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The map label for this gene is patB [H]

Identifier: 138896520

GI number: 138896520

Start: 2992746

End: 2994107

Strand: Direct

Name: patB [H]

Synonym: GTNG_2883

Alternate gene names: 138896520

Gene position: 2992746-2994107 (Clockwise)

Preceding gene: 138896516

Following gene: 138896531

Centisome position: 84.3

GC content: 56.98

Gene sequence:

>1362_bases
ATGATATACGGCCTGAAGCACGTCAATCGCTTCTATCTCGTACGCGTCATTTCCGTAGCCGAACGGATCCCAGGCGCCAA
TGGTCTCAAGAAGCAGCCGGTTCAATTGTTGTCCGTCCATGCGCCGCCATCCACCTTCTTTCTTGATTGGGATATACCAA
TTATAAGCCATCGACCTGAAAAAAAGAAGGGAGAAGATACGATGTTTTCATTTGACCAAGTCATCGACCGCCGGGGCACG
CAGTCGGTGAAATGGGATGATGTTGAGCGTTTGTTCGGCCATAAAGATGTGTGGCCGATGTGGGTCGCCGACATGGATTT
TCCGGCTCCCAAAGCCGTACAAGAAGCGCTGCAAGCGCGAATAGAACACGGAATTTTTGGCTACACCGTCATTCCTGATT
CGTTGAAAGAAGCGGTGGGCGAATGGCTCAAACGTCGCCACGAGTGGGAAATCGATCCGGCCTGGCTTGTGTTTGCCCAC
GGTGTCGTGCCGGCGGTCGCCGCTGCCATTGAGGCGTTTTCAGAGCCTGGAGACCGCGTCGTTGTCTTTTCCCCCGTTTA
CCGGCCGCTGTTTGATCTCGTCCGCCGCCATGATCGCACGCTCGTGCTTAGCCCCCTTCGCTTGACTGAAGACAATTATG
TCATCGACTGGGACGACTTGGAGCGGAAACTGCCCGGAGCAAAATTGCTCATCCTCTGCCACCCGCATAACCCCGGTGGC
AAGGTGTGGACAAAAGAAGAACTCGAACGGCTTGGGGAGCTATGTTTCAACCATGGCGTCTTCGTCCTTTCCGACGAAAT
TCACGCCGATTTGACGTTCCCACCCTATCGGCATATTCCGTTCGCCTCCCTCCATCCGGAGTTGGCGGCGCAAAGCGCCA
CGTTCCGTGCGCCGACGAAAACGTTCAACCTCGCCGGCTTGCAGGCGGCCGAAGCGATCATTCCCGATGAGTCACGGCGT
CGGGCGTTCCGCCGCGTCCAACAGCGGCAAGGGTTTTTCACGCTCAATGCATTTGCCATTGCCGGAGCGGAAGCGGCTTA
CCGCCATGGCGAGGCATGGCTTGACGCCTTGCTTGCGTATTTGCAGCAAAACATCGACACAACCATCGCCCATCTCGCAG
CGGAACTGCCCATTCTTCGCCCCATCCGCCCGCAGGCGACCTATCTCGTCTGGATCGACGGCCGTGGTCTCGGCCTGTCC
GAAGCCGAACTCAAAAAACAGCTTCTCGAAAAAGGAAAAATCGCCGTTGAGTTCGGCAGCAAATTCGGGGCGGAAGGGAG
CGGCTTCCTCCGTCTGAACGTCGCCTGCCCGCGCTCGACGCTAGAAGAAGGACTGCGTCGGTTGGTTCTCGCGCTGCGCT
AG

Upstream 100 bases:

>100_bases
GATTAGCAAGTTTTAGGCAGTCGCGAAAAGGAATTGTTTTGTCAAACGCGAATTCATATATAGACTGAATGCAAGCAGCG
AGCGTGTGGGCATCATCCGT

Downstream 100 bases:

>100_bases
ATCATGCCCATCCATCGGCATGAGGTGGGAGTCTTAAACGCCACGTGTCGTTTGTCGCTCCTCAATAAAAAAGGTGTCCC
GTTGCTTATGTTGGGACACC

Product: aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MIYGLKHVNRFYLVRVISVAERIPGANGLKKQPVQLLSVHAPPSTFFLDWDIPIISHRPEKKKGEDTMFSFDQVIDRRGT
QSVKWDDVERLFGHKDVWPMWVADMDFPAPKAVQEALQARIEHGIFGYTVIPDSLKEAVGEWLKRRHEWEIDPAWLVFAH
GVVPAVAAAIEAFSEPGDRVVVFSPVYRPLFDLVRRHDRTLVLSPLRLTEDNYVIDWDDLERKLPGAKLLILCHPHNPGG
KVWTKEELERLGELCFNHGVFVLSDEIHADLTFPPYRHIPFASLHPELAAQSATFRAPTKTFNLAGLQAAEAIIPDESRR
RAFRRVQQRQGFFTLNAFAIAGAEAAYRHGEAWLDALLAYLQQNIDTTIAHLAAELPILRPIRPQATYLVWIDGRGLGLS
EAELKKQLLEKGKIAVEFGSKFGAEGSGFLRLNVACPRSTLEEGLRRLVLALR

Sequences:

>Translated_453_residues
MIYGLKHVNRFYLVRVISVAERIPGANGLKKQPVQLLSVHAPPSTFFLDWDIPIISHRPEKKKGEDTMFSFDQVIDRRGT
QSVKWDDVERLFGHKDVWPMWVADMDFPAPKAVQEALQARIEHGIFGYTVIPDSLKEAVGEWLKRRHEWEIDPAWLVFAH
GVVPAVAAAIEAFSEPGDRVVVFSPVYRPLFDLVRRHDRTLVLSPLRLTEDNYVIDWDDLERKLPGAKLLILCHPHNPGG
KVWTKEELERLGELCFNHGVFVLSDEIHADLTFPPYRHIPFASLHPELAAQSATFRAPTKTFNLAGLQAAEAIIPDESRR
RAFRRVQQRQGFFTLNAFAIAGAEAAYRHGEAWLDALLAYLQQNIDTTIAHLAAELPILRPIRPQATYLVWIDGRGLGLS
EAELKKQLLEKGKIAVEFGSKFGAEGSGFLRLNVACPRSTLEEGLRRLVLALR
>Mature_453_residues
MIYGLKHVNRFYLVRVISVAERIPGANGLKKQPVQLLSVHAPPSTFFLDWDIPIISHRPEKKKGEDTMFSFDQVIDRRGT
QSVKWDDVERLFGHKDVWPMWVADMDFPAPKAVQEALQARIEHGIFGYTVIPDSLKEAVGEWLKRRHEWEIDPAWLVFAH
GVVPAVAAAIEAFSEPGDRVVVFSPVYRPLFDLVRRHDRTLVLSPLRLTEDNYVIDWDDLERKLPGAKLLILCHPHNPGG
KVWTKEELERLGELCFNHGVFVLSDEIHADLTFPPYRHIPFASLHPELAAQSATFRAPTKTFNLAGLQAAEAIIPDESRR
RAFRRVQQRQGFFTLNAFAIAGAEAAYRHGEAWLDALLAYLQQNIDTTIAHLAAELPILRPIRPQATYLVWIDGRGLGLS
EAELKKQLLEKGKIAVEFGSKFGAEGSGFLRLNVACPRSTLEEGLRRLVLALR

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=334, Percent_Identity=26.9461077844311, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI169881279, Length=334, Percent_Identity=26.9461077844311, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI56713256, Length=290, Percent_Identity=25.1724137931034, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI56713254, Length=290, Percent_Identity=25.1724137931034, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI169881281, Length=192, Percent_Identity=28.6458333333333, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1787909, Length=390, Percent_Identity=37.4358974358974, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1786816, Length=353, Percent_Identity=25.2124645892351, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788627, Length=176, Percent_Identity=25, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=312, Percent_Identity=24.0384615384615, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994472, Length=312, Percent_Identity=24.0384615384615, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17567369, Length=145, Percent_Identity=28.9655172413793, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322401, Length=170, Percent_Identity=27.0588235294118, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573069, Length=261, Percent_Identity=26.4367816091954, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646114, Length=261, Percent_Identity=26.4367816091954, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573067, Length=261, Percent_Identity=26.4367816091954, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573065, Length=261, Percent_Identity=26.4367816091954, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 51270; Mature: 51270

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYGLKHVNRFYLVRVISVAERIPGANGLKKQPVQLLSVHAPPSTFFLDWDIPIISHRPE
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCC
KKKGEDTMFSFDQVIDRRGTQSVKWDDVERLFGHKDVWPMWVADMDFPAPKAVQEALQAR
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHH
IEHGIFGYTVIPDSLKEAVGEWLKRRHEWEIDPAWLVFAHGVVPAVAAAIEAFSEPGDRV
HHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VVFSPVYRPLFDLVRRHDRTLVLSPLRLTEDNYVIDWDDLERKLPGAKLLILCHPHNPGG
EEECHHHHHHHHHHHHCCCEEEEECEEECCCCEEECHHHHHHHCCCCEEEEEECCCCCCC
KVWTKEELERLGELCFNHGVFVLSDEIHADLTFPPYRHIPFASLHPELAAQSATFRAPTK
CCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCHHCCHHHHHCCCCCCCCCC
TFNLAGLQAAEAIIPDESRRRAFRRVQQRQGFFTLNAFAIAGAEAAYRHGEAWLDALLAY
EEECCCHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEHHEECCCHHHHHHHHHHHHHHHHH
LQQNIDTTIAHLAAELPILRPIRPQATYLVWIDGRGLGLSEAELKKQLLEKGKIAVEFGS
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECC
KFGAEGSGFLRLNVACPRSTLEEGLRRLVLALR
CCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIYGLKHVNRFYLVRVISVAERIPGANGLKKQPVQLLSVHAPPSTFFLDWDIPIISHRPE
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCC
KKKGEDTMFSFDQVIDRRGTQSVKWDDVERLFGHKDVWPMWVADMDFPAPKAVQEALQAR
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHH
IEHGIFGYTVIPDSLKEAVGEWLKRRHEWEIDPAWLVFAHGVVPAVAAAIEAFSEPGDRV
HHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VVFSPVYRPLFDLVRRHDRTLVLSPLRLTEDNYVIDWDDLERKLPGAKLLILCHPHNPGG
EEECHHHHHHHHHHHHCCCEEEEECEEECCCCEEECHHHHHHHCCCCEEEEEECCCCCCC
KVWTKEELERLGELCFNHGVFVLSDEIHADLTFPPYRHIPFASLHPELAAQSATFRAPTK
CCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCHHCCHHHHHCCCCCCCCCC
TFNLAGLQAAEAIIPDESRRRAFRRVQQRQGFFTLNAFAIAGAEAAYRHGEAWLDALLAY
EEECCCHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEHHEECCCHHHHHHHHHHHHHHHHH
LQQNIDTTIAHLAAELPILRPIRPQATYLVWIDGRGLGLSEAELKKQLLEKGKIAVEFGS
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECC
KFGAEGSGFLRLNVACPRSTLEEGLRRLVLALR
CCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]