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The map label for this gene is purR [H]

Identifier: 138895586

GI number: 138895586

Start: 2062127

End: 2063179

Strand: Reverse

Name: purR [H]

Synonym: GTNG_1939

Alternate gene names: 138895586

Gene position: 2063179-2062127 (Counterclockwise)

Preceding gene: 138895587

Following gene: 138895585

Centisome position: 58.11

GC content: 54.61

Gene sequence:

>1053_bases
ATGATAAAGCAGGTGATCGGAGTCGTGTCAAATAAAAAGCGCTCCCGCGTGACGCTTGAACAAGTGGCTAAACACGCCGG
CGTGTCGCGGGCAACTGCCTCTCTTGTTGTCCGGGGGAGTCCGAATATTTCGAAAGAAACGCGGGAAAAGGTGCTGCAGT
CCATGAAAGAGTTAGGCTATGTCTACGACCGCGTAGCTGCCAACTTGCGGTCGCAGCGCTCTTCGACGGTCGGTCTGATC
ATTACTGAGCTTGATAACCCATTTTTTTCTGAGCTGCTCGTCGGTGTTCATGAAGCGCTTGACGAGGAAGGATATACTGT
CATTTTAGGAACGACGTTTGATCGGCCAGAAAAACAAGACGCGCTTTTATCGACGATGCTCGAACACCGGGTCGGCGGCG
TCATTATGAGCCCGGTTCCGGGTTGTTCGACAGAGATGCTCGAACGGTTGCGGCAATGGGATATTCCGGTGGTGCTGTTT
GCCCGCGAGGAAATTCCTGCAGGACAATTTGATTATATCGGGATCGATAATGTAGCTGGCGGGCGGCTGGCAACCGAGCA
TTTGATCGATCAAGGGCACCGCCGCATTGCGTTCATTGGCGGTTCCCCGCTTTCTTCTGTATGGAAAGCGCGCAAGGCAG
GATATAGCGAAGCATTGCGCGCAGCAGGCATCGACGTCGATGAAACGCTGTTATTTCCATCAGCGACGGCTCGGCAAGGC
GGAAGGATGGCAGTGAAGCAGGCTTTGCAGCACCCGAACCCGCCAACGGCGTTGTTCTGTTACAATGATGTAGTCGCTTT
CGGCGCGATGCTTGGGTTAAAGGAAGAAGGGCTTGTTCCAGGACGCGATATCGCCGTTGTAGGCTTTGACAACATTCAAG
AGTCGGCGCTGTTTCAGCCCCCGTTAACGACGGTGGCTGCGTTTCCGGAGAACATCGGCGCCTGCGCTGCGCGGCGGCTG
CACGAACGCATGGAAGGGGATGACAGCGAACCGAAACGCATGATTTTAAATCCGGAACTGATTGTTCGGCAATCGTCGGG
AAGGACCGGTTGA

Upstream 100 bases:

>100_bases
GCTTAGTCGTGTGGGAGAAAACGTTTCTTTTTGGCGGCAGCCCGCGCCTTGCATTGACACTGTTTACAGCCAGCATTTAT
ACTTTTGGTAGACTAAAGCA

Downstream 100 bases:

>100_bases
AAAGGGAGTGAAGGAACGTGGAGAAGCAAACCGCCATCCCGCTCCGCGAGCGAAACATCATTTTAATCGGCTTTATGGGA
GCGGGAAAAACGACGATCGG

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Pur regulon repressor; Purine nucleotide synthesis repressor [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MIKQVIGVVSNKKRSRVTLEQVAKHAGVSRATASLVVRGSPNISKETREKVLQSMKELGYVYDRVAANLRSQRSSTVGLI
ITELDNPFFSELLVGVHEALDEEGYTVILGTTFDRPEKQDALLSTMLEHRVGGVIMSPVPGCSTEMLERLRQWDIPVVLF
AREEIPAGQFDYIGIDNVAGGRLATEHLIDQGHRRIAFIGGSPLSSVWKARKAGYSEALRAAGIDVDETLLFPSATARQG
GRMAVKQALQHPNPPTALFCYNDVVAFGAMLGLKEEGLVPGRDIAVVGFDNIQESALFQPPLTTVAAFPENIGACAARRL
HERMEGDDSEPKRMILNPELIVRQSSGRTG

Sequences:

>Translated_350_residues
MIKQVIGVVSNKKRSRVTLEQVAKHAGVSRATASLVVRGSPNISKETREKVLQSMKELGYVYDRVAANLRSQRSSTVGLI
ITELDNPFFSELLVGVHEALDEEGYTVILGTTFDRPEKQDALLSTMLEHRVGGVIMSPVPGCSTEMLERLRQWDIPVVLF
AREEIPAGQFDYIGIDNVAGGRLATEHLIDQGHRRIAFIGGSPLSSVWKARKAGYSEALRAAGIDVDETLLFPSATARQG
GRMAVKQALQHPNPPTALFCYNDVVAFGAMLGLKEEGLVPGRDIAVVGFDNIQESALFQPPLTTVAAFPENIGACAARRL
HERMEGDDSEPKRMILNPELIVRQSSGRTG
>Mature_350_residues
MIKQVIGVVSNKKRSRVTLEQVAKHAGVSRATASLVVRGSPNISKETREKVLQSMKELGYVYDRVAANLRSQRSSTVGLI
ITELDNPFFSELLVGVHEALDEEGYTVILGTTFDRPEKQDALLSTMLEHRVGGVIMSPVPGCSTEMLERLRQWDIPVVLF
AREEIPAGQFDYIGIDNVAGGRLATEHLIDQGHRRIAFIGGSPLSSVWKARKAGYSEALRAAGIDVDETLLFPSATARQG
GRMAVKQALQHPNPPTALFCYNDVVAFGAMLGLKEEGLVPGRDIAVVGFDNIQESALFQPPLTTVAAFPENIGACAARRL
HERMEGDDSEPKRMILNPELIVRQSSGRTG

Specific function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787948, Length=331, Percent_Identity=34.7432024169184, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI1790369, Length=340, Percent_Identity=30.8823529411765, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1790194, Length=331, Percent_Identity=32.6283987915408, Blast_Score=167, Evalue=8e-43,
Organism=Escherichia coli, GI1787906, Length=335, Percent_Identity=29.8507462686567, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789202, Length=332, Percent_Identity=30.421686746988, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1788474, Length=289, Percent_Identity=29.4117647058824, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI48994940, Length=324, Percent_Identity=28.3950617283951, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1786540, Length=321, Percent_Identity=32.7102803738318, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1789068, Length=331, Percent_Identity=29.9093655589124, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787580, Length=291, Percent_Identity=29.553264604811, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790715, Length=319, Percent_Identity=25.0783699059561, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790689, Length=325, Percent_Identity=28.3076923076923, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786268, Length=294, Percent_Identity=25.5102040816327, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790192, Length=302, Percent_Identity=25.1655629139073, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789456, Length=341, Percent_Identity=23.1671554252199, Blast_Score=78, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38186; Mature: 38186

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQVIGVVSNKKRSRVTLEQVAKHAGVSRATASLVVRGSPNISKETREKVLQSMKELGY
CHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHHH
VYDRVAANLRSQRSSTVGLIITELDNPFFSELLVGVHEALDEEGYTVILGTTFDRPEKQD
HHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHH
ALLSTMLEHRVGGVIMSPVPGCSTEMLERLRQWDIPVVLFAREEIPAGQFDYIGIDNVAG
HHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCEECCCCCCC
GRLATEHLIDQGHRRIAFIGGSPLSSVWKARKAGYSEALRAAGIDVDETLLFPSATARQG
CHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCHHHHHHHCCCCCCHHEECCCHHHCCC
GRMAVKQALQHPNPPTALFCYNDVVAFGAMLGLKEEGLVPGRDIAVVGFDNIQESALFQP
CHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHCCCC
PLTTVAAFPENIGACAARRLHERMEGDDSEPKRMILNPELIVRQSSGRTG
CHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCC
>Mature Secondary Structure
MIKQVIGVVSNKKRSRVTLEQVAKHAGVSRATASLVVRGSPNISKETREKVLQSMKELGY
CHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHHH
VYDRVAANLRSQRSSTVGLIITELDNPFFSELLVGVHEALDEEGYTVILGTTFDRPEKQD
HHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHH
ALLSTMLEHRVGGVIMSPVPGCSTEMLERLRQWDIPVVLFAREEIPAGQFDYIGIDNVAG
HHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCEECCCCCCC
GRLATEHLIDQGHRRIAFIGGSPLSSVWKARKAGYSEALRAAGIDVDETLLFPSATARQG
CHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCHHHHHHHCCCCCCHHEECCCHHHCCC
GRMAVKQALQHPNPPTALFCYNDVVAFGAMLGLKEEGLVPGRDIAVVGFDNIQESALFQP
CHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHCCCC
PLTTVAAFPENIGACAARRLHERMEGDDSEPKRMILNPELIVRQSSGRTG
CHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA