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The map label for this gene is czcD [H]

Identifier: 138896420

GI number: 138896420

Start: 2900536

End: 2901489

Strand: Direct

Name: czcD [H]

Synonym: GTNG_2783

Alternate gene names: 138896420

Gene position: 2900536-2901489 (Clockwise)

Preceding gene: 138896414

Following gene: 138896423

Centisome position: 81.7

GC content: 49.69

Gene sequence:

>954_bases
ATGTCTCCTGGAGCATACGATTTTCATCATCTTCCACACGTGAAAACACAAACCCAGTCGAAAAAGGCGCTTTGGATTAC
ACTCGTGCTCACCGTCTTTTTCACGGTTGTTGAAATCATCGGTGGGGTGCTCTCGAACTCGCTCGCTTTGTTGTCTGATT
CGGCCCATATGGCTTCCGATGTCTTAGCGCTCGGCCTGAGCATGGTCGCCCTTTACATGGCGACACGCCCGCCAAACCGC
CGCTTTACGTTCGGGTTTTTGCGGTTTGAAATCATTGCATCGTTTTTAAATGGATTGACGTTGGCAGTCATTGCGGTGTG
GATTTTATGGGAAGGCATTGAGCGGTTTCTTCATCCAGAACCGATCCAGTTTCGCCTCATGCTCGGCATTGCCGCGATCG
GTCTTATCGTCAACTTAACGTTGACCATCGTCTTAAGCCGGAGCACAAAAGAAGAAGATAATTTAAACGTCCAAAGCGCC
CTTTGGCACTTTATCGGCGACTTAATCAGCTCCATCGGCGTCATCATCTCAGCGCTGCTCATTTATTTCACCGGTTGGAC
GATTTTCGACCCGATCATCAGTCTCGTGATCGCCGCCATCATTTTCACCGGCGGGGCGAAAATTATGCGCGAATCGTATC
TCATTCTGATGGAAGCCGTGCCGGATGAATTCGACCTCGAACAAATCCGCGCCGATATACGGAACATCGAAGGGGTCGAA
GACGTGCATGACATGCATTTATGGGCCATCTCGACCGACCATTATTCGCTGTCGGCCCATGTGTTTGTCAATGAGCACAT
CCAGCCGCTTTGTGTCATTTTGGCGGTGAATGAAATGCTGAAGGAAAAATACGGCATCGAGCACGCCACCATTCAAGTGG
AACACGCCATACTTCATGACCACGGCAGCTATGGCAAAGCGTTTTTAGAGAAAAGAAAGGCGTCACAACCATAA

Upstream 100 bases:

>100_bases
TCAAAAATTGTGGGATTTGTCGATAAATTTTTTGCACACCTAGCACTTTTTATATTATAATAGATATAAATTAATAATTA
TTATAAAAAAGAGGTGTATT

Downstream 100 bases:

>100_bases
AGACCGCCCATATCAAACTGGCACGGGCGGTCAAAAACGTAAGGAGGGTGTCTCAAAGGAAATGGGGCATCCTTTTCATC
ATTTATACACAAGTACAACA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSPGAYDFHHLPHVKTQTQSKKALWITLVLTVFFTVVEIIGGVLSNSLALLSDSAHMASDVLALGLSMVALYMATRPPNR
RFTFGFLRFEIIASFLNGLTLAVIAVWILWEGIERFLHPEPIQFRLMLGIAAIGLIVNLTLTIVLSRSTKEEDNLNVQSA
LWHFIGDLISSIGVIISALLIYFTGWTIFDPIISLVIAAIIFTGGAKIMRESYLILMEAVPDEFDLEQIRADIRNIEGVE
DVHDMHLWAISTDHYSLSAHVFVNEHIQPLCVILAVNEMLKEKYGIEHATIQVEHAILHDHGSYGKAFLEKRKASQP

Sequences:

>Translated_317_residues
MSPGAYDFHHLPHVKTQTQSKKALWITLVLTVFFTVVEIIGGVLSNSLALLSDSAHMASDVLALGLSMVALYMATRPPNR
RFTFGFLRFEIIASFLNGLTLAVIAVWILWEGIERFLHPEPIQFRLMLGIAAIGLIVNLTLTIVLSRSTKEEDNLNVQSA
LWHFIGDLISSIGVIISALLIYFTGWTIFDPIISLVIAAIIFTGGAKIMRESYLILMEAVPDEFDLEQIRADIRNIEGVE
DVHDMHLWAISTDHYSLSAHVFVNEHIQPLCVILAVNEMLKEKYGIEHATIQVEHAILHDHGSYGKAFLEKRKASQP
>Mature_316_residues
SPGAYDFHHLPHVKTQTQSKKALWITLVLTVFFTVVEIIGGVLSNSLALLSDSAHMASDVLALGLSMVALYMATRPPNRR
FTFGFLRFEIIASFLNGLTLAVIAVWILWEGIERFLHPEPIQFRLMLGIAAIGLIVNLTLTIVLSRSTKEEDNLNVQSAL
WHFIGDLISSIGVIISALLIYFTGWTIFDPIISLVIAAIIFTGGAKIMRESYLILMEAVPDEFDLEQIRADIRNIEGVED
VHDMHLWAISTDHYSLSAHVFVNEHIQPLCVILAVNEMLKEKYGIEHATIQVEHAILHDHGSYGKAFLEKRKASQP

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=299, Percent_Identity=27.4247491638796, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI64762489, Length=312, Percent_Identity=30.1282051282051, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI289803013, Length=275, Percent_Identity=31.2727272727273, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI289803009, Length=275, Percent_Identity=31.2727272727273, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI289803007, Length=275, Percent_Identity=31.2727272727273, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI289803003, Length=275, Percent_Identity=31.2727272727273, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI21361112, Length=301, Percent_Identity=28.9036544850498, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI21359890, Length=310, Percent_Identity=28.0645161290323, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI20070323, Length=332, Percent_Identity=29.2168674698795, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI14210520, Length=216, Percent_Identity=26.8518518518519, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI222080086, Length=121, Percent_Identity=35.5371900826446, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI40255009, Length=121, Percent_Identity=35.5371900826446, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI52351208, Length=119, Percent_Identity=40.3361344537815, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI52352803, Length=188, Percent_Identity=25, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1786966, Length=284, Percent_Identity=37.3239436619718, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI193210990, Length=299, Percent_Identity=32.4414715719064, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17555794, Length=308, Percent_Identity=31.1688311688312, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17555796, Length=297, Percent_Identity=31.986531986532, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32564488, Length=307, Percent_Identity=34.5276872964169, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17550440, Length=122, Percent_Identity=36.0655737704918, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17550442, Length=119, Percent_Identity=36.9747899159664, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320411, Length=179, Percent_Identity=34.6368715083799, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=149, Percent_Identity=28.8590604026846, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=144, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24583858, Length=314, Percent_Identity=27.0700636942675, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24584409, Length=146, Percent_Identity=36.3013698630137, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574430, Length=146, Percent_Identity=36.3013698630137, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24656728, Length=336, Percent_Identity=29.1666666666667, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24656724, Length=336, Percent_Identity=29.1666666666667, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24656720, Length=336, Percent_Identity=29.1666666666667, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24656715, Length=336, Percent_Identity=29.1666666666667, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21357035, Length=336, Percent_Identity=29.1666666666667, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585900, Length=144, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24585898, Length=144, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24585896, Length=144, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19921672, Length=144, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24645863, Length=106, Percent_Identity=37.7358490566038, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 35453; Mature: 35322

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPGAYDFHHLPHVKTQTQSKKALWITLVLTVFFTVVEIIGGVLSNSLALLSDSAHMASD
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHH
VLALGLSMVALYMATRPPNRRFTFGFLRFEIIASFLNGLTLAVIAVWILWEGIERFLHPE
HHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PIQFRLMLGIAAIGLIVNLTLTIVLSRSTKEEDNLNVQSALWHFIGDLISSIGVIISALL
CHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IYFTGWTIFDPIISLVIAAIIFTGGAKIMRESYLILMEAVPDEFDLEQIRADIRNIEGVE
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHH
DVHDMHLWAISTDHYSLSAHVFVNEHIQPLCVILAVNEMLKEKYGIEHATIQVEHAILHD
HHHHHEEEEEECCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHC
HGSYGKAFLEKRKASQP
CCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SPGAYDFHHLPHVKTQTQSKKALWITLVLTVFFTVVEIIGGVLSNSLALLSDSAHMASD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHH
VLALGLSMVALYMATRPPNRRFTFGFLRFEIIASFLNGLTLAVIAVWILWEGIERFLHPE
HHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PIQFRLMLGIAAIGLIVNLTLTIVLSRSTKEEDNLNVQSALWHFIGDLISSIGVIISALL
CHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IYFTGWTIFDPIISLVIAAIIFTGGAKIMRESYLILMEAVPDEFDLEQIRADIRNIEGVE
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHH
DVHDMHLWAISTDHYSLSAHVFVNEHIQPLCVILAVNEMLKEKYGIEHATIQVEHAILHD
HHHHHEEEEEECCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHC
HGSYGKAFLEKRKASQP
CCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]