Click here to switch to the map view.

The map label for this gene is fosB

Identifier: 138896436

GI number: 138896436

Start: 2914645

End: 2915067

Strand: Direct

Name: fosB

Synonym: GTNG_2799

Alternate gene names: 138896436

Gene position: 2914645-2915067 (Clockwise)

Preceding gene: 138896435

Following gene: 138896437

Centisome position: 82.1

GC content: 36.88

Gene sequence:

>423_bases
TTGCGAATCGGAGGGATTAATCATTTGACGTTCTCTGTATCTGATCTAGAGAAATCCATTCATTTTTATCAAAACGTGTT
CGGAGCAAAGCTATTAGTCAAAGGGAGAAATTTGGCTTACTTTGACTTAAACGGAATCTGGTTAGCTTTAAATGTTCAAC
AAGATATTCCACGCAACGACATCCAGCATTCATACACCCATATCGCTTTCTCTGTAAAGGAAGAAGACTTTGATCATGTC
GTGGAAAAATTGAAAGAGTTGGGCGTCAATATTCTTCCAGGTAGAGAAAGGGATGAAAGAGACAAACGTTCCGTTTATTT
TACAGATCCGGATGGACATAAATTCGAATTTCATACAGGCACGCTAAATGACCGATTATCTTATTACAAAAGTGAAATGC
ACCATATGCAATTTTTTGATTAA

Upstream 100 bases:

>100_bases
TCCCTTCATTTTATCGTTCCCACAGGCAGGAAAATGTTCCATCGTTTAGCGTAATCATAAAAAGTACGAAGAAAAACCAT
TAAGACGGGAGGTAGGACGA

Downstream 100 bases:

>100_bases
AAGAACATTGAAATTACGTCTTTATTTTTATGAAATGAATTCCTAGAAAAAATCAACAATGCGTTCATCATCAAGGCTTT
CCTCTACTTTCGATGTCGAT

Product: fosfomycin resistance protein FosB

Products: NA

Alternate protein names: Fosfomycin resistance protein

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MRIGGINHLTFSVSDLEKSIHFYQNVFGAKLLVKGRNLAYFDLNGIWLALNVQQDIPRNDIQHSYTHIAFSVKEEDFDHV
VEKLKELGVNILPGRERDERDKRSVYFTDPDGHKFEFHTGTLNDRLSYYKSEMHHMQFFD

Sequences:

>Translated_140_residues
MRIGGINHLTFSVSDLEKSIHFYQNVFGAKLLVKGRNLAYFDLNGIWLALNVQQDIPRNDIQHSYTHIAFSVKEEDFDHV
VEKLKELGVNILPGRERDERDKRSVYFTDPDGHKFEFHTGTLNDRLSYYKSEMHHMQFFD
>Mature_140_residues
MRIGGINHLTFSVSDLEKSIHFYQNVFGAKLLVKGRNLAYFDLNGIWLALNVQQDIPRNDIQHSYTHIAFSVKEEDFDHV
VEKLKELGVNILPGRERDERDKRSVYFTDPDGHKFEFHTGTLNDRLSYYKSEMHHMQFFD

Specific function: Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fosfomycin resistance protein family. FosB subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOSB_GEOTN (A4IS40)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001126889.1
- ProteinModelPortal:   A4IS40
- SMR:   A4IS40
- STRING:   A4IS40
- GeneID:   4967725
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_2799
- eggNOG:   COG0346
- HOGENOM:   HBG704761
- OMA:   IPRNDIQ
- ProtClustDB:   PRK04101
- BioCyc:   GTHE420246:GTNG_2799-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01512
- InterPro:   IPR004360
- InterPro:   IPR022858

Pfam domain/function: PF00903 Glyoxalase

EC number: NA

Molecular weight: Translated: 16490; Mature: 16490

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGGINHLTFSVSDLEKSIHFYQNVFGAKLLVKGRNLAYFDLNGIWLALNVQQDIPRND
CCCCCCEEEEEEHHHHHHHHHHHHHHHCCEEEEECCCEEEEECCCEEEEEEECCCCCCCH
IQHSYTHIAFSVKEEDFDHVVEKLKELGVNILPGRERDERDKRSVYFTDPDGHKFEFHTG
HCCCEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCCCCEEEEECCCCCEEEEECC
TLNDRLSYYKSEMHHMQFFD
CHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRIGGINHLTFSVSDLEKSIHFYQNVFGAKLLVKGRNLAYFDLNGIWLALNVQQDIPRND
CCCCCCEEEEEEHHHHHHHHHHHHHHHCCEEEEECCCEEEEECCCEEEEEEECCCCCCCH
IQHSYTHIAFSVKEEDFDHVVEKLKELGVNILPGRERDERDKRSVYFTDPDGHKFEFHTG
HCCCEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCCCCEEEEECCCCCEEEEECC
TLNDRLSYYKSEMHHMQFFD
CHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA