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The map label for this gene is accC2 [H]

Identifier: 138895110

GI number: 138895110

Start: 1533561

End: 1534913

Strand: Direct

Name: accC2 [H]

Synonym: GTNG_1448

Alternate gene names: 138895110

Gene position: 1533561-1534913 (Clockwise)

Preceding gene: 138895109

Following gene: 138895111

Centisome position: 43.2

GC content: 53.44

Gene sequence:

>1353_bases
ATGTTTGCGAAAGTGTTGATTGCCAACCGTGGCGAAATCGCCGTCCGCATCATTCGCACATGCCAAAAGCTCGGCATCCA
AACGGTTGCTGTCTACTCGGAAGCGGATGCGGATTCGCTCCATGTTCAGCTCGCTGATGAAGCGTATTTGATCGGCAAGC
CGCGCGTAGCGGAAAGCTACTTAAATATCGAAAAAATCATCGAAGTCGCCAAAGCGGCGAAAGCGGAAGCGATTCATCCC
GGTTACGGACTGCTCTCGGAAAACCCAGCGTTTGCCCGTCGCTGTGAGGAAGAAGGGATTGTCTTTATCGGCCCGAAGGC
GGACGTCATTGCTGCGATGGGCAGCAAAATCGAAGCACGCCAGACGATGGAAAAAGCTGGCGTTCCGATCGTTCCGGGCG
TTTCCTTTGCATTAGACAGCCCCGATGAAGCGGCTGCAGCCGCAGCTTCCATCGGTTATCCAGTCATGCTGAAGGCATCA
TCAGGCGGCGGCGGTATTGGCATGCACATCGCTCACGATGAAGCCGAGCTGCGCCAAGCGTTTGAAGGCAGTCAAAAACG
AGCTGCTTCGTTTTTCGGCGACGGGACGATGTATATCGAAAAATATATTGAACGCCCGCGCCATATTGAAATTCAGCTGC
TCGCCGATGGGCACGGCAACTGCGTCTACTTATGGGAACGCGAATGCTCGATCCAGCGCCGCCATCAAAAAGTGGTTGAG
GAAGCGCCATCGCCGTTTTTGGATGAAGAAACGCGGCGGAAAATGGGTGAAGCCGCCGTCCAGGCAGCACGTTATATCGG
TTATGCGAACGCCGGTACAATCGAGTTTTTGGTTGATGAACAAAAAAACTTTTATTTTCTCGAGATGAATACTCGTCTCC
AAGTCGAACATCCGGTGACCGAGGAAATCACCGGCATTGACATCGTCGAAGAGCAACTGCGCATCGCTGCCGGCGAGCCG
CTTCGGTATAAGCAGGAAGACATTCGCCGCGATGGACACGCCATTGAAGTGCGAATTTATGCGGAAGACCCGAACACGTT
TTACCCGTCGCCTGGCCGCATTGCCGCCTTTTCCGTTCCTCAAGGTGAAGGGATTCGTCATGAAACGGCGGTTCAAAGCG
GCATCACCGTTACGCCGTTTTACGACCCGATGATCGCCAAAATGATCGCCAAAGGTTCGGATCGAACATCGGCGATTGAA
CGCTTGCTCGAAGCGCTTCGGGATTATCACGTCGAAGGCATTAAAACGAACATCCCGCTGCTTGAGGCGGTGTTGTCCCA
CCCGGCGTTCCGTGCTGGGGAAACGACGACCGATTTTCTTTCGAACTATTGGCAGCCAACTAAAACAAAATGA

Upstream 100 bases:

>100_bases
AAATGGCGAAACAGCGCCTCGGCTTGACGACTTAAACCGCCGCGCCGGGCGGGCGAACCGTCCGGCGCCGGCAGCCCACT
TTTTGTGAAAGGGTGAGAGG

Downstream 100 bases:

>100_bases
AGCAGAAACGGAGGAAGAAACGATGAACAAAGTCACTGCCACAATGGCCGGAAGTGTATGGAAAATTGTTGTCGCCGTCG
GTGACCGTGTTGAAGAAGGA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 2; ACC 2 [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MFAKVLIANRGEIAVRIIRTCQKLGIQTVAVYSEADADSLHVQLADEAYLIGKPRVAESYLNIEKIIEVAKAAKAEAIHP
GYGLLSENPAFARRCEEEGIVFIGPKADVIAAMGSKIEARQTMEKAGVPIVPGVSFALDSPDEAAAAAASIGYPVMLKAS
SGGGGIGMHIAHDEAELRQAFEGSQKRAASFFGDGTMYIEKYIERPRHIEIQLLADGHGNCVYLWERECSIQRRHQKVVE
EAPSPFLDEETRRKMGEAAVQAARYIGYANAGTIEFLVDEQKNFYFLEMNTRLQVEHPVTEEITGIDIVEEQLRIAAGEP
LRYKQEDIRRDGHAIEVRIYAEDPNTFYPSPGRIAAFSVPQGEGIRHETAVQSGITVTPFYDPMIAKMIAKGSDRTSAIE
RLLEALRDYHVEGIKTNIPLLEAVLSHPAFRAGETTTDFLSNYWQPTKTK

Sequences:

>Translated_450_residues
MFAKVLIANRGEIAVRIIRTCQKLGIQTVAVYSEADADSLHVQLADEAYLIGKPRVAESYLNIEKIIEVAKAAKAEAIHP
GYGLLSENPAFARRCEEEGIVFIGPKADVIAAMGSKIEARQTMEKAGVPIVPGVSFALDSPDEAAAAAASIGYPVMLKAS
SGGGGIGMHIAHDEAELRQAFEGSQKRAASFFGDGTMYIEKYIERPRHIEIQLLADGHGNCVYLWERECSIQRRHQKVVE
EAPSPFLDEETRRKMGEAAVQAARYIGYANAGTIEFLVDEQKNFYFLEMNTRLQVEHPVTEEITGIDIVEEQLRIAAGEP
LRYKQEDIRRDGHAIEVRIYAEDPNTFYPSPGRIAAFSVPQGEGIRHETAVQSGITVTPFYDPMIAKMIAKGSDRTSAIE
RLLEALRDYHVEGIKTNIPLLEAVLSHPAFRAGETTTDFLSNYWQPTKTK
>Mature_450_residues
MFAKVLIANRGEIAVRIIRTCQKLGIQTVAVYSEADADSLHVQLADEAYLIGKPRVAESYLNIEKIIEVAKAAKAEAIHP
GYGLLSENPAFARRCEEEGIVFIGPKADVIAAMGSKIEARQTMEKAGVPIVPGVSFALDSPDEAAAAAASIGYPVMLKAS
SGGGGIGMHIAHDEAELRQAFEGSQKRAASFFGDGTMYIEKYIERPRHIEIQLLADGHGNCVYLWERECSIQRRHQKVVE
EAPSPFLDEETRRKMGEAAVQAARYIGYANAGTIEFLVDEQKNFYFLEMNTRLQVEHPVTEEITGIDIVEEQLRIAAGEP
LRYKQEDIRRDGHAIEVRIYAEDPNTFYPSPGRIAAFSVPQGEGIRHETAVQSGITVTPFYDPMIAKMIAKGSDRTSAIE
RLLEALRDYHVEGIKTNIPLLEAVLSHPAFRAGETTTDFLSNYWQPTKTK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=446, Percent_Identity=54.7085201793722, Blast_Score=490, Evalue=1e-139,
Organism=Homo sapiens, GI65506442, Length=446, Percent_Identity=54.7085201793722, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI295821183, Length=446, Percent_Identity=54.7085201793722, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=52.7027027027027, Blast_Score=474, Evalue=1e-134,
Organism=Homo sapiens, GI106049528, Length=443, Percent_Identity=46.9525959367946, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI106049295, Length=443, Percent_Identity=46.9525959367946, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI106049292, Length=443, Percent_Identity=46.9525959367946, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI38679960, Length=499, Percent_Identity=29.8597194388778, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI38679971, Length=499, Percent_Identity=29.8597194388778, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI38679977, Length=499, Percent_Identity=29.8597194388778, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI38679967, Length=499, Percent_Identity=29.8597194388778, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI38679974, Length=499, Percent_Identity=29.8597194388778, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI134142062, Length=500, Percent_Identity=30, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI18105007, Length=192, Percent_Identity=26.5625, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789654, Length=441, Percent_Identity=53.968253968254, Blast_Score=453, Evalue=1e-128,
Organism=Escherichia coli, GI1786216, Length=242, Percent_Identity=24.7933884297521, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=446, Percent_Identity=49.1031390134529, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=51.8099547511312, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17562816, Length=461, Percent_Identity=47.5054229934924, Blast_Score=415, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI133931226, Length=483, Percent_Identity=30.4347826086957, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI71997168, Length=473, Percent_Identity=30.8668076109937, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71997163, Length=473, Percent_Identity=30.8668076109937, Blast_Score=219, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6319685, Length=450, Percent_Identity=45.7777777777778, Blast_Score=408, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6319695, Length=450, Percent_Identity=44.2222222222222, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6321376, Length=450, Percent_Identity=45.1111111111111, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6323863, Length=470, Percent_Identity=32.1276595744681, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6324343, Length=511, Percent_Identity=29.5499021526419, Blast_Score=236, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6322331, Length=327, Percent_Identity=24.1590214067278, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24651757, Length=442, Percent_Identity=49.7737556561086, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24652212, Length=453, Percent_Identity=49.0066225165563, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652210, Length=453, Percent_Identity=49.0066225165563, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652214, Length=453, Percent_Identity=49.0066225165563, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI19921944, Length=453, Percent_Identity=49.0066225165563, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652216, Length=453, Percent_Identity=49.0066225165563, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI281363050, Length=453, Percent_Identity=49.0066225165563, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652224, Length=453, Percent_Identity=49.0066225165563, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652222, Length=453, Percent_Identity=49.0066225165563, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652220, Length=453, Percent_Identity=49.0066225165563, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652218, Length=453, Percent_Identity=49.0066225165563, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24651759, Length=404, Percent_Identity=48.7623762376238, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI161076409, Length=494, Percent_Identity=30.3643724696356, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI161076407, Length=494, Percent_Identity=30.3643724696356, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24586460, Length=494, Percent_Identity=30.3643724696356, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24586458, Length=494, Percent_Identity=30.3643724696356, Blast_Score=230, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49722; Mature: 49722

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAKVLIANRGEIAVRIIRTCQKLGIQTVAVYSEADADSLHVQLADEAYLIGKPRVAESY
CCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCHHHHHH
LNIEKIIEVAKAAKAEAIHPGYGLLSENPAFARRCEEEGIVFIGPKADVIAAMGSKIEAR
HCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHCCCHHHH
QTMEKAGVPIVPGVSFALDSPDEAAAAAASIGYPVMLKASSGGGGIGMHIAHDEAELRQA
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCHHHHHHH
FEGSQKRAASFFGDGTMYIEKYIERPRHIEIQLLADGHGNCVYLWERECSIQRRHQKVVE
HCCCHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHH
EAPSPFLDEETRRKMGEAAVQAARYIGYANAGTIEFLVDEQKNFYFLEMNTRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCH
EEITGIDIVEEQLRIAAGEPLRYKQEDIRRDGHAIEVRIYAEDPNTFYPSPGRIAAFSVP
HHCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEEEEECCCCCCCCCCCCEEEEECC
QGEGIRHETAVQSGITVTPFYDPMIAKMIAKGSDRTSAIERLLEALRDYHVEGIKTNIPL
CCCCCCHHHHHHCCCEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHH
LEAVLSHPAFRAGETTTDFLSNYWQPTKTK
HHHHHCCCCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFAKVLIANRGEIAVRIIRTCQKLGIQTVAVYSEADADSLHVQLADEAYLIGKPRVAESY
CCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCHHHHHH
LNIEKIIEVAKAAKAEAIHPGYGLLSENPAFARRCEEEGIVFIGPKADVIAAMGSKIEAR
HCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHCCCHHHH
QTMEKAGVPIVPGVSFALDSPDEAAAAAASIGYPVMLKASSGGGGIGMHIAHDEAELRQA
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCHHHHHHH
FEGSQKRAASFFGDGTMYIEKYIERPRHIEIQLLADGHGNCVYLWERECSIQRRHQKVVE
HCCCHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHH
EAPSPFLDEETRRKMGEAAVQAARYIGYANAGTIEFLVDEQKNFYFLEMNTRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCH
EEITGIDIVEEQLRIAAGEPLRYKQEDIRRDGHAIEVRIYAEDPNTFYPSPGRIAAFSVP
HHCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEEEEECCCCCCCCCCCCEEEEECC
QGEGIRHETAVQSGITVTPFYDPMIAKMIAKGSDRTSAIERLLEALRDYHVEGIKTNIPL
CCCCCCHHHHHHCCCEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHH
LEAVLSHPAFRAGETTTDFLSNYWQPTKTK
HHHHHCCCCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]