Click here to switch to the map view.

The map label for this gene is thlA [H]

Identifier: 138895169

GI number: 138895169

Start: 1590864

End: 1592033

Strand: Direct

Name: thlA [H]

Synonym: GTNG_1507

Alternate gene names: 138895169

Gene position: 1590864-1592033 (Clockwise)

Preceding gene: 138895168

Following gene: 138895170

Centisome position: 44.81

GC content: 57.86

Gene sequence:

>1170_bases
ATGAAACGAGATGCCGTCATTGTGTCGGCTGTAAGAACGGCCATCGCCCGCCAAGGGGGCGCCTTGGCGACGCTGCCAGC
GCACGTTTACGGTGCGGAAGTCATCAAAGAAGCGATGCGGCGGGCGAACATCGGCCCGGAACTTGTCGCTGATGTCATCA
TGGGCAATGTCTTAAGCGGCGGTGGCAACATTGCCCGGCTGACGGCGTTGCAGACGGGGCTGTCGCTTGAGCTGACCGGG
CTGACCGTCGACCGCCAATGCGGTTCAGGCATTAATGCCGTCAATTTAGCGGCGCAAGCCATTTGGGCAGGCGACGGGGA
CGTCTATATCGCTGGAGGGGTGGAAAGCATGAGCCGCGCGCCGTATTTGATGGACCGCCCGGAAAAGCCGTACAGTTCGA
CGCCGCCAAGCTTCCGTAAATCGCAGTTGTCGCCGAAAGAGATTGGCGACCCGCCGATGGGCATCACGGCAGAAAATTTA
GTGAAAAAATACGGCATCAGTCGTGAAGAACAAGATGCCTTTGCCCTGCGCAGCCAGCAGCGCATGGCGCGTGCTATGCA
AGAAGGGCGGTTTGACGAACAAATTGTGCCGATTACCGTTCCGGTGAAAAAAGGGGAGCCGTTTGTCTTCGATACGGATG
AACACCCGCGTCCGAACACGACGATGGAAGCACTCGCGAAACTGCCGCCGGCGTTTTTGGAAGGCGGAACAGTGACGGCA
GGGAATAGTTCGGGACTCAATGACGCCGCTGCTGCACTCGTCGTCATGTCGCGGGAAAAAGCGGAACAGCTCGGCTTAAC
ACCGCTTGCCGTCGTCCGCGCCTATGCGGTCGCCGGAGTCGACCCGAACATTATGGGCATCGGTCCGGTACCAGCGACAA
GAAAGGTGCTTGAAAAGGTTGGACTGACGCTTGATGAGATGGATATCATCGAAATTAATGAAGCGTTTGCCGCTCAGGTG
ATCGCCTGTGACCGCGAGCTTGAGATGAATCCGGAAAAAGTAAATGTCAACGGCGGCGCCATCGCCCACGGCCATCCGCT
TGGTGCGACGGGTGCAATTTTGATTACGAAAGCCGTGTATGAACTAAAGCGTCGCGGTGGGACATACGCCCTCATTACGG
CGTGCATCGGCGGCGGCCAAGGGATCGCGACGATCATTGAACGAGCCTGA

Upstream 100 bases:

>100_bases
CCGCTCCCTTTCCGCATACAGCACAAACGGGGGCTCGTCTCTCTCTGTTTAAACGCCGAGTCGATTCGGAGCCGTCTAAA
AAAGTGAGGGGGGAATCGCG

Downstream 100 bases:

>100_bases
ACACATGGAGACAATGGATATGAAAGAAAAACTGATGGAAGCCAGCATAGAGCTATTTGACCGCAAAGGGTTCAAAGAAA
CGTCTGTACAGGAAATCGTC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKRDAVIVSAVRTAIARQGGALATLPAHVYGAEVIKEAMRRANIGPELVADVIMGNVLSGGGNIARLTALQTGLSLELTG
LTVDRQCGSGINAVNLAAQAIWAGDGDVYIAGGVESMSRAPYLMDRPEKPYSSTPPSFRKSQLSPKEIGDPPMGITAENL
VKKYGISREEQDAFALRSQQRMARAMQEGRFDEQIVPITVPVKKGEPFVFDTDEHPRPNTTMEALAKLPPAFLEGGTVTA
GNSSGLNDAAAALVVMSREKAEQLGLTPLAVVRAYAVAGVDPNIMGIGPVPATRKVLEKVGLTLDEMDIIEINEAFAAQV
IACDRELEMNPEKVNVNGGAIAHGHPLGATGAILITKAVYELKRRGGTYALITACIGGGQGIATIIERA

Sequences:

>Translated_389_residues
MKRDAVIVSAVRTAIARQGGALATLPAHVYGAEVIKEAMRRANIGPELVADVIMGNVLSGGGNIARLTALQTGLSLELTG
LTVDRQCGSGINAVNLAAQAIWAGDGDVYIAGGVESMSRAPYLMDRPEKPYSSTPPSFRKSQLSPKEIGDPPMGITAENL
VKKYGISREEQDAFALRSQQRMARAMQEGRFDEQIVPITVPVKKGEPFVFDTDEHPRPNTTMEALAKLPPAFLEGGTVTA
GNSSGLNDAAAALVVMSREKAEQLGLTPLAVVRAYAVAGVDPNIMGIGPVPATRKVLEKVGLTLDEMDIIEINEAFAAQV
IACDRELEMNPEKVNVNGGAIAHGHPLGATGAILITKAVYELKRRGGTYALITACIGGGQGIATIIERA
>Mature_389_residues
MKRDAVIVSAVRTAIARQGGALATLPAHVYGAEVIKEAMRRANIGPELVADVIMGNVLSGGGNIARLTALQTGLSLELTG
LTVDRQCGSGINAVNLAAQAIWAGDGDVYIAGGVESMSRAPYLMDRPEKPYSSTPPSFRKSQLSPKEIGDPPMGITAENL
VKKYGISREEQDAFALRSQQRMARAMQEGRFDEQIVPITVPVKKGEPFVFDTDEHPRPNTTMEALAKLPPAFLEGGTVTA
GNSSGLNDAAAALVVMSREKAEQLGLTPLAVVRAYAVAGVDPNIMGIGPVPATRKVLEKVGLTLDEMDIIEINEAFAAQV
IACDRELEMNPEKVNVNGGAIAHGHPLGATGAILITKAVYELKRRGGTYALITACIGGGQGIATIIERA

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=44.3877551020408, Blast_Score=318, Evalue=5e-87,
Organism=Homo sapiens, GI148539872, Length=395, Percent_Identity=44.5569620253165, Blast_Score=315, Evalue=4e-86,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=45.959595959596, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=40.1015228426396, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=34.3529411764706, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=31.6195372750643, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1787663, Length=399, Percent_Identity=48.1203007518797, Blast_Score=340, Evalue=9e-95,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=50.6361323155216, Blast_Score=335, Evalue=2e-93,
Organism=Escherichia coli, GI87082165, Length=396, Percent_Identity=46.2121212121212, Blast_Score=325, Evalue=2e-90,
Organism=Escherichia coli, GI48994986, Length=395, Percent_Identity=43.2911392405063, Blast_Score=261, Evalue=4e-71,
Organism=Escherichia coli, GI1788683, Length=407, Percent_Identity=36.6093366093366, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=45.7583547557841, Blast_Score=307, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI17535921, Length=391, Percent_Identity=35.5498721227622, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=34.8717948717949, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=32.8605200945626, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=28.498727735369, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322031, Length=394, Percent_Identity=38.8324873096447, Blast_Score=225, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=35.0617283950617, Blast_Score=217, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=43.8461538461538, Blast_Score=315, Evalue=3e-86,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=42.4164524421594, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=37.8787878787879, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=33.5680751173709, Blast_Score=192, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40974; Mature: 40974

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRDAVIVSAVRTAIARQGGALATLPAHVYGAEVIKEAMRRANIGPELVADVIMGNVLSG
CCCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
GGNIARLTALQTGLSLELTGLTVDRQCGSGINAVNLAAQAIWAGDGDVYIAGGVESMSRA
CCCEEEEEEHHCCCEEEEEEEEEEHHHCCCCCHHHHHHHHEEECCCCEEEECCHHHHHCC
PYLMDRPEKPYSSTPPSFRKSQLSPKEIGDPPMGITAENLVKKYGISREEQDAFALRSQQ
CCCCCCCCCCCCCCCCCHHHCCCCHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
RMARAMQEGRFDEQIVPITVPVKKGEPFVFDTDEHPRPNTTMEALAKLPPAFLEGGTVTA
HHHHHHHHCCCCCEEEEEEEEECCCCCEEECCCCCCCCCHHHHHHHHCCHHHHCCCEEEC
GNSSGLNDAAAALVVMSREKAEQLGLTPLAVVRAYAVAGVDPNIMGIGPVPATRKVLEKV
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHH
GLTLDEMDIIEINEAFAAQVIACDRELEMNPEKVNVNGGAIAHGHPLGATGAILITKAVY
CCCCCCCCEEEECHHHHHHHHHCCCCCCCCCCEEECCCCEEECCCCCCCCHHHHHHHHHH
ELKRRGGTYALITACIGGGQGIATIIERA
HHHHCCCCEEEEEEHHCCCCHHHHHHHCC
>Mature Secondary Structure
MKRDAVIVSAVRTAIARQGGALATLPAHVYGAEVIKEAMRRANIGPELVADVIMGNVLSG
CCCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
GGNIARLTALQTGLSLELTGLTVDRQCGSGINAVNLAAQAIWAGDGDVYIAGGVESMSRA
CCCEEEEEEHHCCCEEEEEEEEEEHHHCCCCCHHHHHHHHEEECCCCEEEECCHHHHHCC
PYLMDRPEKPYSSTPPSFRKSQLSPKEIGDPPMGITAENLVKKYGISREEQDAFALRSQQ
CCCCCCCCCCCCCCCCCHHHCCCCHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHH
RMARAMQEGRFDEQIVPITVPVKKGEPFVFDTDEHPRPNTTMEALAKLPPAFLEGGTVTA
HHHHHHHHCCCCCEEEEEEEEECCCCCEEECCCCCCCCCHHHHHHHHCCHHHHCCCEEEC
GNSSGLNDAAAALVVMSREKAEQLGLTPLAVVRAYAVAGVDPNIMGIGPVPATRKVLEKV
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHH
GLTLDEMDIIEINEAFAAQVIACDRELEMNPEKVNVNGGAIAHGHPLGATGAILITKAVY
CCCCCCCCEEEECHHHHHHHHHCCCCCCCCCCEEECCCCEEECCCCCCCCHHHHHHHHHH
ELKRRGGTYALITACIGGGQGIATIIERA
HHHHCCCCEEEEEEHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]