Click here to switch to the map view.

The map label for this gene is mco [H]

Identifier: 138895231

GI number: 138895231

Start: 1656775

End: 1658238

Strand: Direct

Name: mco [H]

Synonym: GTNG_1571

Alternate gene names: 138895231

Gene position: 1656775-1658238 (Clockwise)

Preceding gene: 138895230

Following gene: 138895232

Centisome position: 46.67

GC content: 46.45

Gene sequence:

>1464_bases
ATGATGAAACGAAGACGCATATTTGCTACTCTTTTATTTGGATTGATCGCTTTATGTTTGACAGGATGTGATGGGGATAC
AACGACGAATGTCGGGAAGCTGACGTTTCAGAATGAATTGAACATCCCGCCACTTCTTGAACCGACAGTGGGCTCTGATG
GCACGAAACAATTCACGTTAACGATGCAAACTGGAACCACCGAATTTTTTGAAGGTAAGAAAACACCAACTTGGGGGATC
AACGGCTCTTACTTAGGGCCGACGATACGTGTGTCACGCGGTGACAAAGTGGCGTTTGATGTTGTCAATCACCTTCCAGA
AACTTCAACCTTGCATTGGCACGGGATGCGTTTGCCGGCTGCGATGGATGGTGGACCGCACCAAATGATTGAAGCCGGAT
CGACTTGGAATCCTAGCTGGACGATTGAGCAACCCGCAGCAACTACGTGGTATCATCCGCATTTGCACGGCAAAACGGCA
CTTCATGTGTATCGAGGACTTGCAGGCTTGTTTTTAATCGAGGATCAAGATTCAAAAAAATTACCTTCAAATTATGGCGT
TGACGACATTCCGATCATTATTCAGGATAAAATGTTCAACGGGGACGGTTCCTTCAATGAAAGCATGGATCTTACCCCGT
TTGGAATGTTAGGGAATCAGATTTTGGTCAATGGAACTTATGATCCGTATTTACGCATCACTTCAAGCCAAGTCCGATTC
CGGTTGCTCAACGGCTCGAATGCGAGAGCTTATCATGTCGGTTTTTCCGATAACCGTTCATTTTATCTAGTCGGAAATGA
TGCGGGATTGCTGCCGGAACCGATCAAAATGAAGCGCATTTTGTTAAGTCCGGGTGAACGTGCAGAGATTGTGGTCGAAT
TTAAGGAAGGAGAAGAAACGATCTTGCACAGTTTTGCCGGCAAAGACGGGATTGAAAATGGAGAGTTTGATCTCGTCAAA
TTGATCGCCGATCAGCGTCTGACCGCAGCAACGCCATTGCCTCAAACACTCACCAGCGAACCGCCGATCGAAGTTCCAGC
GGATGCGAAGGTCCGAACGTTTGTACTGACTACCGAATCGGCGATCAACGGAAAGAAAATGGATATGAACCGGATTGATG
AGGTTGTTCCTGCCAGATCGCGCGAAATTTGGGAAATAACAAATAAAGGCTGGGATCATAACTTTCATATTCACGATGCG
ACATTCACTATCCTTGATAAGAATGGTGAATTGCCGCCGAAATACGAACGGGGAAGGAAGGATACCGTTTTCATACCGAG
CGGGACGAAAGTCAGATTGGCTGTTGATTTTGGAAGCTATCCAGACCCGACAACGCCTTACATGTATCATTGCCATCTGT
TATATCATGAAGACAGCGGGATGATGGGGCAATTCGTGATCGTCGAGCCAGGAACAGAATCCCAAGTGTCACAACAACTT
CATCGACGCCCTCATCATCATTAA

Upstream 100 bases:

>100_bases
ACCAATGCTGTTTGGGGAGTCATAACTGGATGGATTGCTGCTGCCGTTCAACGAACAATGAGGAGGAACTAGCTATTTTT
CGAGAAAAAGAGGGAGCTGA

Downstream 100 bases:

>100_bases
GGGGATCTCATGGGATCGTGAGTATCGTAGTGTCATCTTTCGATCTAGGTCAGCTTCTTTCTCGGGGCGAACCTGAACGG
TTTGCCCCCTTCCGCATTTG

Product: putative multicopper oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MMKRRRIFATLLFGLIALCLTGCDGDTTTNVGKLTFQNELNIPPLLEPTVGSDGTKQFTLTMQTGTTEFFEGKKTPTWGI
NGSYLGPTIRVSRGDKVAFDVVNHLPETSTLHWHGMRLPAAMDGGPHQMIEAGSTWNPSWTIEQPAATTWYHPHLHGKTA
LHVYRGLAGLFLIEDQDSKKLPSNYGVDDIPIIIQDKMFNGDGSFNESMDLTPFGMLGNQILVNGTYDPYLRITSSQVRF
RLLNGSNARAYHVGFSDNRSFYLVGNDAGLLPEPIKMKRILLSPGERAEIVVEFKEGEETILHSFAGKDGIENGEFDLVK
LIADQRLTAATPLPQTLTSEPPIEVPADAKVRTFVLTTESAINGKKMDMNRIDEVVPARSREIWEITNKGWDHNFHIHDA
TFTILDKNGELPPKYERGRKDTVFIPSGTKVRLAVDFGSYPDPTTPYMYHCHLLYHEDSGMMGQFVIVEPGTESQVSQQL
HRRPHHH

Sequences:

>Translated_487_residues
MMKRRRIFATLLFGLIALCLTGCDGDTTTNVGKLTFQNELNIPPLLEPTVGSDGTKQFTLTMQTGTTEFFEGKKTPTWGI
NGSYLGPTIRVSRGDKVAFDVVNHLPETSTLHWHGMRLPAAMDGGPHQMIEAGSTWNPSWTIEQPAATTWYHPHLHGKTA
LHVYRGLAGLFLIEDQDSKKLPSNYGVDDIPIIIQDKMFNGDGSFNESMDLTPFGMLGNQILVNGTYDPYLRITSSQVRF
RLLNGSNARAYHVGFSDNRSFYLVGNDAGLLPEPIKMKRILLSPGERAEIVVEFKEGEETILHSFAGKDGIENGEFDLVK
LIADQRLTAATPLPQTLTSEPPIEVPADAKVRTFVLTTESAINGKKMDMNRIDEVVPARSREIWEITNKGWDHNFHIHDA
TFTILDKNGELPPKYERGRKDTVFIPSGTKVRLAVDFGSYPDPTTPYMYHCHLLYHEDSGMMGQFVIVEPGTESQVSQQL
HRRPHHH
>Mature_487_residues
MMKRRRIFATLLFGLIALCLTGCDGDTTTNVGKLTFQNELNIPPLLEPTVGSDGTKQFTLTMQTGTTEFFEGKKTPTWGI
NGSYLGPTIRVSRGDKVAFDVVNHLPETSTLHWHGMRLPAAMDGGPHQMIEAGSTWNPSWTIEQPAATTWYHPHLHGKTA
LHVYRGLAGLFLIEDQDSKKLPSNYGVDDIPIIIQDKMFNGDGSFNESMDLTPFGMLGNQILVNGTYDPYLRITSSQVRF
RLLNGSNARAYHVGFSDNRSFYLVGNDAGLLPEPIKMKRILLSPGERAEIVVEFKEGEETILHSFAGKDGIENGEFDLVK
LIADQRLTAATPLPQTLTSEPPIEVPADAKVRTFVLTTESAINGKKMDMNRIDEVVPARSREIWEITNKGWDHNFHIHDA
TFTILDKNGELPPKYERGRKDTVFIPSGTKVRLAVDFGSYPDPTTPYMYHCHLLYHEDSGMMGQFVIVEPGTESQVSQQL
HRRPHHH

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=489, Percent_Identity=34.7648261758691, Blast_Score=272, Evalue=4e-74,
Organism=Escherichia coli, GI1789394, Length=460, Percent_Identity=35, Blast_Score=265, Evalue=7e-72,
Organism=Drosophila melanogaster, GI18859919, Length=266, Percent_Identity=27.8195488721804, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24650186, Length=295, Percent_Identity=25.0847457627119, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 54474; Mature: 54474

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKRRRIFATLLFGLIALCLTGCDGDTTTNVGKLTFQNELNIPPLLEPTVGSDGTKQFTL
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEE
TMQTGTTEFFEGKKTPTWGINGSYLGPTIRVSRGDKVAFDVVNHLPETSTLHWHGMRLPA
EEECCCHHHHCCCCCCCCCCCCCCCCCEEEECCCCEEHHHHHHHCCCCCEEEEECEECCC
AMDGGPHQMIEAGSTWNPSWTIEQPAATTWYHPHLHGKTALHVYRGLAGLFLIEDQDSKK
CCCCCHHHHHCCCCCCCCCEEECCCCCCEEECCCCCCCHHHHHHHCCCEEEEEECCCCCC
LPSNYGVDDIPIIIQDKMFNGDGSFNESMDLTPFGMLGNQILVNGTYDPYLRITSSQVRF
CCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHCCCCEEEEECCCCCEEEEECCEEEE
RLLNGSNARAYHVGFSDNRSFYLVGNDAGLLPEPIKMKRILLSPGERAEIVVEFKEGEET
EEEECCCCEEEEEECCCCCEEEEEECCCCCCCCCHHHHEEEECCCCCEEEEEEEECCCHH
ILHSFAGKDGIENGEFDLVKLIADQRLTAATPLPQTLTSEPPIEVPADAKVRTFVLTTES
HHHHHCCCCCCCCCCHHEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCCCEEEEEEEECC
AINGKKMDMNRIDEVVPARSREIWEITNKGWDHNFHIHDATFTILDKNGELPPKYERGRK
CCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCHHHCCCC
DTVFIPSGTKVRLAVDFGSYPDPTTPYMYHCHLLYHEDSGMMGQFVIVEPGTESQVSQQL
CEEEECCCCEEEEEEECCCCCCCCCCEEEEEEEEEECCCCCEEEEEEECCCCHHHHHHHH
HRRPHHH
HHCCCCC
>Mature Secondary Structure
MMKRRRIFATLLFGLIALCLTGCDGDTTTNVGKLTFQNELNIPPLLEPTVGSDGTKQFTL
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEE
TMQTGTTEFFEGKKTPTWGINGSYLGPTIRVSRGDKVAFDVVNHLPETSTLHWHGMRLPA
EEECCCHHHHCCCCCCCCCCCCCCCCCEEEECCCCEEHHHHHHHCCCCCEEEEECEECCC
AMDGGPHQMIEAGSTWNPSWTIEQPAATTWYHPHLHGKTALHVYRGLAGLFLIEDQDSKK
CCCCCHHHHHCCCCCCCCCEEECCCCCCEEECCCCCCCHHHHHHHCCCEEEEEECCCCCC
LPSNYGVDDIPIIIQDKMFNGDGSFNESMDLTPFGMLGNQILVNGTYDPYLRITSSQVRF
CCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHCCCCEEEEECCCCCEEEEECCEEEE
RLLNGSNARAYHVGFSDNRSFYLVGNDAGLLPEPIKMKRILLSPGERAEIVVEFKEGEET
EEEECCCCEEEEEECCCCCEEEEEECCCCCCCCCHHHHEEEECCCCCEEEEEEEECCCHH
ILHSFAGKDGIENGEFDLVKLIADQRLTAATPLPQTLTSEPPIEVPADAKVRTFVLTTES
HHHHHCCCCCCCCCCHHEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCCCEEEEEEEECC
AINGKKMDMNRIDEVVPARSREIWEITNKGWDHNFHIHDATFTILDKNGELPPKYERGRK
CCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCHHHCCCC
DTVFIPSGTKVRLAVDFGSYPDPTTPYMYHCHLLYHEDSGMMGQFVIVEPGTESQVSQQL
CEEEECCCCEEEEEEECCCCCCCCCCEEEEEEEEEECCCCCEEEEEEECCCCHHHHHHHH
HRRPHHH
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA