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The map label for this gene is hom [H]

Identifier: 138895909

GI number: 138895909

Start: 2383821

End: 2384885

Strand: Reverse

Name: hom [H]

Synonym: GTNG_2268

Alternate gene names: 138895909

Gene position: 2384885-2383821 (Counterclockwise)

Preceding gene: 138895910

Following gene: 138895908

Centisome position: 67.17

GC content: 41.13

Gene sequence:

>1065_bases
ATGGTTCATAAACTAGCACTCATTGGATTTGGCGTTGTCGGTCAAGGGTTAGTGGAAATTTTATTAAATAAACAAGAAAA
ATTACAAAAAGAAGAAGGCTTTGAAGCGGTTGTTGTAGCCATTTCGGATTTAATGAAAGGATCGATTTATCATCCAGATG
GTTTACATCTTGAGACAGTCTTGAAAGTGCTAAAGGAAACAGGGAATATTGAGAACTATCCTGATGTGCCAGGGATTATA
AAAGGGTGGGACAGCTTTAAAACCATTCGTGAAACGAACGCTGATACGATTGTGGAAGTTTCCTATACCGATGTGAAAAC
AGGACAGCCCGCCATCGATCATTGCAAGGCTGCTTTTGAAAGCGGGAAAAATGTCATTATGACAAACAAAGGACCGGTCG
CATTAGCGTATAAAGAATTGTCGCAAATGGCTAAGAAGTATGGAGTGTACTGGGGATTTGAGGGAACGGTAATGAGCGGA
ACCCCAGCGTTAAGAATGCCGATTACATCTCTGGCAGGCAATGATATTACAGAGATCAAAGGAATTTTAAATGGAACTAC
CAATTATATCCTTACCAAAATGGAAGAAGAAGGATGGACATATGAAGAAGCGTTAAGAGAAGCGCAAAGGCTTGGTTACG
CTGAAGCTGACCCTACTAGTGACGTCGAAGGGTATGATGCAAAATTTAAAATTGTTATTCTAGCTAATTATGTGATGAAT
GTCCCTTTGTCAGCAGAGGAAGTCATATGCAAAGGAATTACAGATATTACCTTAGACGATATTGAGGAAGCAAAACAGCA
AGGAAAAAGATGGAAACTGATAGCGAAAGTTCGTAAAGAGCAGGATAAAGTAATCGCCTCTGTCGCTCCGGAAAAAGTGG
ATTTAACAGATCCCCTCGCATCAATTAGCGGTACCACGAATGCCGTTACGTACGAATGTGATCTTCTCGGCCCAGTCACA
TTAGTAGGCGCGGGAGCAGGAAAAATGGAAACGGGTTTTTCGCTTCTTATCGATCTCATCAATATCCAACGCGCCGCTCA
TCAGCAAAAGTTAGTGAAAATTTAA

Upstream 100 bases:

>100_bases
TGTTTGCCAATCGGTACAGCGATTTTAGCACAAACAGTTGTTCATTTTTTGAATGGTAAAGTTTCCTTGTCAGCAAATGA
GATGTTGGAGGTATAATCAT

Downstream 100 bases:

>100_bases
TTGGGGAAAGGTGGTATGTTGATGACAACTCAAGTGATTGGTCGAAAAATGTATTTGGCAGGAAAGTGGGTAAAAAGAGA
TCGGATTATAGAGGTGCGCG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MVHKLALIGFGVVGQGLVEILLNKQEKLQKEEGFEAVVVAISDLMKGSIYHPDGLHLETVLKVLKETGNIENYPDVPGII
KGWDSFKTIRETNADTIVEVSYTDVKTGQPAIDHCKAAFESGKNVIMTNKGPVALAYKELSQMAKKYGVYWGFEGTVMSG
TPALRMPITSLAGNDITEIKGILNGTTNYILTKMEEEGWTYEEALREAQRLGYAEADPTSDVEGYDAKFKIVILANYVMN
VPLSAEEVICKGITDITLDDIEEAKQQGKRWKLIAKVRKEQDKVIASVAPEKVDLTDPLASISGTTNAVTYECDLLGPVT
LVGAGAGKMETGFSLLIDLINIQRAAHQQKLVKI

Sequences:

>Translated_354_residues
MVHKLALIGFGVVGQGLVEILLNKQEKLQKEEGFEAVVVAISDLMKGSIYHPDGLHLETVLKVLKETGNIENYPDVPGII
KGWDSFKTIRETNADTIVEVSYTDVKTGQPAIDHCKAAFESGKNVIMTNKGPVALAYKELSQMAKKYGVYWGFEGTVMSG
TPALRMPITSLAGNDITEIKGILNGTTNYILTKMEEEGWTYEEALREAQRLGYAEADPTSDVEGYDAKFKIVILANYVMN
VPLSAEEVICKGITDITLDDIEEAKQQGKRWKLIAKVRKEQDKVIASVAPEKVDLTDPLASISGTTNAVTYECDLLGPVT
LVGAGAGKMETGFSLLIDLINIQRAAHQQKLVKI
>Mature_354_residues
MVHKLALIGFGVVGQGLVEILLNKQEKLQKEEGFEAVVVAISDLMKGSIYHPDGLHLETVLKVLKETGNIENYPDVPGII
KGWDSFKTIRETNADTIVEVSYTDVKTGQPAIDHCKAAFESGKNVIMTNKGPVALAYKELSQMAKKYGVYWGFEGTVMSG
TPALRMPITSLAGNDITEIKGILNGTTNYILTKMEEEGWTYEEALREAQRLGYAEADPTSDVEGYDAKFKIVILANYVMN
VPLSAEEVICKGITDITLDDIEEAKQQGKRWKLIAKVRKEQDKVIASVAPEKVDLTDPLASISGTTNAVTYECDLLGPVT
LVGAGAGKMETGFSLLIDLINIQRAAHQQKLVKI

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=263, Percent_Identity=26.615969581749, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790376, Length=362, Percent_Identity=24.3093922651934, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 38694; Mature: 38694

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHKLALIGFGVVGQGLVEILLNKQEKLQKEEGFEAVVVAISDLMKGSIYHPDGLHLETV
CCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHH
LKVLKETGNIENYPDVPGIIKGWDSFKTIRETNADTIVEVSYTDVKTGQPAIDHCKAAFE
HHHHHHCCCCCCCCCCCHHHHCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHH
SGKNVIMTNKGPVALAYKELSQMAKKYGVYWGFEGTVMSGTPALRMPITSLAGNDITEIK
CCCEEEEECCCCEEHHHHHHHHHHHHHCEEECCCCEEECCCCCCCCCHHHHCCCCHHHHH
GILNGTTNYILTKMEEEGWTYEEALREAQRLGYAEADPTSDVEGYDAKFKIVILANYVMN
HHHCCCCHHEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEHHHHC
VPLSAEEVICKGITDITLDDIEEAKQQGKRWKLIAKVRKEQDKVIASVAPEKVDLTDPLA
CCCCHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
SISGTTNAVTYECDLLGPVTLVGAGAGKMETGFSLLIDLINIQRAAHQQKLVKI
HCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVHKLALIGFGVVGQGLVEILLNKQEKLQKEEGFEAVVVAISDLMKGSIYHPDGLHLETV
CCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHH
LKVLKETGNIENYPDVPGIIKGWDSFKTIRETNADTIVEVSYTDVKTGQPAIDHCKAAFE
HHHHHHCCCCCCCCCCCHHHHCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHH
SGKNVIMTNKGPVALAYKELSQMAKKYGVYWGFEGTVMSGTPALRMPITSLAGNDITEIK
CCCEEEEECCCCEEHHHHHHHHHHHHHCEEECCCCEEECCCCCCCCCHHHHCCCCHHHHH
GILNGTTNYILTKMEEEGWTYEEALREAQRLGYAEADPTSDVEGYDAKFKIVILANYVMN
HHHCCCCHHEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEHHHHC
VPLSAEEVICKGITDITLDDIEEAKQQGKRWKLIAKVRKEQDKVIASVAPEKVDLTDPLA
CCCCHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
SISGTTNAVTYECDLLGPVTLVGAGAGKMETGFSLLIDLINIQRAAHQQKLVKI
HCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]