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The map label for this gene is folE [H]

Identifier: 138895792

GI number: 138895792

Start: 2277787

End: 2278377

Strand: Reverse

Name: folE [H]

Synonym: GTNG_2148

Alternate gene names: 138895792

Gene position: 2278377-2277787 (Counterclockwise)

Preceding gene: 138895793

Following gene: 138895791

Centisome position: 64.17

GC content: 52.79

Gene sequence:

>591_bases
ATGACGCAGGAGGATGTTGTTTGTATGTCAGAGATCAATTATGAACAAATTGAATATGCGGTCCGCCTCATCTTGGAAGC
GATCGGCGAAGATCCGAACCGTGAAGGGCTTATTGATACACCAAAACGGGTGGCAAAAATGTATGCTGAGGTGTTCGCCG
GGCTTCGGGAAGACCCGAAGCAGCATTTTCAAACCGTATTCAGCGAGGAACATGAGGAGCTCGTGCTTGTTAAAGACATT
CCGTTTTATTCGATGTGCGAACACCATTTAGTGCCGTTTTTCGGCGTCGCTCATGTCGCTTATATTCCGCGCGAAGGAAA
AGTGACCGGGTTGAGCAAACTTGCCCGGGCTGTCGAAGCGGTGGCGCGCCGTCCGCAGTTGCAAGAGCGCATCACGGCGA
CAGTGGCCGATTCAATCGTCGAAGCGCTCGAGCCGCACGGAGTCATGGTTGTCGTTGAGGCGGAGCATATGTGTATGACG
ATGCGCGGCGTAAAGAAACCGGGGGCGAAAACAGTCACAACGGCGGTGCGTGGTGTGTTTGAAACAGACGCCAACGCCCG
GTCCGAAGTGCTTTCGTTAATTAAAGCGTAA

Upstream 100 bases:

>100_bases
GCCGAAGCAGGAGCTTAGGAGGGAAGGGCAGGTGATCAACTGCCCTTCTTTTTTGTTTTTTTTCGCTCCCTATGCTAGAA
TCGGATTACATGCAGCTTTT

Downstream 100 bases:

>100_bases
GGAGGGCAAATGATGTATACGAACAGCGATTTTGTCGTCATTAAAGCGCTCGAAGACGGAGTGAACGTCATTGGGCTGAC
GCGCGGCGCGGATACGAGGT

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MTQEDVVCMSEINYEQIEYAVRLILEAIGEDPNREGLIDTPKRVAKMYAEVFAGLREDPKQHFQTVFSEEHEELVLVKDI
PFYSMCEHHLVPFFGVAHVAYIPREGKVTGLSKLARAVEAVARRPQLQERITATVADSIVEALEPHGVMVVVEAEHMCMT
MRGVKKPGAKTVTTAVRGVFETDANARSEVLSLIKA

Sequences:

>Translated_196_residues
MTQEDVVCMSEINYEQIEYAVRLILEAIGEDPNREGLIDTPKRVAKMYAEVFAGLREDPKQHFQTVFSEEHEELVLVKDI
PFYSMCEHHLVPFFGVAHVAYIPREGKVTGLSKLARAVEAVARRPQLQERITATVADSIVEALEPHGVMVVVEAEHMCMT
MRGVKKPGAKTVTTAVRGVFETDANARSEVLSLIKA
>Mature_195_residues
TQEDVVCMSEINYEQIEYAVRLILEAIGEDPNREGLIDTPKRVAKMYAEVFAGLREDPKQHFQTVFSEEHEELVLVKDIP
FYSMCEHHLVPFFGVAHVAYIPREGKVTGLSKLARAVEAVARRPQLQERITATVADSIVEALEPHGVMVVVEAEHMCMTM
RGVKKPGAKTVTTAVRGVFETDANARSEVLSLIKA

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=194, Percent_Identity=48.4536082474227, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI4503949, Length=194, Percent_Identity=48.4536082474227, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI66932970, Length=162, Percent_Identity=45.0617283950617, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI66932972, Length=152, Percent_Identity=47.3684210526316, Blast_Score=134, Evalue=4e-32,
Organism=Escherichia coli, GI1788476, Length=176, Percent_Identity=37.5, Blast_Score=109, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17560486, Length=177, Percent_Identity=49.7175141242938, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6321706, Length=182, Percent_Identity=48.3516483516484, Blast_Score=171, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24656782, Length=178, Percent_Identity=48.314606741573, Blast_Score=163, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24656796, Length=178, Percent_Identity=48.314606741573, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24656791, Length=178, Percent_Identity=48.314606741573, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 21895; Mature: 21763

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQEDVVCMSEINYEQIEYAVRLILEAIGEDPNREGLIDTPKRVAKMYAEVFAGLREDPK
CCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHH
QHFQTVFSEEHEELVLVKDIPFYSMCEHHLVPFFGVAHVAYIPREGKVTGLSKLARAVEA
HHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
VARRPQLQERITATVADSIVEALEPHGVMVVVEAEHMCMTMRGVKKPGAKTVTTAVRGVF
HHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHH
ETDANARSEVLSLIKA
HCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TQEDVVCMSEINYEQIEYAVRLILEAIGEDPNREGLIDTPKRVAKMYAEVFAGLREDPK
CCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHH
QHFQTVFSEEHEELVLVKDIPFYSMCEHHLVPFFGVAHVAYIPREGKVTGLSKLARAVEA
HHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
VARRPQLQERITATVADSIVEALEPHGVMVVVEAEHMCMTMRGVKKPGAKTVTTAVRGVF
HHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHH
ETDANARSEVLSLIKA
HCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA