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The map label for this gene is prsA [H]

Identifier: 138894238

GI number: 138894238

Start: 624435

End: 625271

Strand: Direct

Name: prsA [H]

Synonym: GTNG_0564

Alternate gene names: 138894238

Gene position: 624435-625271 (Clockwise)

Preceding gene: 138894237

Following gene: 138894240

Centisome position: 17.59

GC content: 44.44

Gene sequence:

>837_bases
ATGAAAAAATGGATGATGGCTACCGCCGTTGTTTCGCTTATGGCTTTGTCGGCCTGCAATAACGGCGATTCAGAAGCAGT
TGTGGAAACGAAAAACGGTGCTATTACGAAAGATGAATTTTATAATGAGATGAAAGAGCGTGTCGGCAAGACAGTGCTAC
GCGACTTGATTGATGAAAAAGTGTTGAGCAAAAAGTACAAGGTGACCGATGAGGAAATTGACCGTGAAATCGAACGGATT
AAGGAAGCGTACGGCACACAGTACGACCTGGCTGTACAGCAAAATGGAGAAAAAGTGATCCGCGAGATGATCAAGCTCGA
CCTGCTACGGGCGAAAGCGGCTATTGAAGACATTAAAGTGACGGATAAAGAGCTGAAAGAGTATTATGACAATTACAAGC
CGAAAGTTCGCGCCAGCCATATTTTAGTGGAAGATGAAAAAACGGCGAAAGAAGTGAAAGCGAAGTTGGACAAAGGCGAG
GACTTCGCCAAGTTGGCGAAAGAATACTCGCAAGATCCTGGCTCGGCTTCTAACGGCGGTGACTTAGGCTGGTTTGGCGC
AGGGAAAATGGTCAAAGAGTTTGAAGAAGCTGCCTACAAGCTGAAAGTCGGCGAAGTGAGCGACCCGATCAAGACGGATT
ACGGTTACCATATCATTAAAGTGACGGATAAGGAAAAGAAAAAAACGTTTGACAAAATGAAAGAAGAAATAACGTTTGAA
GTGAAACGGAGCAAACTCGACCCGTCAACGATGCAGTCGAAAGTGGACAAGCTTGTGAAAGATGCTAATGTCAAGATCAA
AGACAAAGATTTGCAAGATGTGCTTGAGCAACAATAA

Upstream 100 bases:

>100_bases
GTTGACATGTTGAACAGGTCTAAAAGCTTGATGCCGGAACATCAATAGCCGGCCTCGCGGAAAAGGAAAAACGAAAAAAG
ATATAGGGGTTGTGAAACAA

Downstream 100 bases:

>100_bases
AAACCGGGAGCAGGAAACCCCTGCTTCCGGTTTTTTAGTTGAGCTGTTCGCGGATTGTGGCGGCGATCGCTTGCAAGTCG
GCAGGCGTATAGTCGCTTGC

Product: protein export protein prsA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MKKWMMATAVVSLMALSACNNGDSEAVVETKNGAITKDEFYNEMKERVGKTVLRDLIDEKVLSKKYKVTDEEIDREIERI
KEAYGTQYDLAVQQNGEKVIREMIKLDLLRAKAAIEDIKVTDKELKEYYDNYKPKVRASHILVEDEKTAKEVKAKLDKGE
DFAKLAKEYSQDPGSASNGGDLGWFGAGKMVKEFEEAAYKLKVGEVSDPIKTDYGYHIIKVTDKEKKKTFDKMKEEITFE
VKRSKLDPSTMQSKVDKLVKDANVKIKDKDLQDVLEQQ

Sequences:

>Translated_278_residues
MKKWMMATAVVSLMALSACNNGDSEAVVETKNGAITKDEFYNEMKERVGKTVLRDLIDEKVLSKKYKVTDEEIDREIERI
KEAYGTQYDLAVQQNGEKVIREMIKLDLLRAKAAIEDIKVTDKELKEYYDNYKPKVRASHILVEDEKTAKEVKAKLDKGE
DFAKLAKEYSQDPGSASNGGDLGWFGAGKMVKEFEEAAYKLKVGEVSDPIKTDYGYHIIKVTDKEKKKTFDKMKEEITFE
VKRSKLDPSTMQSKVDKLVKDANVKIKDKDLQDVLEQQ
>Mature_278_residues
MKKWMMATAVVSLMALSACNNGDSEAVVETKNGAITKDEFYNEMKERVGKTVLRDLIDEKVLSKKYKVTDEEIDREIERI
KEAYGTQYDLAVQQNGEKVIREMIKLDLLRAKAAIEDIKVTDKELKEYYDNYKPKVRASHILVEDEKTAKEVKAKLDKGE
DFAKLAKEYSQDPGSASNGGDLGWFGAGKMVKEFEEAAYKLKVGEVSDPIKTDYGYHIIKVTDKEKKKTFDKMKEEITFE
VKRSKLDPSTMQSKVDKLVKDANVKIKDKDLQDVLEQQ

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=95, Percent_Identity=41.0526315789474, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1786645, Length=197, Percent_Identity=35.0253807106599, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1790211, Length=84, Percent_Identity=46.4285714285714, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1786238, Length=98, Percent_Identity=37.7551020408163, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17537235, Length=95, Percent_Identity=41.0526315789474, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322478, Length=103, Percent_Identity=42.7184466019417, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356303, Length=95, Percent_Identity=42.1052631578947, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF05698 Trigger_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 31743; Mature: 31743

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKWMMATAVVSLMALSACNNGDSEAVVETKNGAITKDEFYNEMKERVGKTVLRDLIDEK
CCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLSKKYKVTDEEIDREIERIKEAYGTQYDLAVQQNGEKVIREMIKLDLLRAKAAIEDIKV
HHHHHHCCCHHHHHHHHHHHHHHHCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
TDKELKEYYDNYKPKVRASHILVEDEKTAKEVKAKLDKGEDFAKLAKEYSQDPGSASNGG
CHHHHHHHHHCCCCCEEHHEEEEECHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCC
DLGWFGAGKMVKEFEEAAYKLKVGEVSDPIKTDYGYHIIKVTDKEKKKTFDKMKEEITFE
CCCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHH
VKRSKLDPSTMQSKVDKLVKDANVKIKDKDLQDVLEQQ
HHHHCCCHHHHHHHHHHHHHHCCCEEECCHHHHHHHCC
>Mature Secondary Structure
MKKWMMATAVVSLMALSACNNGDSEAVVETKNGAITKDEFYNEMKERVGKTVLRDLIDEK
CCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLSKKYKVTDEEIDREIERIKEAYGTQYDLAVQQNGEKVIREMIKLDLLRAKAAIEDIKV
HHHHHHCCCHHHHHHHHHHHHHHHCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
TDKELKEYYDNYKPKVRASHILVEDEKTAKEVKAKLDKGEDFAKLAKEYSQDPGSASNGG
CHHHHHHHHHCCCCCEEHHEEEEECHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCC
DLGWFGAGKMVKEFEEAAYKLKVGEVSDPIKTDYGYHIIKVTDKEKKKTFDKMKEEITFE
CCCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHH
VKRSKLDPSTMQSKVDKLVKDANVKIKDKDLQDVLEQQ
HHHHCCCHHHHHHHHHHHHHHCCCEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA