Click here to switch to the map view.

The map label for this gene is leuS [H]

Identifier: 138896379

GI number: 138896379

Start: 2859590

End: 2862025

Strand: Reverse

Name: leuS [H]

Synonym: GTNG_2742

Alternate gene names: 138896379

Gene position: 2862025-2859590 (Counterclockwise)

Preceding gene: 138896380

Following gene: 138896378

Centisome position: 80.61

GC content: 52.59

Gene sequence:

>2436_bases
ATGAGGAGGAGTGCGACGATGAGTTTCAACCATCGCGAAATTGAGAAAAAGTGGCAGGATTATTGGGAACAGCATAAAAC
GTTCCGCACCCCGGATGAAAGCGATAAACCGAAGTTTTACGTGTTGGATATGTTTCCGTATCCGTCTGGCGCTGGCTTGC
ACGTCGGCCATCCGGAAGGGTATACGGCGACCGATATTTTGGCGCGCATGAAGCGGATGCAAGGGTACAATGTCCTTCAC
CCGATGGGGTGGGACGCGTTCGGATTGCCGGCGGAACAATATGCGCTCGATACCGGCAACGACCCGGCCGAATTTACGCA
AAAAAACATCGACAACTTCCGTCGGCAAATTAAGTCGCTTGGTTTTTCGTATGACTGGGATCGGGAAATTAACACGACTG
ATCCGAACTATTACAAATGGACGCAATGGATTTTCTTGAAGCTGTATGAAAAAGGGCTCGCCTACATGGACGAAGTACCG
GTCAACTGGTGTCCGGCGCTTGGCACCGTGCTGGCGAACGAAGAAGTCATCAATGGCCGGAGCGAGCGCGGTGGGCATCC
GGTCATCCGCAAGCCGATGCGGCAATGGATGCTGAAAATTACCGCCTATGCCGACCGGCTGCTCGAAGATTTGGAGGAGC
TTGACTGGCCGGAAAGCATTAAAGAAATGCAACGCAACTGGATCGGCCGTTCAGAAGGGGCGGAAATTGAGTTTGCTGTC
GACGGCCATGACGAGTCGTTCACAGTATTTACGACGCGGCCAGATACGCTGTTTGGCGCCACGTACGCAGTGTTGGCTCC
GGAACATCCGCTTGTTGAGAAAATTACAACGCCGGAGCAAAAACCAGCCGTTGATGCTTACTTAAAAGAAGTGCAAAGCA
AAAGCGACCTCGAGCGCACCGACTTGGCGAAAGAAAAAACAGGCGTGTTCACTGGTGCGTACGCCATCCATCCAGTTACC
GGCGACAAGCTGCCGATTTGGATCGCCGACTACGTGTTGATGGGCTACGGCACTGGGGCGATCATGGCTGTACCGGCGCA
CGATGAGCGCGACTACGAGTTTGCGAAAACATTCAACTTGCCGATCAAAGAAGTCGTTGCCGGCGGGAATGTCGAAAACG
AGCCGTACACTGGCGACGGGGAGCACATCAACTCTGAGTTTTTGAACGGCTTGAACAAACAAGAAGCGATTGAAAAAATG
ATCGCCTGGCTTGAAGAAAACGGAAAAGGACAAAAGAAAGTGTCGTACCGGCTGCGCGACTGGTTGTTCAGCCGCCAGCG
CTACTGGGGTGAGCCGATTCCGGTCATCCATTGGGAAGATGGGACGATGACGACGGTGCCGGAAGAAGAATTGCCGCTTG
TCTTGCCAAAAACGGATGAAATTAAACCGTCGGGAACGGGTGAATCGCCGCTCGCCAACATCGAAGAATGGGTCAATGTT
GTCGATCCGAAAACCGGGAAAAAAGGGCGGCGTGAAACAAACACGATGCCGCAATGGGCGGGAAGCTGCTGGTATTATTT
GCGCTACATCGACCCGCATAACGACAAACAGCTCGCCGATCCGGAAAAGTTGAAACAATGGCTGCCGGTTGACGTCTACA
TCGGCGGGGCGGAGCATGCGGTCTTGCACTTGCTGTACGCTCGCTTCTGGCATAAAGTGTTGTACGACCTTGGCATCGTG
CCGACGAAAGAGCCGTTCCAAAAGCTGTTTAACCAAGGGATGATCTTAGGCGAAAACAATGAAAAGATGAGCAAATCGAA
AGGCAATGTCGTCAACCCGGATGATATCGTCGAAAGCCATGGCGCGGATACGTTGCGGCTGTATGAAATGTTTATGGGGC
CGCTTGAAGCGTCGATCGCCTGGTCGACGAAAGGGCTTGACGGAGCGCGCCGTTTCTTAGAGCGCGTCTGGCGCCTGTTT
GTCACCGAAGATGGTCAACTGAACCCGAACATCGTTGACGAGCCAGCGAACGATACGCTCGAGCGCGTCTACCATCAAAC
GGTGAAAAAAGTGACGGAAGACTACGAAGCGCTGCGCTTCAACACTGCCATTTCGCAGCTGATGGTGTTCATTAACGAAG
CGTATAAAGCGGAGCAGATGAAAAAAGAATATATGGAAGGGTTCGTCAAGCTCTTATCGCCGGTTTGCCCGCATATTGGC
GAAGAGCTCTGGCAAAAGCTCGGCCATACTGACACCATCGCCTATGAACCATGGCCGACATATGACGAAGCGAAACTCGT
CGAAGACGTCGTTGAAATCGTCATCCAAATCAATGGCAAAGTGCGGGCGAAACTGAACGTGCCGGCGGACTTATCGAAAG
AAGCGCTAGAAGAACGGGCGCTCGCCGATGAAAAAATTAAAGAGCAGCTTGCAGGGAAAACGGTGCGTAAGGTGATCACT
GTCCCTGGTAAGCTCGTCAATATCGTCGCCAACTAA

Upstream 100 bases:

>100_bases
AAAAAGGGTGGTACCGCGGGAATTGTGCCTCTCGTCCCTTTTCATTGGGATGGGAGGTTTTTTTATATATATTTCCGTCA
ATGATGCAAAGTAGAAATCG

Downstream 100 bases:

>100_bases
CGAGACGGGTGGGGCGGGCAGTCCGCTGCCACCCTCTTATATGGATGAAAGGAGCGAACTTGGATGGAAGAAATCAAGGA
AATCACCGCGGCGGAAGTGA

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 811; Mature: 811

Protein sequence:

>811_residues
MRRSATMSFNHREIEKKWQDYWEQHKTFRTPDESDKPKFYVLDMFPYPSGAGLHVGHPEGYTATDILARMKRMQGYNVLH
PMGWDAFGLPAEQYALDTGNDPAEFTQKNIDNFRRQIKSLGFSYDWDREINTTDPNYYKWTQWIFLKLYEKGLAYMDEVP
VNWCPALGTVLANEEVINGRSERGGHPVIRKPMRQWMLKITAYADRLLEDLEELDWPESIKEMQRNWIGRSEGAEIEFAV
DGHDESFTVFTTRPDTLFGATYAVLAPEHPLVEKITTPEQKPAVDAYLKEVQSKSDLERTDLAKEKTGVFTGAYAIHPVT
GDKLPIWIADYVLMGYGTGAIMAVPAHDERDYEFAKTFNLPIKEVVAGGNVENEPYTGDGEHINSEFLNGLNKQEAIEKM
IAWLEENGKGQKKVSYRLRDWLFSRQRYWGEPIPVIHWEDGTMTTVPEEELPLVLPKTDEIKPSGTGESPLANIEEWVNV
VDPKTGKKGRRETNTMPQWAGSCWYYLRYIDPHNDKQLADPEKLKQWLPVDVYIGGAEHAVLHLLYARFWHKVLYDLGIV
PTKEPFQKLFNQGMILGENNEKMSKSKGNVVNPDDIVESHGADTLRLYEMFMGPLEASIAWSTKGLDGARRFLERVWRLF
VTEDGQLNPNIVDEPANDTLERVYHQTVKKVTEDYEALRFNTAISQLMVFINEAYKAEQMKKEYMEGFVKLLSPVCPHIG
EELWQKLGHTDTIAYEPWPTYDEAKLVEDVVEIVIQINGKVRAKLNVPADLSKEALEERALADEKIKEQLAGKTVRKVIT
VPGKLVNIVAN

Sequences:

>Translated_811_residues
MRRSATMSFNHREIEKKWQDYWEQHKTFRTPDESDKPKFYVLDMFPYPSGAGLHVGHPEGYTATDILARMKRMQGYNVLH
PMGWDAFGLPAEQYALDTGNDPAEFTQKNIDNFRRQIKSLGFSYDWDREINTTDPNYYKWTQWIFLKLYEKGLAYMDEVP
VNWCPALGTVLANEEVINGRSERGGHPVIRKPMRQWMLKITAYADRLLEDLEELDWPESIKEMQRNWIGRSEGAEIEFAV
DGHDESFTVFTTRPDTLFGATYAVLAPEHPLVEKITTPEQKPAVDAYLKEVQSKSDLERTDLAKEKTGVFTGAYAIHPVT
GDKLPIWIADYVLMGYGTGAIMAVPAHDERDYEFAKTFNLPIKEVVAGGNVENEPYTGDGEHINSEFLNGLNKQEAIEKM
IAWLEENGKGQKKVSYRLRDWLFSRQRYWGEPIPVIHWEDGTMTTVPEEELPLVLPKTDEIKPSGTGESPLANIEEWVNV
VDPKTGKKGRRETNTMPQWAGSCWYYLRYIDPHNDKQLADPEKLKQWLPVDVYIGGAEHAVLHLLYARFWHKVLYDLGIV
PTKEPFQKLFNQGMILGENNEKMSKSKGNVVNPDDIVESHGADTLRLYEMFMGPLEASIAWSTKGLDGARRFLERVWRLF
VTEDGQLNPNIVDEPANDTLERVYHQTVKKVTEDYEALRFNTAISQLMVFINEAYKAEQMKKEYMEGFVKLLSPVCPHIG
EELWQKLGHTDTIAYEPWPTYDEAKLVEDVVEIVIQINGKVRAKLNVPADLSKEALEERALADEKIKEQLAGKTVRKVIT
VPGKLVNIVAN
>Mature_811_residues
MRRSATMSFNHREIEKKWQDYWEQHKTFRTPDESDKPKFYVLDMFPYPSGAGLHVGHPEGYTATDILARMKRMQGYNVLH
PMGWDAFGLPAEQYALDTGNDPAEFTQKNIDNFRRQIKSLGFSYDWDREINTTDPNYYKWTQWIFLKLYEKGLAYMDEVP
VNWCPALGTVLANEEVINGRSERGGHPVIRKPMRQWMLKITAYADRLLEDLEELDWPESIKEMQRNWIGRSEGAEIEFAV
DGHDESFTVFTTRPDTLFGATYAVLAPEHPLVEKITTPEQKPAVDAYLKEVQSKSDLERTDLAKEKTGVFTGAYAIHPVT
GDKLPIWIADYVLMGYGTGAIMAVPAHDERDYEFAKTFNLPIKEVVAGGNVENEPYTGDGEHINSEFLNGLNKQEAIEKM
IAWLEENGKGQKKVSYRLRDWLFSRQRYWGEPIPVIHWEDGTMTTVPEEELPLVLPKTDEIKPSGTGESPLANIEEWVNV
VDPKTGKKGRRETNTMPQWAGSCWYYLRYIDPHNDKQLADPEKLKQWLPVDVYIGGAEHAVLHLLYARFWHKVLYDLGIV
PTKEPFQKLFNQGMILGENNEKMSKSKGNVVNPDDIVESHGADTLRLYEMFMGPLEASIAWSTKGLDGARRFLERVWRLF
VTEDGQLNPNIVDEPANDTLERVYHQTVKKVTEDYEALRFNTAISQLMVFINEAYKAEQMKKEYMEGFVKLLSPVCPHIG
EELWQKLGHTDTIAYEPWPTYDEAKLVEDVVEIVIQINGKVRAKLNVPADLSKEALEERALADEKIKEQLAGKTVRKVIT
VPGKLVNIVAN

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=877, Percent_Identity=34.3215507411631, Blast_Score=480, Evalue=1e-135,
Organism=Homo sapiens, GI5454158, Length=434, Percent_Identity=24.1935483870968, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI94721239, Length=181, Percent_Identity=27.6243093922652, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI94721241, Length=181, Percent_Identity=27.6243093922652, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1786861, Length=858, Percent_Identity=43.9393939393939, Blast_Score=700, Evalue=0.0,
Organism=Escherichia coli, GI1790708, Length=377, Percent_Identity=25.9946949602122, Blast_Score=110, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71997510, Length=841, Percent_Identity=29.1319857312723, Blast_Score=327, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI71997517, Length=806, Percent_Identity=29.2803970223325, Blast_Score=325, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI212645227, Length=352, Percent_Identity=26.9886363636364, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71980946, Length=819, Percent_Identity=22.3443223443223, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17510661, Length=453, Percent_Identity=25.1655629139073, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17554638, Length=319, Percent_Identity=26.6457680250784, Blast_Score=84, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323414, Length=873, Percent_Identity=35.8533791523482, Blast_Score=486, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6321531, Length=395, Percent_Identity=26.0759493670886, Blast_Score=107, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6319395, Length=186, Percent_Identity=29.0322580645161, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6325217, Length=363, Percent_Identity=23.6914600550964, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21355409, Length=832, Percent_Identity=32.9326923076923, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI17864482, Length=388, Percent_Identity=26.8041237113402, Blast_Score=110, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24653289, Length=388, Percent_Identity=26.8041237113402, Blast_Score=110, Evalue=5e-24,
Organism=Drosophila melanogaster, GI281366294, Length=155, Percent_Identity=34.1935483870968, Blast_Score=74, Evalue=6e-13,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 93049; Mature: 93049

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSATMSFNHREIEKKWQDYWEQHKTFRTPDESDKPKFYVLDMFPYPSGAGLHVGHPEG
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCEECCCCCC
YTATDILARMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPAEFTQKNIDNFRRQIKSL
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHC
GFSYDWDREINTTDPNYYKWTQWIFLKLYEKGLAYMDEVPVNWCPALGTVLANEEVINGR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCCC
SERGGHPVIRKPMRQWMLKITAYADRLLEDLEELDWPESIKEMQRNWIGRSEGAEIEFAV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEE
DGHDESFTVFTTRPDTLFGATYAVLAPEHPLVEKITTPEQKPAVDAYLKEVQSKSDLERT
CCCCCEEEEEECCCCCHHCCEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCHHH
DLAKEKTGVFTGAYAIHPVTGDKLPIWIADYVLMGYGTGAIMAVPAHDERDYEFAKTFNL
HHHHHHCCCEECCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCC
PIKEVVAGGNVENEPYTGDGEHINSEFLNGLNKQEAIEKMIAWLEENGKGQKKVSYRLRD
CHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
WLFSRQRYWGEPIPVIHWEDGTMTTVPEEELPLVLPKTDEIKPSGTGESPLANIEEWVNV
HHHHHHHHCCCCCCEEEECCCCEECCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHH
VDPKTGKKGRRETNTMPQWAGSCWYYLRYIDPHNDKQLADPEKLKQWLPVDVYIGGAEHA
CCCCCCCCCCCCCCCCCHHCCCEEEEEEEECCCCCCCCCCHHHHHHHCCEEEEECCHHHH
VLHLLYARFWHKVLYDLGIVPTKEPFQKLFNQGMILGENNEKMSKSKGNVVNPDDIVESH
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEECCCCCHHHHCCCCCCCHHHHHHHC
GADTLRLYEMFMGPLEASIAWSTKGLDGARRFLERVWRLFVTEDGQLNPNIVDEPANDTL
CCCHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
ERVYHQTVKKVTEDYEALRFNTAISQLMVFINEAYKAEQMKKEYMEGFVKLLSPVCPHIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EELWQKLGHTDTIAYEPWPTYDEAKLVEDVVEIVIQINGKVRAKLNVPADLSKEALEERA
HHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
LADEKIKEQLAGKTVRKVITVPGKLVNIVAN
HHHHHHHHHHHHHHHHHHHHCCCHHHHEECC
>Mature Secondary Structure
MRRSATMSFNHREIEKKWQDYWEQHKTFRTPDESDKPKFYVLDMFPYPSGAGLHVGHPEG
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCEECCCCCC
YTATDILARMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPAEFTQKNIDNFRRQIKSL
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHC
GFSYDWDREINTTDPNYYKWTQWIFLKLYEKGLAYMDEVPVNWCPALGTVLANEEVINGR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCCC
SERGGHPVIRKPMRQWMLKITAYADRLLEDLEELDWPESIKEMQRNWIGRSEGAEIEFAV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEE
DGHDESFTVFTTRPDTLFGATYAVLAPEHPLVEKITTPEQKPAVDAYLKEVQSKSDLERT
CCCCCEEEEEECCCCCHHCCEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCHHH
DLAKEKTGVFTGAYAIHPVTGDKLPIWIADYVLMGYGTGAIMAVPAHDERDYEFAKTFNL
HHHHHHCCCEECCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCC
PIKEVVAGGNVENEPYTGDGEHINSEFLNGLNKQEAIEKMIAWLEENGKGQKKVSYRLRD
CHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
WLFSRQRYWGEPIPVIHWEDGTMTTVPEEELPLVLPKTDEIKPSGTGESPLANIEEWVNV
HHHHHHHHCCCCCCEEEECCCCEECCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHH
VDPKTGKKGRRETNTMPQWAGSCWYYLRYIDPHNDKQLADPEKLKQWLPVDVYIGGAEHA
CCCCCCCCCCCCCCCCCHHCCCEEEEEEEECCCCCCCCCCHHHHHHHCCEEEEECCHHHH
VLHLLYARFWHKVLYDLGIVPTKEPFQKLFNQGMILGENNEKMSKSKGNVVNPDDIVESH
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEECCCCCHHHHCCCCCCCHHHHHHHC
GADTLRLYEMFMGPLEASIAWSTKGLDGARRFLERVWRLFVTEDGQLNPNIVDEPANDTL
CCCHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
ERVYHQTVKKVTEDYEALRFNTAISQLMVFINEAYKAEQMKKEYMEGFVKLLSPVCPHIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EELWQKLGHTDTIAYEPWPTYDEAKLVEDVVEIVIQINGKVRAKLNVPADLSKEALEERA
HHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHH
LADEKIKEQLAGKTVRKVITVPGKLVNIVAN
HHHHHHHHHHHHHHHHHHHHCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA