272374, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34893; Mature: 34762

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYSSYACFYFPDGNEGLALRYEHCEEDQRWFYRFSWFHLMRPLTWSGTISPVLAATALA
CCCCCEEEEEECCCCCCEEEEHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
AKKGAVRIDVLLAMLAASVLIQSAVNMLNDYFDRLRGQDVDKWTNKHDDGPAHRSIPAVA
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHH
SAMLTAAVALGAYLAWQSYAAIAWIGTVAIICGIAYSAGPRPLASLGLGELTAATCMGPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHH
VTVLAYAVQRHAPNAAPFALSIPFALLIASMILTNNIRDIEKDRPFRRTLAIRLGRKNAA
HHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHCCCHHH
RLLAVLLASTYLSIAVLIFWHVVPLLAAITVLALPLAIRLCLCFRPSASRAEEISGMKWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHH
ARHHWAVGLLLTLSLWLSP
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYSSYACFYFPDGNEGLALRYEHCEEDQRWFYRFSWFHLMRPLTWSGTISPVLAATALA
CCCCEEEEEECCCCCCEEEEHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
AKKGAVRIDVLLAMLAASVLIQSAVNMLNDYFDRLRGQDVDKWTNKHDDGPAHRSIPAVA
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHH
SAMLTAAVALGAYLAWQSYAAIAWIGTVAIICGIAYSAGPRPLASLGLGELTAATCMGPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHH
VTVLAYAVQRHAPNAAPFALSIPFALLIASMILTNNIRDIEKDRPFRRTLAIRLGRKNAA
HHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHCCCHHH
RLLAVLLASTYLSIAVLIFWHVVPLLAAITVLALPLAIRLCLCFRPSASRAEEISGMKWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHH
ARHHWAVGLLLTLSLWLSP
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]