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The map label for this gene is ctpB [H]

Identifier: 138896677

GI number: 138896677

Start: 3136799

End: 3138217

Strand: Reverse

Name: ctpB [H]

Synonym: GTNG_3040

Alternate gene names: 138896677

Gene position: 3138217-3136799 (Counterclockwise)

Preceding gene: 138896678

Following gene: 138896675

Centisome position: 88.39

GC content: 49.47

Gene sequence:

>1419_bases
ATGGCCCTATCGATGCTCATCGGGGCCGGTGGGACGTATGTCGGCTTGCAGCTGGCCGGCGGAGCAGAGGACAGTCCGAT
GTCAGCAGTCATTCCGAATGAATCGTCCAAGGGGGCAAACGACGAAGAAGAGATAAAAAAAATCCGCCAGGCATATGAGC
TGATCAAAAGCCGGTACGTGGAAAAAGTAGATGAGGAAAAATTGGCGGAAGGCGCCATTCAAGGGATGATTGGTACGCTT
GACGATCCGTATTCTGTCTATATGGATGCGGAAACGACCGAACAGTTTAACGAATCGCTTGATTCATCATTTGAGGGGAT
CGGTGCTGAAGTGAGCATGATTGACGGGAAAGTGACGATCGTTGCACCGATTAAAAACTCGCCGGCGGAAAAAGCGGGGC
TGAAACCGAACGATCAAATTTTGCGCGTCAACGGGGAAAGCCTTGAGGGGCTCGATTTGTATGAGGCAGTGCTGAAAATC
CGCGGCAAAAAAGGGACGACGGTGGAGCTTGAGATTCTCCGCCCGGGCGCCAAAAATGCGATGAAAGTCAAAGTCGTCCG
TGACGAAATCCCGATCGAAACGGTGTATGAGGCGGTGAAAACGTATGATGGCAAAAAGGCCGGCTATTTGCAAATCACAT
CGTTTTCGGAAAATACAGCCGCCGATTTTAAAAAGAAACTAGCGAAGCTTGAGGCTGAGAAAATCGACGGGCTCATTATC
GACGTGCGCGGCAATCCGGGGGGCTATTTGCAAAGCATCGAGGAAATTTTAAAAGACCTTGTCCCGAAACATAAACCGTA
CGTGCAAATTGAAGAGCGCAATGGCGACAAGCAAAAATTTTATTCTGATATAACAGAGAAAAAGCCATACCCGATCGTTG
TGCTCATTGACAAAGGCAGTGCGTCGGCATCGGAAATTTTAGCGGGAGCGATGAAGGAAGCCGGCGGTTACAAGCTCGTC
GGTGAGACGACGTTCGGTAAAGGAACGGTGCAGCAGGCGATTCCAATGGGCGATGGCAGCAACATTAAGCTGACGCTTTA
CAAATGGCTGACGCCGGATGGGCATTGGATCCATGGAAAAGGAATCAAGCCAGATGTGGCCGTTGAGCAGCCTGAGTTTT
TCCACGTCGCTCCGCTTCATGTAGAAAAACCGTTCACGTATGATATGAATGATGAACAAATTGCGAATGCACAAAAAATG
TTAAAAGGACTCGGTTTTGACCCGGGCCGTACGGACGGCTATTTCAGCAAAGAAACGGAAACAGCGGTGAAAGCATTCCA
AAAAGCGAATAAGCTTCCGGCCACCGGTCGTATCGATGAAACGACGGCTAACGTACTGCAAACAAAAATTATGGAAGCGA
TCCGCGATCCGAAGCACGATGTACAGCTGAAAGCGGCGTTACACGTATTGTTCCCATAA

Upstream 100 bases:

>100_bases
ATGATGGAGATAAGGGCATGGCACGGCATGATGCGGTGCTTTTCCTTTATGTATAGGGTGAGGAGGAAACAACGTGAAAA
AAACAACGACGGCCGTATTG

Downstream 100 bases:

>100_bases
ATAGCGATGGGGCTCCCGAGCAAGGGAGCTCTTTTCTATCAACATGAGCGTTTCGTCTCGGGATGAAGTGTCAAATCCAT
TCATGAACGTTTTTGTGCAA

Product: putative protease

Products: NA

Alternate protein names: C-terminal processing protease [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MALSMLIGAGGTYVGLQLAGGAEDSPMSAVIPNESSKGANDEEEIKKIRQAYELIKSRYVEKVDEEKLAEGAIQGMIGTL
DDPYSVYMDAETTEQFNESLDSSFEGIGAEVSMIDGKVTIVAPIKNSPAEKAGLKPNDQILRVNGESLEGLDLYEAVLKI
RGKKGTTVELEILRPGAKNAMKVKVVRDEIPIETVYEAVKTYDGKKAGYLQITSFSENTAADFKKKLAKLEAEKIDGLII
DVRGNPGGYLQSIEEILKDLVPKHKPYVQIEERNGDKQKFYSDITEKKPYPIVVLIDKGSASASEILAGAMKEAGGYKLV
GETTFGKGTVQQAIPMGDGSNIKLTLYKWLTPDGHWIHGKGIKPDVAVEQPEFFHVAPLHVEKPFTYDMNDEQIANAQKM
LKGLGFDPGRTDGYFSKETETAVKAFQKANKLPATGRIDETTANVLQTKIMEAIRDPKHDVQLKAALHVLFP

Sequences:

>Translated_472_residues
MALSMLIGAGGTYVGLQLAGGAEDSPMSAVIPNESSKGANDEEEIKKIRQAYELIKSRYVEKVDEEKLAEGAIQGMIGTL
DDPYSVYMDAETTEQFNESLDSSFEGIGAEVSMIDGKVTIVAPIKNSPAEKAGLKPNDQILRVNGESLEGLDLYEAVLKI
RGKKGTTVELEILRPGAKNAMKVKVVRDEIPIETVYEAVKTYDGKKAGYLQITSFSENTAADFKKKLAKLEAEKIDGLII
DVRGNPGGYLQSIEEILKDLVPKHKPYVQIEERNGDKQKFYSDITEKKPYPIVVLIDKGSASASEILAGAMKEAGGYKLV
GETTFGKGTVQQAIPMGDGSNIKLTLYKWLTPDGHWIHGKGIKPDVAVEQPEFFHVAPLHVEKPFTYDMNDEQIANAQKM
LKGLGFDPGRTDGYFSKETETAVKAFQKANKLPATGRIDETTANVLQTKIMEAIRDPKHDVQLKAALHVLFP
>Mature_471_residues
ALSMLIGAGGTYVGLQLAGGAEDSPMSAVIPNESSKGANDEEEIKKIRQAYELIKSRYVEKVDEEKLAEGAIQGMIGTLD
DPYSVYMDAETTEQFNESLDSSFEGIGAEVSMIDGKVTIVAPIKNSPAEKAGLKPNDQILRVNGESLEGLDLYEAVLKIR
GKKGTTVELEILRPGAKNAMKVKVVRDEIPIETVYEAVKTYDGKKAGYLQITSFSENTAADFKKKLAKLEAEKIDGLIID
VRGNPGGYLQSIEEILKDLVPKHKPYVQIEERNGDKQKFYSDITEKKPYPIVVLIDKGSASASEILAGAMKEAGGYKLVG
ETTFGKGTVQQAIPMGDGSNIKLTLYKWLTPDGHWIHGKGIKPDVAVEQPEFFHVAPLHVEKPFTYDMNDEQIANAQKML
KGLGFDPGRTDGYFSKETETAVKAFQKANKLPATGRIDETTANVLQTKIMEAIRDPKHDVQLKAALHVLFP

Specific function: Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein

COG id: COG0793

COG function: function code M; Periplasmic protease

Gene ontology:

Cell location: Forespore intermembrane space. Note=Is expressed in both the mother cell and forespore compartments but that synthesis in the forespore is both necessary and sufficient for the proper timing of pro-sigma-K processing [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Escherichia coli, GI1788134, Length=362, Percent_Identity=33.4254143646409, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR005151
- InterPro:   IPR004447
- InterPro:   IPR002477 [H]

Pfam domain/function: PF00595 PDZ; PF03572 Peptidase_S41; PF01471 PG_binding_1 [H]

EC number: =3.4.21.102 [H]

Molecular weight: Translated: 51656; Mature: 51524

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSMLIGAGGTYVGLQLAGGAEDSPMSAVIPNESSKGANDEEEIKKIRQAYELIKSRYV
CCEEEEEECCCCEEEEEEECCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EKVDEEKLAEGAIQGMIGTLDDPYSVYMDAETTEQFNESLDSSFEGIGAEVSMIDGKVTI
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCEEEE
VAPIKNSPAEKAGLKPNDQILRVNGESLEGLDLYEAVLKIRGKKGTTVELEILRPGAKNA
EEECCCCCHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCC
MKVKVVRDEIPIETVYEAVKTYDGKKAGYLQITSFSENTAADFKKKLAKLEAEKIDGLII
EEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCEEEE
DVRGNPGGYLQSIEEILKDLVPKHKPYVQIEERNGDKQKFYSDITEKKPYPIVVLIDKGS
EEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCC
ASASEILAGAMKEAGGYKLVGETTFGKGTVQQAIPMGDGSNIKLTLYKWLTPDGHWIHGK
CCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCCCCCEEEEEEEEECCCCCEEECC
GIKPDVAVEQPEFFHVAPLHVEKPFTYDMNDEQIANAQKMLKGLGFDPGRTDGYFSKETE
CCCCCCCCCCCCEEEEEEEEECCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
TAVKAFQKANKLPATGRIDETTANVLQTKIMEAIRDPKHDVQLKAALHVLFP
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCC
>Mature Secondary Structure 
ALSMLIGAGGTYVGLQLAGGAEDSPMSAVIPNESSKGANDEEEIKKIRQAYELIKSRYV
CEEEEEECCCCEEEEEEECCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EKVDEEKLAEGAIQGMIGTLDDPYSVYMDAETTEQFNESLDSSFEGIGAEVSMIDGKVTI
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCEEEE
VAPIKNSPAEKAGLKPNDQILRVNGESLEGLDLYEAVLKIRGKKGTTVELEILRPGAKNA
EEECCCCCHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCC
MKVKVVRDEIPIETVYEAVKTYDGKKAGYLQITSFSENTAADFKKKLAKLEAEKIDGLII
EEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCEEEE
DVRGNPGGYLQSIEEILKDLVPKHKPYVQIEERNGDKQKFYSDITEKKPYPIVVLIDKGS
EEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCC
ASASEILAGAMKEAGGYKLVGETTFGKGTVQQAIPMGDGSNIKLTLYKWLTPDGHWIHGK
CCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCCCCCEEEEEEEEECCCCCEEECC
GIKPDVAVEQPEFFHVAPLHVEKPFTYDMNDEQIANAQKMLKGLGFDPGRTDGYFSKETE
CCCCCCCCCCCCEEEEEEEEECCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
TAVKAFQKANKLPATGRIDETTANVLQTKIMEAIRDPKHDVQLKAALHVLFP
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9570401; 9384377 [H]