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The map label for this gene is trxA [H]

Identifier: 138896249

GI number: 138896249

Start: 2720007

End: 2720321

Strand: Reverse

Name: trxA [H]

Synonym: GTNG_2612

Alternate gene names: 138896249

Gene position: 2720321-2720007 (Counterclockwise)

Preceding gene: 138896250

Following gene: 138896248

Centisome position: 76.62

GC content: 50.79

Gene sequence:

>315_bases
ATGGCCATTATCAATGCGACAGACCAAACGTTCGCCGCGGAAACGAAAGACGGCGTCACTCTTGTCGACTTTTGGGCGCC
ATGGTGCGGTCCATGCCGTATGATCGCCCCGGTGCTTGAGGAGCTTGATCAAGAAATGGGCGACAAAGTGAAAATTGTCA
AAGTCAACGTTGATGAAAACCAAGAAACAGCAGCAAAGTTCGGGGTGATGAGCATTCCGACGCTGCTCGTGTTTAAAAAC
GGCGAACTCGTTGATAAAGCCGTCGGCTACCAACCGAAAGAAGCACTTGCTCAGCTTGTCGGCAAACATGTGTAG

Upstream 100 bases:

>100_bases
CGCGAAGCGAATATTAGAAACGAGGCAAAATATTCGCGTCGTTTTAAATTTCCATGGTATACTGTGCTTACAGCATTCTA
GAATATGGGAGGGAAATGGC

Downstream 100 bases:

>100_bases
TGATGGCATAGGAAAAATCCAGAGGCCTCTTCCTCTGGATTTTTATTTTTTGCTGAAAAATGGTTGACAGATGGCAGATA
ATTCTTTATATTTATAACCA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MAIINATDQTFAAETKDGVTLVDFWAPWCGPCRMIAPVLEELDQEMGDKVKIVKVNVDENQETAAKFGVMSIPTLLVFKN
GELVDKAVGYQPKEALAQLVGKHV

Sequences:

>Translated_104_residues
MAIINATDQTFAAETKDGVTLVDFWAPWCGPCRMIAPVLEELDQEMGDKVKIVKVNVDENQETAAKFGVMSIPTLLVFKN
GELVDKAVGYQPKEALAQLVGKHV
>Mature_103_residues
AIINATDQTFAAETKDGVTLVDFWAPWCGPCRMIAPVLEELDQEMGDKVKIVKVNVDENQETAAKFGVMSIPTLLVFKNG
ELVDKAVGYQPKEALAQLVGKHV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=95, Percent_Identity=36.8421052631579, Blast_Score=72, Evalue=7e-14,
Organism=Homo sapiens, GI21361657, Length=84, Percent_Identity=36.9047619047619, Blast_Score=66, Evalue=6e-12,
Organism=Homo sapiens, GI42794771, Length=101, Percent_Identity=31.6831683168317, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI224493972, Length=101, Percent_Identity=31.6831683168317, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI38505222, Length=95, Percent_Identity=33.6842105263158, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI87082331, Length=100, Percent_Identity=48, Blast_Score=102, Evalue=4e-24,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=50, Blast_Score=102, Evalue=5e-24,
Organism=Escherichia coli, GI87081747, Length=82, Percent_Identity=36.5853658536585, Blast_Score=63, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=85, Percent_Identity=34.1176470588235, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=75, Percent_Identity=44, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=80, Percent_Identity=38.75, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=83, Percent_Identity=43.3734939759036, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=83, Percent_Identity=42.1686746987952, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=81, Percent_Identity=38.2716049382716, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=88, Percent_Identity=36.3636363636364, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=88, Percent_Identity=36.3636363636364, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=100, Percent_Identity=38, Blast_Score=76, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=89, Percent_Identity=43.8202247191011, Blast_Score=76, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=72, Percent_Identity=41.6666666666667, Blast_Score=67, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24639826, Length=88, Percent_Identity=43.1818181818182, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28573567, Length=90, Percent_Identity=38.8888888888889, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17648013, Length=76, Percent_Identity=40.7894736842105, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583090, Length=76, Percent_Identity=40.7894736842105, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24664269, Length=60, Percent_Identity=46.6666666666667, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24658597, Length=89, Percent_Identity=38.2022471910112, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11376; Mature: 11245

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIINATDQTFAAETKDGVTLVDFWAPWCGPCRMIAPVLEELDQEMGDKVKIVKVNVDEN
CEEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
QETAAKFGVMSIPTLLVFKNGELVDKAVGYQPKEALAQLVGKHV
HHHHHHHCHHCCCEEEEEECCCHHHHHCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
AIINATDQTFAAETKDGVTLVDFWAPWCGPCRMIAPVLEELDQEMGDKVKIVKVNVDEN
EEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
QETAAKFGVMSIPTLLVFKNGELVDKAVGYQPKEALAQLVGKHV
HHHHHHHCHHCCCEEEEEECCCHHHHHCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2559145; 8969504; 9384377; 8755892 [H]