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The map label for this gene is ribBA [H]

Identifier: 138895864

GI number: 138895864

Start: 2345812

End: 2347011

Strand: Reverse

Name: ribBA [H]

Synonym: GTNG_2223

Alternate gene names: 138895864

Gene position: 2347011-2345812 (Counterclockwise)

Preceding gene: 138895865

Following gene: 138895863

Centisome position: 66.11

GC content: 51.33

Gene sequence:

>1200_bases
GTGGCCATGTTTGATACGATTGAAGCGGCGTTGGCCGCACTGAAAAACGGAGAAGTGATCATCGTTTGCGATGACGAAGA
CCGGGAAAATGAGGGGGATTTTGTCGCGCTGGCTGAAAAAGCGACACCGGATGTCATTAATTTTATGATTACGCATGGCC
GCGGGCTCGTCTGCGTCCCGATTACAGAAGAATTGGCGGCGCGTCTCGAGCTTGAGCCGATGGTCGCCCATAACACCGAT
GCGCATGGCACGGCGTTTACGGTAAGCGTCGACTACAAAACAACGACGACGGGAATCAGTGCTTACGAGCGAGCAGCGAC
CATTCAGGCGCTGCTTGATCCGAACGTAAAAGCGAGCGATTTCAAACGGCCAGGGCATATTTTTCCATTGATTGCTAAAA
AAGGCGGTGTCTTGCGACGTGCTGGCCATACGGAGGCGGCAGTCGATTTGGCCCGCTTATGCGGGGCGAAGCCGGCTGGC
GTCATCTGTGAGATTATTAAAGAAGACGGGACGATGGCGCGTGTTCCTGATTTACGGCACATTGCCGATCAGTTCGGACT
AAAAATGATTACGATTAAAGATTTAATCGCGTACCGAAGTCAAAGAGAAAAACTCGTGAAACGCGAAGTGGAAATTTCGC
TGCCGACTGAGTTCGGTGAGTTTCGTGCTATCGGCTATACGAACATTCTTGACGGAAAAGAGCATGTCGCGCTTGTGAAA
GGTGAGATCGTTCCGGACAAAGCGATACTCGTGCGCGTCCATTCCGAATGTTTAACCGGTGATGTGTTCGGTTCGTACCG
GTGTGATTGCGGTCCGCAGTTGCATGCGGCGTTGCGGCAAATTGAAGCGGAAGGAAACGGGGTGCTGCTTTACATGCGCC
AAGAAGGGCGCGGCATTGGTCTCATGAACAAACTGCGCGCCTACAAGCTGCAGGAGCAAGGGTATGATACCGTTGAGGCG
AACGAAAAACTCGGCTTTCCGGCCGATTTGCGCGACTATGGCATCGGGGCGCAAATTTTAAAAGATCTTGGCGTGACGAA
AATGCGCCTGTTAACGAATAATCCGCGCAAAATCGCGGGTTTAAAAGGGCATGGGCTCGAAGTCGTCGAACGGGTGCCGC
TTCAAATGCCACCGACGAAGGAAAACGAAAAATATTTGCGCACGAAATATGAAAAATTAGGACATATGCTTCATTTTTAA

Upstream 100 bases:

>100_bases
ACGTCGCTGCCTTTCTCGCAGGAAAGGAAACGACGCCTTCGGGATTGACAATGGAATTTTTGGAGCAACACGGCTATAAA
TAAGCGAGAAAAGGGGGCAA

Downstream 100 bases:

>100_bases
TGAAAGGGGAAAGAAACATGAACGTCATCGAAGGAAATTTAGTCGGCACCGGGTTGAAAATTGGTATCGTCGTCTCGCGC
TTTAACGAATTTATTACGAG

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MAMFDTIEAALAALKNGEVIIVCDDEDRENEGDFVALAEKATPDVINFMITHGRGLVCVPITEELAARLELEPMVAHNTD
AHGTAFTVSVDYKTTTTGISAYERAATIQALLDPNVKASDFKRPGHIFPLIAKKGGVLRRAGHTEAAVDLARLCGAKPAG
VICEIIKEDGTMARVPDLRHIADQFGLKMITIKDLIAYRSQREKLVKREVEISLPTEFGEFRAIGYTNILDGKEHVALVK
GEIVPDKAILVRVHSECLTGDVFGSYRCDCGPQLHAALRQIEAEGNGVLLYMRQEGRGIGLMNKLRAYKLQEQGYDTVEA
NEKLGFPADLRDYGIGAQILKDLGVTKMRLLTNNPRKIAGLKGHGLEVVERVPLQMPPTKENEKYLRTKYEKLGHMLHF

Sequences:

>Translated_399_residues
MAMFDTIEAALAALKNGEVIIVCDDEDRENEGDFVALAEKATPDVINFMITHGRGLVCVPITEELAARLELEPMVAHNTD
AHGTAFTVSVDYKTTTTGISAYERAATIQALLDPNVKASDFKRPGHIFPLIAKKGGVLRRAGHTEAAVDLARLCGAKPAG
VICEIIKEDGTMARVPDLRHIADQFGLKMITIKDLIAYRSQREKLVKREVEISLPTEFGEFRAIGYTNILDGKEHVALVK
GEIVPDKAILVRVHSECLTGDVFGSYRCDCGPQLHAALRQIEAEGNGVLLYMRQEGRGIGLMNKLRAYKLQEQGYDTVEA
NEKLGFPADLRDYGIGAQILKDLGVTKMRLLTNNPRKIAGLKGHGLEVVERVPLQMPPTKENEKYLRTKYEKLGHMLHF
>Mature_398_residues
AMFDTIEAALAALKNGEVIIVCDDEDRENEGDFVALAEKATPDVINFMITHGRGLVCVPITEELAARLELEPMVAHNTDA
HGTAFTVSVDYKTTTTGISAYERAATIQALLDPNVKASDFKRPGHIFPLIAKKGGVLRRAGHTEAAVDLARLCGAKPAGV
ICEIIKEDGTMARVPDLRHIADQFGLKMITIKDLIAYRSQREKLVKREVEISLPTEFGEFRAIGYTNILDGKEHVALVKG
EIVPDKAILVRVHSECLTGDVFGSYRCDCGPQLHAALRQIEAEGNGVLLYMRQEGRGIGLMNKLRAYKLQEQGYDTVEAN
EKLGFPADLRDYGIGAQILKDLGVTKMRLLTNNPRKIAGLKGHGLEVVERVPLQMPPTKENEKYLRTKYEKLGHMLHF

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=56.9948186528497, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1789420, Length=202, Percent_Identity=49.009900990099, Blast_Score=202, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=41.747572815534, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6319438, Length=187, Percent_Identity=46.524064171123, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44043; Mature: 43911

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMFDTIEAALAALKNGEVIIVCDDEDRENEGDFVALAEKATPDVINFMITHGRGLVCVP
CCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHEECCCCEEEEE
ITEELAARLELEPMVAHNTDAHGTAFTVSVDYKTTTTGISAYERAATIQALLDPNVKASD
CHHHHHHHCCCCEEEECCCCCCCEEEEEEEECEECCCCHHHHHHHHHHHHHHCCCCCHHC
FKRPGHIFPLIAKKGGVLRRAGHTEAAVDLARLCGAKPAGVICEIIKEDGTMARVPDLRH
CCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEECCCHHHH
IADQFGLKMITIKDLIAYRSQREKLVKREVEISLPTEFGEFRAIGYTNILDGKEHVALVK
HHHHHCEEEEHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEECCCCCCCCCCEEEEEE
GEIVPDKAILVRVHSECLTGDVFGSYRCDCGPQLHAALRQIEAEGNGVLLYMRQEGRGIG
CCCCCCCEEEEEEHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCC
LMNKLRAYKLQEQGYDTVEANEKLGFPADLRDYGIGAQILKDLGVTKMRLLTNNPRKIAG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHCCCEEEEEECCCCCEEEC
LKGHGLEVVERVPLQMPPTKENEKYLRTKYEKLGHMLHF
CCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AMFDTIEAALAALKNGEVIIVCDDEDRENEGDFVALAEKATPDVINFMITHGRGLVCVP
CCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHEECCCCEEEEE
ITEELAARLELEPMVAHNTDAHGTAFTVSVDYKTTTTGISAYERAATIQALLDPNVKASD
CHHHHHHHCCCCEEEECCCCCCCEEEEEEEECEECCCCHHHHHHHHHHHHHHCCCCCHHC
FKRPGHIFPLIAKKGGVLRRAGHTEAAVDLARLCGAKPAGVICEIIKEDGTMARVPDLRH
CCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEECCCHHHH
IADQFGLKMITIKDLIAYRSQREKLVKREVEISLPTEFGEFRAIGYTNILDGKEHVALVK
HHHHHCEEEEHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEECCCCCCCCCCEEEEEE
GEIVPDKAILVRVHSECLTGDVFGSYRCDCGPQLHAALRQIEAEGNGVLLYMRQEGRGIG
CCCCCCCEEEEEEHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCC
LMNKLRAYKLQEQGYDTVEANEKLGFPADLRDYGIGAQILKDLGVTKMRLLTNNPRKIAG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHCCCEEEEEECCCCCEEEC
LKGHGLEVVERVPLQMPPTKENEKYLRTKYEKLGHMLHF
CCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA