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The map label for this gene is yhcA [H]

Identifier: 138895118

GI number: 138895118

Start: 1540497

End: 1542038

Strand: Direct

Name: yhcA [H]

Synonym: GTNG_1456

Alternate gene names: 138895118

Gene position: 1540497-1542038 (Clockwise)

Preceding gene: 138895117

Following gene: 138895119

Centisome position: 43.39

GC content: 52.2

Gene sequence:

>1542_bases
GTGCGCCCGGCTACCTCGTCCGGACAAAGTCAAGGTGGATTAGGTGACATCGGCAGCCGCGGCAAAGTGGTCGTGACGGT
CATGCTTGGGGCGTTTGTAGCCATCTTGAACCAAACGTTGATTAACGTCGCACTGCCGCATATGATGCAAGATTTCAATG
TCGAGACAGCGACGATCCAGTGGCTCGTTACGGGGTACATGCTTGTCAACGGGGTGCTCATCCCAATCAGTCCGTTTTTA
ATCGCCAAGTTTCCGACGAAAACATTGTTTGTCTCAAGCATGTCGTTTTTCGCCATCGGGGCGTTTGTCTGCTCGATCGC
TCCAACATTTGCGGTCATGCTCGCAGGACGGCTGACGCAAGCGGTTGGAGCGGGCATTATTATGCAGCTCATGATGGTCA
TTATGCTGTCGATTTTCCCGCCGGAACGCCGTGGGGTGGCGATGGGAACAGTCGGGATTGCGATGATGTTTGCGCCGGCG
GTCGGTCCGACGCTTTCGGGTTGGCTCGTCGAGCATTATACGTGGCGCCTTTTGTTTTATGTCGTGTTGCCGATCGCCAT
TGTGGATCTTGTCCTCGCTTCTCTTTGGTTGAAAAAAACGCCGCGCAAAGGAAATCCCGTTCTCGATATGAAAGGAGCGA
TTTATTCGACGATCGGGTTTGGCGGCGTTTTGTACGGGTTCAGTGAGGCCGGAAGCAATGGATGGGGGCAGACGGAAGTC
GTCGTCTCGCTTGTTGTTGGTTCTTTGTTCCTCGTCTTGTTTACATGGCGTTCGCTCCGTTCGGAGCACCCAGTGTTAAA
TTTCCGCGTGTTTCGTTATCCAGTGTTTACGTTGTCAACGGTGATCGGTTCGGTCATTAATATGGCCATGTTTGCCGCAA
TGGTCTTGCTTCCGGTCTATTTGCAAAATTTGCGCGGCTTTACGCCGCTCGATGCGGGTTTGCTCTTGTTGCCGGGGGCG
ATTGTGATGGCGATCATGTCGCCGATTTCCGGTTGGGTGTTTGACCGCATCGGTGCGCGGGCGCTTGCCATCGTCGGCTT
GATCATCACTGCCGTGACAACATGGGAATTTAGCAAACTGACGATGGATACACCATATAGTCATTTAATTTGGCTTTACA
TTTTCCGCATGTTTGGCATGTCGATGCTCGGGATGCCAATTATGACGGAAGGGTTAAACGCGTTGCCGCGCCATCTATAC
AGCCACGGCACAGCGATGGCGAACACGCTCCGCCAAGTGGCAGCTTCGCTCGGCACAGCCTTTTTGGTGACCGTCATGTC
AAACCGGACAAAATTTCATGTGGAACAGTATCGCAATGAAATGACAGAAACGAATCCGTTCTTTATGGATGTTGTTAGCC
AGCTAAAACAAGTGATCCCGAGTGACGAAGCCGTTAGTGAGCTGCTATATGGGCTTGTGCAGCAGCGCGCCACGGTCGAG
GGGATCAATGACGCCTTTTTTGTCGCCACTGGCTTGACGGTGTTAGCACTATTGATGGCGTTCTTCTTAAAAGGAAAAAA
ACATAAATCGCCGTCGGCGTAA

Upstream 100 bases:

>100_bases
CATATTTGCCGTTTTCGTCCTAGCGGTCCTCAACATCATGTTGCGCCGGCGCAAATCAGCTCCGGCCGCGGTTGAGACAG
CAGATGGCGCAAGGGCGGAT

Downstream 100 bases:

>100_bases
ATGAAGGAATAGAAGCGGCTTTGAACGGCCGCTTCTTTTTTTACAAGCTTGCCGGCAGGTGATAGACGAAACCAATCAGC
CGCTTGCGAACGGTATAACC

Product: multidrug resistance protein B-like protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MRPATSSGQSQGGLGDIGSRGKVVVTVMLGAFVAILNQTLINVALPHMMQDFNVETATIQWLVTGYMLVNGVLIPISPFL
IAKFPTKTLFVSSMSFFAIGAFVCSIAPTFAVMLAGRLTQAVGAGIIMQLMMVIMLSIFPPERRGVAMGTVGIAMMFAPA
VGPTLSGWLVEHYTWRLLFYVVLPIAIVDLVLASLWLKKTPRKGNPVLDMKGAIYSTIGFGGVLYGFSEAGSNGWGQTEV
VVSLVVGSLFLVLFTWRSLRSEHPVLNFRVFRYPVFTLSTVIGSVINMAMFAAMVLLPVYLQNLRGFTPLDAGLLLLPGA
IVMAIMSPISGWVFDRIGARALAIVGLIITAVTTWEFSKLTMDTPYSHLIWLYIFRMFGMSMLGMPIMTEGLNALPRHLY
SHGTAMANTLRQVAASLGTAFLVTVMSNRTKFHVEQYRNEMTETNPFFMDVVSQLKQVIPSDEAVSELLYGLVQQRATVE
GINDAFFVATGLTVLALLMAFFLKGKKHKSPSA

Sequences:

>Translated_513_residues
MRPATSSGQSQGGLGDIGSRGKVVVTVMLGAFVAILNQTLINVALPHMMQDFNVETATIQWLVTGYMLVNGVLIPISPFL
IAKFPTKTLFVSSMSFFAIGAFVCSIAPTFAVMLAGRLTQAVGAGIIMQLMMVIMLSIFPPERRGVAMGTVGIAMMFAPA
VGPTLSGWLVEHYTWRLLFYVVLPIAIVDLVLASLWLKKTPRKGNPVLDMKGAIYSTIGFGGVLYGFSEAGSNGWGQTEV
VVSLVVGSLFLVLFTWRSLRSEHPVLNFRVFRYPVFTLSTVIGSVINMAMFAAMVLLPVYLQNLRGFTPLDAGLLLLPGA
IVMAIMSPISGWVFDRIGARALAIVGLIITAVTTWEFSKLTMDTPYSHLIWLYIFRMFGMSMLGMPIMTEGLNALPRHLY
SHGTAMANTLRQVAASLGTAFLVTVMSNRTKFHVEQYRNEMTETNPFFMDVVSQLKQVIPSDEAVSELLYGLVQQRATVE
GINDAFFVATGLTVLALLMAFFLKGKKHKSPSA
>Mature_513_residues
MRPATSSGQSQGGLGDIGSRGKVVVTVMLGAFVAILNQTLINVALPHMMQDFNVETATIQWLVTGYMLVNGVLIPISPFL
IAKFPTKTLFVSSMSFFAIGAFVCSIAPTFAVMLAGRLTQAVGAGIIMQLMMVIMLSIFPPERRGVAMGTVGIAMMFAPA
VGPTLSGWLVEHYTWRLLFYVVLPIAIVDLVLASLWLKKTPRKGNPVLDMKGAIYSTIGFGGVLYGFSEAGSNGWGQTEV
VVSLVVGSLFLVLFTWRSLRSEHPVLNFRVFRYPVFTLSTVIGSVINMAMFAAMVLLPVYLQNLRGFTPLDAGLLLLPGA
IVMAIMSPISGWVFDRIGARALAIVGLIITAVTTWEFSKLTMDTPYSHLIWLYIFRMFGMSMLGMPIMTEGLNALPRHLY
SHGTAMANTLRQVAASLGTAFLVTVMSNRTKFHVEQYRNEMTETNPFFMDVVSQLKQVIPSDEAVSELLYGLVQQRATVE
GINDAFFVATGLTVLALLMAFFLKGKKHKSPSA

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=489, Percent_Identity=25.5623721881391, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI1788710, Length=491, Percent_Identity=25.050916496945, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI87081983, Length=414, Percent_Identity=26.8115942028986, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1790195, Length=405, Percent_Identity=24.6913580246914, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788392, Length=402, Percent_Identity=25.8706467661692, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325455, Length=234, Percent_Identity=29.0598290598291, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323735, Length=322, Percent_Identity=23.2919254658385, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321663, Length=129, Percent_Identity=31.0077519379845, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322958, Length=533, Percent_Identity=20.4502814258912, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55944; Mature: 55944

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure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CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]