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The map label for this gene is tdcB [H]

Identifier: 138895102

GI number: 138895102

Start: 1526575

End: 1527783

Strand: Direct

Name: tdcB [H]

Synonym: GTNG_1440

Alternate gene names: 138895102

Gene position: 1526575-1527783 (Clockwise)

Preceding gene: 138895097

Following gene: 138895104

Centisome position: 43.0

GC content: 51.45

Gene sequence:

>1209_bases
ATGTTGACGTTGACAGACATTGAGCAAGCGCGGTTGAAAATGAAAGGCATTGTTCATGAAACACCACTTGAGCATTCGCA
AACGTTCAGCCGGTTGTCCGGCAATAATGTATATATGAAACTCGAAAACTTGCAAAAAACGGGCTCATTTAAAGTAAGAG
GGTCATTCAATAAAATTATGTCGTTGACCGATGAAGAGCGGTCGCGCGGCGTCATCGCCGCCTCCGCCGGCAACCATGCT
CAGGGGGTCGCCTATGCAAGCGGCATGCTTCATATTCCGTGCACGATCGTTATGCCAAAAGGTGCGCCGCTGAGCAAAAT
AGAAGCGACGAAAAACTATGGAGCGGAAGTCGTTTTGCACGGCGATGTGTTTGATGAGTCGCTCGAGTATGCGCTCGAAC
TGCAGCGCGAGCGGGGGATGACGTTTGTACATCCGTTCGACGATTTGGCCGTCATGGCCGGCCAAGGAACGATCGGCTTG
GAGTTGGTTGAGCAGCTTCCTGATGTGGACGTCGTCCTTTGCCCGGTCGGTGGCGGCGGCTTGCTCGCGGGGTTAGCGTT
TACATTAAAACAGCTGAAACCGTCTGTCGAGGTGTACGGCGTCGAATCGTCAGCCTGCCCTGGAATGACAGCAGCCCTCC
GCCATAAACAGCCGGTCGCCATCGCTGCATCGGATACGATCGCCGATGGCATCGCCGTGAAAAAGCCAGGCAATATTACG
TACCAATATATTGAGCAGTACGTCGATGGAATCGTTTGCGTTGAAGAGGCGGAAATTTCACGGACGATGCTTTATTTACT
TGAACGGAACAAATTGCTCGTCGAAGGGTCGGCGGCTTGTCCGCTGGCGGCGCTTTTGTACCAAAAGTTGCCGTTTCGTG
ATAAAAAAGTCGCCGCCATTTTAAGCGGCGGCAACGTCGACGTGACATTGATTTCCCGCATCATCGAGCGCGGTCTTGTC
GAGGCCGGTCGGTTTGTGACGTTTACGACGATCATTTCCGATAAGCCGGGCCAATTGAACAAGCTGCTTCGCATTATCGC
CGAACTAGAAGCAAATGTGATGTCGATCCACCATCAACGCATCGGTGCCAAAGTGTTGCCAGGCCAGGCGGAAATCCACT
TTTCGCTTGAGACGAAAAATGAGGATCATATCCAGCAAATTTACCAAGTGTTATTGAAAGAAGGCTATGATGTACAGTTT
TATCGGTAG

Upstream 100 bases:

>100_bases
GCCGAGGAAAAAGCAATATTTGTCGGCGATGAAACGTTTTGTATATAATAAAGCCGGGTGAAAAAGAACCGGTTGCCTGA
TCAGAAAGGGTGGTTTAGTG

Downstream 100 bases:

>100_bases
GTGGCTCGAAAACGTTTTTTCTTTATTCTTTATTTCAAAAGAAGCGCTCCGGTTTCTAAGCGGGGCGAAAGTGGGAGACG
TATTCGCTGTGGGTTGATGG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MLTLTDIEQARLKMKGIVHETPLEHSQTFSRLSGNNVYMKLENLQKTGSFKVRGSFNKIMSLTDEERSRGVIAASAGNHA
QGVAYASGMLHIPCTIVMPKGAPLSKIEATKNYGAEVVLHGDVFDESLEYALELQRERGMTFVHPFDDLAVMAGQGTIGL
ELVEQLPDVDVVLCPVGGGGLLAGLAFTLKQLKPSVEVYGVESSACPGMTAALRHKQPVAIAASDTIADGIAVKKPGNIT
YQYIEQYVDGIVCVEEAEISRTMLYLLERNKLLVEGSAACPLAALLYQKLPFRDKKVAAILSGGNVDVTLISRIIERGLV
EAGRFVTFTTIISDKPGQLNKLLRIIAELEANVMSIHHQRIGAKVLPGQAEIHFSLETKNEDHIQQIYQVLLKEGYDVQF
YR

Sequences:

>Translated_402_residues
MLTLTDIEQARLKMKGIVHETPLEHSQTFSRLSGNNVYMKLENLQKTGSFKVRGSFNKIMSLTDEERSRGVIAASAGNHA
QGVAYASGMLHIPCTIVMPKGAPLSKIEATKNYGAEVVLHGDVFDESLEYALELQRERGMTFVHPFDDLAVMAGQGTIGL
ELVEQLPDVDVVLCPVGGGGLLAGLAFTLKQLKPSVEVYGVESSACPGMTAALRHKQPVAIAASDTIADGIAVKKPGNIT
YQYIEQYVDGIVCVEEAEISRTMLYLLERNKLLVEGSAACPLAALLYQKLPFRDKKVAAILSGGNVDVTLISRIIERGLV
EAGRFVTFTTIISDKPGQLNKLLRIIAELEANVMSIHHQRIGAKVLPGQAEIHFSLETKNEDHIQQIYQVLLKEGYDVQF
YR
>Mature_402_residues
MLTLTDIEQARLKMKGIVHETPLEHSQTFSRLSGNNVYMKLENLQKTGSFKVRGSFNKIMSLTDEERSRGVIAASAGNHA
QGVAYASGMLHIPCTIVMPKGAPLSKIEATKNYGAEVVLHGDVFDESLEYALELQRERGMTFVHPFDDLAVMAGQGTIGL
ELVEQLPDVDVVLCPVGGGGLLAGLAFTLKQLKPSVEVYGVESSACPGMTAALRHKQPVAIAASDTIADGIAVKKPGNIT
YQYIEQYVDGIVCVEEAEISRTMLYLLERNKLLVEGSAACPLAALLYQKLPFRDKKVAAILSGGNVDVTLISRIIERGLV
EAGRFVTFTTIISDKPGQLNKLLRIIAELEANVMSIHHQRIGAKVLPGQAEIHFSLETKNEDHIQQIYQVLLKEGYDVQF
YR

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=316, Percent_Identity=40.5063291139241, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI33469958, Length=148, Percent_Identity=35.8108108108108, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI19923959, Length=144, Percent_Identity=37.5, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1789505, Length=323, Percent_Identity=45.5108359133127, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1790207, Length=345, Percent_Identity=37.6811594202899, Blast_Score=196, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71991565, Length=397, Percent_Identity=40.0503778337531, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17537387, Length=398, Percent_Identity=36.6834170854271, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17508781, Length=314, Percent_Identity=33.1210191082803, Blast_Score=175, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6322631, Length=314, Percent_Identity=39.171974522293, Blast_Score=202, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6320930, Length=400, Percent_Identity=33.25, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319788, Length=290, Percent_Identity=27.9310344827586, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322024, Length=194, Percent_Identity=26.8041237113402, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355833, Length=400, Percent_Identity=40, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24645328, Length=304, Percent_Identity=38.8157894736842, Blast_Score=175, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43948; Mature: 43948

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLTDIEQARLKMKGIVHETPLEHSQTFSRLSGNNVYMKLENLQKTGSFKVRGSFNKIM
CCEECCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECHHHHH
SLTDEERSRGVIAASAGNHAQGVAYASGMLHIPCTIVMPKGAPLSKIEATKNYGAEVVLH
HCCCHHHCCCEEEECCCCCCCCEEEECCEEEEEEEEEECCCCCHHHHHHHHCCCCEEEEE
GDVFDESLEYALELQRERGMTFVHPFDDLAVMAGQGTIGLELVEQLPDVDVVLCPVGGGG
CCHHHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCHHHHHHHHCCCCCEEEEECCCCH
LLAGLAFTLKQLKPSVEVYGVESSACPGMTAALRHKQPVAIAASDTIADGIAVKKPGNIT
HHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCCEEEEECCHHHCCEEEECCCCCH
YQYIEQYVDGIVCVEEAEISRTMLYLLERNKLLVEGSAACPLAALLYQKLPFRDKKVAAI
HHHHHHHHCCEEEEEHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEE
LSGGNVDVTLISRIIERGLVEAGRFVTFTTIISDKPGQLNKLLRIIAELEANVMSIHHQR
EECCCEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
IGAKVLPGQAEIHFSLETKNEDHIQQIYQVLLKEGYDVQFYR
CCCEECCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEC
>Mature Secondary Structure
MLTLTDIEQARLKMKGIVHETPLEHSQTFSRLSGNNVYMKLENLQKTGSFKVRGSFNKIM
CCEECCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECHHHHH
SLTDEERSRGVIAASAGNHAQGVAYASGMLHIPCTIVMPKGAPLSKIEATKNYGAEVVLH
HCCCHHHCCCEEEECCCCCCCCEEEECCEEEEEEEEEECCCCCHHHHHHHHCCCCEEEEE
GDVFDESLEYALELQRERGMTFVHPFDDLAVMAGQGTIGLELVEQLPDVDVVLCPVGGGG
CCHHHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCHHHHHHHHCCCCCEEEEECCCCH
LLAGLAFTLKQLKPSVEVYGVESSACPGMTAALRHKQPVAIAASDTIADGIAVKKPGNIT
HHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCCEEEEECCHHHCCEEEECCCCCH
YQYIEQYVDGIVCVEEAEISRTMLYLLERNKLLVEGSAACPLAALLYQKLPFRDKKVAAI
HHHHHHHHCCEEEEEHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEE
LSGGNVDVTLISRIIERGLVEAGRFVTFTTIISDKPGQLNKLLRIIAELEANVMSIHHQR
EECCCEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
IGAKVLPGQAEIHFSLETKNEDHIQQIYQVLLKEGYDVQFYR
CCCEECCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA