BacMap

Definition	Geobacillus thermodenitrificans NG80-2 chromosome, complete genome.
Accession	NC_009328
Length	3,550,319

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The map label for this gene is fabG [H]

Identifier: 138894809

GI number: 138894809

Start: 1208897

End: 1209613

Strand: Direct

Name: fabG [H]

Synonym: GTNG_1143

Alternate gene names: 138894809

Gene position: 1208897-1209613 (Clockwise)

Preceding gene: 138894808

Following gene: 138894810

Centisome position: 34.05

GC content: 55.93

Gene sequence:

>717_bases
ATGAACTACGCGTTAATCACCGGCGCTTCAGGCGGCATCGGGCAAAGCATTGCCCGCGAGCTTGCTAAAGCCGGCTACGG
GCTGCTGCTTCATTACTATCGGCGGCGGGCACCGGTCGAAGCGTTACAAGAAGAGCTTCCTGATACACACATCGTCCCGC
TCGAAGCCGACTTGTCCGCGCCCGGTGGAGTCGAGGCGCTCCTTTCGCAAATCGACCGCCCGGTGGACGCCATCATTTAT
AACAGCGGGGCGAGCTATTACGGATTGTTGACCGATATGAACGATGAATTGATCGAGCGGATGGTGCGCCTTCATGTGAC
AAGTCCGGCGCAGCTCGTGAAAAAACTGCTTCCACCGATGATTTCGAAAAAACGCGGCCATATTGTGTTGATTTCATCGA
TTTGGGGGCTTTGCGGCGCATCGTGTGAAGCAGTTTATTCGATGGTAAAAGGCGGGCAAAATGCATTTGCCAAAGCGCTC
GCCAAAGAGCTCGCCCCGAGCGGCATCCGCGTCAACGCTGTCGCGCCTGGAGCGATTGCTACCGATATGTTGCGAGCATT
CAGCGCCGAGGAGCTCGAAGCGCTGGCTGACGAAATCCCGGTCGGCCGGCTCGGCACTCCTGAAGAAGTAGCAAAAACAG
TGGCGTTTCTTTTATCGGACGCCGCTTCGTACATTACTGGCCAAGTCATTTCTGTCAACGGCGGTTGGCATTGCTAA

Upstream 100 bases:

>100_bases
CTCGCAAATCGCTGTTTGTGAAGTTGTGCCAAAAGGGCAATGATGGCATCCTTCATGAGAAGGATGCTTTTTTACGGCAA
AAGGAAGGGGAGAATGTTTG

Downstream 100 bases:

>100_bases
ACGTATATTTTCTGCGCGGGCAGGCAAACTATCCTTGAAACGTTCATCAAGGAGGGAATGCACATGTCGGTATTGGATAA
CTTTGAACAATGGAAACACT

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MNYALITGASGGIGQSIARELAKAGYGLLLHYYRRRAPVEALQEELPDTHIVPLEADLSAPGGVEALLSQIDRPVDAIIY
NSGASYYGLLTDMNDELIERMVRLHVTSPAQLVKKLLPPMISKKRGHIVLISSIWGLCGASCEAVYSMVKGGQNAFAKAL
AKELAPSGIRVNAVAPGAIATDMLRAFSAEELEALADEIPVGRLGTPEEVAKTVAFLLSDAASYITGQVISVNGGWHC

Sequences:

>Translated_238_residues
MNYALITGASGGIGQSIARELAKAGYGLLLHYYRRRAPVEALQEELPDTHIVPLEADLSAPGGVEALLSQIDRPVDAIIY
NSGASYYGLLTDMNDELIERMVRLHVTSPAQLVKKLLPPMISKKRGHIVLISSIWGLCGASCEAVYSMVKGGQNAFAKAL
AKELAPSGIRVNAVAPGAIATDMLRAFSAEELEALADEIPVGRLGTPEEVAKTVAFLLSDAASYITGQVISVNGGWHC
>Mature_238_residues
MNYALITGASGGIGQSIARELAKAGYGLLLHYYRRRAPVEALQEELPDTHIVPLEADLSAPGGVEALLSQIDRPVDAIIY
NSGASYYGLLTDMNDELIERMVRLHVTSPAQLVKKLLPPMISKKRGHIVLISSIWGLCGASCEAVYSMVKGGQNAFAKAL
AKELAPSGIRVNAVAPGAIATDMLRAFSAEELEALADEIPVGRLGTPEEVAKTVAFLLSDAASYITGQVISVNGGWHC

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=235, Percent_Identity=34.0425531914894, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=31.0483870967742, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI15277342, Length=245, Percent_Identity=30.6122448979592, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=30.3643724696356, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI19923817, Length=252, Percent_Identity=28.968253968254, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI7705925, Length=238, Percent_Identity=28.9915966386555, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI20149619, Length=222, Percent_Identity=30.1801801801802, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI66933014, Length=187, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI126723750, Length=243, Percent_Identity=28.8065843621399, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI7706318, Length=197, Percent_Identity=30.4568527918782, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI226371731, Length=195, Percent_Identity=29.2307692307692, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI59889578, Length=211, Percent_Identity=30.3317535545024, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI33667109, Length=194, Percent_Identity=29.8969072164948, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI7657478, Length=184, Percent_Identity=29.3478260869565, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4503301, Length=193, Percent_Identity=27.4611398963731, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI7705855, Length=192, Percent_Identity=26.0416666666667, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI10190704, Length=242, Percent_Identity=26.8595041322314, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI40807363, Length=189, Percent_Identity=29.6296296296296, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=36.734693877551, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI87082100, Length=246, Percent_Identity=33.739837398374, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=32.7935222672065, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI87082160, Length=238, Percent_Identity=26.890756302521, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789208, Length=243, Percent_Identity=28.8065843621399, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790717, Length=239, Percent_Identity=25.5230125523013, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI2367365, Length=235, Percent_Identity=27.2340425531915, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1787905, Length=238, Percent_Identity=29.8319327731092, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1786812, Length=246, Percent_Identity=29.6747967479675, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788459, Length=240, Percent_Identity=29.5833333333333, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786701, Length=177, Percent_Identity=30.5084745762712, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1789378, Length=249, Percent_Identity=26.9076305220884, Blast_Score=67, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=244, Percent_Identity=33.1967213114754, Blast_Score=121, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=34.4, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=33.6, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17555706, Length=242, Percent_Identity=33.0578512396694, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI115534694, Length=237, Percent_Identity=30.8016877637131, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25147288, Length=237, Percent_Identity=29.1139240506329, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17538480, Length=257, Percent_Identity=31.5175097276265, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17562910, Length=258, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17560332, Length=259, Percent_Identity=31.2741312741313, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17531453, Length=258, Percent_Identity=29.8449612403101, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17536025, Length=248, Percent_Identity=30.6451612903226, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562906, Length=259, Percent_Identity=29.3436293436293, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17561402, Length=244, Percent_Identity=28.6885245901639, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17562908, Length=254, Percent_Identity=29.9212598425197, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17551412, Length=258, Percent_Identity=29.8449612403101, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17538486, Length=256, Percent_Identity=31.640625, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560150, Length=253, Percent_Identity=29.6442687747036, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=255, Percent_Identity=30.1960784313725, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=252, Percent_Identity=30.952380952381, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17561272, Length=193, Percent_Identity=29.0155440414508, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17536651, Length=247, Percent_Identity=28.7449392712551, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=28.8973384030418, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI193204405, Length=255, Percent_Identity=28.2352941176471, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17565030, Length=255, Percent_Identity=29.8039215686275, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17562904, Length=254, Percent_Identity=26.7716535433071, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI72000259, Length=253, Percent_Identity=28.4584980237154, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17508651, Length=260, Percent_Identity=26.1538461538462, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=192, Percent_Identity=29.1666666666667, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17557668, Length=194, Percent_Identity=29.8969072164948, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25152911, Length=193, Percent_Identity=29.5336787564767, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559552, Length=194, Percent_Identity=28.3505154639175, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=254, Percent_Identity=25.9842519685039, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=193, Percent_Identity=28.4974093264249, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=193, Percent_Identity=28.4974093264249, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=256, Percent_Identity=25, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=167, Percent_Identity=31.7365269461078, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322067, Length=187, Percent_Identity=30.4812834224599, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=189, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319635, Length=203, Percent_Identity=29.064039408867, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI23397609, Length=241, Percent_Identity=34.0248962655602, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21355319, Length=239, Percent_Identity=33.0543933054393, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=36.3636363636364, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21357041, Length=246, Percent_Identity=32.1138211382114, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24639444, Length=240, Percent_Identity=30.4166666666667, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24644339, Length=252, Percent_Identity=30.5555555555556, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24643142, Length=236, Percent_Identity=29.2372881355932, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24644337, Length=119, Percent_Identity=39.4957983193277, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24584748, Length=241, Percent_Identity=25.7261410788382, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI161076933, Length=241, Percent_Identity=25.7261410788382, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21358495, Length=190, Percent_Identity=33.1578947368421, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24584744, Length=244, Percent_Identity=28.2786885245902, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574402, Length=244, Percent_Identity=28.2786885245902, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24640442, Length=192, Percent_Identity=30.7291666666667, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI116007236, Length=236, Percent_Identity=26.6949152542373, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355631, Length=166, Percent_Identity=25.3012048192771, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24641232, Length=197, Percent_Identity=27.9187817258883, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25271; Mature: 25271

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYALITGASGGIGQSIARELAKAGYGLLLHYYRRRAPVEALQEELPDTHIVPLEADLSA
CCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCC
PGGVEALLSQIDRPVDAIIYNSGASYYGLLTDMNDELIERMVRLHVTSPAQLVKKLLPPM
CCCHHHHHHHHCCCHHHEEECCCCCEEEEHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
ISKKRGHIVLISSIWGLCGASCEAVYSMVKGGQNAFAKALAKELAPSGIRVNAVAPGAIA
HCCCCCCEEEHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCHHH
TDMLRAFSAEELEALADEIPVGRLGTPEEVAKTVAFLLSDAASYITGQVISVNGGWHC
HHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCC
>Mature Secondary Structure
MNYALITGASGGIGQSIARELAKAGYGLLLHYYRRRAPVEALQEELPDTHIVPLEADLSA
CCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCC
PGGVEALLSQIDRPVDAIIYNSGASYYGLLTDMNDELIERMVRLHVTSPAQLVKKLLPPM
CCCHHHHHHHHCCCHHHEEECCCCCEEEEHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
ISKKRGHIVLISSIWGLCGASCEAVYSMVKGGQNAFAKALAKELAPSGIRVNAVAPGAIA
HCCCCCCEEEHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCHHH
TDMLRAFSAEELEALADEIPVGRLGTPEEVAKTVAFLLSDAASYITGQVISVNGGWHC
HHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]