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The map label for this gene is lytR [H]

Identifier: 138895219

GI number: 138895219

Start: 1642323

End: 1643060

Strand: Direct

Name: lytR [H]

Synonym: GTNG_1559

Alternate gene names: 138895219

Gene position: 1642323-1643060 (Clockwise)

Preceding gene: 138895218

Following gene: 138895220

Centisome position: 46.26

GC content: 41.46

Gene sequence:

>738_bases
TTGAATGATTTAAAAGTCGTGATCGCTGATGACGATGCAGTTTCAAGAGCGATTTTGCGGAATTTTGTTCGTTTGTTTCC
GAACTACGATGTTGTAGCGGAAGCGGCTACCGGAAAGGAGCTGTTGCAGCTTACATTCGAACTGCGGCCACATATTGTCC
TCGTTGATATCTACATGCCTGAACTCGATGGGATGGAGGCGGTTAAACTATGCAGACAGTTTTTGCCGTCTGTTCAAGTG
ATTTTTACTACTGGGGATGACCAATTTGCTGTCAAAGCGTTTGAAATATCCGCGACCGATTATATCGTGAAACCAGTCGA
GCGCATACGCCTCTTTCAAGCACTGGAAAAAGCGCGTACATTCATTGAAATCGTCAACCAACCGGTTACATCAATGAAGC
CGCTCAATAAAAGACTGGAGATCCGCATGAAACATTCCATTGTTTGGTTGCCAATGGAAGATATTTTGTTCGTGGAGAAA
GAAAATAGAAAAACAATCATTCATACGGCTGATGAGCAATATGAGACAACCCTCCCTCTAAACGAGGTGGAAAAGAGGCT
CACTCATTGTTTTTTTAAAACCCATCGTTCTTATATCGTCAATTTAAAAAAGGTAGTGAAAATTACACACGTTGGTGAAA
CGTACAAGGTCCACTTTTTCAGTTGTGAAAAAGTAGCCTATATTTCGAAATTGAAATTTCACGAGGTACAACGGAGAATG
GTGACGATTCATCTTTAG

Upstream 100 bases:

>100_bases
AACCCTCTCTTGTAAGTTTCTTGTTTGTACAAATATATTTGATCCAGATTGTCCAGAATAAGGGAAGGTGAGGGAAGAAG
AGGGAAGGAGAGAGGATTCG

Downstream 100 bases:

>100_bases
CTAAGCGTTTCAAGTGATGGGGAAGGAAGCGCTGAACGGTATTCGCATCCTTTTGAAACCTTTCTTATGGAGGATTTGGA
ACAAGTGGAGACAACATTGA

Product: two-component system regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MNDLKVVIADDDAVSRAILRNFVRLFPNYDVVAEAATGKELLQLTFELRPHIVLVDIYMPELDGMEAVKLCRQFLPSVQV
IFTTGDDQFAVKAFEISATDYIVKPVERIRLFQALEKARTFIEIVNQPVTSMKPLNKRLEIRMKHSIVWLPMEDILFVEK
ENRKTIIHTADEQYETTLPLNEVEKRLTHCFFKTHRSYIVNLKKVVKITHVGETYKVHFFSCEKVAYISKLKFHEVQRRM
VTIHL

Sequences:

>Translated_245_residues
MNDLKVVIADDDAVSRAILRNFVRLFPNYDVVAEAATGKELLQLTFELRPHIVLVDIYMPELDGMEAVKLCRQFLPSVQV
IFTTGDDQFAVKAFEISATDYIVKPVERIRLFQALEKARTFIEIVNQPVTSMKPLNKRLEIRMKHSIVWLPMEDILFVEK
ENRKTIIHTADEQYETTLPLNEVEKRLTHCFFKTHRSYIVNLKKVVKITHVGETYKVHFFSCEKVAYISKLKFHEVQRRM
VTIHL
>Mature_245_residues
MNDLKVVIADDDAVSRAILRNFVRLFPNYDVVAEAATGKELLQLTFELRPHIVLVDIYMPELDGMEAVKLCRQFLPSVQV
IFTTGDDQFAVKAFEISATDYIVKPVERIRLFQALEKARTFIEIVNQPVTSMKPLNKRLEIRMKHSIVWLPMEDILFVEK
ENRKTIIHTADEQYETTLPLNEVEKRLTHCFFKTHRSYIVNLKKVVKITHVGETYKVHFFSCEKVAYISKLKFHEVQRRM
VTIHL

Specific function: Member of the two-component regulatory system lytR/lytS that regulates genes involved in autolysis and cell wall metabolism. Regulates the activity of the cell wall-associated murein hydrolase through regulation of lrgA and lrgB [H]

COG id: COG3279

COG function: function code KT; Response regulator of the LytR/AlgR family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788724, Length=209, Percent_Identity=27.7511961722488, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI87082052, Length=212, Percent_Identity=31.1320754716981, Blast_Score=88, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR007492
- InterPro:   IPR001789 [H]

Pfam domain/function: PF04397 LytTR; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 28665; Mature: 28665

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50930 HTH_LYTTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLKVVIADDDAVSRAILRNFVRLFPNYDVVAEAATGKELLQLTFELRPHIVLVDIYMP
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEEECC
ELDGMEAVKLCRQFLPSVQVIFTTGDDQFAVKAFEISATDYIVKPVERIRLFQALEKART
CCCCHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
FIEIVNQPVTSMKPLNKRLEIRMKHSIVWLPMEDILFVEKENRKTIIHTADEQYETTLPL
HHHHHCCCHHHHCCCCHHHEEEEECEEEEEEHHHEEEEEECCCEEEEEECCCCCCCCCCH
NEVEKRLTHCFFKTHRSYIVNLKKVVKITHVGETYKVHFFSCEKVAYISKLKFHEVQRRM
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEEEECHHHHHHHHHHHHHHHHHE
VTIHL
EEEEC
>Mature Secondary Structure
MNDLKVVIADDDAVSRAILRNFVRLFPNYDVVAEAATGKELLQLTFELRPHIVLVDIYMP
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEEECC
ELDGMEAVKLCRQFLPSVQVIFTTGDDQFAVKAFEISATDYIVKPVERIRLFQALEKART
CCCCHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
FIEIVNQPVTSMKPLNKRLEIRMKHSIVWLPMEDILFVEKENRKTIIHTADEQYETTLPL
HHHHHCCCHHHHCCCCHHHEEEEECEEEEEEHHHEEEEEECCCEEEEEECCCCCCCCCCH
NEVEKRLTHCFFKTHRSYIVNLKKVVKITHVGETYKVHFFSCEKVAYISKLKFHEVQRRM
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEEEECHHHHHHHHHHHHHHHHHE
VTIHL
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA