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The map label for this gene is clpP [H]

Identifier: 138896648

GI number: 138896648

Start: 3109383

End: 3109973

Strand: Direct

Name: clpP [H]

Synonym: GTNG_3011

Alternate gene names: 138896648

Gene position: 3109383-3109973 (Clockwise)

Preceding gene: 138896638

Following gene: 138896676

Centisome position: 87.58

GC content: 50.93

Gene sequence:

>591_bases
ATGTATTTAATCCCGACTGTCATTGAACAGACCAACCGCGGGGAGCGGGCGTATGACATTTATTCACGGTTGTTGAAAGA
CCGGATTATTTTCCTCGGCAGCCCAATCGATGATCAAGTGGCGAACTCGATCGTGTCACAGCTGTTGTTCTTGGCCGCTG
AAGATCCGGAAAAAGACATTTCTCTCTACATTAACAGCCCGGGCGGCTCGATCACAGCGGGCTTAGCGATTTACGACACG
ATGCAATTCATTAAACCGGACGTGTCGACGATTTGCATCGGCATGGCCGCGTCGATGGGAGCGTTTTTGTTAGCAGCGGG
AGCGAAAGGAAAACGGTTTGCGCTTCCGAACAGCGAAGTGATGATTCACCAACCGCTCGGCGGTGCCCAAGGGCAAGCGA
CAGAAATCGAAATCGCAGCGAAACGCATCTTGTTCTTGCGTGACAAATTAAACCGCATTTTGGCGGAAAATACTGGCCAG
CCGATCGAAGTAATCGAGCGCGATACGGATCGCGACAACTTTATGACGGCGCAAAAAGCGCAAGAATACGGCATTATTGA
CCGCGTGCTGACACGCTTGGAAGATAAGTAA

Upstream 100 bases:

>100_bases
AGGTGAATGGGAGAAGGCGTTTTGTTTGACCTTCATTGACCATTCATGTATGATTAAGGCGTACATAGGGACCCTTATAG
TGGAAAAGGAGGCGTTTTGC

Downstream 100 bases:

>100_bases
ACGCAAAAGGCTGCTTCCGTTACGAACGGAGCAGCCTTTTTTCTTGTTTGCCTTCCTCCGGTGAAACTTTCCACATCACC
CGTACAAGCGCGCCTCTCAT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MYLIPTVIEQTNRGERAYDIYSRLLKDRIIFLGSPIDDQVANSIVSQLLFLAAEDPEKDISLYINSPGGSITAGLAIYDT
MQFIKPDVSTICIGMAASMGAFLLAAGAKGKRFALPNSEVMIHQPLGGAQGQATEIEIAAKRILFLRDKLNRILAENTGQ
PIEVIERDTDRDNFMTAQKAQEYGIIDRVLTRLEDK

Sequences:

>Translated_196_residues
MYLIPTVIEQTNRGERAYDIYSRLLKDRIIFLGSPIDDQVANSIVSQLLFLAAEDPEKDISLYINSPGGSITAGLAIYDT
MQFIKPDVSTICIGMAASMGAFLLAAGAKGKRFALPNSEVMIHQPLGGAQGQATEIEIAAKRILFLRDKLNRILAENTGQ
PIEVIERDTDRDNFMTAQKAQEYGIIDRVLTRLEDK
>Mature_196_residues
MYLIPTVIEQTNRGERAYDIYSRLLKDRIIFLGSPIDDQVANSIVSQLLFLAAEDPEKDISLYINSPGGSITAGLAIYDT
MQFIKPDVSTICIGMAASMGAFLLAAGAKGKRFALPNSEVMIHQPLGGAQGQATEIEIAAKRILFLRDKLNRILAENTGQ
PIEVIERDTDRDNFMTAQKAQEYGIIDRVLTRLEDK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=57.8947368421053, Blast_Score=234, Evalue=3e-62,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=68.75, Blast_Score=285, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17538017, Length=189, Percent_Identity=53.968253968254, Blast_Score=216, Evalue=5e-57,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=56.3829787234042, Blast_Score=224, Evalue=4e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21649; Mature: 21649

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLIPTVIEQTNRGERAYDIYSRLLKDRIIFLGSPIDDQVANSIVSQLLFLAAEDPEKDI
CCCCCHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCE
SLYINSPGGSITAGLAIYDTMQFIKPDVSTICIGMAASMGAFLLAAGAKGKRFALPNSEV
EEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCE
MIHQPLGGAQGQATEIEIAAKRILFLRDKLNRILAENTGQPIEVIERDTDRDNFMTAQKA
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHH
QEYGIIDRVLTRLEDK
HHCCHHHHHHHHHCCC
>Mature Secondary Structure
MYLIPTVIEQTNRGERAYDIYSRLLKDRIIFLGSPIDDQVANSIVSQLLFLAAEDPEKDI
CCCCCHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCE
SLYINSPGGSITAGLAIYDTMQFIKPDVSTICIGMAASMGAFLLAAGAKGKRFALPNSEV
EEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCE
MIHQPLGGAQGQATEIEIAAKRILFLRDKLNRILAENTGQPIEVIERDTDRDNFMTAQKA
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHH
QEYGIIDRVLTRLEDK
HHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA