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The map label for this gene is yrkH [H]

Identifier: 138895625

GI number: 138895625

Start: 2099113

End: 2100249

Strand: Reverse

Name: yrkH [H]

Synonym: GTNG_1978

Alternate gene names: 138895625

Gene position: 2100249-2099113 (Counterclockwise)

Preceding gene: 138895626

Following gene: 138895624

Centisome position: 59.16

GC content: 51.1

Gene sequence:

>1137_bases
ATGATGAAAGAAATGACTGTGCAACAAATGACGGAAAAGGTGTTAAACAAAGAATCGTTGTTTATCTTGGATGTTCGCAA
TGAAAGTGATTTTCGCGATTGGAAAATCGAAGGGGAAAACTTCGCGTATTTGAACGTACCGTATTTTGAGTTGGTTCACG
GAGTTGACTCCATTGTCGACCGTCTTCCGAAAGACCAAGACATCGTCGTCGTGTGCGCGAAGGGTGGATCGGCGGCATTT
GTCGCTGAGCAGCTGGCAGAAGCCGGGTTTGACAACGTGTATACGCTCGCCGGCGGGATGCAGGCGTGGAGCGAGCATCT
CCATCAAGCCAAGGTATACGAAGATGATCAATTAAAAATTTACCAATTCATTCGTGTCGGCAAAGGATGTCTGTCGTACA
TGGTCCTCTCCGGCGACGAAGCACTGGTTGTCGATCCACTCCGGTTCATTGATGTGTACGAACAAGTTGCCCAACAAGAA
GGAGTAACGATCACGCATATCGTGGACTCGCACTTGCATGCCGATCACTTATCCGGAGGCAAAGCGCTGGCCGAACGAAC
GGGAGCAGCATATTACTTGATGAAAAGCGAAGGGGCGGTGTTCGATTTTGAGCCGCTTGAGCAACATGAAACGATCGACT
TTGAAAACGTCCATCTTGAAGTGCTGGCGGTGAAAACGCCGGGTCATACGCCAGGCAGCGTCTCGTTCTTCGTCAATGGC
AAATGGTTGTTCTCAGGTGACACCATCTTTGTCGGTGGTCTCGGACGCCCGGACCTTGGCGGCAAAGTGGCCGAATGGGC
GGAAGATTTGTATCACACCGTATATGAAAAAGTGGCGGCCATGGCTGATGATGTCATCGTCTTGCCGGCGCACTACGCGA
ACTTAGATGAAGAAATCAACGCGGAGGGGTATGTCGGTGATACGCTGGGCCGCATCCGTGCCCGCAATGAGATGATGCAA
AACAAAGCGAAAGACGAATTCATCGATCTCGTCATCCAAGGCGCCAAGACGGAAACCCCGCCGAACTTTGAAGACATTGT
TGCCATCAACCGCGGTCTCAAAACGGTGGATATCGAAACACAACGGGAGCTTGAGATCGGTCCGAACCGCTGCGCGCTGC
ATCATACTCATGCCTAA

Upstream 100 bases:

>100_bases
ATTCCAGGCATGTCGCAGTGGAATGGGCCGCTTGATTCCGCTCAATCATAATTGAGCGGCCTTTTTTAACAAACTAATAT
ACACTAGGGGGTATATAAAC

Downstream 100 bases:

>100_bases
TGGGCGGTTGCTTAGGTAGAGGGGGATGTGCTGAACAGATCCCCCTCGTTTTTCAATGAAGATTAGGAGAGGGGGCACGA
AGGATGGACTTATCGCTCCA

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MMKEMTVQQMTEKVLNKESLFILDVRNESDFRDWKIEGENFAYLNVPYFELVHGVDSIVDRLPKDQDIVVVCAKGGSAAF
VAEQLAEAGFDNVYTLAGGMQAWSEHLHQAKVYEDDQLKIYQFIRVGKGCLSYMVLSGDEALVVDPLRFIDVYEQVAQQE
GVTITHIVDSHLHADHLSGGKALAERTGAAYYLMKSEGAVFDFEPLEQHETIDFENVHLEVLAVKTPGHTPGSVSFFVNG
KWLFSGDTIFVGGLGRPDLGGKVAEWAEDLYHTVYEKVAAMADDVIVLPAHYANLDEEINAEGYVGDTLGRIRARNEMMQ
NKAKDEFIDLVIQGAKTETPPNFEDIVAINRGLKTVDIETQRELEIGPNRCALHHTHA

Sequences:

>Translated_378_residues
MMKEMTVQQMTEKVLNKESLFILDVRNESDFRDWKIEGENFAYLNVPYFELVHGVDSIVDRLPKDQDIVVVCAKGGSAAF
VAEQLAEAGFDNVYTLAGGMQAWSEHLHQAKVYEDDQLKIYQFIRVGKGCLSYMVLSGDEALVVDPLRFIDVYEQVAQQE
GVTITHIVDSHLHADHLSGGKALAERTGAAYYLMKSEGAVFDFEPLEQHETIDFENVHLEVLAVKTPGHTPGSVSFFVNG
KWLFSGDTIFVGGLGRPDLGGKVAEWAEDLYHTVYEKVAAMADDVIVLPAHYANLDEEINAEGYVGDTLGRIRARNEMMQ
NKAKDEFIDLVIQGAKTETPPNFEDIVAINRGLKTVDIETQRELEIGPNRCALHHTHA
>Mature_378_residues
MMKEMTVQQMTEKVLNKESLFILDVRNESDFRDWKIEGENFAYLNVPYFELVHGVDSIVDRLPKDQDIVVVCAKGGSAAF
VAEQLAEAGFDNVYTLAGGMQAWSEHLHQAKVYEDDQLKIYQFIRVGKGCLSYMVLSGDEALVVDPLRFIDVYEQVAQQE
GVTITHIVDSHLHADHLSGGKALAERTGAAYYLMKSEGAVFDFEPLEQHETIDFENVHLEVLAVKTPGHTPGSVSFFVNG
KWLFSGDTIFVGGLGRPDLGGKVAEWAEDLYHTVYEKVAAMADDVIVLPAHYANLDEEINAEGYVGDTLGRIRARNEMMQ
NKAKDEFIDLVIQGAKTETPPNFEDIVAINRGLKTVDIETQRELEIGPNRCALHHTHA

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=167, Percent_Identity=32.9341317365269, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1787158, Length=203, Percent_Identity=30.0492610837438, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221330176, Length=164, Percent_Identity=29.2682926829268, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR001763 [H]

Pfam domain/function: PF00753 Lactamase_B; PF00581 Rhodanese [H]

EC number: NA

Molecular weight: Translated: 42191; Mature: 42191

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKEMTVQQMTEKVLNKESLFILDVRNESDFRDWKIEGENFAYLNVPYFELVHGVDSIVD
CCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCCCEEEEECHHHHHHHHHHHHHH
RLPKDQDIVVVCAKGGSAAFVAEQLAEAGFDNVYTLAGGMQAWSEHLHQAKVYEDDQLKI
HCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEHHCCHHHHHHHHHHHHCCCCCCHHH
YQFIRVGKGCLSYMVLSGDEALVVDPLRFIDVYEQVAQQEGVTITHIVDSHLHADHLSGG
HHHHHHHHHHHEEEEECCCCEEEECHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHCCCC
KALAERTGAAYYLMKSEGAVFDFEPLEQHETIDFENVHLEVLAVKTPGHTPGSVSFFVNG
HHHHHHCCCEEEEEECCCCEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCCEEEEEEEC
KWLFSGDTIFVGGLGRPDLGGKVAEWAEDLYHTVYEKVAAMADDVIVLPAHYANLDEEIN
EEEEECCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHCCCCHHCC
AEGYVGDTLGRIRARNEMMQNKAKDEFIDLVIQGAKTETPPNFEDIVAINRGLKTVDIET
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHCCCEEEECCC
QRELEIGPNRCALHHTHA
CCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MMKEMTVQQMTEKVLNKESLFILDVRNESDFRDWKIEGENFAYLNVPYFELVHGVDSIVD
CCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCCCEEEEECHHHHHHHHHHHHHH
RLPKDQDIVVVCAKGGSAAFVAEQLAEAGFDNVYTLAGGMQAWSEHLHQAKVYEDDQLKI
HCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEHHCCHHHHHHHHHHHHCCCCCCHHH
YQFIRVGKGCLSYMVLSGDEALVVDPLRFIDVYEQVAQQEGVTITHIVDSHLHADHLSGG
HHHHHHHHHHHEEEEECCCCEEEECHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHCCCC
KALAERTGAAYYLMKSEGAVFDFEPLEQHETIDFENVHLEVLAVKTPGHTPGSVSFFVNG
HHHHHHCCCEEEEEECCCCEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCCEEEEEEEC
KWLFSGDTIFVGGLGRPDLGGKVAEWAEDLYHTVYEKVAAMADDVIVLPAHYANLDEEIN
EEEEECCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHCCCCHHCC
AEGYVGDTLGRIRARNEMMQNKAKDEFIDLVIQGAKTETPPNFEDIVAINRGLKTVDIET
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHCCCEEEECCC
QRELEIGPNRCALHHTHA
CCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]