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The map label for this gene is pdp [H]

Identifier: 138895884

GI number: 138895884

Start: 2360891

End: 2362192

Strand: Reverse

Name: pdp [H]

Synonym: GTNG_2243

Alternate gene names: 138895884

Gene position: 2362192-2360891 (Counterclockwise)

Preceding gene: 138895885

Following gene: 138895883

Centisome position: 66.53

GC content: 54.61

Gene sequence:

>1302_bases
ATGAGAATGGTCGATTTGATTGCCAAAAAACGAGATGGGCAGGCGCTGACGAAAGAAGAAATTGAATGGATCATCCGCGG
TTATACAAACGGAGACATTCCAGATTACCAAATGAGCGCACTGGCGATGGCGGTATATTTTCGCGGCATGACGGACGAAG
AAACGGCGGTGTTGACGATGGCCATGGTGCACTCCGGCGAAGTCATCGATTTGTCAGGCATTCGTGGCATGAAAGTTGAC
AAACATTCAACAGGCGGGGTCGGCGATACGACGACGCTCGTTTTAGGCCCGCTTGTCGCCTCCGTTGGCGTGCCGGTGGC
GAAAATGTCTGGGCGCGGCCTCGGTCATACGGGCGGAACGATTGACAAGCTCGAGTCCGTGCCTGGATTTCACGTAGAAA
TCAGCAAAGATGAATTTCTCCGGCTCGTCAATGAGAATAAGATCGCCATTATTGGCCAAACTGGCGACTTGACACCAGCT
GACAAAAAGCTGTATGCGCTCCGCGACGTGACAGCGACTGTCAACAGCATTCCGCTTATCGCTTCCTCAATCATGAGCAA
AAAAATCGCTGCCGGGGCTGATGCCATCGTCTTAGATGTGAAAACCGGCGCCGGGGCGTTTATGAAGGAACTCGACAGGG
CACGCGAACTGGCCCGGGCGATGGTCGATATCGGCAAGCGTGTTGGCCGACAGACGATGGCCGTTATTTCCGATATGAGC
CAGCCGCTCGGCTATGCGGTCGGCAACGCTTTGGAAGTGAAAGAGGCGATCGCTACGCTGAAAGGAAACGGCCCGCGCGA
TTTGACAGAACTTTGTTTGACGCTTGGCAGCCATATGGTTTACTTGGCGAAGAAGGCGTCGTCGCTTGATGAGGCGCGCC
GCCTGCTTGAAGAGGCGATGCATGATGGATCCGCCATCGCAGCGTTCAAAACGTTTTTGGCGGCCCAAGGTGGCGATCCG
TCGGTCGTCGATGACCCGGACAAACTGCCGCAAGCAGCGTATACGTTTGACGTTGCAGCTAGCGAGGACGGTTATGTTGC
TGAGATTGTTGCAGATGAAATCGGTACTGCTGCCATGTGGCTTGGTGCCGGACGAGCAAAAAAAGAGGACGAGATTGACT
TGGCGGTCGGAATCGTGCTCCATAAGAAGGTTGGCGACCGTGTGCGGAAAGGGGAGGCGCTTGCTACCATCCACAGCAAC
CGGCAAGATGTGCGCACAGTGGAAGAAAAACTTGCAACTGCCATTCGGATCTCACCGCAGCCAGTCGCTCCGCCGCCGCT
CATTTATGAGACGATTGTATAA

Upstream 100 bases:

>100_bases
CGAAGTCGTCGAAACAGCCGAACGGGTGAAAGCCGACTTTTTGCGGCTTATTAAAGCGGTTGTCGCCGAGCTGGCGAAAT
AAGGAGAAAAGGTGATCGGG

Downstream 100 bases:

>100_bases
AGACAAGACCGTGGCTGATGTACAAATTAAAGAAGGCGTCGTTCAAGGAAAAACGCTCGAAACATTCGTTTCGAGCGTTT
TTTATTTTGGTTCATTTGTA

Product: pyrimidine nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MRMVDLIAKKRDGQALTKEEIEWIIRGYTNGDIPDYQMSALAMAVYFRGMTDEETAVLTMAMVHSGEVIDLSGIRGMKVD
KHSTGGVGDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGTIDKLESVPGFHVEISKDEFLRLVNENKIAIIGQTGDLTPA
DKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKELDRARELARAMVDIGKRVGRQTMAVISDMS
QPLGYAVGNALEVKEAIATLKGNGPRDLTELCLTLGSHMVYLAKKASSLDEARRLLEEAMHDGSAIAAFKTFLAAQGGDP
SVVDDPDKLPQAAYTFDVAASEDGYVAEIVADEIGTAAMWLGAGRAKKEDEIDLAVGIVLHKKVGDRVRKGEALATIHSN
RQDVRTVEEKLATAIRISPQPVAPPPLIYETIV

Sequences:

>Translated_433_residues
MRMVDLIAKKRDGQALTKEEIEWIIRGYTNGDIPDYQMSALAMAVYFRGMTDEETAVLTMAMVHSGEVIDLSGIRGMKVD
KHSTGGVGDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGTIDKLESVPGFHVEISKDEFLRLVNENKIAIIGQTGDLTPA
DKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKELDRARELARAMVDIGKRVGRQTMAVISDMS
QPLGYAVGNALEVKEAIATLKGNGPRDLTELCLTLGSHMVYLAKKASSLDEARRLLEEAMHDGSAIAAFKTFLAAQGGDP
SVVDDPDKLPQAAYTFDVAASEDGYVAEIVADEIGTAAMWLGAGRAKKEDEIDLAVGIVLHKKVGDRVRKGEALATIHSN
RQDVRTVEEKLATAIRISPQPVAPPPLIYETIV
>Mature_433_residues
MRMVDLIAKKRDGQALTKEEIEWIIRGYTNGDIPDYQMSALAMAVYFRGMTDEETAVLTMAMVHSGEVIDLSGIRGMKVD
KHSTGGVGDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGTIDKLESVPGFHVEISKDEFLRLVNENKIAIIGQTGDLTPA
DKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKELDRARELARAMVDIGKRVGRQTMAVISDMS
QPLGYAVGNALEVKEAIATLKGNGPRDLTELCLTLGSHMVYLAKKASSLDEARRLLEEAMHDGSAIAAFKTFLAAQGGDP
SVVDDPDKLPQAAYTFDVAASEDGYVAEIVADEIGTAAMWLGAGRAKKEDEIDLAVGIVLHKKVGDRVRKGEALATIHSN
RQDVRTVEEKLATAIRISPQPVAPPPLIYETIV

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=440, Percent_Identity=40.2272727272727, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI4503445, Length=440, Percent_Identity=40.2272727272727, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI166158922, Length=440, Percent_Identity=40.2272727272727, Blast_Score=296, Evalue=2e-80,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=44.3069306930693, Blast_Score=316, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46177; Mature: 46177

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMVDLIAKKRDGQALTKEEIEWIIRGYTNGDIPDYQMSALAMAVYFRGMTDEETAVLTM
CCHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHEEH
AMVHSGEVIDLSGIRGMKVDKHSTGGVGDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGT
HHHCCCCEEEECCCCCCEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLESVPGFHVEISKDEFLRLVNENKIAIIGQTGDLTPADKKLYALRDVTATVNSIPLI
HHHHHCCCCCEEEECHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKELDRARELARAMVDIGKRVGRQTMAVISDMS
HHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QPLGYAVGNALEVKEAIATLKGNGPRDLTELCLTLGSHMVYLAKKASSLDEARRLLEEAM
HHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHEEHHHHHCCHHHHHHHHHHHH
HDGSAIAAFKTFLAAQGGDPSVVDDPDKLPQAAYTFDVAASEDGYVAEIVADEIGTAAMW
CCCCHHHHHHHHHHCCCCCCCCCCCHHHCCCCCEEEEEECCCCCEEHHHHHHHHCHHHHH
LGAGRAKKEDEIDLAVGIVLHKKVGDRVRKGEALATIHSNRQDVRTVEEKLATAIRISPQ
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHEEECCC
PVAPPPLIYETIV
CCCCCCCHHHCCC
>Mature Secondary Structure
MRMVDLIAKKRDGQALTKEEIEWIIRGYTNGDIPDYQMSALAMAVYFRGMTDEETAVLTM
CCHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHEEH
AMVHSGEVIDLSGIRGMKVDKHSTGGVGDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGT
HHHCCCCEEEECCCCCCEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLESVPGFHVEISKDEFLRLVNENKIAIIGQTGDLTPADKKLYALRDVTATVNSIPLI
HHHHHCCCCCEEEECHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKELDRARELARAMVDIGKRVGRQTMAVISDMS
HHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QPLGYAVGNALEVKEAIATLKGNGPRDLTELCLTLGSHMVYLAKKASSLDEARRLLEEAM
HHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHEEHHHHHCCHHHHHHHHHHHH
HDGSAIAAFKTFLAAQGGDPSVVDDPDKLPQAAYTFDVAASEDGYVAEIVADEIGTAAMW
CCCCHHHHHHHHHHCCCCCCCCCCCHHHCCCCCEEEEEECCCCCEEHHHHHHHHCHHHHH
LGAGRAKKEDEIDLAVGIVLHKKVGDRVRKGEALATIHSNRQDVRTVEEKLATAIRISPQ
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHEEECCC
PVAPPPLIYETIV
CCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]