Click here to switch to the map view.

The map label for this gene is tpx [H]

Identifier: 138896327

GI number: 138896327

Start: 2799765

End: 2800268

Strand: Reverse

Name: tpx [H]

Synonym: GTNG_2690

Alternate gene names: 138896327

Gene position: 2800268-2799765 (Counterclockwise)

Preceding gene: 138896328

Following gene: 138896326

Centisome position: 78.87

GC content: 52.38

Gene sequence:

>504_bases
ATGATGGCTAATGTGACGTTTAAAGGAAATCCGGTCACGCTCGTCGGAAACGAAGTGAACGTCGGTGACAAGGCGCCGGA
TTTTACGGTGCTTGACCAAAACTTGCAAGAAGTAACGCTCGCCGATACGAAAGGACACGTCCGCTTAATCAGCGTCGTTC
CGTCGCTTGACACTGGGGTTTGTGATGCGCAGACGCGCCGATTTAACGAAGAAGCGGCGAAGCTTGACAATGTGAAAGTG
TTAACCATCAGCGTCGATTTGCCGTTTGCACAAAAACGGTGGTGCGGCGCTGCCGGCATTGACAACGTCCAAGTATTGTC
CGACCATCGTGACGTTTCGTTCGGACAAGCGTACGGCGTCTTGATCAAAGAACTGCGCTTGCTCGCCCGCGCGGTGTTTG
TCATCGACAGCAATGATACGGTGACGTACGTAGAATACGTGCCGGAAGTGACGAACCATCCGAACTACGAAGCCGCGATT
GAAGCAGCAAAAGCAGCGAAATAA

Upstream 100 bases:

>100_bases
TTCATTCAAATTAACTTTCTAGCGAAGGCAAAACGATTGCAAAAATCTTTTCCGTGTTCTAATATGGAAATAGTACATAT
TTTTTCTTAAGGGGAGAGAA

Downstream 100 bases:

>100_bases
TGGAAAAAGGCCCCGATCCGTTCGGGGTCTTTTCTTTCCTGCCGACGCTTTTCTTGCCGCACAGGGGGAATCCGGCGTAC
AATAGCAAAAGGAAATGGCC

Product: thioredoxin peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: Superoxide-inducible protein 8; SOI8 [H]

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MMANVTFKGNPVTLVGNEVNVGDKAPDFTVLDQNLQEVTLADTKGHVRLISVVPSLDTGVCDAQTRRFNEEAAKLDNVKV
LTISVDLPFAQKRWCGAAGIDNVQVLSDHRDVSFGQAYGVLIKELRLLARAVFVIDSNDTVTYVEYVPEVTNHPNYEAAI
EAAKAAK

Sequences:

>Translated_167_residues
MMANVTFKGNPVTLVGNEVNVGDKAPDFTVLDQNLQEVTLADTKGHVRLISVVPSLDTGVCDAQTRRFNEEAAKLDNVKV
LTISVDLPFAQKRWCGAAGIDNVQVLSDHRDVSFGQAYGVLIKELRLLARAVFVIDSNDTVTYVEYVPEVTNHPNYEAAI
EAAKAAK
>Mature_167_residues
MMANVTFKGNPVTLVGNEVNVGDKAPDFTVLDQNLQEVTLADTKGHVRLISVVPSLDTGVCDAQTRRFNEEAAKLDNVKV
LTISVDLPFAQKRWCGAAGIDNVQVLSDHRDVSFGQAYGVLIKELRLLARAVFVIDSNDTVTYVEYVPEVTNHPNYEAAI
EAAKAAK

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=168, Percent_Identity=48.2142857142857, Blast_Score=156, Evalue=8e-40,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 18202; Mature: 18202

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMANVTFKGNPVTLVGNEVNVGDKAPDFTVLDQNLQEVTLADTKGHVRLISVVPSLDTGV
CCEEEEECCCCEEEECCEECCCCCCCCEEEECCCCCEEEEECCCCCEEEEEECCCCCCCC
CDAQTRRFNEEAAKLDNVKVLTISVDLPFAQKRWCGAAGIDNVQVLSDHRDVSFGQAYGV
CCHHHHHCCHHHHHCCCEEEEEEEEECCCHHHHCCCCCCCCCEEEECCCCCCCCHHHHHH
LIKELRLLARAVFVIDSNDTVTYVEYVPEVTNHPNYEAAIEAAKAAK
HHHHHHHHHHEEEEECCCCCEEEEEECCHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MMANVTFKGNPVTLVGNEVNVGDKAPDFTVLDQNLQEVTLADTKGHVRLISVVPSLDTGV
CCEEEEECCCCEEEECCEECCCCCCCCEEEECCCCCEEEEECCCCCEEEEEECCCCCCCC
CDAQTRRFNEEAAKLDNVKVLTISVDLPFAQKRWCGAAGIDNVQVLSDHRDVSFGQAYGV
CCHHHHHCCHHHHHCCCEEEEEEEEECCCHHHHCCCCCCCCCEEEECCCCCCCCHHHHHH
LIKELRLLARAVFVIDSNDTVTYVEYVPEVTNHPNYEAAIEAAKAAK
HHHHHHHHHHEEEEECCCCCEEEEEECCHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 9298659 [H]